FR2918663A1 - Cyclohexenones d'antrodia camphorata pour le traitement du virus de l'hepatite b et compositions pharmaceutiques les contenant - Google Patents
Cyclohexenones d'antrodia camphorata pour le traitement du virus de l'hepatite b et compositions pharmaceutiques les contenant Download PDFInfo
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- FR2918663A1 FR2918663A1 FR0802140A FR0802140A FR2918663A1 FR 2918663 A1 FR2918663 A1 FR 2918663A1 FR 0802140 A FR0802140 A FR 0802140A FR 0802140 A FR0802140 A FR 0802140A FR 2918663 A1 FR2918663 A1 FR 2918663A1
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- Prior art keywords
- cyclohexenone
- hbv
- antrodia camphorata
- hbeag
- hbsag
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- DVORYMAGXQGBQK-UHFFFAOYSA-N zhankuic acid A Natural products CC12CCC(=O)C(C)C1CC(=O)C1=C2C(=O)CC2(C)C(C(CCC(=C)C(C)C(O)=O)C)CCC21 DVORYMAGXQGBQK-UHFFFAOYSA-N 0.000 description 1
- TXEJUZMIQVTZHO-JNXQNPAGSA-N zhankuic acid B Chemical compound C([C@@]12C)C[C@@H](O)[C@@H](C)[C@@H]1CC(=O)C1=C2C(=O)C[C@]2(C)[C@@H]([C@@H](CCC(=C)C(C)C(O)=O)C)CC[C@H]21 TXEJUZMIQVTZHO-JNXQNPAGSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW096124892A TWI394575B (zh) | 2007-07-09 | 2007-07-09 | Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B Virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2918663A1 true FR2918663A1 (fr) | 2009-01-16 |
Family
ID=39048358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0802140A Pending FR2918663A1 (fr) | 2007-07-09 | 2008-04-17 | Cyclohexenones d'antrodia camphorata pour le traitement du virus de l'hepatite b et compositions pharmaceutiques les contenant |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7411003B1 (ja) |
| JP (1) | JP5085222B2 (ja) |
| KR (1) | KR101218510B1 (ja) |
| DE (1) | DE102007043187A1 (ja) |
| FR (1) | FR2918663A1 (ja) |
| GB (1) | GB2450949B (ja) |
| TW (1) | TWI394575B (ja) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI394573B (zh) * | 2007-06-14 | 2013-05-01 | Golden Biotechnology Corp | Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for Liver Protection |
| TWI394575B (zh) * | 2007-07-09 | 2013-05-01 | Golden Biotechnology Corp | Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B Virus |
| JP5203644B2 (ja) * | 2007-07-13 | 2013-06-05 | 國鼎生物科技股▲ふん▼有限公司 | 自己免疫疾病の治療に用いるベニクスノキタケ由来の化合物 |
| EP2329816B1 (en) * | 2009-11-26 | 2016-04-13 | National Taiwan University | An anti-cancer active substance from antrodia camphorata, method for preparing the same and use thereof |
| JP2012012343A (ja) * | 2010-07-01 | 2012-01-19 | Taiwan Leader Biotech Corp | 肝炎を治療するための医薬組成物及びその用途 |
| TW201231474A (en) * | 2011-01-26 | 2012-08-01 | Univ Kaohsiung Medical | Triterpenoid composition of Antrodia cinnamomea, preparation and analysis method thereof |
| US20130172424A1 (en) * | 2011-12-30 | 2013-07-04 | Golden Biotechnology Corporation | Methods and compositions for treating diabetes |
| CN102603619B (zh) * | 2012-02-15 | 2013-09-18 | 合肥工业大学 | 一种具有抗癌活性的化合物及其制备方法 |
| US9789153B2 (en) | 2014-07-02 | 2017-10-17 | Hsiu-Hsien Tsai | Composition for preventing cancer and treating cancer and intensifying the effects of other anticancer drugs |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10179131B2 (en) * | 2015-07-13 | 2019-01-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10280175B2 (en) | 2016-02-02 | 2019-05-07 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| PL3426245T3 (pl) | 2016-03-07 | 2023-05-22 | Enanta Pharmaceuticals, Inc. | Środki przeciwwirusowe zapalenia wątroby typu b |
| CN109843296A (zh) | 2016-06-10 | 2019-06-04 | 英安塔制药有限公司 | 乙型肝炎抗病毒药剂 |
| SG11202001685TA (en) | 2017-08-28 | 2020-03-30 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| WO2019113175A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| TW201927789A (zh) | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
| WO2019143902A2 (en) | 2018-01-22 | 2019-07-25 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US10729688B2 (en) | 2018-03-29 | 2020-08-04 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| CA3113235A1 (en) | 2018-09-21 | 2020-03-26 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| WO2020106816A1 (en) | 2018-11-21 | 2020-05-28 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| US11253527B2 (en) * | 2019-02-25 | 2022-02-22 | Arjil Biotech Holding Company Limited | Method and composition for inhibiting virus infection |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| EP4146180A4 (en) * | 2020-05-08 | 2024-06-26 | Golden Biotechnology Corporation | METHODS AND COMPOSITIONS FOR TREATING RNA VIRUS-INDUCED DISEASE |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030113297A1 (en) * | 2001-05-18 | 2003-06-19 | Jinn-Chu Chen | Liver-caring medicine containing antrodia camphorata |
