FR2846974A1 - Procede de production d'une substance cible par fermentation - Google Patents

Procede de production d'une substance cible par fermentation

Info

Publication number
FR2846974A1
FR2846974A1 FR0313178A FR0313178A FR2846974A1 FR 2846974 A1 FR2846974 A1 FR 2846974A1 FR 0313178 A FR0313178 A FR 0313178A FR 0313178 A FR0313178 A FR 0313178A FR 2846974 A1 FR2846974 A1 FR 2846974A1
Authority
FR
France
Prior art keywords
culturing
bacterium
nucleoid
inactivated
escherichia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR0313178A
Other languages
English (en)
Other versions
FR2846974B1 (fr
Inventor
Rie Takikawa
Akira Imaizumi
Kazuhiko Matsui
Hiroyuki Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of FR2846974A1 publication Critical patent/FR2846974A1/fr
Application granted granted Critical
Publication of FR2846974B1 publication Critical patent/FR2846974B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé pour produire une substance cible (L-lysine) au moyen d'un micro-organisme qui comprend la culture d'une bactérie du genre Escherichia dans un milieu pour produire et accumuler la substance cible dans le milieu ou les cellules bactériennes et la collecte de la substance cible, où la bactérie utilisée est de préférence une souche dans le chromosome de laquelle le gène fis est détruit (souche WC196Δfis) de sorte que la protéine FIS n'est pas fonctionnelle dans les cellules bactériennes.
FR0313178A 2002-11-11 2003-11-10 Procede de production d'une substance cible par fermentation Expired - Fee Related FR2846974B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002327205 2002-11-11

Publications (2)

Publication Number Publication Date
FR2846974A1 true FR2846974A1 (fr) 2004-05-14
FR2846974B1 FR2846974B1 (fr) 2008-04-04

Family

ID=32171346

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0313178A Expired - Fee Related FR2846974B1 (fr) 2002-11-11 2003-11-10 Procede de production d'une substance cible par fermentation

Country Status (4)

Country Link
US (1) US20040265956A1 (fr)
CN (1) CN100366750C (fr)
BR (1) BR0304860A (fr)
FR (1) FR2846974B1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2313878T3 (es) * 2000-01-21 2009-03-16 Ajinomoto Co., Inc. Procedimiento para la produccion de l-lisina.
US7468262B2 (en) * 2003-05-16 2008-12-23 Ajinomoto Co., Inc. Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum
EP1649403A2 (fr) * 2003-07-29 2006-04-26 Ajinomoto Co., Inc. Procede permettant de detecter la production d'une substance influen ant les flux metaboliques
KR100786987B1 (ko) * 2004-01-30 2007-12-18 아지노모토 가부시키가이샤 Ｌ-아미노산 생산 미생물 및 ｌ-아미노산 생산 방법
JP4595506B2 (ja) * 2004-11-25 2010-12-08 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造方法
JP2007117082A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2009095237A (ja) * 2006-02-02 2009-05-07 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
RU2338784C2 (ru) * 2006-03-24 2008-11-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты)
JP2010017081A (ja) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2008072761A2 (fr) * 2006-12-11 2008-06-19 Ajinomoto Co., Inc. Procédé de production d'acide l-aminé
JP5540504B2 (ja) * 2007-01-22 2014-07-02 味の素株式会社 Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
JP2010110217A (ja) * 2007-02-22 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2010130899A (ja) 2007-03-14 2010-06-17 Ajinomoto Co Inc Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法
WO2008133131A1 (fr) * 2007-04-16 2008-11-06 Ajinomoto Co., Inc. Procédé de fabrication d'un acide organique
WO2008133161A1 (fr) * 2007-04-17 2008-11-06 Ajinomoto Co., Inc. Procédé de fabrication d'une substance acide ayant un groupe carboxyle
JP2010263790A (ja) * 2007-09-04 2010-11-25 Ajinomoto Co Inc アミノ酸生産微生物及びアミノ酸の製造法
RU2395579C2 (ru) * 2007-12-21 2010-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
JP5598329B2 (ja) * 2008-09-08 2014-10-01 味の素株式会社 Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796912A1 (fr) * 1994-12-09 1997-09-24 Ajinomoto Co., Inc. Nouveau gene de decarboxylase de lysine et procede de production de lysine l

