FR3050212B1 - Procede de detection et/ou de caracterisation de cellules tumorales et appareil associe - Google Patents

Procede de detection et/ou de caracterisation de cellules tumorales et appareil associe Download PDF

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Publication number
FR3050212B1
FR3050212B1 FR1653383A FR1653383A FR3050212B1 FR 3050212 B1 FR3050212 B1 FR 3050212B1 FR 1653383 A FR1653383 A FR 1653383A FR 1653383 A FR1653383 A FR 1653383A FR 3050212 B1 FR3050212 B1 FR 3050212B1
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FR
France
Prior art keywords
tumor cell
cell detection
associated apparatus
characterization method
detecting
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Active
Application number
FR1653383A
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English (en)
Other versions
FR3050212A1 (fr
Inventor
- Panabieres Catherine Michele Marilou Alix
Andrew David Griffiths
Raphael Clement Li-Ming Doineau
Clement Nizak
Philippe Chi-Thanh Nghe
Jean-Marie Pierre Baudry
Elodie Michele Christine Brient-Litzler
Klaus Eyer
Jerome Bibette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Montpellier I
Centre Hospitalier Universitaire de Montpellier CHUM
Ecole Superieure de Physique et Chimie Industrielles de Ville Paris
Universite de Montpellier
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Montpellier I
Centre Hospitalier Universitaire de Montpellier CHUM
Ecole Superieure de Physique et Chimie Industrielles de Ville Paris
Universite de Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1653383A priority Critical patent/FR3050212B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Montpellier I, Centre Hospitalier Universitaire de Montpellier CHUM, Ecole Superieure de Physique et Chimie Industrielles de Ville Paris , Universite de Montpellier filed Critical Centre National de la Recherche Scientifique CNRS
Priority to US16/093,934 priority patent/US11525826B2/en
Priority to JP2019505289A priority patent/JP6982057B2/ja
Priority to CN201780036311.5A priority patent/CN109863398B/zh
Priority to EP17716939.8A priority patent/EP3443347A1/fr
Priority to AU2017248682A priority patent/AU2017248682A1/en
Priority to CA3020964A priority patent/CA3020964A1/fr
Priority to PCT/EP2017/059209 priority patent/WO2017178662A1/fr
Publication of FR3050212A1 publication Critical patent/FR3050212A1/fr
Application granted granted Critical
Publication of FR3050212B1 publication Critical patent/FR3050212B1/fr
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid

Abstract

La présente invention s'inscrit dans le domaine du diagnostic biologique en cancérologie. Elle a pour objet un procédé et un appareil de détection et/ou de caractérisation de cellules tumorales par détection d'un ou plusieurs éléments du sécrétome de cellule tumorale, en particulier un ou plusieurs peptides ou protéines, et notamment un ou plusieurs marqueurs tumoraux. L'invention concerne également, des gouttes de détection et/ou de caractérisation de cellules tumorales et leur procédé de préparation.
FR1653383A 2016-04-15 2016-04-15 Procede de detection et/ou de caracterisation de cellules tumorales et appareil associe Active FR3050212B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR1653383A FR3050212B1 (fr) 2016-04-15 2016-04-15 Procede de detection et/ou de caracterisation de cellules tumorales et appareil associe
JP2019505289A JP6982057B2 (ja) 2016-04-15 2017-04-18 腫瘍細胞を検出および／または特徴づけするための方法、および関連装置
CN201780036311.5A CN109863398B (zh) 2016-04-15 2017-04-18 用于检测和/或表征肿瘤细胞的方法及相关装置
EP17716939.8A EP3443347A1 (fr) 2016-04-15 2017-04-18 Procédé de détection et/ou de caractérisation de cellules tumorales et appareil associé
US16/093,934 US11525826B2 (en) 2016-04-15 2017-04-18 Method for detecting and/or characterising tumour cells and associated apparatus
AU2017248682A AU2017248682A1 (en) 2016-04-15 2017-04-18 Method for detecting and/or characterising tumour cells and associated apparatus
CA3020964A CA3020964A1 (fr) 2016-04-15 2017-04-18 Procede de detection et/ou de caracterisation de cellules tumorales et appareil associe
PCT/EP2017/059209 WO2017178662A1 (fr) 2016-04-15 2017-04-18 Procédé de détection et/ou de caractérisation de cellules tumorales et appareil associé

