GB0724051D0 - Mutant proteins and methods for producing them - Google Patents

Mutant proteins and methods for producing them

Info

Publication number
GB0724051D0
GB0724051D0 GBGB0724051.8A GB0724051A GB0724051D0 GB 0724051 D0 GB0724051 D0 GB 0724051D0 GB 0724051 A GB0724051 A GB 0724051A GB 0724051 D0 GB0724051 D0 GB 0724051D0
Authority
GB
United Kingdom
Prior art keywords
producing
methods
mutant proteins
mutant
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0724051.8A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council filed Critical Medical Research Council
Priority to GBGB0724051.8A priority Critical patent/GB0724051D0/en
Publication of GB0724051D0 publication Critical patent/GB0724051D0/en
Priority to JP2010536531A priority patent/JP2011505800A/ja
Priority to DK08856833.2T priority patent/DK2220229T3/da
Priority to AU2008332896A priority patent/AU2008332896B2/en
Priority to US12/746,674 priority patent/US8748182B2/en
Priority to GB1000387.9A priority patent/GB2467830B/en
Priority to ES12196192T priority patent/ES2972473T3/es
Priority to PL12196192.4T priority patent/PL2568045T3/pl
Priority to CA2708037A priority patent/CA2708037C/en
Priority to EP12196192.4A priority patent/EP2568045B1/en
Priority to PCT/GB2008/004032 priority patent/WO2009071914A2/en
Priority to EP08856833.2A priority patent/EP2220229B1/en
Priority to JP2015032798A priority patent/JP6567291B2/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Ecology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
GBGB0724051.8A 2007-12-08 2007-12-08 Mutant proteins and methods for producing them Ceased GB0724051D0 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GBGB0724051.8A GB0724051D0 (en) 2007-12-08 2007-12-08 Mutant proteins and methods for producing them
EP08856833.2A EP2220229B1 (en) 2007-12-08 2008-12-08 Mutant g-protein coupled receptors and methods for selecting them
ES12196192T ES2972473T3 (es) 2007-12-08 2008-12-08 Receptores acoplados a proteína G mutantes y métodos para elaborarlos
DK08856833.2T DK2220229T3 (da) 2007-12-08 2008-12-08 Mutant g-protein coupled receptors and methods for selecting them
AU2008332896A AU2008332896B2 (en) 2007-12-08 2008-12-08 Mutant proteins and methods for producing them
US12/746,674 US8748182B2 (en) 2007-12-08 2008-12-08 Mutant proteins and methods for producing them
GB1000387.9A GB2467830B (en) 2007-12-08 2008-12-08 Mutant proteins and methods for producing them
JP2010536531A JP2011505800A (ja) 2007-12-08 2008-12-08 変異体タンパク質とその製造方法
PL12196192.4T PL2568045T3 (pl) 2007-12-08 2008-12-08 Zmutowane receptory sprzężone z białkiem g i sposoby ich wytwarzania
CA2708037A CA2708037C (en) 2007-12-08 2008-12-08 Mutant g-protein coupled receptors with increased conformational stability and methods for producing them
EP12196192.4A EP2568045B1 (en) 2007-12-08 2008-12-08 Mutant g-protein coupled receptors and methods for making them
PCT/GB2008/004032 WO2009071914A2 (en) 2007-12-08 2008-12-08 Mutant proteins and methods for producing them
JP2015032798A JP6567291B2 (ja) 2007-12-08 2015-02-23 変異体タンパク質とその製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0724051.8A GB0724051D0 (en) 2007-12-08 2007-12-08 Mutant proteins and methods for producing them

Publications (1)

Publication Number Publication Date
GB0724051D0 true GB0724051D0 (en) 2008-01-16

Family

ID=38983182

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB0724051.8A Ceased GB0724051D0 (en) 2007-12-08 2007-12-08 Mutant proteins and methods for producing them
GB1000387.9A Active GB2467830B (en) 2007-12-08 2008-12-08 Mutant proteins and methods for producing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1000387.9A Active GB2467830B (en) 2007-12-08 2008-12-08 Mutant proteins and methods for producing them

Country Status (10)

