FR2839892A1 - Pre-filled disposable syringe has axially-sliding needle hub released by needle-cap removal, and advanced away from seal by initial fluid pressure - Google Patents

Abstract

The tubular body (1) is a sealed (10, 15) liquid-filled chamber. A channel (13) can be released, to pass liquid from the chamber and through a further channel in the needle boss (20), to reach the needle. This occurs when the boss is moved between an axially-retracted position, in which the channel (13) is sealed, and an advanced position permitting flow from the chamber to and through the needle (28). A cap (30) covers the base and has a detachment location (35) connecting it to the tubular body. An axial stop (32) holds the boss in the sealing position when it is covered by the cap. A further axial stop (23) limits advancement of the hub, following cap removal.

Description

-

  SINGLE USE INJECTION DEVICE

TO BE PRE-FILLED

  The invention relates to an injection device of the single-use type designed to be pre-filled with a dose of liquid, in particular

medicated, to inject.

  The disposable injection devices intended to be pre-filled comprise a syringe body, either equipped with a base in which is sealed a needle protected by a protective cap, or io comprising a male conical locking connection allowing adaptation on said syringe body a female conical connector with locking carries an injection needle protected by a protective cap, said conical connectors defining an assembly commonly known under the name "assembly

conical LUER ".

  s The most conventional so-called "wet needle" injection devices of the type provided with a syringe body comprising a base in which is sealed a needle closed by means of an elastomeric protective cap, pierced with an ales internal blind age housed in the bottom of said cap, and inside which is forcibly accommodated the end of said

  o needle to guarantee the tightness of the injection device before injection.

  The first disadvantage of such injection devices lies in the fact that they require, when the protective cap is put in place, to perfectly center the injection needle relative to the bore in said cap. However, in practice, this centering is sometimes approximate, so that the mounting of the cap frequently leads to deterioration of said cap or the needle, with consequent non-negligible manufacturing rejects. In addition, according to this principle, the quality of the needle (sharpening, siliconization) is systematically affected due to the friction of the point of said needle against the internal wall of the blind bore of the cap.

  when forcibly mounting this behind.

  Finally, the liquid contained in these injection devices must be in contact with the materials constituting the injection needle and the protective cap which can, for certain types of liquid, affect

conservation of these.

  s To overcome these drawbacks, multiple "dry needle" injection devices have been designed, for which the injection needle is isolated from the liquid contained in the syringe body until the moment of injection. . A first type of “dry needle” injection device o is that commonly used in the dental field and comprises a bottle containing the liquid to be injected and sealed with a membrane, and a twin-pointed needle capable of being displaced axially with respect to said vial, so as to pierce the membrane at the time of injection. Such injection devices are described in particular in patents DE-847473, FR-2347055, US-4639250,

  5 EP-602883, DE-2008751, DE-1909794.

  The disadvantages of this type of injection device are twofold. Indeed, and in the first place, the fact of requiring a twin-pointed needle leads to an additional cost concerning the cost price of these injection devices, resulting on the one hand from the cost in itself of said needle, and on the other hand, the obligation to carry out two sharpening operations in place of the only sharpening operation required for a conventional needle. In addition, it frequently happens, especially for small needle diameters, that one is confronted with coring problems leading to the inclusion of membrane particles inside the lumen of the needle, which is blocked. this light,

  A / 5 or wind injected with the liquid.

  A second type of “dry needle” injection device comprises a syringe body housing two plugs delimiting a chamber containing the liquid, and on which a base is crimped either carry a needle, or of the male conical connector type, said body syringe having, in addition, a compartment provided with a conduit for communication with the injection needle, so as to be connected to the chamber only

  after axial displacement of the pistons.