| JP2004091780A (ja) * | 2002-08-30 | 2004-03-25 | Taiso Seibutsu Kagi Kofun Yugenkoshi | Ａｎｔｒｏｄｉａｃａｍｐｈｏｒａｔａ菌体の多糖類 |
| US20060135623A1 (en) * | 2004-05-21 | 2006-06-22 | Cutler Richard G | Decrease in oxidative stress status through the administration of natural products and pharmaceutical drugs |
| CN1799562A (zh) * | 2005-09-28 | 2006-07-12 | 莱阳农学院 | 一种樟芝菌丝体发酵提取物及其应用 |
| FR2911133A1 (fr) * | 2007-01-08 | 2008-07-11 | Golden Biotechnology Corp | Nouveaux composes de cyclohexenone provenant d'antrodia camphorata et application de ceux-ci |
| WO2008089674A1 (fr) * | 2007-01-18 | 2008-07-31 | Golden Biotechnology Corporation | Cyclohexénone extraite d'antrodia camphorata |
| FR2917408A1 (fr) * | 2007-06-12 | 2008-12-19 | Golden Biotechnology Corp | Cyclohexenones d'antrodia camphorata pour le traitement de maladies auto-immunes et compositions pharmaceutiques les contenant |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3064012A (en) * | 1960-07-20 | 1962-11-13 | Merck & Co Inc | Derivatives of coenzyme q10 |
| US6740517B2 (en) * | 2001-12-14 | 2004-05-25 | Ming-Huang Lan | Incubation method for obtaining solid culture of Zang Zhi, solid culture obtained therefrom, processed products and use thereof |
| KR20050091464A (ko) * | 2004-03-12 | 2005-09-15 | 심프슨 바이오테크 컴퍼니 리미티드 | 안트로디아 캄포라타 균사체 유래의 신규한 혼합물 및화합물, 및 그의 용도 |
| JP5403844B2 (ja) * | 2004-03-02 | 2014-01-29 | 善笙生物科技股▲分▼有限公司 | ＡｎｔｒｏｄｉａＣａｍｐｈｏｒａｔａの菌糸体から得た新規な混合物及び化合物、並びにその使用 |
| CN100394927C (zh) * | 2005-09-28 | 2008-06-18 | 莱阳农学院 | 一种抗肝癌的樟芝胶囊及其制备方法 |
| TWI394575B (zh) * | 2007-07-09 | 2013-05-01 | Golden Biotechnology Corp | Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B Virus |
-
2007
- 2007-07-09 TW TW096124892A patent/TWI394575B/zh active
- 2007-08-06 JP JP2007203975A patent/JP5085222B2/ja active Active
- 2007-08-21 US US11/842,795 patent/US7411003B1/en active Active
- 2007-08-28 KR KR1020070086411A patent/KR101218510B1/ko not_active IP Right Cessation
- 2007-09-11 DE DE102007043187A patent/DE102007043187A1/de not_active Withdrawn
- 2007-12-19 GB GB0724754.7A patent/GB2450949B/en not_active Expired - Fee Related
-
2008
- 2008-04-17 FR FR0802140A patent/FR2918663A1/fr active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030113297A1 (en) * | 2001-05-18 | 2003-06-19 | Jinn-Chu Chen | Liver-caring medicine containing antrodia camphorata |
| JP2004091780A (ja) * | 2002-08-30 | 2004-03-25 | Taiso Seibutsu Kagi Kofun Yugenkoshi | Ａｎｔｒｏｄｉａｃａｍｐｈｏｒａｔａ菌体の多糖類 |
| US20060135623A1 (en) * | 2004-05-21 | 2006-06-22 | Cutler Richard G | Decrease in oxidative stress status through the administration of natural products and pharmaceutical drugs |
| CN1799562A (zh) * | 2005-09-28 | 2006-07-12 | 莱阳农学院 | 一种樟芝菌丝体发酵提取物及其应用 |
| FR2911133A1 (fr) * | 2007-01-08 | 2008-07-11 | Golden Biotechnology Corp | Nouveaux composes de cyclohexenone provenant d'antrodia camphorata et application de ceux-ci |
| WO2008089674A1 (fr) * | 2007-01-18 | 2008-07-31 | Golden Biotechnology Corporation | Cyclohexénone extraite d'antrodia camphorata |
| FR2917408A1 (fr) * | 2007-06-12 | 2008-12-19 | Golden Biotechnology Corp | Cyclohexenones d'antrodia camphorata pour le traitement de maladies auto-immunes et compositions pharmaceutiques les contenant |
Non-Patent Citations (1)
| Title |
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| TZONG-HUEI LEE ET AL: "A New Cytotoxic Agent from Solid-State Fermented Mycelium of Antrodia camphorata", PLANTA MEDICA, THIEME VERLAG, DE, vol. 73, no. 13, 1 October 2007 (2007-10-01), pages 1412 - 1415, XP002626076, ISSN: 0032-0943, [retrieved on 20071011], DOI: 10.1055/S-2007-990232 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101218510B1 (ko) | 2013-01-03 |
| TWI394575B (zh) | 2013-05-01 |
| GB0724754D0 (en) | 2008-01-30 |
| GB2450949A (en) | 2009-01-14 |
| TW200902041A (en) | 2009-01-16 |
| GB2450949B (en) | 2012-04-11 |
| US7411003B1 (en) | 2008-08-12 |
| JP5085222B2 (ja) | 2012-11-28 |
| DE102007043187A1 (de) | 2009-01-15 |
| KR20090005932A (ko) | 2009-01-14 |
| JP2009013152A (ja) | 2009-01-22 |
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