GB1002344A - Substituted triiodobenzoic acids - Google Patents
Substituted triiodobenzoic acidsInfo
- Publication number
- GB1002344A GB1002344A GB39021/63A GB3902163A GB1002344A GB 1002344 A GB1002344 A GB 1002344A GB 39021/63 A GB39021/63 A GB 39021/63A GB 3902163 A GB3902163 A GB 3902163A GB 1002344 A GB1002344 A GB 1002344A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- nitro
- acylation
- benzoic acid
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 6
- 150000007513 acids Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000010933 acylation Effects 0.000 abstract 4
- 238000005917 acylation reaction Methods 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- -1 aliphatic alcohols Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- JBJLEUTWAFDYOV-UHFFFAOYSA-N 3-amino-5-(aminomethyl)-2,4,6-triiodobenzoic acid Chemical compound NCC=1C(=C(C(=O)O)C(=C(C1I)N)I)I JBJLEUTWAFDYOV-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- LZHUTAUPAKOTFY-UHFFFAOYSA-N CCO[Mg].CCOC(=O)CC(=O)OCC Chemical compound CCO[Mg].CCOC(=O)CC(=O)OCC LZHUTAUPAKOTFY-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 229940039231 contrast media Drugs 0.000 abstract 1
- 230000020176 deacylation Effects 0.000 abstract 1
- 238000005947 deacylation reaction Methods 0.000 abstract 1
- YYVRCXIYWUPSMW-UHFFFAOYSA-N diethyl 2-(3-methoxycarbonyl-5-nitrobenzoyl)propanedioate Chemical compound CCOC(=O)C(C(=O)OCC)C(=O)C1=CC(C(=O)OC)=CC([N+]([O-])=O)=C1 YYVRCXIYWUPSMW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- XMYQHJDBLRZMLW-UHFFFAOYSA-N methanolamine Chemical compound NCO XMYQHJDBLRZMLW-UHFFFAOYSA-N 0.000 abstract 1
- DQTOZIJNMYYCJE-UHFFFAOYSA-N methyl 3-carbonochloridoyl-5-nitrobenzoate Chemical compound COC(=O)C1=CC(C(Cl)=O)=CC([N+]([O-])=O)=C1 DQTOZIJNMYYCJE-UHFFFAOYSA-N 0.000 abstract 1
- 230000000802 nitrating effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1378862A CH414063A (de) | 1962-11-23 | 1962-11-23 | Röntgenkontrastmittel |
| CH985763A CH435563A (de) | 1962-11-23 | 1963-08-09 | Röntgenkontrastmittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1002344A true GB1002344A (en) | 1965-08-25 |
Family
ID=25705437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB39021/63A Expired GB1002344A (en) | 1962-11-23 | 1963-10-03 | Substituted triiodobenzoic acids |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT249263B (cs) |
| BE (1) | BE640222A (cs) |
| BR (1) | BR6354529D0 (cs) |
| CH (1) | CH435563A (cs) |
| DE (1) | DE1273747B (cs) |
| DK (1) | DK107965C (cs) |
| ES (1) | ES293218A1 (cs) |
| FI (1) | FI42984C (cs) |
| FR (1) | FR3449M (cs) |
| GB (1) | GB1002344A (cs) |
| NL (2) | NL130868C (cs) |
| SE (2) | SE316870B (cs) |
-
1963
- 1963-08-09 CH CH985763A patent/CH435563A/de unknown
- 1963-09-24 DE DEE25581A patent/DE1273747B/de active Pending
- 1963-10-03 GB GB39021/63A patent/GB1002344A/en not_active Expired
- 1963-11-05 ES ES293218A patent/ES293218A1/es not_active Expired
- 1963-11-13 BR BR154529/63A patent/BR6354529D0/pt unknown
- 1963-11-18 AT AT922963A patent/AT249263B/de active
- 1963-11-20 BE BE640222A patent/BE640222A/xx unknown
- 1963-11-21 FR FR954579A patent/FR3449M/fr not_active Expired
- 1963-11-21 SE SE12875/63A patent/SE316870B/xx unknown
- 1963-11-22 FI FI632280A patent/FI42984C/fi active
- 1963-11-22 NL NL300867A patent/NL130868C/xx active
- 1963-11-22 DK DK548263AA patent/DK107965C/da active
- 1963-11-22 NL NL300867D patent/NL300867A/xx unknown
-
1966
- 1966-08-08 SE SE10725/66A patent/SE327193B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE327193B (cs) | 1970-08-17 |
| DE1273747B (de) | 1968-07-25 |
| FI42984B (cs) | 1970-09-02 |
| BE640222A (cs) | 1964-05-20 |
| SE316870B (cs) | 1969-11-03 |
| DK107965C (da) | 1967-07-24 |
| AT249263B (de) | 1966-09-12 |
| CH435563A (de) | 1967-05-15 |
| BR6354529D0 (pt) | 1973-02-22 |
| ES293218A1 (es) | 1964-01-16 |
| FR3449M (fr) | 1965-07-26 |
| NL130868C (cs) | 1971-03-15 |
| NL300867A (cs) | 1965-09-27 |
| FI42984C (fi) | 1970-12-10 |
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