  - Such injection devices, in particular described in patents FR2412320, FR-2208684, EP-191508, EP-588148 and EP-720857, make it possible to overcome the disadvantages of the injection devices described above. However, they also have two drawbacks themselves. In fact, and first of all, the operation of crimping the base on the syringe body proves to be delicate and requires special attention in order to guarantee perfect sealing between said base and said syringe body. In addition and above all, such injection devices may be subject to accidental spillage of the liquid contained in the chamber, resulting for example from an expansion of the volume of gas contained in said chamber, or from depressurization in particular during '' air transport, which lead to the axial displacement of the access cap to the compartment

liquid discharge.

  A third type of "dry needle" injection device described in particular in patents EP-150681, EP-111796, FR-2330413 W0-8404252, FR-2784033 makes it possible to alleviate all of the above-mentioned drawbacks. To this end, these devices dtinjectiot1 component, on the one hand, a syringe body provided with a chamber closed by a rubber stopper pierced with a longitudinal through bore, and on the other hand a base, either carry an A [ O needle, either of the male conical connector type, movable axially inside the bore to said plug, and provided with ducts so as to bring the injection needle and the chamber into communication during an axial displacement of

  said base tending to push it into the plug.

  However, such injection devices present in practice a major drawback resulting from the fact that their activation, for injection, requires to insert the base inside the protective cap. From this state of affairs in fact follows the obligation for the user to perform a specific action aimed at bringing about the activation of the injection device, which results in a modification of ancestral gestural habits which consist, with so syringes with "wet needle", to simply operate a withdrawal of the needle-protective cap, by gripping and then pulling the latter. However, this imposed modification of their gestural habits turns out to be very badly accepted by users of the medical profession, and in practice, "dry needle" injection devices currently represent a very low market share. compared to that of "wet needle" injection devices, despite the disadvantages

  inherent in the design of these.

  The present invention aims to overcome this drawback of injection devices "your dry needle" of the third type described above, and has the main objective of providing an injection device combining the advantages of these injection devices (sealing, guaranteed against the risks of eventual discharge ...), the activation of which for an injection takes place naturally during

  io the removal of the cap covering the base.

  To this end, the invention relates to an injection device comprising in combination: - a tubular container provided with sealing means sealed at one of its longitudinal ends, said sealed sealing means delimiting a chamber intended to be filled with 'a liquid, and comprising a liquid distribution conduit opening into said chamber, - a needle holder base pierced with a liquid supply conduit for said needle, said base being axially movable relative to the sealing means, so as to be able to move o between a backward position, cites the closed position where it closes the distribution duct, and an advanced position, cites the injection position, where it allows the flow of liquid from the chamber towards the needle through the supply duct of said base, - a cap of suitable shape for covering the base, provided with detachable connection means with the sealing means, - means for axial stop conjugate households on the base and the cap, and arranged so as to maintain * said base in its retracted position of obturation when this behind is capped with said cap linked to the sealing means, so - and axial stop means arranged so as to limit the axial displacement stroke of the base, once the cap detaches from the

watertight sealing means.

  (It should be noted that, in this patent application, it is meant to define generally, by the term "needle holder base" either a base in which an injection needle is sealed, or a base consisting of a conical connection male locking.) According to the invention, the injection device is therefore in the "inactive" position in its configuration of conditioning before use, in which the base is capped by the cap which ensures that said base is kept in its closed position due to the connection of this cap with the

watertight sealing means.

  In this configuration, the injection device therefore consists of an injection device of the "dry needle" type combining all the advantages linked to such injection devices. In addition, the activation of this injection device requires, for its part, simply to exert traction on the cap, in view of detaching the latter from the sealing means and thereby releasing the base . This activation therefore results from a simple natural gesture identical to that carried out at the present time with a view to releasing the needle from a "wet needle" injection device. This simple gesture leads, in fact, due to the removal of the cap, to remove the axial stop holding the base in its closed position, and thus to authorize the subsequent axial displacement of

  o said base towards its injection position.

  This axial displacement of the base can also be caused only just before the injection, under the effect of the pressure exerted by the liquid flowing out of the chamber of the container following the actuation of the

injection device piston.

