GB1055927A - 24-nor-5-ß-cholane steroids - Google Patents
24-nor-5-ß-cholane steroidsInfo
- Publication number
- GB1055927A GB1055927A GB3723866A GB3723866A GB1055927A GB 1055927 A GB1055927 A GB 1055927A GB 3723866 A GB3723866 A GB 3723866A GB 3723866 A GB3723866 A GB 3723866A GB 1055927 A GB1055927 A GB 1055927A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- carboxy
- oic
- general formula
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel 24-nor-5b -cholane steroids of the general formula <FORM:1055927/C2/1> in which R represents a hydrogen atom or the acyl radical of a carboxylic acid, Z is the oxygen atom of a keto group, or a hydroxy group and a hydrogen atom, or two hydrogen atoms and R1 represents any one of the groups <FORM:1055927/C2/2> (where R2 is an alkyl residue) are obtained by treating a compound of the general formula <FORM:1055927/C2/3> (wherein Y represents =O or two hydrogen atoms and R3 is an iodine atom or the mesyloxy group) with an alkali metal cyanide to form the corresponding 21,22-dicyano compound which may be hydrolysed to form the corresponding 21-carboxy-23-oic compound. The 21,22-diacid ester may be obtained by subjecting a 20-carboxy-21-oic acid to the action of a chlorinating agent to form the corresponding 21,21-di-(acid chloride) which is condensed with diazomethane to form the corresponding bisdiazo derivative and the latter reacted with an alcohol R2OH. Hydrolysis of the diacid ester yields the corresponding 21-carboxy-23-oic acid compound. missing page 176
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR926732A FR1453206A (en) | 1963-03-04 | 1963-03-04 | Diamino steroids and method of preparation |
FR933956A FR2810M (en) | 1963-03-04 | 1963-05-07 | New drug in particular for the treatment of spasms of coronary or visceral origin. |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1055927A true GB1055927A (en) | 1967-01-18 |
Family
ID=26200070
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB921064A Expired GB1055926A (en) | 1963-03-04 | 1964-03-04 | A novel class of steroid compounds |
GB3723866A Expired GB1055927A (en) | 1963-03-04 | 1964-03-04 | 24-nor-5-ß-cholane steroids |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB921064A Expired GB1055926A (en) | 1963-03-04 | 1964-03-04 | A novel class of steroid compounds |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH429719A (en) |
DK (1) | DK115471B (en) |
GB (2) | GB1055926A (en) |
-
1964
- 1964-02-18 CH CH195964A patent/CH429719A/en unknown
- 1964-03-02 DK DK103364A patent/DK115471B/en unknown
- 1964-03-04 GB GB921064A patent/GB1055926A/en not_active Expired
- 1964-03-04 GB GB3723866A patent/GB1055927A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB1055926A (en) | 1967-01-18 |
DK115471B (en) | 1969-10-13 |
CH429719A (en) | 1967-02-15 |
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