FR3061177B1 - Nouveaux derives piperidinyles hetero(aryle)-substitues, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents
Nouveaux derives piperidinyles hetero(aryle)-substitues, procede pour leur preparation et compositions pharmaceutiques les contenant Download PDFInfo
- Publication number
- FR3061177B1 FR3061177B1 FR1663463A FR1663463A FR3061177B1 FR 3061177 B1 FR3061177 B1 FR 3061177B1 FR 1663463 A FR1663463 A FR 1663463A FR 1663463 A FR1663463 A FR 1663463A FR 3061177 B1 FR3061177 B1 FR 3061177B1
- Authority
- FR
- France
- Prior art keywords
- group
- methyl
- formula
- branched
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (44)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1663463A FR3061177B1 (fr) | 2016-12-28 | 2016-12-28 | Nouveaux derives piperidinyles hetero(aryle)-substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| PL17728567T PL3468971T3 (pl) | 2016-06-10 | 2017-06-09 | Nowe pochodne (hetero)arylo-piperydynylowe, sposoby ich wytwarzania oraz zawierające je kompozycje |
| MX2018015212A MX2018015212A (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparacion y composiciones farmaceuticas que los contienen. |
| PT177285673T PT3468971T (pt) | 2016-06-10 | 2017-06-09 | Novos derivados de piperidinilo substituídos em (hetero)arilo, um processo para a sua preparação e composições farmacêuticas que os contêm |
| ES17728567T ES2778700T3 (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados de piperidinilo sustituidos con (hetero)arilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| KR1020197000798A KR102003532B1 (ko) | 2016-06-10 | 2017-06-09 | 새로운 (헤테로)아릴-치환된-피페리디닐 유도체, 이의 제조를 위한 방법 및 이를 함유하는 약학적 조성물 |
| CR20180563A CR20180563A (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que lo contienen |
| PCT/EP2017/064062 WO2017212010A1 (en) | 2016-06-10 | 2017-06-09 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| CU2018000146A CU20180146A7 (es) | 2016-06-10 | 2017-06-09 | Compuestos derivados de (piperidin-1-ilo)(piperidin-4-ilo) sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen |
| PE2018003132A PE20220948A1 (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
| AU2017277732A AU2017277732B2 (en) | 2016-06-10 | 2017-06-09 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| US16/306,941 US10654849B2 (en) | 2016-06-10 | 2017-06-09 | (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| RS20200510A RS60279B1 (sr) | 2016-06-10 | 2017-06-09 | Novi derivati piperidinila supstituisanog (hetero)arilom, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže |
| RU2018147424A RU2742271C2 (ru) | 2016-06-10 | 2017-06-09 | Новые (гетеро)арил-замещенные пиперидинильные производные, способ их получения и фармацевтические композиции, содержащие их |
| MDE20190461T MD3468971T2 (ro) | 2016-06-10 | 2017-06-09 | Noi derivați de piperidinil (hetero)aril-substituiţi, procedeu de obţinere a acestora și compoziții farmaceutice care îi conțin |
| CN201780047088.4A CN109563094B (zh) | 2016-06-10 | 2017-06-09 | 新的(杂)芳基取代的哌啶基衍生物、它们的制备方法和含有它们的药物组合物 |
| HUE17728567A HUE048590T2 (hu) | 2016-06-10 | 2017-06-09 | Új (hetero)aril-szubsztituált piperidinil-származékok, eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények |
| SI201730267T SI3468971T1 (sl) | 2016-06-10 | 2017-06-09 | Novi derivati piperidinila, substituiranega s (hetero)arilom, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo |
| TNP/2018/000395A TN2018000395A1 (en) | 2016-06-10 | 2017-06-09 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| UAA201900070A UA123793C2 (uk) | 2016-06-10 | 2017-06-09 | Нові (гетеро)арил-заміщені похідні піперидинілу, спосіб їхнього одержання та фармацевтичні композиції, що їх містять |
| MA45223A MA45223B1 (fr) | 2016-06-10 | 2017-06-09 | Nouveaux dérivés de pipéridinyle subsitués par (hétéro)aryle, leur procédé de préparation et compositions pharmaceutiques les contenant |
| BR112018075284-3A BR112018075284A2 (pt) | 2016-06-10 | 2017-06-09 | derivados de piperidinila substituída por (hetero)arila, processo para sua preparação e composições farmacêuticas contendo-os |
| SG11201810576QA SG11201810576QA (en) | 2016-06-10 | 2017-06-09 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| CA3027008A CA3027008C (en) | 2016-06-10 | 2017-06-09 | (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| MYPI2018002417A MY196328A (en) | 2016-06-10 | 2017-06-09 | New (Hetero)Aryl-Substituted-Piperidinyl Derivatives, A Process For Their Preparation And Pharmaceutical Compositions Containing Them |
| EA201892831A EA037563B1 (ru) | 2016-12-28 | 2017-06-09 | Новые (гетеро)арил-замещенные пиперидинильные производные, способ их получения и фармацевтические композиции, содержащие их |
