GB0905328D0 - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number
GB0905328D0
GB0905328D0 GBGB0905328.1A GB0905328A GB0905328D0 GB 0905328 D0 GB0905328 D0 GB 0905328D0 GB 0905328 A GB0905328 A GB 0905328A GB 0905328 D0 GB0905328 D0 GB 0905328D0
Authority
GB
United Kingdom
Prior art keywords
indole derivatives
indole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0905328.1A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Priority to GBGB0905328.1A priority Critical patent/GB0905328D0/en
Publication of GB0905328D0 publication Critical patent/GB0905328D0/en
Priority to MX2011010154A priority patent/MX2011010154A/es
Priority to HK12108073.9A priority patent/HK1167393B/xx
Priority to SG2011070018A priority patent/SG174589A1/en
Priority to EP10710356.6A priority patent/EP2411362B1/en
Priority to NZ595227A priority patent/NZ595227A/xx
Priority to JP2012501315A priority patent/JP5651163B2/ja
Priority to RU2011138850/04A priority patent/RU2525196C2/ru
Priority to ES10710356.6T priority patent/ES2635310T3/es
Priority to US13/258,465 priority patent/US8790619B2/en
Priority to KR1020117025305A priority patent/KR101692090B1/ko
Priority to PCT/EP2010/053998 priority patent/WO2010109007A2/en
Priority to AU2010227527A priority patent/AU2010227527B2/en
Priority to CN201080023868.3A priority patent/CN102448933B/zh
Priority to CA2756887A priority patent/CA2756887C/en
Priority to BRPI1010261A priority patent/BRPI1010261A2/pt
Priority to US12/880,218 priority patent/US8501153B2/en
Priority to IL215019A priority patent/IL215019A0/en
Priority to ZA2011/06708A priority patent/ZA201106708B/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GBGB0905328.1A 2009-03-27 2009-03-27 Indole derivatives Ceased GB0905328D0 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GBGB0905328.1A GB0905328D0 (en) 2009-03-27 2009-03-27 Indole derivatives
BRPI1010261A BRPI1010261A2 (pt) 2009-03-27 2010-03-26 agente e método de formação de imagem in vivo, composto precursos, métodos para a preparação de um composto precursor e do agente de formação de imagem in vivo, e para diagnostico de uma condição, kit, cassete,e , composição radiofarmaceutica.
ES10710356.6T ES2635310T3 (es) 2009-03-27 2010-03-26 Derivados tricíclicos de indol como ligandos PBR
KR1020117025305A KR101692090B1 (ko) 2009-03-27 2010-03-26 Ｐｂｒ 리간드로서의 트리시클릭 인돌 유도체
SG2011070018A SG174589A1 (en) 2009-03-27 2010-03-26 Tricyclic indole derivates as pbr ligands
EP10710356.6A EP2411362B1 (en) 2009-03-27 2010-03-26 Tricyclic indole derivatives as PBR ligands
NZ595227A NZ595227A (en) 2009-03-27 2010-03-26 Tricyclic indole derivates as pbr ligands
JP2012501315A JP5651163B2 (ja) 2009-03-27 2010-03-26 Ｐｂｒリガンドとしての三環系インドール誘導体
RU2011138850/04A RU2525196C2 (ru) 2009-03-27 2010-03-26 Трициклические индольные производные в качестве лигандов pbr
MX2011010154A MX2011010154A (es) 2009-03-27 2010-03-26 Derivados de indol triciclico como ligandos pbr.
US13/258,465 US8790619B2 (en) 2009-03-27 2010-03-26 Indole derivatives
HK12108073.9A HK1167393B (en) 2009-03-27 2010-03-26 Tricyclic indole derivates as pbr ligands
PCT/EP2010/053998 WO2010109007A2 (en) 2009-03-27 2010-03-26 Indole derivatives
AU2010227527A AU2010227527B2 (en) 2009-03-27 2010-03-26 Tricyclic indole derivates as PBR ligands
CN201080023868.3A CN102448933B (zh) 2009-03-27 2010-03-26 作为pbr配体的吲哚衍生物
CA2756887A CA2756887C (en) 2009-03-27 2010-03-26 Indole derivatives
US12/880,218 US8501153B2 (en) 2009-03-27 2010-09-13 Active enantiomer
IL215019A IL215019A0 (en) 2009-03-27 2011-09-07 Tricyclic indole derivates as pbr ligands
ZA2011/06708A ZA201106708B (en) 2009-03-27 2011-09-13 Tricyclic indole derivatives as pbr ligands

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0905328.1A GB0905328D0 (en) 2009-03-27 2009-03-27 Indole derivatives

Publications (1)

Publication Number Publication Date
GB0905328D0 true GB0905328D0 (en) 2009-05-13

Family

ID=40671850

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0905328.1A Ceased GB0905328D0 (en) 2009-03-27 2009-03-27 Indole derivatives

Country Status (17)

