FR2880020B1 - NOUVEAUX LIGANDS MODULATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE - Google Patents

NOUVEAUX LIGANDS MODULATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE

Info

Publication number
FR2880020B1
FR2880020B1 FR0413848A FR0413848A FR2880020B1 FR 2880020 B1 FR2880020 B1 FR 2880020B1 FR 0413848 A FR0413848 A FR 0413848A FR 0413848 A FR0413848 A FR 0413848A FR 2880020 B1 FR2880020 B1 FR 2880020B1
Authority
FR
France
Prior art keywords
cosmetics
human medicine
rar receptors
ligands
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0413848A
Other languages
English (en)
Other versions
FR2880020A1 (fr
Inventor
Thibaud Biadatti
Laurence Dumais
Catherine Soulet
Sandrine Talano
Sebastien Daver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0413848A priority Critical patent/FR2880020B1/fr
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Priority to RU2007127867A priority patent/RU2440973C3/ru
Priority to PCT/EP2005/014217 priority patent/WO2006066978A1/fr
Priority to BRPI0517500A priority patent/BRPI0517500B8/pt
Priority to MX2007007696A priority patent/MX2007007696A/es
Priority to SI200531509T priority patent/SI1831149T1/sl
Priority to DK05824484.9T priority patent/DK1831149T3/da
Priority to CN2005800447781A priority patent/CN101087752B/zh
Priority to JP2007547399A priority patent/JP5258299B2/ja
Priority to ES05824484T priority patent/ES2380777T3/es
Priority to PT05824484T priority patent/PT1831149E/pt
Priority to PL05824484T priority patent/PL1831149T3/pl
Priority to KR1020077014372A priority patent/KR101316992B1/ko
Priority to AT05824484T priority patent/ATE542791T1/de
Priority to EP05824484A priority patent/EP1831149B1/fr
Priority to AU2005318292A priority patent/AU2005318292B2/en
Priority to CA2590246A priority patent/CA2590246C/fr
Priority to ARP050105474A priority patent/AR055297A1/es
Publication of FR2880020A1 publication Critical patent/FR2880020A1/fr
Application granted granted Critical
Publication of FR2880020B1 publication Critical patent/FR2880020B1/fr
Priority to US11/819,068 priority patent/US7807708B2/en
Priority to ZA200705930A priority patent/ZA200705930B/en
Priority to US12/842,347 priority patent/US8227507B2/en
Priority to CY20121100388T priority patent/CY1112721T1/el
Priority to US13/527,299 priority patent/US8470871B2/en
Priority to NL301042C priority patent/NL301042I2/nl
Priority to HUS2200006C priority patent/HUS2200006I1/hu
Priority to LTPA2022002C priority patent/LTC1831149I2/lt
Priority to CY2022031C priority patent/CY2022031I2/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR0413848A 2004-12-23 2004-12-23 NOUVEAUX LIGANDS MODULATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE Expired - Fee Related FR2880020B1 (fr)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FR0413848A FR2880020B1 (fr) 2004-12-23 2004-12-23 NOUVEAUX LIGANDS MODULATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE
KR1020077014372A KR101316992B1 (ko) 2004-12-23 2005-12-21 Ｒａｒ 수용체를 조절하는 신규 리간드, 및 인간 의학 및화장품에서의 그의 용도
AU2005318292A AU2005318292B2 (en) 2004-12-23 2005-12-21 Novel ligands that modulate RAR receptors, and use thereof in human medicine and in cosmetics
MX2007007696A MX2007007696A (es) 2004-12-23 2005-12-21 Compuestos ligandos moduladores de los receptores nucleares del acido retinoico(rars) y uso en medicina humana y en cosmeticos.