| UY0001037289A UY37289A (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| EP17728567.3A EP3468971B1 (en) | 2016-06-10 | 2017-06-09 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| DK17728567.3T DK3468971T3 (da) | 2016-06-10 | 2017-06-09 | Nye (hetero)aryl-substituterede piperidinyl-derivativer, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende dem |
| GEAP201714982A GEP20207161B (en) | 2016-06-10 | 2017-06-09 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| LTEP17728567.3T LT3468971T (lt) | 2016-06-10 | 2017-06-09 | Nauji (hetero)aril-pakeistieji-piperidinilo dariniai, jų gamybos būdas ir juos turinčios farmacinės kompozicijos |
| TW106119243A TWI647228B (zh) | 2016-06-10 | 2017-06-09 | 新穎之經(雜)芳基取代之哌啶基衍生物、其製備方法及含其之醫藥組合物 |
| JP2018564752A JP6985299B2 (ja) | 2016-06-10 | 2017-06-09 | 新規（ヘテロ）アリール置換ピペリジニル誘導体、それを調製するためのプロセス、及びそれを含有する医薬組成物 |
| PH12018502516A PH12018502516B1 (en) | 2016-06-10 | 2018-11-28 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| SV2018005792A SV2018005792A (es) | 2016-06-10 | 2018-11-29 | Nuevos derivados piperidinilo sustituidos con hetero (arilo), un proceso para su preparacion y composiciones farmaceuticas que los contienen |
| DO2018000264A DOP2018000264A (es) | 2016-06-10 | 2018-12-03 | Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen |
| IL263455A IL263455B (en) | 2016-06-10 | 2018-12-03 | New (hetero)aryl-converted-piperidinyl compounds, a process for their preparation and pharmaceutical preparations containing them |
| ECSENADI201890046A ECSP18090046A (es) | 2016-06-10 | 2018-12-04 | Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen |
| CL2018003473A CL2018003473A1 (es) | 2016-06-10 | 2018-12-04 | Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen. |
| CONC2018/0013141A CO2018013141A2 (es) | 2016-06-10 | 2018-12-04 | Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen |
| ZA2018/08286A ZA201808286B (en) | 2016-06-10 | 2018-12-07 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| NI201800133A NI201800133A (es) | 2016-06-10 | 2018-12-07 | Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| HRP20200556TT HRP20200556T1 (hr) | 2016-06-10 | 2020-04-03 | Novi (hetero) aril-supstituirani-piperidinil derivati, postupak za njihovu pripravu i farmaceutski pripravci koji ih sadrže |
| CY20201100451T CY1123069T1 (el) | 2016-06-10 | 2020-05-18 | Νεα (ετερο)αρυλ-υποκατεστημενα-πιπεριδινυλ παραγωγα, μεθοδος για παρασκευη αυτων και φαρμακευτικες συνθεσεις που περιεχουν αυτα |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1663463 | 2016-12-28 | ||
| FR1663463A FR3061177B1 (fr) | 2016-12-28 | 2016-12-28 | Nouveaux derives piperidinyles hetero(aryle)-substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR3061177A1 FR3061177A1 (fr) | 2018-06-29 |
| FR3061177B1 true FR3061177B1 (fr) | 2019-09-27 |
Family
ID=58547622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR1663463A Expired - Fee Related FR3061177B1 (fr) | 2016-06-10 | 2016-12-28 | Nouveaux derives piperidinyles hetero(aryle)-substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
Country Status (2)
| Country | Link |
|---|---|
| EA (1) | EA037563B1 (ru) |
| FR (1) | FR3061177B1 (ru) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR065494A1 (es) * | 2007-03-02 | 2009-06-10 | Schering Corp | Derivados de piperidina y metodos de uso de los mismos |
| EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| TWI698436B (zh) * | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
| MA41291A (fr) * | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| WO2016126926A1 (en) * | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
| EP3253759A1 (en) * | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| JP2018504431A (ja) * | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ７阻害物質としてのチエノピリミジノン |
-
2016
- 2016-12-28 FR FR1663463A patent/FR3061177B1/fr not_active Expired - Fee Related
-
2017
- 2017-06-09 EA EA201892831A patent/EA037563B1/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA037563B1 (ru) | 2021-04-14 |
| EA201892831A1 (ru) | 2019-06-28 |
| FR3061177A1 (fr) | 2018-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PLFP | Fee payment |
Year of fee payment: 2 |
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| PLSC | Publication of the preliminary search report |
Effective date: 20180629 |
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| PLFP | Fee payment |
Year of fee payment: 3 |
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| PLFP | Fee payment |
Year of fee payment: 4 |
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| PLFP | Fee payment |
Year of fee payment: 5 |
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| ST | Notification of lapse |
Effective date: 20220808 |