Country Link
US (2) US8790619B2 (enExample)
EP (1) EP2411362B1 (enExample)
JP (1) JP5651163B2 (enExample)
KR (1) KR101692090B1 (enExample)
CN (1) CN102448933B (enExample)
AU (1) AU2010227527B2 (enExample)
BR (1) BRPI1010261A2 (enExample)
CA (1) CA2756887C (enExample)
ES (1) ES2635310T3 (enExample)
GB (1) GB0905328D0 (enExample)
IL (1) IL215019A0 (enExample)
MX (1) MX2011010154A (enExample)
NZ (1) NZ595227A (enExample)
RU (1) RU2525196C2 (enExample)
SG (1) SG174589A1 (enExample)
WO (1) WO2010109007A2 (enExample)
ZA (1) ZA201106708B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0905328D0 (en) 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
EP2552891B1 (en) * 2010-03-26 2018-08-08 GE Healthcare Limited Tricyclic indole derivatives as pbr ligands
GB201016038D0 (en) * 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) * 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
GB201021263D0 (en) * 2010-12-15 2011-01-26 Ge Healthcare Ltd Solid phase extraction method
EP2694505B1 (en) * 2011-04-05 2022-04-27 Sloan-kettering Institute For Cancer Research Hsp90 inhibitors
EP2718464A1 (en) 2011-06-06 2014-04-16 Imperial Innovations Limited Methods to predict binding affinity of tspo imaging agents to tspo
ES2562656T3 (es) * 2011-09-30 2016-03-07 Ge Healthcare Limited Sistemas de calibración y normalización y métodos para sintetizadores radiofarmacéuticos
WO2014083163A1 (en) 2012-11-30 2014-06-05 Ge Healthcare Limited Zinc halide mediated cyclization process leading to tricyclic indoles
CN111362863A (zh) * 2012-11-30 2020-07-03 通用电气健康护理有限公司 三环吲哚衍生物的结晶方法
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
GB201316766D0 (en) * 2013-09-20 2013-11-06 Ge Healthcare Uk Ltd Macrophage Imaging
GB201316764D0 (en) * 2013-09-20 2013-11-06 Ge Healthcare Ltd Novel compounds
GB201316762D0 (en) * 2013-09-20 2013-11-06 Ge Healthcare Ltd Novel compounds
WO2016087653A1 (en) 2014-12-04 2016-06-09 Ge Healthcare Limited Method of removing acetaldehyde from radioactive pharmaceuticals
CN106748802B (zh) * 2016-12-26 2018-11-13 南京理工大学 一种制备含氟仲胺的方法
CN110997068B (zh) * 2017-05-24 2022-12-06 宾夕法尼亚大学董事会 用于成像和放射疗法的经放射标记的荧光parp抑制剂
US11200669B2 (en) * 2019-11-19 2021-12-14 Uih America, Inc. Systems and methods for determining plasma input function used in positron emission tomography imaging

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
FR2599740B1 (fr) * 1986-06-05 1988-08-12 Rhone Poulenc Sante Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant
US5270030A (en) * 1988-12-29 1993-12-14 Bio-Technology General Corp. Fibrin binding domain polypeptide and method of producing
EP1043991A4 (en) 1997-11-14 2005-02-02 Lilly Co Eli TREATMENT OF ALZHEIMER DISEASE
US6281355B1 (en) * 1997-12-03 2001-08-28 Taisho Pharmaceutical Co., Ltd. Nitrogen-containing tetracyclic compounds
JPH11228539A (ja) * 1997-12-03 1999-08-24 Taisho Pharmaceut Co Ltd 含窒素四環性化合物
MXPA01005905A (es) * 1998-12-11 2002-09-18 Univ Virginia Commonwealth Ligandos selectivos de receptores de 5-ht6.
FR2788776B1 (fr) 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
GB0115927D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
JP2005527464A (ja) 2001-08-09 2005-09-15 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体
ES2252497T3 (es) 2001-08-09 2006-05-16 Eli Lilly And Company Derivados ciclohept(b)indol como inhibidores de spla2.
GB0523506D0 (en) * 2005-11-18 2005-12-28 Hammersmith Imanet Ltd Novel in vivo imaging compounds
GB0905328D0 (en) 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives

Also Published As

Publication number Publication date
KR101692090B1 (ko) 2017-01-02
AU2010227527A1 (en) 2011-10-13
RU2011138850A (ru) 2013-05-10
US20110070161A1 (en) 2011-03-24
BRPI1010261A2 (pt) 2016-03-22
WO2010109007A3 (en) 2010-11-25
EP2411362A2 (en) 2012-02-01
JP2012521973A (ja) 2012-09-20
ZA201106708B (en) 2013-02-27
JP5651163B2 (ja) 2015-01-07
AU2010227527B2 (en) 2015-03-12
IL215019A0 (en) 2011-11-30
CN102448933B (zh) 2014-07-02
NZ595227A (en) 2013-11-29
RU2525196C2 (ru) 2014-08-10
US20120020884A1 (en) 2012-01-26
ES2635310T3 (es) 2017-10-03
CN102448933A (zh) 2012-05-09
US8501153B2 (en) 2013-08-06
HK1167393A1 (en) 2012-11-30
EP2411362B1 (en) 2017-05-31
WO2010109007A2 (en) 2010-09-30
US8790619B2 (en) 2014-07-29
SG174589A1 (en) 2011-10-28
CA2756887A1 (en) 2010-09-30
CA2756887C (en) 2018-06-19
KR20110133492A (ko) 2011-12-12
MX2011010154A (es) 2011-10-21

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)