  : 5 This axial displacement can also be obtained by

  providing friction surfaces between the base and the cap.

  However, advantageously, in order to cause this axial displacement of the base towards its injection position, when the cap is removed, said base and said cap comprise so relative locking members in translation conjugate, arranged, d on the one hand, so as to cooperate in the closed position of the base, or the latter is in abutment against the axial abutment means determining said closed position, and on the other hand,

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  so as to allow a relative axial displacement of the cap relative to the base, in the injection position of the base where this behind is in abutment

  against the axial stop means determining said injection position.

  According to an advantageous embodiment, the sealed closure means and the base comprise means for relative locking in translation of said base with respect to said sealed closure means, housed on the one hand, so as to allow displacement of the base from its closed position to its injection position, and, on the other hand, for blocking in translation said base relative to said sealed closure means in

o said injection position.

  Thus, once the cap has been removed, the base is automatically locked mechanically in its injection position, and therefore allows in particular to perform a prior conventional suction maneuver before injection, by pulling on the piston rod, without risk of causing a recur of s said base being able to prohibit this aspiration by closing the distribution duct. Furthermore, according to another advantageous embodiment, the sealed closure means comprise: - a closure plug made of an elastic or waterproof material, having the shape of a cylindrical hollow body of section adapted to be inserted into the container , said closure plug comprising a bottom wall delimiting the chamber of said container, in which there is a through distribution duct, - a cover provided with a front wall pierced with an orifice s of diameter adapted to allow the passage of the base, and of a cylindrical sleeve of suitable diameter for embotting with the closure plug, so that said sleeve and plug define a guide conduit for said base, - relative locking means in translation of the closure plug so as and the lercercule, - and relative locking means in translation of

  ['closure cap / seal relative to the container.

i

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  According to this embodiment, the waterproof sealing means therefore dissociated into two separate elements of unitary alsee manufacturing: - a sealing plug made of a conventional material such as rubber, adapted to ensure the sealing between the means of watertight sealing and the container, and between said sealing means and the base, - and a cover for example made of injected plastic, adapted to block and maintain the sealing plug inside the container, and to ensure, in collaboration with said closure plug io, the guiding of the base during its displacement from its position

  obturation towards its injection position.

  In addition, according to this embodiment, and advantageously, the means for blocking in translation of the base in its injection position, comprise at least one radially deformable abutment element, so as to be kept compressed inside the top of the cap, in the closed position of the base and when moving this behind towards its injection position, and to expand in a reservation

  blocking device, suitable for housing it in the injection position of the base.

  Furthermore, concerning the detachable connection between the cap and the sealing means, two alternative embodiments

  advantageous can be considered.

  Thus, according to a first advantageous alternative embodiment, the cap and the wind seal made in one piece and the wind connected by detachable connection means consist of a stable seeable connection.

  : 5 between said cap and the front wall of said cover.

  On the other hand, according to a second advantageous variant embodiment, the cap and the air seal consist of two separate parts.

  comprising assembly means combined by screwing.

  In this second case, moreover, the injection device so advantageously comprises, for the purpose of inviolability, an annular ring made in one piece with the cap and connected to the rear end of the latter by a seeable connection. , said annular ring being adapted to be housed inside the sleeve of the cover, in a fixed position in

  translation inside said sleeve.