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3613218A (en) * 1969-08-25 1971-10-19 Caterpillar Tractor Co Welder power and drive system
JPS51151391A (en) * 1975-06-19 1976-12-25 Ajinomoto Co Inc Process for preparing l-sulfur- containing amino acids
US4016037A (en) * 1975-10-15 1977-04-05 Ajinomoto Co., Inc. Method for producing L-amino acid
JPS5618596A (en) * 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
JPH0746994B2 (ja) * 1984-10-04 1995-05-24 味の素株式会社 発酵法によるｌ−アミノ酸の製造法
US5164307A (en) * 1987-01-23 1992-11-17 Ajinomoto Co., Inc. Process for producing L-amino acids by fermentation
JP2817157B2 (ja) * 1989-01-13 1998-10-27 味の素株式会社 発酵法によるｌ‐アミノ酸の製造法
DE69330518T2 (de) * 1992-11-10 2002-05-08 Ajinomoto Kk Dna, die aspartokinase iii-mutanten kodiert und ihre verwendung zur herstellung von l-threonin durch fermentation
HU219600B (hu) * 1993-08-24 2001-05-28 Ajinomoto Co., Inc. Mutáns foszfo-enolpiruvát-karboxiláz, ennek génje, valamint eljárás aminosav előállítására
JPH07155184A (ja) * 1993-12-08 1995-06-20 Ajinomoto Co Inc 発酵法によるｌ−リジンの製造法
DE69534592T2 (de) * 1994-03-04 2006-08-10 Ajinomoto Co., Inc. Verfahren für die herstellung von l-lysin
US5998178A (en) * 1994-05-30 1999-12-07 Ajinomoto Co., Ltd. L-isoleucine-producing bacterium and method for preparing L-isoleucine through fermentation
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
WO1996041871A1 (fr) * 1995-06-13 1996-12-27 Ajinomoto Co., Inc. Procede de production de l-lysine par fermentation
JP4088982B2 (ja) * 1996-10-15 2008-05-21 味の素株式会社 発酵法によるｌ−アミノ酸の製造法
WO2000016609A1 (fr) * 1998-09-21 2000-03-30 Commonwealth Scientific And Industrial Research Organisation Nouveau procede de regulation du developpement de graines chez des vegetaux et sequences genetiques utiles a cet effet
WO2000018935A1 (fr) * 1998-09-25 2000-04-06 Ajinomoto Co.,Inc. Procede de construction d'une bacterie produisant des acides amines, et procede de production d'acides amines par une technique de fermentation utilisant ladite bacterie
JP2003506030A (ja) * 1999-08-02 2003-02-18 アーカー−ダニエルズ−ミッドランド カンパニー アミノ酸産生の代謝工学
TW200734459A (en) * 1999-10-04 2007-09-16 Ajinomoto Kk Genes for heat resistant enzymes of amino acid biosynthetic pathway derived from thermophilic coryneform bacteria
US6838239B1 (en) * 1999-10-13 2005-01-04 San Diego State University Foundation Chitobiase as a reporter enzyme
WO2001046393A2 (fr) * 1999-12-21 2001-06-28 E.I. Du Pont De Nemours And Company Aspartate kinase
US6927046B1 (en) * 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
JP4380029B2 (ja) * 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
JP4265093B2 (ja) * 2000-08-11 2009-05-20 味の素株式会社 スレオニン及びイソロイシンの製造法
DE60120619T2 (de) * 2000-12-22 2007-06-14 Ajinomoto Co., Inc. Verfahren zur Herstellung einer Zielsubstanz durch Fermentation
CA2444195A1 (fr) * 2001-04-19 2002-10-31 Invitrogen Corporation Compositions et procedes destines au clonage recombinant de molecules d'acides nucleiques
AU2003205041A1 (en) * 2002-07-12 2004-01-29 Ajinomoto Co., Inc. Method for producing target substance by fermentation
RU2245919C2 (ru) * 2002-09-06 2005-02-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислоты, штамм escherichia coli tdh7δ mlc::cat/pprt614-продуцент l-треонина
DE602004031088D1 (de) * 2003-02-20 2011-03-03 Takeda Pharmaceutical Mutierte SREBP-1c Promoteren und deren Verwendung
US7468262B2 (en) * 2003-05-16 2008-12-23 Ajinomoto Co., Inc. Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum
ATE531803T1 (de) * 2003-06-05 2011-11-15 Ajinomoto Kk Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten
EP1649403A2 (fr) * 2003-07-29 2006-04-26 Ajinomoto Co., Inc. Procede permettant de detecter la production d'une substance influen ant les flux metaboliques
RU2276686C2 (ru) * 2003-08-29 2006-05-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Бактерия, принадлежащая к роду escherichia, - продуцент l-аргинина и способ получения l-аргинина
KR100786987B1 (ko) * 2004-01-30 2007-12-18 아지노모토 가부시키가이샤 Ｌ-아미노산 생산 미생물 및 ｌ-아미노산 생산 방법
US20060281110A1 (en) * 2005-05-26 2006-12-14 Michigan State University Methods to identify antimicrobial compounds that interrupt ribosome biogenesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796912A1 (fr) * 1994-12-09 1997-09-24 Ajinomoto Co., Inc. Nouveau gene de decarboxylase de lysine et procede de production de lysine l

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GONZALEZ-GIL G ET AL: "FIS IS A REGULATOR OF METABOLISM IN ESCHERICHIA COLI", MOLECULAR MICROBIOLOGY, vol. 22, no. 1, October 1996 (1996-10-01), Oxford, GB, pages 21 - 29, XP009030475, ISSN: 0950-382X *
SHIN DONGWOO ET AL: "Selective regulation of ptsG expression by Fis: Formation of either activating or repressing nucleoprotein complex in response to glucose", J. BIOL. CHEM.;JOURNAL OF BIOLOGICAL CHEMISTRY APR 25 2003, vol. 278, no. 17, 25 April 2003 (2003-04-25), pages 14776 - 14781, XP002283896 *

Also Published As

Publication number Publication date
CN100366750C (zh) 2008-02-06
US20040265956A1 (en) 2004-12-30
FR2846974B1 (fr) 2008-04-04
CN1498969A (zh) 2004-05-26
BR0304860A (pt) 2004-08-31

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Year of fee payment: 13

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