PL3943493T3 - Wzbogacony diastereoizomerycznie kompleks gadolinu i ligandu chelatującego pochodzącego z pcta oraz sposób wytwarzania i oczyszczania - Google Patents

Wzbogacony diastereoizomerycznie kompleks gadolinu i ligandu chelatującego pochodzącego z pcta oraz sposób wytwarzania i oczyszczania

Info

Publication number
PL3943493T3
PL3943493T3 PL21190088.1T PL21190088T PL3943493T3 PL 3943493 T3 PL3943493 T3 PL 3943493T3 PL 21190088 T PL21190088 T PL 21190088T PL 3943493 T3 PL3943493 T3 PL 3943493T3
Authority
PL
Poland
Prior art keywords
gadoline
pcta
diastereoisomeric
enriched
production
Prior art date
Application number
PL21190088.1T
Other languages
English (en)
Polish (pl)
Inventor
Soizic Le Greneur
Alain CHÉNEDÉ
Martine Cerf
Myriam Petta
Emmanuelle MARAIS
Bruno François
Caroline ROBIC
Stéphanie LOUGUET
Original Assignee
Guerbet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet filed Critical Guerbet
Publication of PL3943493T3 publication Critical patent/PL3943493T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL21190088.1T 2019-01-17 2020-01-17 Wzbogacony diastereoizomerycznie kompleks gadolinu i ligandu chelatującego pochodzącego z pcta oraz sposób wytwarzania i oczyszczania PL3943493T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1900432A FR3091873B1 (fr) 2019-01-17 2019-01-17 Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

Publications (1)

Publication Number Publication Date
PL3943493T3 true PL3943493T3 (pl) 2023-08-07

Family

ID=67001953

Family Applications (2)

Application Number Title Priority Date Filing Date
PL21190088.1T PL3943493T3 (pl) 2019-01-17 2020-01-17 Wzbogacony diastereoizomerycznie kompleks gadolinu i ligandu chelatującego pochodzącego z pcta oraz sposób wytwarzania i oczyszczania
PL20701709.6T PL3902800T3 (pl) 2019-01-17 2020-01-17 Wzbogacony diastereoizomerycznie kompleks gadolinu i ligandu chelatującego pochodzącego z pcta oraz sposób wytwarzania i oczyszczania

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL20701709.6T PL3902800T3 (pl) 2019-01-17 2020-01-17 Wzbogacony diastereoizomerycznie kompleks gadolinu i ligandu chelatującego pochodzącego z pcta oraz sposób wytwarzania i oczyszczania

Country Status (28)

Country Link
US (3) US11590246B2 (https=)
EP (2) EP3902800B1 (https=)
JP (2) JP7071596B2 (https=)
KR (2) KR102438394B1 (https=)
CN (3) CN113646308B (https=)
AR (1) AR117835A1 (https=)
AU (1) AU2020208794B2 (https=)
BR (1) BR112021014006B1 (https=)
CA (1) CA3126268C (https=)
CL (1) CL2021001868A1 (https=)
CO (1) CO2021009261A2 (https=)
DK (2) DK3943493T3 (https=)
ES (2) ES2930136T3 (https=)
FI (1) FI3943493T3 (https=)
FR (1) FR3091873B1 (https=)
HR (2) HRP20230678T1 (https=)
HU (2) HUE062554T2 (https=)
IL (1) IL284884B2 (https=)
MA (2) MA54626A (https=)
MX (1) MX2021008651A (https=)
PH (1) PH12021551725A1 (https=)
PL (2) PL3943493T3 (https=)
PT (2) PT3943493T (https=)
RS (1) RS64334B1 (https=)
SG (1) SG11202107779SA (https=)
TW (1) TWI811518B (https=)
WO (1) WO2020148436A1 (https=)
ZA (1) ZA202104994B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT4151637T (pt) 2018-08-06 2025-03-26 Bracco Imaging Spa Agentes de contraste à base de pcta que suportam gadolínio
FR3091873B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
KR20230041007A (ko) * 2020-07-17 2023-03-23 게르브 Pcta로부터 유도된 킬레이팅 리간드의 제조 방법
KR20230074593A (ko) * 2020-10-02 2023-05-30 이글 하버 테크놀로지스, 인코포레이티드 이온 전류 드룹 보상
WO2024049087A1 (ko) * 2022-09-01 2024-03-07 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
KR102845061B1 (ko) * 2022-09-01 2025-08-13 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
WO2026027591A1 (en) 2024-07-31 2026-02-05 Bracco Imaging Spa Synthesis of an intermediate of a gadolinium-based contrast agent