  Other features, objects and advantages of the invention

  will emerge from the detailed description which follows with reference to the accompanying drawings

  s which represent, by way of nonlimiting examples, three variant embodiments of an injection device according to the invention, as well as a variant of the needle-protective cap which can replace the needle-protective cap equipping the first two devices. injection respectively shown in Figures 2-4 and 5-6. In these figures: o - Figure 1 is a general longitudinal view of a first injection device according to the invention, in its configuration of packaging before use, - Figure 2 is a longitudinal section of a first mode of realization of the injection device as represented in FIG. 1, S represented in its packaging configuration before use, - FIG. 3 is a partial longitudinal section on an enlarged scale of the injection device according to FIG. 2, - FIG. 4 is a partial longitudinal section on an enlarged scale representing the injection device according to FIG. 2, in its active o injection position, ready for use, - Figure S is a partial longitudinal section on enlarged scale of a second embodiment of injection device as shown in Figure 1, shown in its packaging configuration before use, s - Figure 6 is a partial longitudinal section on an enlarged scale representing this second embodiment in its active injection position, ready for use, - Figure 7 is a longitudinal section of a variant needle holder cap which can replace that shown in Figures 1, 2, 3, 5 fitted the first two variants of injection devices according to the invention,

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  - Figure 7a is a partial perspective view of this needle holder cap, - Figure 8 is a partial longitudinal section in a third embodiment of the injection device according to the invention, represented in its packaging configuration before use, - and FIG. 9 is a partial longitudinal section of this third variant of the injection device according to the invention represented in

  its active injection position, ready for use.

  The three injection device trots represented by way of non-limiting examples in FIGS. 1-6 and 8, 9 are single-use injection devices, that is to say intended for 8ke pre-filled with dose of liquid to inject. It should also be noted that, although the injection devices shown do not have a protective case intended to protect the needle after injection and thus avoid any risk of pricking with the contaminated needle, these devices injection can be fitted with all types of protective cases, of conventional designs known per se, fulfilling this protective function

after use.

  As represented in FIG. 1, each of the injection devices according to the invention comprises, firstly, a syringe body 1 o consisting of a simple cylindrical tube, for example made of glass, provided with an external collar 2 d digital support at one of its longitudinal extremities posterior. At its opposite end, cited above, this cylindrical tube 1 has, in addition, an internal annular rib

  3 projecting inside said tube.

  Each injection device according to the invention further comprises, in a conventional manner, a piston 6 of diameter adapted to slide in a sealed manner inside the syringe body 1, and a piston rod 4 secured by screwing to the piston. 6 at its anterior longitudinal end, and endowed

  a push button 5 finger support at its rear end.

  n / a In addition to these trots elements, cylindrical tube 1, piston 6 and piston rod 4, which are strictly identical for each of the variant trots represented in the figures, each of the injection devices according to the invention further comprises four elements fulfilling a function specific common to the various variant embodiments and consist of: - a stopper made of a conventional waterproof elastic material such as rubber, sealing off the anterior end of the syringe body 1, - a needle holder base movable axially with respect to to the syringe body 1 and done with respect to the obturation cap, - a cover for blocking and maintaining the ob turati on cap, o - and a needle-protective cap suitable for clipping the base and ensuring the protection of the needle carried by this behind, in the

  packaging configuration before use of the injection device.

  According to the embodiment shown in Figures 2 to 4, the closure plug 10 is in the form of a cylindrical hollow body of external diameter combines with the internal diameter of the syringe body 1, adapted

  for stinser tightly inside said syringe body.

  Internally, this closure plug 10 is subdivided into two longitudinal cylindrical sections of different internal diameters separated by a radial shoulder lOb, and consist of an anterior section lOa and a section

  posterior lOb of internal diameter smaller than that of the anterior trunk lOa.

  This closure plug 10 further comprises an anterior external flange 11 of abutment against the longitudinal end

syringe barrel 1.

  This closure plug 10 finally comprises a wall of: 5 bottom 12 of delimitation, inside the syringe body 1, and with the piston 6, of the chamber containing the liquid to be injected. This bottom wall 12 has - a frustoconical shape so as to form, posteriorly, a concave seat 12a for supporting the piston 6, and previously, a convex seat 12b for supporting the face

  rear end of the base described below.

  n / a The bottom wall 12 of the closure plug 10 is. finally, longitudinally pierced through a conduit 13 for distributing the liquid contained in the chamber of the syringe body 1. This distribution conduit 13

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  is furthermore eccentric with respect to the longitudinal axis of the closure plug 10, and is arranged so as to open out at the periphery of the rear section 10b at said plug. The cover 15 of this first embodiment consists, for its part, of a cylindrical sleeve 16 of external diameter combined with the internal diameter of the front section 10a of the plug 10 and of length less than that at said front section, suitable for to be inserted in the latter so as to maintain said piece stopper between said sleeve and the syringe body 1, and blocks in translation by deformation of the latter at

  o level of the internal rib 3 at said syringe body.