Country Link
US (1) US8748182B2 (enExample)
EP (2) EP2220229B1 (enExample)
JP (2) JP2011505800A (enExample)
AU (1) AU2008332896B2 (enExample)
CA (1) CA2708037C (enExample)
DK (1) DK2220229T3 (enExample)
ES (1) ES2972473T3 (enExample)
GB (2) GB0724051D0 (enExample)
PL (1) PL2568045T3 (enExample)
WO (1) WO2009071914A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20120336T1 (hr) 2007-03-22 2012-05-31 Heptares Therapeutics Limited Receptori vezani na mutacije g-proteina i metode njihovog odabira
GB0724051D0 (en) 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
GB0802474D0 (en) 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
US20110112037A1 (en) * 2008-03-05 2011-05-12 Heptares Therapeutics Limited BioPark Crystal structure
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
WO2012022928A2 (en) * 2010-08-20 2012-02-23 Heptares Therapeutic Ltd Biological materials and uses thereof
US20140031525A1 (en) 2011-01-21 2014-01-30 Heptares Therapeutics Limited Mutant g-protein coupled receptor proteins and methods for producing them
JP6263773B2 (ja) 2011-02-23 2018-01-24 マサチューセッツ インスティテュート オブ テクノロジー 水溶性膜タンパク質およびその調製および使用方法
WO2012120315A2 (en) 2011-03-10 2012-09-13 Heptares Therapeutics Limited Mutant proteins and methods for producing them
WO2013021206A2 (en) 2011-08-10 2013-02-14 Heptares Therapeutics Limited Stable proteins
US10458993B2 (en) 2012-06-01 2019-10-29 Heptares Therapeutics Limited Assay for assessing conformational stability of membrane protein
CU24181B1 (es) * 2012-11-09 2016-04-25 Ct De Inmunología Molecular POLIPÉPTIDOS DERIVADOS DEL TGFß
US9593157B2 (en) 2013-01-30 2017-03-14 Vib Vzw Chimeric polypeptides comprising G protein-coupled receptors and VHH antibodies
WO2014140586A2 (en) 2013-03-15 2014-09-18 Medical Research Council Mutant proteins and methods for their production
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof
EP3212784B1 (en) 2014-10-31 2019-05-29 Abilita Bio, Inc. Modified membrane spanning proteins and methods for the preparation and use thereof
US20190144912A1 (en) * 2015-09-04 2019-05-16 The Scripps Research Institute Methods for identifying novel antibiotics and related compositions
GB201601690D0 (en) 2016-01-29 2016-03-16 Heptares Therapeutics Ltd G proteins
ES2737307T3 (es) 2016-02-29 2020-01-13 Ose Immunotherapeutics Anticuerpos no antagonistas dirigidos contra la cadena alfa del dominio extracelular del receptor de IL7 y uso del mismo en el tratamiento del cáncer
CN109415445A (zh) 2016-05-04 2019-03-01 阿比利塔生物公司 用于制备多跨膜蛋白的方法和平台
WO2018150260A1 (en) * 2017-02-16 2018-08-23 Institut Pasteur Method for the identification of mutated proteins having modified thermal stability

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GB0724051D0 (en) 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
GB0802474D0 (en) 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
US20110112037A1 (en) 2008-03-05 2011-05-12 Heptares Therapeutics Limited BioPark Crystal structure
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Also Published As

Publication number Publication date
CA2708037A1 (en) 2009-06-11
JP2015133973A (ja) 2015-07-27
CA2708037C (en) 2018-09-18
JP6567291B2 (ja) 2019-08-28
WO2009071914A3 (en) 2009-10-15
AU2008332896A1 (en) 2009-06-11
DK2220229T3 (da) 2020-09-07
EP2220229B1 (en) 2020-06-24
AU2008332896B2 (en) 2014-05-08
PL2568045T3 (pl) 2024-05-13
WO2009071914A2 (en) 2009-06-11
ES2972473T3 (es) 2024-06-12
JP2011505800A (ja) 2011-03-03
GB201000387D0 (en) 2010-02-24
EP2568045B1 (en) 2024-01-24
EP2220229A2 (en) 2010-08-25
US20110028700A1 (en) 2011-02-03
GB2467830B (en) 2013-05-15
GB2467830A (en) 2010-08-18
EP2568045A1 (en) 2013-03-13
US8748182B2 (en) 2014-06-10

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Legal Events

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AT Applications terminated before publication under section 16(1)