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE4001655A1 (de) 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JPH04154729A (ja) 1990-10-16 1992-05-27 Nippon Mejifuijitsukusu Kk 磁気共鳴造影剤
IT1292128B1 (it) 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
EP0992245A1 (en) 1998-09-16 2000-04-12 Goldham Bioglan Pharma GmbH Radio-contrast agents
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2794744B1 (fr) 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
FR2891830B1 (fr) 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
US8119817B2 (en) * 2009-09-29 2012-02-21 Degussa-Huels Ag Process for separating the diastereomers of RSS-and SSS-N- α [1-carboxy-3-phenylpropyl] lysylproline
EP2786768A1 (en) 2013-04-04 2014-10-08 Agfa Healthcare Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide
CN105142649A (zh) * 2013-04-26 2015-12-09 法国加柏公司 造影剂配制品与有关制备方法
CN104188957B (zh) * 2014-05-28 2017-04-26 中国中医科学院西苑医院 一种防治再狭窄的药物及其制备和使用方法
WO2018199040A1 (ja) * 2017-04-28 2018-11-01 株式会社大塚製薬工場 クエン酸誘導体のジアステレオマーの製造方法
PT4151637T (pt) * 2018-08-06 2025-03-26 Bracco Imaging Spa Agentes de contraste à base de pcta que suportam gadolínio
FR3091873B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese

Also Published As

Publication number Publication date
AU2020208794A1 (en) 2021-08-05
US20230149568A1 (en) 2023-05-18
KR102502862B1 (ko) 2023-02-23
WO2020148436A1 (fr) 2020-07-23
TWI811518B (zh) 2023-08-11
PT3943493T (pt) 2023-07-12
HUE060343T2 (hu) 2023-02-28
HRP20230678T1 (hr) 2023-09-29
CN113735854B (zh) 2024-05-14
FI3943493T3 (fi) 2023-07-19
CN113646308B (zh) 2024-12-13
MA55389A (fr) 2022-01-26
FR3091873B1 (fr) 2020-12-25
IL284884B2 (en) 2025-09-01
US12064487B2 (en) 2024-08-20
BR112021014006A2 (pt) 2021-09-21
CN113735854A (zh) 2021-12-03
EP3902800A1 (fr) 2021-11-03
CL2021001868A1 (es) 2022-01-21
HRP20221402T1 (hr) 2023-01-06
JP2022508496A (ja) 2022-01-19
KR102438394B1 (ko) 2022-09-01
ES2930136T3 (es) 2022-12-07
CO2021009261A2 (es) 2021-12-10
AR117835A1 (es) 2021-08-25
CA3126268A1 (fr) 2020-07-23
KR20210138134A (ko) 2021-11-18
PH12021551725A1 (en) 2022-04-11
US20240358863A1 (en) 2024-10-31
DK3943493T3 (da) 2023-07-24
ES2950118T3 (es) 2023-10-05
JP2022009463A (ja) 2022-01-14
TW202043227A (zh) 2020-12-01
PL3902800T3 (pl) 2022-12-27
EP3943493A1 (fr) 2022-01-26
JP7071596B2 (ja) 2022-05-19
JP7321230B2 (ja) 2023-08-04
MA54626A (fr) 2022-04-20
SG11202107779SA (en) 2021-08-30
RS64334B1 (sr) 2023-08-31
CN119552163A (zh) 2025-03-04
MX2021008651A (es) 2021-10-26
PT3902800T (pt) 2022-11-16
US20220062443A1 (en) 2022-03-03
FR3091873A1 (fr) 2020-07-24
AU2020208794B2 (en) 2023-01-12
EP3943493B1 (fr) 2023-04-19
IL284884A (en) 2021-08-31
DK3902800T3 (da) 2022-11-28
KR20210109039A (ko) 2021-09-03
CN113646308A (zh) 2021-11-12
ZA202104994B (en) 2023-04-26
BR112021014006B1 (pt) 2023-05-02
EP3902800B1 (fr) 2022-09-07
IL284884B1 (en) 2025-05-01
HUE062554T2 (hu) 2023-11-28
CA3126268C (fr) 2024-01-09
US11590246B2 (en) 2023-02-28

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