GB961697A - Improvements in or relating to furostene derivatives and the intermediates thereof and processes for making them - Google Patents

Improvements in or relating to furostene derivatives and the intermediates thereof and processes for making them

Info

Publication number
GB961697A
GB961697A GB1640063A GB1640063A GB961697A GB 961697 A GB961697 A GB 961697A GB 1640063 A GB1640063 A GB 1640063A GB 1640063 A GB1640063 A GB 1640063A GB 961697 A GB961697 A GB 961697A
Authority
GB
United Kingdom
Prior art keywords
acid
give
furostene
furostan
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1640063A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB961697A publication Critical patent/GB961697A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Abstract

The invention comprises (1) 3b -hydroxy-5a , 22b -spirostan-16a -acetic acid and the methyl esters of this compound and the 3b -acetate thereof; (2) furostenes of the formula: <FORM:0961697/C1/1> wherein R and R111 are hydrogen atoms or acyl group of at most 10 carbon atoms and R11 is a hydrogen atom or an alkyl group of at most 10 carbon atoms; and (3) a process for the preparation of the above named compounds in which a 5, 6-dihydrokryptogenin-3, 26-diacylate is reacted with a haloacetic acid alkyl ester in the presence of zinc, the resulting addition product is hydrolysed with dilute acid to give a furostan of the general formula given above but containing no 20(22)-double bond, this furostan is treated with alkali and then mineral acid to give a compound as in (1) or a similarly acylate or alkyl ester, and this is heated with an acid anhydride in the presence of pyridine hydrochloride or a Lewis acid to give a furostene of the above general formula. The esters, free acids and free alcohols of this process may be interconverted by conventional procedures. Detailed examples are given.
GB1640063A 1960-12-19 1961-12-19 Improvements in or relating to furostene derivatives and the intermediates thereof and processes for making them Expired GB961697A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5011660 1960-12-19

Publications (1)

Publication Number Publication Date
GB961697A true GB961697A (en) 1964-06-24

Family

ID=12850121

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1640063A Expired GB961697A (en) 1960-12-19 1961-12-19 Improvements in or relating to furostene derivatives and the intermediates thereof and processes for making them
GB3967863A Expired GB961698A (en) 1960-12-19 1961-12-19 Pregnen-acetic acid and preparation thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB3967863A Expired GB961698A (en) 1960-12-19 1961-12-19 Pregnen-acetic acid and preparation thereof

Country Status (1)

Country Link
GB (2) GB961697A (en)

Also Published As

Publication number Publication date
GB961698A (en) 1964-06-24

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