FR3091873B1 - Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification - Google Patents
Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification Download PDFInfo
- Publication number
- FR3091873B1 FR3091873B1 FR1900432A FR1900432A FR3091873B1 FR 3091873 B1 FR3091873 B1 FR 3091873B1 FR 1900432 A FR1900432 A FR 1900432A FR 1900432 A FR1900432 A FR 1900432A FR 3091873 B1 FR3091873 B1 FR 3091873B1
- Authority
- FR
- France
- Prior art keywords
- complex
- pcta
- gadolinium
- purification
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (43)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1900432A FR3091873B1 (fr) | 2019-01-17 | 2019-01-17 | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| PH1/2021/551725A PH12021551725A1 (en) | 2019-01-17 | 2020-01-17 | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched pcta and preparation and purification process |
| ARP200100125A AR117835A1 (es) | 2019-01-17 | 2020-01-17 | Complejo diastereoisomérico enriquecido de gadolinio y de un ligando quelante a base de pcta, y proceso de preparación y purificación del mismo |
| EP20701709.6A EP3902800B1 (fr) | 2019-01-17 | 2020-01-17 | Complexe de gadolinium et d'un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| CN202111049738.3A CN113735854B (zh) | 2019-01-17 | 2020-01-17 | 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法 |
| RS20230530A RS64334B1 (sr) | 2019-01-17 | 2020-01-17 | Kompleks gadolinijuma i helirajućeg liganda dobijenog od dijastereoizomerno obogaćenog pcta i postupak za pripremu i prečišćavanje |
| HUE20701709A HUE060343T2 (hu) | 2019-01-17 | 2020-01-17 | Gadolínium és egy diasztereomeresen dúsított PCTA-ból származó kelátképzõ ligandum komplexe, és elõállítási és tisztítási eljárása |
| CN202080009625.8A CN113646308B (zh) | 2019-01-17 | 2020-01-17 | 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法 |
| IL284884A IL284884B2 (en) | 2019-01-17 | 2020-01-17 | Gadolinium complexes and ligand derived from diastereomeric enriched PCTA and a process for their preparation |
| MA054626A MA54626A (fr) | 2019-01-17 | 2020-01-17 | Complexe de gadolinium et d'un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| SG11202107779SA SG11202107779SA (en) | 2019-01-17 | 2020-01-17 | Diastereoisomerically enriched complex of gadolinium and of a pcta-based chelating ligand, and process for preparing and purifying same |
| MA055389A MA55389A (fr) | 2019-01-17 | 2020-01-17 | Complexe de gadolinium et d'un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| US17/423,638 US11590246B2 (en) | 2019-01-17 | 2020-01-17 | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
| AU2020208794A AU2020208794B2 (en) | 2019-01-17 | 2020-01-17 | Diastereoisomerically enriched complex of gadolinium and of a PCTA-based chelating ligand, and process for preparing and purifying same |
| KR1020217025766A KR102438394B1 (ko) | 2019-01-17 | 2020-01-17 | 가돌리늄과 부분입체이성질체적으로 풍부한 pcta로부터 유래된 킬레이트화 리간드의 착물, 및 제조 및 정제 공정 |
| PL21190088.1T PL3943493T3 (pl) | 2019-01-17 | 2020-01-17 | Wzbogacony diastereoizomerycznie kompleks gadolinu i ligandu chelatującego pochodzącego z pcta oraz sposób wytwarzania i oczyszczania |
| ES21190088T ES2950118T3 (es) | 2019-01-17 | 2020-01-17 | Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisoméricamente enriquecido y método de preparación y de purificación |
