GB1001093A - New derivatives of 2-amino-4h-5,6-dihydro-1,3-thiazine - Google Patents
New derivatives of 2-amino-4h-5,6-dihydro-1,3-thiazineInfo
- Publication number
- GB1001093A GB1001093A GB3818863A GB3818863A GB1001093A GB 1001093 A GB1001093 A GB 1001093A GB 3818863 A GB3818863 A GB 3818863A GB 3818863 A GB3818863 A GB 3818863A GB 1001093 A GB1001093 A GB 1001093A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenylated
- phenyl
- amino
- propyl
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of formula <FORM:1001093/C2/1> wherein R is a hydrogen atom or an acyl radical and R1 is a phenyl radical optionally substituted by one or more halogen atoms and/ or alkyl, hydroxy, alkoxy, nitro, amino and/or acylamino radicals, physiologically acceptable acid addition salts thereof, and their preparation by (a) reacting phenylated g -thiocyanopropylamines with a weak alkali, (b) reacting a phenylated N-t-butyl-N1-g -hydroxypropylthiourea, or a phenylated N-g -hydroxypropylthiourea, with an acid, (c) reacting a phenylated g - halopropylisothiocyanate or a phenylated 2 - mercapto- or 2 - alkylmercapto - 4H - 5,6-dihydro - 1,3 - thiazine with ammonia or an ammonia-yielding agent, (d) heating a phenylated g - aminopropylisothiourea ether hydrohalide, or (e) reacting a phenylated 1,3-dihalopropane with thiourea, and, if desired, acylating the product obtained. The compounds of the invention have circulation-stimulating activity. 3 - Chloro - 1 - phenyl - propyl - 1 - isothiocyanate is prepared by reaction of 3-chloro-1-phenyl -propyl-1-amine and thiophosgene. 1 - Phenyl - 1 - amino - propyl - 3 - isothiourea hydrobromide is prepared by reaction of 3-amino-3-phenyl-propyl-1-bromide and thiourea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF37926A DE1176148B (en) | 1962-09-29 | 1962-09-29 | Process for the preparation of new derivatives of 2-amino-4H-5, 6-dihydro-1, 3-thiazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1001093A true GB1001093A (en) | 1965-08-11 |
Family
ID=7097125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3818863A Expired GB1001093A (en) | 1962-09-29 | 1963-09-27 | New derivatives of 2-amino-4h-5,6-dihydro-1,3-thiazine |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT251594B (en) |
| BE (1) | BE637923A (en) |
| CH (1) | CH484184A (en) |
| DE (1) | DE1176148B (en) |
| DK (1) | DK113365B (en) |
| GB (1) | GB1001093A (en) |
| SE (1) | SE322514B (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2296240A (en) * | 1994-12-14 | 1996-06-26 | Japan Tobacco Inc | Thiazine- or thiazepine-derivatives |
| US8168630B2 (en) | 2007-04-24 | 2012-05-01 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
| US8173642B2 (en) | 2005-10-25 | 2012-05-08 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives |
| US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
| US8653067B2 (en) | 2007-04-24 | 2014-02-18 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating Alzheimer's disease |
| US8703785B2 (en) | 2008-10-22 | 2014-04-22 | Shionogi & Co., Ltd. | 2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity |
| US8883779B2 (en) | 2011-04-26 | 2014-11-11 | Shinogi & Co., Ltd. | Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them |
| US8927721B2 (en) | 2010-10-29 | 2015-01-06 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| US8999980B2 (en) | 2009-12-11 | 2015-04-07 | Shionogi & Co., Ltd. | Oxazine derivatives |
| US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
| US9540359B2 (en) | 2012-10-24 | 2017-01-10 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1277486B1 (en) * | 1994-12-14 | 1997-11-10 | Japan Tobacco Inc | Derivatives of thiazine or thiazepine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE928710C (en) * | 1953-04-03 | 1955-06-10 | Alfons Dr Schoeberl | Process for the preparation of 2-aminopenthiazoline or its salts |
-
0
- BE BE637923D patent/BE637923A/xx unknown
-
1962
- 1962-09-29 DE DEF37926A patent/DE1176148B/en active Pending
-
1963
- 1963-09-19 CH CH1158063A patent/CH484184A/en not_active IP Right Cessation
- 1963-09-25 DK DK452363A patent/DK113365B/en unknown
- 1963-09-27 AT AT778163A patent/AT251594B/en active
- 1963-09-27 SE SE1062863A patent/SE322514B/xx unknown
- 1963-09-27 GB GB3818863A patent/GB1001093A/en not_active Expired
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2296240A (en) * | 1994-12-14 | 1996-06-26 | Japan Tobacco Inc | Thiazine- or thiazepine-derivatives |
| US8815851B2 (en) | 2005-10-25 | 2014-08-26 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives |
| US9029358B2 (en) | 2005-10-25 | 2015-05-12 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives |
| US8173642B2 (en) | 2005-10-25 | 2012-05-08 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives |
| US8546380B2 (en) | 2005-10-25 | 2013-10-01 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives |
| US8633188B2 (en) | 2005-10-25 | 2014-01-21 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives |
| US8895548B2 (en) | 2007-04-24 | 2014-11-25 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating alzheimer's disease |
| US8653067B2 (en) | 2007-04-24 | 2014-02-18 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating Alzheimer's disease |
| US8884062B2 (en) | 2007-04-24 | 2014-11-11 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
| US8541408B2 (en) | 2007-04-24 | 2013-09-24 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
| US8168630B2 (en) | 2007-04-24 | 2012-05-01 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
| US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
| US9650371B2 (en) | 2008-06-13 | 2017-05-16 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
| US9273053B2 (en) | 2008-06-13 | 2016-03-01 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having Beta secretase inhibitory activity |
| US8703785B2 (en) | 2008-10-22 | 2014-04-22 | Shionogi & Co., Ltd. | 2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity |
| US9656974B2 (en) | 2009-12-11 | 2017-05-23 | Shionogi & Co., Ltd. | Oxazine derivatives |
| US9290466B2 (en) | 2009-12-11 | 2016-03-22 | Shionogi & Co., Ltd. | Oxazine derivatives |
| US8999980B2 (en) | 2009-12-11 | 2015-04-07 | Shionogi & Co., Ltd. | Oxazine derivatives |
| US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
| US8927721B2 (en) | 2010-10-29 | 2015-01-06 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| US8883779B2 (en) | 2011-04-26 | 2014-11-11 | Shinogi & Co., Ltd. | Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them |
| US9540359B2 (en) | 2012-10-24 | 2017-01-10 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
| US9758513B2 (en) | 2012-10-24 | 2017-09-12 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
Also Published As
| Publication number | Publication date |
|---|---|
| AT251594B (en) | 1967-01-10 |
| DE1176148B (en) | 1964-08-20 |
| SE322514B (en) | 1970-04-13 |
| DK113365B (en) | 1969-03-17 |
| CH484184A (en) | 1970-01-15 |
| BE637923A (en) |
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