SI200531509T SI1831149T1 (sl) 2004-12-23 2005-12-21 Novi ligandi, ki modulirajo RAR receptorje in njihova uporaba v humani medicini in v kozmetiki
DK05824484.9T DK1831149T3 (da) 2004-12-23 2005-12-21 Hidtil ukendte ligander, der modulerer rar-receptorer, og anvendelse deraf i human medicin og i kosmetik
CN2005800447781A CN101087752B (zh) 2004-12-23 2005-12-21 调节rar受体的新配体，及其在人类药品和化妆品中的用途
JP2007547399A JP5258299B2 (ja) 2004-12-23 2005-12-21 Ｒａｒ受容体を調節する新規リガンド、並びにヒトの医薬品及び化粧品におけるその使用
ES05824484T ES2380777T3 (es) 2004-12-23 2005-12-21 Nuevos ligandos que modulan los receptores RAR y su uso en la medicina humana y en la cosmética
PT05824484T PT1831149E (pt) 2004-12-23 2005-12-21 Novos ligandos que modulam recetores rar e sua utilização em medicina humana e em cosmética
PL05824484T PL1831149T3 (pl) 2004-12-23 2005-12-21 Nowe ligandy, które modulują receptory RAR, i ich zastosowanie w medycynie i kosmetyce
PCT/EP2005/014217 WO2006066978A1 (fr) 2004-12-23 2005-12-21 Nouveaux ligands qui modulent les recepteurs rar, et leur utilisation en medecine et en cosmetique
AT05824484T ATE542791T1 (de) 2004-12-23 2005-12-21 Neue liganden als rar-rezeptormodulatoren und deren verwendung in der humanmedizin und kosmetik
EP05824484A EP1831149B1 (fr) 2004-12-23 2005-12-21 Nouveaux ligands qui modulent les recepteurs rar, et leur utilisation en medecine et en cosmetique
RU2007127867A RU2440973C3 (ru) 2005-12-21 Новые лиганды, модулирующие rar рецепторы, и их применение в медицине и в косметических изделиях
CA2590246A CA2590246C (fr) 2004-12-23 2005-12-21 Nouveaux ligands qui modulent les recepteurs rar, et leur utilisation en medecine et en cosmetique
BRPI0517500A BRPI0517500B8 (pt) 2004-12-23 2005-12-21 composto, uso de uma composição, composição farmacêutica, composição cosmética, usos não-terapêuticos de uma composição cosmética e processo cosmético para melhorar a aparência da pele
ARP050105474A AR055297A1 (es) 2004-12-23 2005-12-22 Ligandos moduladores de los receptores rars, utilizacion en medicina humana asi como en cosmetica
US11/819,068 US7807708B2 (en) 2004-12-23 2007-06-25 Ligands that modulate RAR receptors and pharmaceutical/cosmetic compositions comprised thereof
ZA200705930A ZA200705930B (en) 2004-12-23 2007-07-17 Novel ligands that modulate rar receptors, and use thereof in human medicine and in cosmetics
US12/842,347 US8227507B2 (en) 2004-12-23 2010-07-23 Ligands that modulate RAR receptors
CY20121100388T CY1112721T1 (el) 2004-12-23 2012-04-25 Νεοι συνδετες που διαμορφωνουν τους υποδοχεις rαr, και χρηση αυτων στην ιατρικη για τον ανθρωπο και στα καλλυντικα
US13/527,299 US8470871B2 (en) 2004-12-23 2012-06-19 Ligands that modulate RAR receptors
NL301042C NL301042I2 (nl) 2004-12-23 2020-06-10 Trifaroteen, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout
HUS2200006C HUS2200006I1 (hu) 2004-12-23 2022-02-07 A RAR receptorokat moduláló új ligandumok, valamint alkalmazásuk humán gyógyászatban és kozmetikumokban
LTPA2022002C LTC1831149I2 (fr) 2004-12-23 2022-03-10
CY2022031C CY2022031I2 (el) 2004-12-23 2022-10-20 Νεοι συνδετες που διαμορφωνουν τους υποδοχεις rαr, και χρηση αυτων στην ιατρικη για τον ανθρωπο και στα καλλυντικα