| CN202411689939.3A CN119552163A (zh) | 2019-01-17 | 2020-01-17 | 钆和基于非对映异构体富集的pcta的螯合配体的络合物及其制备和纯化方法 |
| FIEP21190088.1T FI3943493T3 (fi) | 2019-01-17 | 2020-01-17 | Gadoliniumin ja diastereoisomeerisesti rikastetusta pcta:sta johdetun kelaattoriligandin kompleksi sekä valmistus- ja puhdistusmenetelmä |
| HUE21190088A HUE062554T2 (hu) | 2019-01-17 | 2020-01-17 | Gadolínium és egy diasztereomeresen dúsított PCTA-ból származó kelátképzõ ligandum komplexe, és elõállítási és tisztítási eljárás |
| CA3126268A CA3126268C (fr) | 2019-01-17 | 2020-01-17 | Complexe de gadolinium et d'un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| BR112021014006-9A BR112021014006B1 (pt) | 2019-01-17 | 2020-01-17 | Processo para purificar um complexo de gadolínio |
| EP21190088.1A EP3943493B1 (fr) | 2019-01-17 | 2020-01-17 | Complexe de gadolinium et d'un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| PT207017096T PT3902800T (pt) | 2019-01-17 | 2020-01-17 | Complexo de gadolínio e um ligando quelante derivado de pcta diastereoisomericamente enriquecido e processo de preparação e purificação |
| ES20701709T ES2930136T3 (es) | 2019-01-17 | 2020-01-17 | Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisoméricamente enriquecido y método de preparación y de purificación |
| JP2021541202A JP7071596B2 (ja) | 2019-01-17 | 2020-01-17 | ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス |
| DK20701709.6T DK3902800T3 (da) | 2019-01-17 | 2020-01-17 | Kompleksforbindelse af gadolinium og af en chelaterende ligand afledt af diastereoisomerisk beriget pcta og fremgangsmåde til fremstilling og oprensning heraf |
| TW109101779A TWI811518B (zh) | 2019-01-17 | 2020-01-17 | 釓和基於ｐｃｔａ的螯合配位基的非鏡像異構物富集的錯合物及其製備和純化方法 |
| HRP20221402TT HRP20221402T1 (hr) | 2019-01-17 | 2020-01-17 | Kompleks gadolinija i kelirajućeg liganda dobivenog iz diastereoizomerno obogaćenog pcta te postupak pripreme i pročišćavanja |
| KR1020217036451A KR102502862B1 (ko) | 2019-01-17 | 2020-01-17 | 가돌리늄과 부분입체이성질체적으로 풍부한 pcta로부터 유래된 킬레이트화 리간드의 착물, 및 제조 및 정제 공정 |
| DK21190088.1T DK3943493T3 (da) | 2019-01-17 | 2020-01-17 | Kompleksforbindelse af gadolinium og af en chelaterende ligand afledt af diastereoisomerisk beriget pcta og fremgangsmåde til fremstilling og oprensning heraf |
| PT211900881T PT3943493T (pt) | 2019-01-17 | 2020-01-17 | Complexo de gadolínio e um ligano quelante dirivado de pcta diastereoisomericamente enriquecido e processo de preparação e purificação |
| PCT/EP2020/051153 WO2020148436A1 (fr) | 2019-01-17 | 2020-01-17 | Complexe de gadolinium et d'un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| MX2021008651A MX2021008651A (es) | 2019-01-17 | 2020-01-17 | Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisomericamente enriquecido y metodo de preparacion y de purificacion. |
| HRP20230678TT HRP20230678T1 (hr) | 2019-01-17 | 2020-01-17 | Kompleks gadolinija i kelirajućeg liganda izvedenog iz dijastereoizomerno obogaćenog pcta i postupak za njegovu pripremu i pročišćavanje |
| PL20701709.6T PL3902800T3 (pl) | 2019-01-17 | 2020-01-17 | Wzbogacony diastereoizomerycznie kompleks gadolinu i ligandu chelatującego pochodzącego z pcta oraz sposób wytwarzania i oczyszczania |
| CL2021001868A CL2021001868A1 (es) | 2019-01-17 | 2021-07-14 | Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisoméricamente enriquecido y método de preparación y de purificación. |