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1653383A FR3050212B1 (fr) 2016-04-15 2016-04-15 Procede de detection et/ou de caracterisation de cellules tumorales et appareil associe

Publications (2)

Publication Number Publication Date
FR3050212A1 FR3050212A1 (fr) 2017-10-20
FR3050212B1 true FR3050212B1 (fr) 2020-09-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FR1653383A Active FR3050212B1 (fr) 2016-04-15 2016-04-15 Procede de detection et/ou de caracterisation de cellules tumorales et appareil associe

Country Status (8)

Country Link
US (1) US11525826B2 (fr)
EP (1) EP3443347A1 (fr)
JP (1) JP6982057B2 (fr)
CN (1) CN109863398B (fr)
AU (1) AU2017248682A1 (fr)
CA (1) CA3020964A1 (fr)
FR (1) FR3050212B1 (fr)
WO (1) WO2017178662A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6779483B2 (ja) 2016-09-29 2020-11-04 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
JP7109719B2 (ja) 2018-02-14 2022-08-01 住友ゴム工業株式会社 特定細胞捕捉方法
JP7170254B2 (ja) * 2018-02-14 2022-11-14 住友ゴム工業株式会社 特定細胞捕捉方法
US11162143B2 (en) 2018-10-21 2021-11-02 The University Of Kansas Methods for generating therapeutic delivery platforms
US11614440B2 (en) 2019-01-24 2023-03-28 Sumitomo Rubber Industries, Ltd. Specific cell fractionating and capturing methods
CN111079579B (zh) * 2019-12-02 2023-07-25 英华达（上海）科技有限公司 细胞图像的识别方法、装置以及系统
WO2023137432A2 (fr) * 2022-01-14 2023-07-20 Seer, Inc. Systèmes et procédés de dosage de sécrétome

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ATE331958T1 (de) 2002-03-13 2006-07-15 Biomerieux Sa Verfahren zum nachweis und zur quantifizierung von -aus soliden tumoren abstammenden- zirkulierenden tumorzellen
US20060078893A1 (en) * 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
WO2005049787A2 (fr) * 2003-11-24 2005-06-02 Yeda Research And Development Co.Ltd. Compositions et procedes de tri in vitro de banques moleculaires et cellulaires
US7301133B2 (en) * 2005-01-21 2007-11-27 Photon Dynamics, Inc. Tracking auto focus system
EP2530168B1 (fr) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Dispositifs microfluidiques
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
WO2008021123A1 (fr) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
US20090068170A1 (en) * 2007-07-13 2009-03-12 President And Fellows Of Harvard College Droplet-based selection
DK2271657T3 (en) * 2008-03-04 2017-05-15 Crystal Bioscience Inc GEL-MICRO-DROP COMPOSITION AND METHOD OF USING IT
EP4047367A1 (fr) * 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Procedé de détection d'analytes cibles au moyens des bibliothèques de gouttelettes
US9575061B2 (en) 2009-10-20 2017-02-21 Vanderbilt University Liquid drop diagnostic assays
WO2012001073A2 (fr) * 2010-07-01 2012-01-05 Glaxo Group Limited Procédé amélioré de sélection de lignées cellulaires à capacité de production élevée
WO2012045012A2 (fr) * 2010-09-30 2012-04-05 Raindance Technologies, Inc. Dosages sandwich dans des gouttelettes
WO2013041983A1 (fr) * 2011-09-19 2013-03-28 Centre National De La Recherche Scientifique Système micro-fluidique
ITRM20130700A1 (it) * 2013-12-19 2015-06-20 Stichting Katholieke Univ Metodo per il rilevamento di cellule tumorali circolanti
FR3027396B1 (fr) * 2014-10-15 2016-11-25 Espci Innov Procede d'analyse du contenu de gouttes et appareil associe

Also Published As

Publication number Publication date
EP3443347A1 (fr) 2019-02-20
AU2017248682A1 (en) 2018-11-22
FR3050212A1 (fr) 2017-10-20
JP2019514027A (ja) 2019-05-30
CN109863398A (zh) 2019-06-07
WO2017178662A1 (fr) 2017-10-19
US11525826B2 (en) 2022-12-13
CN109863398B (zh) 2022-05-31
US20190170741A1 (en) 2019-06-06
JP6982057B2 (ja) 2021-12-17
CA3020964A1 (fr) 2017-10-19

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