GB1025044A - N-substituted amides and the manufacture thereof - Google Patents

N-substituted amides and the manufacture thereof

Info

Publication number
GB1025044A
GB1025044A GB2729164A GB2729164A GB1025044A GB 1025044 A GB1025044 A GB 1025044A GB 2729164 A GB2729164 A GB 2729164A GB 2729164 A GB2729164 A GB 2729164A GB 1025044 A GB1025044 A GB 1025044A
Authority
GB
United Kingdom
Prior art keywords
group
amino
formula
alkoxy
benzylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2729164A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US292768A external-priority patent/US3282949A/en
Priority claimed from US292749A external-priority patent/US3270026A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1025044A publication Critical patent/GB1025044A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of formula <FORM:1025044/C2/1> wherein R1 is a hydrogen or halogen atom or a nitro, amino, C1- 7 alkylamino, di-(C1- 7 alkyl)-amino, benzylamino, halobenzylamino, or (C1- 7 alkoxy)-benzylamino group, or a group R5CH=N-, wherein R5 is a halophenyl or (C1- 7 alkoxy)-phenyl group, R2 and R3 are C1- 7 alkyl groups, and n is 1, 2 or 3, pharmaceutically acceptable acid addition salts thereof, and their preparation by reaction of a compound of formula <FORM:1025044/C2/2> with a compound of the formula <FORM:1025044/C2/3> wherein R10 has one of the values of R1 other than an amino or substituted imino group, and, if desired, reducing a nitro group to an amino group and converting this to a substituted amino-group R1, for example by conversion to a Schiff's base, followed by reduction. The compounds of the invention, other than where R1 is a substituted imino-group, have hypotensive and analgesic activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral, parenteral or rectal administration, such as tablets, capsules, dragees, ampoules, solutions, emulsions, suspensions and suppositories.
GB2729164A 1963-07-03 1964-07-02 N-substituted amides and the manufacture thereof Expired GB1025044A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US292768A US3282949A (en) 1963-07-03 1963-07-03 Substituted lower fatty acid amides and processes
US292749A US3270026A (en) 1963-07-03 1963-07-03 Substituted benzamidotetrahydro-pyridines and processes

Publications (1)

Publication Number Publication Date
GB1025044A true GB1025044A (en) 1966-04-06

Family

ID=26967538

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2729064A Expired GB1018807A (en) 1963-07-03 1964-07-02 Novel tetrahydro-pyridine derivatives and the manufacture thereof
GB2729164A Expired GB1025044A (en) 1963-07-03 1964-07-02 N-substituted amides and the manufacture thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2729064A Expired GB1018807A (en) 1963-07-03 1964-07-02 Novel tetrahydro-pyridine derivatives and the manufacture thereof

Country Status (2)

Country Link
GB (2) GB1018807A (en)
NL (1) NL6407463A (en)

Also Published As

Publication number Publication date
NL6407463A (en) 1965-01-04
GB1018807A (en) 1966-02-02

Similar Documents

Publication Publication Date Title
GB1046506A (en) Guanidine compounds and process for their manufacture
GB964143A (en) Substituted quinolines
GB1025044A (en) N-substituted amides and the manufacture thereof
GB1017433A (en) New substituted coumarins and process for the preparation thereof
ES266788A1 (en) New derivatives of dialkyl xanthines and the preparation thereof
GB1167711A (en) Diarylcyclopropane Derivatives
ES295039A1 (en) 10-(basic substituted)-dibenz[b, f][1, 4] oxazepinones
GB1144935A (en) Anthrol derivatives and the preparation thereof
GB1023203A (en) Propylamine derivatives
GB1036278A (en) Piperidine derivatives
GB1042893A (en) Anilides
GB1015618A (en) Glutarimide therapeutic compositions
GB1056045A (en) 5-aminoalkyl dibenzodiazepines
GB1087840A (en) 2,4,6-triiodoisophthalic acid derivatives and preparation thereof
GB1032880A (en) Novel benzamide derivatives and a process for the manufacture thereof
GB1011039A (en) Improvements in or relating to propynylamides
GB1006156A (en) 6-basic substituted morphanthridines
ES253914A1 (en) 2, 4-diaminoquinazolines and their preparation
ES270687A1 (en) Morpholinones
ES368607A1 (en) 1-substituted-2 5-diphenylpyrroles
GB1004927A (en) Improvements in or relating to amino-ketones, their preparation and compositions containing them
ES267045A1 (en) New dialkyl xanthine derivatives and the preparation thereof
GB1041693A (en) Ethers of dibenzocyclohepten-10-ols
GB1007621A (en) Novel isoquinoline derivatives and a process for the manufacture thereof
GB1015026A (en) New derivatives of 2-oxazolidinone and the preparation thereof