| CONC2021/0009261A CO2021009261A2 (es) | 2019-01-17 | 2021-07-15 | Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisoméricamente enriquecido y método de preparación y de purificación |
| ZA2021/04994A ZA202104994B (en) | 2019-01-17 | 2021-07-15 | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched pcta and preparation and purification process |
| US17/403,610 US11370804B2 (en) | 2019-01-17 | 2021-08-16 | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
| JP2021173867A JP7321230B2 (ja) | 2019-01-17 | 2021-10-25 | ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス |
| US18/154,894 US12064487B2 (en) | 2019-01-17 | 2023-01-16 | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
| US18/766,792 US20240358863A1 (en) | 2019-01-17 | 2024-07-09 | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched pcta and preparation and purification process |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1900432 | 2019-01-17 | ||
| FR1900432A FR3091873B1 (fr) | 2019-01-17 | 2019-01-17 | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR3091873A1 FR3091873A1 (fr) | 2020-07-24 |
| FR3091873B1 true FR3091873B1 (fr) | 2020-12-25 |
Family
ID=67001953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR1900432A Active FR3091873B1 (fr) | 2019-01-17 | 2019-01-17 | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US11590246B2 (https=) |
| EP (2) | EP3902800B1 (https=) |
| JP (2) | JP7071596B2 (https=) |
| KR (2) | KR102438394B1 (https=) |
| CN (3) | CN113646308B (https=) |
| AR (1) | AR117835A1 (https=) |
| AU (1) | AU2020208794B2 (https=) |
| BR (1) | BR112021014006B1 (https=) |
| CA (1) | CA3126268C (https=) |
| CL (1) | CL2021001868A1 (https=) |
| CO (1) | CO2021009261A2 (https=) |
| DK (2) | DK3943493T3 (https=) |
| ES (2) | ES2930136T3 (https=) |
| FI (1) | FI3943493T3 (https=) |
| FR (1) | FR3091873B1 (https=) |
| HR (2) | HRP20230678T1 (https=) |
| HU (2) | HUE062554T2 (https=) |
| IL (1) | IL284884B2 (https=) |
| MA (2) | MA54626A (https=) |
| MX (1) | MX2021008651A (https=) |
| PH (1) | PH12021551725A1 (https=) |
| PL (2) | PL3943493T3 (https=) |
| PT (2) | PT3943493T (https=) |
| RS (1) | RS64334B1 (https=) |
| SG (1) | SG11202107779SA (https=) |
| TW (1) | TWI811518B (https=) |
| WO (1) | WO2020148436A1 (https=) |
| ZA (1) | ZA202104994B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT4151637T (pt) | 2018-08-06 | 2025-03-26 | Bracco Imaging Spa | Agentes de contraste à base de pcta que suportam gadolínio |
| FR3091873B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| FR3091872B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
| KR20230041007A (ko) * | 2020-07-17 | 2023-03-23 | 게르브 | Pcta로부터 유도된 킬레이팅 리간드의 제조 방법 |
| KR20230074593A (ko) * | 2020-10-02 | 2023-05-30 | 이글 하버 테크놀로지스, 인코포레이티드 | 이온 전류 드룹 보상 |
| WO2024049087A1 (ko) * | 2022-09-01 | 2024-03-07 | 주식회사 테라노큐어 | 신규한 화합물 및 이를 포함하는 mri 조영제 |
| KR102845061B1 (ko) * | 2022-09-01 | 2025-08-13 | 주식회사 테라노큐어 | 신규한 화합물 및 이를 포함하는 mri 조영제 |
| WO2026027591A1 (en) | 2024-07-31 | 2026-02-05 | Bracco Imaging Spa | Synthesis of an intermediate of a gadolinium-based contrast agent |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
| DE4001655A1 (de) | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| JPH04154729A (ja) | 1990-10-16 | 1992-05-27 | Nippon Mejifuijitsukusu Kk | 磁気共鳴造影剤 |
