GB1018807A - Novel tetrahydro-pyridine derivatives and the manufacture thereof - Google Patents
Novel tetrahydro-pyridine derivatives and the manufacture thereofInfo
- Publication number
- GB1018807A GB1018807A GB2729064A GB2729064A GB1018807A GB 1018807 A GB1018807 A GB 1018807A GB 2729064 A GB2729064 A GB 2729064A GB 2729064 A GB2729064 A GB 2729064A GB 1018807 A GB1018807 A GB 1018807A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- alkyl
- groups
- phenylalkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of formula <FORM:1018807/C2/1> wherein R1, R2, R3 and R4 are hydrogen or halogen atoms or alkyl, alkoxy, trifluoromethyl, nitro or phenylalkylamino groups, R5 is an alkyl or phenylalkyl group and R6 is an alkyl, phenylalkyl or cycloalkyl group, alkyl moieties having 1 to 7 carbon atoms, non-toxic acid addition salts thereof, and their preparation by reaction of a compound of formula <FORM:1018807/C2/2> or of formula <FORM:1018807/C2/3> with a compound of formula <FORM:1018807/C2/4> in the presence of either sulphuric acid or a mixture of phosphorus pentoxide and orthophosphoric acid and, if desired, reducing any nitro group or groups in the product and converting the resulting amino group or groups into N-phenylalkyl derivatives, for example by reaction with benzaldehyde and reduction. The compounds of the invention have analgesic, antirheumatic, antipyretic and psychostimulant activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral, parenteral or rectal administration, such as tablets, capsules, dragees, granules, ampoules, solutions, suspensions, emulsions or suppositories.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US292768A US3282949A (en) | 1963-07-03 | 1963-07-03 | Substituted lower fatty acid amides and processes |
| US292749A US3270026A (en) | 1963-07-03 | 1963-07-03 | Substituted benzamidotetrahydro-pyridines and processes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1018807A true GB1018807A (en) | 1966-02-02 |
Family
ID=26967538
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2729164A Expired GB1025044A (en) | 1963-07-03 | 1964-07-02 | N-substituted amides and the manufacture thereof |
| GB2729064A Expired GB1018807A (en) | 1963-07-03 | 1964-07-02 | Novel tetrahydro-pyridine derivatives and the manufacture thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2729164A Expired GB1025044A (en) | 1963-07-03 | 1964-07-02 | N-substituted amides and the manufacture thereof |
Country Status (2)
| Country | Link |
|---|---|
| GB (2) | GB1025044A (en) |
| NL (1) | NL6407463A (en) |
-
1964
- 1964-07-01 NL NL6407463A patent/NL6407463A/xx unknown
- 1964-07-02 GB GB2729164A patent/GB1025044A/en not_active Expired
- 1964-07-02 GB GB2729064A patent/GB1018807A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1025044A (en) | 1966-04-06 |
| NL6407463A (en) | 1965-01-04 |
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