ES267045A1 - New dialkyl xanthine derivatives and the preparation thereof - Google Patents
New dialkyl xanthine derivatives and the preparation thereofInfo
- Publication number
- ES267045A1 ES267045A1 ES0267045A ES267045A ES267045A1 ES 267045 A1 ES267045 A1 ES 267045A1 ES 0267045 A ES0267045 A ES 0267045A ES 267045 A ES267045 A ES 267045A ES 267045 A1 ES267045 A1 ES 267045A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- reacted
- solutions
- compounds
- appropriate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of general formula: <FORM:0947496/C2/1> in which R1 and R2 represent alkyl radicals, X represents an alkylene radical, R3 and R3 represent hydrogen atoms or aralkyl (e.g. furfuryl) alkyl or alkenyl groups, or R3 is hydrogen and R4 is a cycloalkyl, dialkylaminoalkyl, alkoxyalkyl or heterocyclic radical, or R3 and R4 together form a heterocyclic ring which may be substituted and their acid addition salts and processes for the preparation thereof wherein (1) an appropriate 7-haloalkylxanthine is reacted with a compound HNR3R4, or (2) an appropriate 7-unsubstituted xanthine is reacted with a compound Hal.X.NR3R4, Hal being a halogen atom. Pharmaceutical compositions comprise an acceptable carrier or diluent together with the above compounds. Forms suitable for oral (tablets, capsules, solutions, suspensions), parenteral (solutions) and rectal (suppositories) administration are mentioned. The compounds stimulate the central nervous system, and have spasmolytic action on smooth muscles and a positive inotropic action on the heart. Specification 947,494 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB15617/60A GB947496A (en) | 1960-05-03 | 1960-05-03 | New dialkyl xanthine derivatives and the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES267045A1 true ES267045A1 (en) | 1961-12-01 |
Family
ID=10062377
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0267045A Expired ES267045A1 (en) | 1960-05-03 | 1961-05-02 | New dialkyl xanthine derivatives and the preparation thereof |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE603114A (en) |
DE (1) | DE1246744B (en) |
ES (1) | ES267045A1 (en) |
FR (1) | FR1357M (en) |
GB (1) | GB947496A (en) |
LU (1) | LU40076A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0011399A1 (en) * | 1978-11-11 | 1980-05-28 | FISONS plc | N-substituted theophyllines, processes for their preparation and pharmaceutical compositions containing them |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1011424B (en) * | 1954-04-17 | 1957-07-04 | Chemiewerk Homburg Ag | Process for the preparation of basic substituted 7-alkyl-xanthine derivatives or their salts |
US2887486A (en) * | 1956-10-29 | 1959-05-19 | S E Massengill Company | Theophylline derivatives |
-
1960
- 1960-05-03 GB GB15617/60A patent/GB947496A/en not_active Expired
-
1961
- 1961-04-27 BE BE603114A patent/BE603114A/en unknown
- 1961-04-28 FR FR860289A patent/FR1357M/en not_active Expired
- 1961-04-29 DE DEM48899A patent/DE1246744B/en active Pending
- 1961-04-29 LU LU40076A patent/LU40076A1/xx unknown
- 1961-05-02 ES ES0267045A patent/ES267045A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
LU40076A1 (en) | 1961-10-30 |
DE1246744B (en) | 1967-08-10 |
BE603114A (en) | 1961-10-27 |
GB947496A (en) | 1964-01-22 |
FR1357M (en) | 1962-06-18 |
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