| IT1292128B1 (it) | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
| EP0992245A1 (en) | 1998-09-16 | 2000-04-12 | Goldham Bioglan Pharma GmbH | Radio-contrast agents |
| FR2793795B1 (fr) * | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
| FR2794744B1 (fr) | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| US20090208421A1 (en) * | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
| US8119817B2 (en) * | 2009-09-29 | 2012-02-21 | Degussa-Huels Ag | Process for separating the diastereomers of RSS-and SSS-N- α [1-carboxy-3-phenylpropyl] lysylproline |
| EP2786768A1 (en) | 2013-04-04 | 2014-10-08 | Agfa Healthcare | Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide |
| CN105142649A (zh) * | 2013-04-26 | 2015-12-09 | 法国加柏公司 | 造影剂配制品与有关制备方法 |
| CN104188957B (zh) * | 2014-05-28 | 2017-04-26 | 中国中医科学院西苑医院 | 一种防治再狭窄的药物及其制备和使用方法 |
| WO2018199040A1 (ja) * | 2017-04-28 | 2018-11-01 | 株式会社大塚製薬工場 | クエン酸誘導体のジアステレオマーの製造方法 |
| PT4151637T (pt) * | 2018-08-06 | 2025-03-26 | Bracco Imaging Spa | Agentes de contraste à base de pcta que suportam gadolínio |
| FR3091873B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| FR3091872B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
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2019
- 2019-01-17 FR FR1900432A patent/FR3091873B1/fr active Active
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2020
- 2020-01-17 MA MA054626A patent/MA54626A/fr unknown
- 2020-01-17 PL PL21190088.1T patent/PL3943493T3/pl unknown
- 2020-01-17 HU HUE21190088A patent/HUE062554T2/hu unknown
- 2020-01-17 HR HRP20230678TT patent/HRP20230678T1/hr unknown
- 2020-01-17 ES ES20701709T patent/ES2930136T3/es active Active
- 2020-01-17 HR HRP20221402TT patent/HRP20221402T1/hr unknown
- 2020-01-17 KR KR1020217025766A patent/KR102438394B1/ko active Active
- 2020-01-17 TW TW109101779A patent/TWI811518B/zh active
- 2020-01-17 SG SG11202107779SA patent/SG11202107779SA/en unknown
- 2020-01-17 HU HUE20701709A patent/HUE060343T2/hu unknown
- 2020-01-17 DK DK21190088.1T patent/DK3943493T3/da active
- 2020-01-17 ES ES21190088T patent/ES2950118T3/es active Active
- 2020-01-17 PT PT211900881T patent/PT3943493T/pt unknown
- 2020-01-17 FI FIEP21190088.1T patent/FI3943493T3/fi active
- 2020-01-17 DK DK20701709.6T patent/DK3902800T3/da active
- 2020-01-17 WO PCT/EP2020/051153 patent/WO2020148436A1/fr not_active Ceased
- 2020-01-17 US US17/423,638 patent/US11590246B2/en active Active
- 2020-01-17 PT PT207017096T patent/PT3902800T/pt unknown
- 2020-01-17 MA MA055389A patent/MA55389A/fr unknown
- 2020-01-17 BR BR112021014006-9A patent/BR112021014006B1/pt active IP Right Grant
- 2020-01-17 AR ARP200100125A patent/AR117835A1/es unknown
- 2020-01-17 CN CN202080009625.8A patent/CN113646308B/zh active Active
- 2020-01-17 CN CN202111049738.3A patent/CN113735854B/zh active Active
- 2020-01-17 EP EP20701709.6A patent/EP3902800B1/fr active Active
- 2020-01-17 KR KR1020217036451A patent/KR102502862B1/ko active Active
- 2020-01-17 EP EP21190088.1A patent/EP3943493B1/fr active Active
- 2020-01-17 RS RS20230530A patent/RS64334B1/sr unknown
- 2020-01-17 PH PH1/2021/551725A patent/PH12021551725A1/en unknown
- 2020-01-17 CA CA3126268A patent/CA3126268C/fr active Active
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