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0413848A FR2880020B1 (fr) 2004-12-23 2004-12-23 NOUVEAUX LIGANDS MODULATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE

Publications (2)

Publication Number Publication Date
FR2880020A1 FR2880020A1 (fr) 2006-06-30
FR2880020B1 true FR2880020B1 (fr) 2007-02-16

Family

ID=34952934

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0413848A Expired - Fee Related FR2880020B1 (fr) 2004-12-23 2004-12-23 NOUVEAUX LIGANDS MODULATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE

Country Status (12)

Country Link
US (3) US7807708B2 (fr)
CN (1) CN101087752B (fr)
AR (1) AR055297A1 (fr)
AT (1) ATE542791T1 (fr)
DK (1) DK1831149T3 (fr)
ES (1) ES2380777T3 (fr)
FR (1) FR2880020B1 (fr)
HU (1) HUS2200006I1 (fr)
LT (1) LTC1831149I2 (fr)
PT (1) PT1831149E (fr)
SI (1) SI1831149T1 (fr)
ZA (1) ZA200705930B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702604B2 (en) 2012-06-01 2020-07-07 Galderma Research & Development Lipid nanocapsules comprising a retinoid, nanodispersion and composition containing the same, process for preparing the same and use thereof in dermatology
FR2991174B1 (fr) * 2012-06-01 2014-12-26 Galderma Res & Dev Composition dermatologique comprenant des oleosomes et des retinoides, son procede de preparation et son utilisation
FR2991171B1 (fr) * 2012-06-01 2014-05-23 Galderma Res & Dev Procede de preparation d'une composition dermatologique comprenant des oleosomes
FR2991176B1 (fr) * 2012-06-01 2014-12-19 Galderma Res & Dev Compositions topiques, contenant un retinoide solubilise, de type gel hydroglycolique
FR2991175B1 (fr) * 2012-06-01 2014-12-19 Galderma Res & Dev Compositions pharmaceutiques topiques de type emulsion h/e contenant un retinoide
FR2991172A1 (fr) * 2012-06-01 2013-12-06 Galderma Res & Dev Compositions pharmaceutiques topiques comprenant des microcapsules
JP6235294B2 (ja) * 2013-10-07 2017-11-22 東京エレクトロン株式会社 基板搬送室及び容器接続機構
JP2016539161A (ja) 2013-12-04 2016-12-15 ガルデルマ・リサーチ・アンド・デヴェロップメント 好ましくは親油性活性物質を含む脂質マイクロカプセル、並びにそれを含有する組成物、それらの製造のための方法、並びに皮膚科学及び化粧品におけるそれらの使用
US11197831B2 (en) * 2015-05-29 2021-12-14 Galderma Research And Development Compositions comprising at least one dispersed active principle and lipid microcapsules
CN114929678B (zh) * 2019-11-29 2023-08-15 石家庄迪斯凯威医药科技有限公司 一种取代的间三联苯类化合物及其药物组合物和用途
WO2021216628A1 (fr) 2020-04-21 2021-10-28 Teva Pharmaceuticals International Gmbh Formes solides de trifarotène et leur procédé de préparation
CN115246856A (zh) * 2021-04-27 2022-10-28 上海旭成医药科技有限公司 视黄酸受体激动剂、其制备方法、中间体、药物组合物和应用
CN113501758B (zh) * 2021-09-10 2021-11-23 南京迈诺威医药科技有限公司 一种联苯化合物的制备方法
CN115745913B (zh) * 2022-09-16 2024-05-24 南京迈诺威医药科技有限公司 曲法罗汀多晶型及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2763588B1 (fr) * 1997-05-23 1999-07-09 Cird Galderma Composes triaromatiques, compositions les contenant et utilisations
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant

Also Published As

Publication number Publication date
US8227507B2 (en) 2012-07-24
ES2380777T3 (es) 2012-05-18
CN101087752A (zh) 2007-12-12
US20080015246A1 (en) 2008-01-17
CN101087752B (zh) 2011-11-16
ATE542791T1 (de) 2012-02-15
LTC1831149I2 (fr) 2022-09-26
SI1831149T1 (sl) 2012-06-29
PT1831149E (pt) 2012-04-13
US7807708B2 (en) 2010-10-05
HUS2200006I1 (hu) 2022-03-28
LTPA2022002I1 (fr) 2022-04-11
US20100292296A1 (en) 2010-11-18
ZA200705930B (en) 2008-07-30
FR2880020A1 (fr) 2006-06-30
US8470871B2 (en) 2013-06-25
US20120258996A1 (en) 2012-10-11
AR055297A1 (es) 2007-08-15
DK1831149T3 (da) 2012-05-07

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