GB1002341A - Isoxazole derivatives of sulfanilamide and their preparation - Google Patents

Isoxazole derivatives of sulfanilamide and their preparation

Info

Publication number
GB1002341A
GB1002341A GB2773/63A GB277363A GB1002341A GB 1002341 A GB1002341 A GB 1002341A GB 2773/63 A GB2773/63 A GB 2773/63A GB 277363 A GB277363 A GB 277363A GB 1002341 A GB1002341 A GB 1002341A
Authority
GB
United Kingdom
Prior art keywords
amino
group
preparation
substituent
convertible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2773/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB1002341A publication Critical patent/GB1002341A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles

Abstract

The invention comprises sulpha-isoxazole compounds of the formula <FORM:1002341/C2/1> wherein R is an alkyl group of 1-5 carbon atoms and X is chlorine, bromine, or iodine and their preparation by condensing a 3-amino-4-halogeno - 5 - alkylisoxazole with a para-substituted benzenesulphonic acid derivative Z.C6H4.SO2Y, wherein Y is a halogen atom or a hydroxyl, alkoxy, aryloxy or aralkoxy groups and Z is a group convertible to amino by hydrolysis or reduction and subsequently converting the p-substituent into an amino group. The substituent convertible to amino may suitably be an acylamino, e.g. acetylamino, aroylamino or aralkanoylamino, nitro or azo group, in which latter case the intermediate product may be a bis - isoxazolylsulphamoyl - azobenzene derivative. Pharmaceutical preparations having anti-bacterial activity comprise the above sulphanilamides and a carrier. The preparations may take forms suitable for oral and parenteral use such as tablets, powders, capsules, solutions, dispersions and suspensions. Specifications 814,276 and 1,002,342 are referred to.
GB2773/63A 1962-08-21 1963-01-22 Isoxazole derivatives of sulfanilamide and their preparation Expired GB1002341A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3603062 1962-08-21

Publications (1)

Publication Number Publication Date
GB1002341A true GB1002341A (en) 1965-08-25

Family

ID=12458301

Family Applications (2)

Application Number Title Priority Date Filing Date
GB26091/64A Expired GB1002342A (en) 1962-08-21 1963-01-22 3-amino-4-halogeno-5-alkylisoxazoles and their preparation
GB2773/63A Expired GB1002341A (en) 1962-08-21 1963-01-22 Isoxazole derivatives of sulfanilamide and their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB26091/64A Expired GB1002342A (en) 1962-08-21 1963-01-22 3-amino-4-halogeno-5-alkylisoxazoles and their preparation

Country Status (4)

Country Link
CH (1) CH431526A (en)
DE (1) DE1263771B (en)
FR (2) FR3357M (en)
GB (2) GB1002342A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2888455A (en) * 1956-09-04 1959-05-26 Shionogi & Co New sulfonamide and process for producing the same

Also Published As

Publication number Publication date
CH431526A (en) 1967-03-15
DE1263771B (en) 1968-03-21
GB1002342A (en) 1965-08-25
FR3357M (en) 1965-06-08
FR1387009A (en) 1965-01-29

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