  This cover 15 further comprises an anterior annular front wall 17 forming a flange on the periphery of the sleeve 16, of

  axial stop against the front flange 11 of the plug 10.

  Finally, the cylindrical wall of the sleeve 16 of the cover 15 is cut longitudinally, from its rear end, in longitudinal sectors such as 18 each delimited by two longitudinal slots, so as to each form a longitudinal tongue 18 deformable radially. In addition, a circumferential boss 19 is formed at the rear end of each tongue 18 so as to protrude inside the sleeve 16 of the cover 15 in the absence of external stress.

exerted on said tongue.

  The base 20 of the first embodiment of the injection device according to the invention, has, for its part, the general shape of a cylindrical shaft 21 of external diameter combines with the internal diameter of the posterior trunk 10b of the sealing plug 10, adapted so that a sealed volume 50 is delimited inside said rear section by respectively the bottom wall 12 of the closure plug 10 and the rear end face 22 of said base. This posterior end face 22 also has a concave shape combined with the convex shape of the front seat 12b formed by the bottom wall 12 of the closure plug 10, and suitable for closing.

  in a sealed manner the distribution duct 13 opening out at the level of said seat.

  The base 20 further comprises an external annular rib 23 formed at a distance from the rear end face 22 of this base 20, adapted so that said rib abuts longitudinally against the internal radial shoulder lOb of the plug. obturation 10, in a longitudinal position of said emb a s or its posterior end face 22

  rests against its support sidge 12b.

  The base 20 furthermore comprises a retentive peripheral annular groove 24, offset longitudinally forwards with respect to the annular rib 23 and adjoining this rear, said groove being formed so as to be positioned longitudinally: part, set back posteriorly relative to the bosses 19 of the sleeve 16 of the cover 15, in the retracted position of the base or this behind closes the distribution duct 13 of the closure plug? - And secondly, so as to accommodate these bosses 19, in an advanced position of the base 20 or the rear face 22 of this rear is moved away from the bottom wall 12 of the closure plug 10, and or a volume

  watertight 50 is delimited between these rear face 22 and bottom wall 12.

  The base 20 also includes an annular groove or non-retentive peripheral 25 formed longitudinally at a short distance from its anterior end, and intended for the drive of said base from its position for closing the distribution duct 13 towards its position of release from ['liquid outlet port to said conduit, as explained below. The base 20 comprises, lastly, an axial bore 27 opening out at its front end face, intended conventionally for sealing a single-point injection needle 28, and in the extension of which s' extends an axial duct 29 for supplying liquid

  said needle, emerging at the rear face 22 of said base.

  The needle guard cap 30 is. as for it, consists of a cap of external conventional cylindrical general shape. Internally,

13 2839892

  this cap 30 is subdivided into two longitudinal sections 31, 33 of different diameters, separated by a radial shoulder 32: - - - a posterior section 33 of falble length relative to the total length of the cap 30, and of combined internal diameter of the diameter external of the base 20, adapted to cover the rear, - and an anterior section 31 of internal diameter smaller than that of the rear section 33, adapted so that the shoulder 32 acts as

axial stop for the base 20.

  In addition, the posterior section 33 of the cap 30 has a non-retentive internal annular rib 34, positioned and of a shape adapted to be housed in the annular groove 25 of the base 20, when this cap 30

  sticks the needle 28 and said base.

  - Finally, and according to the invention, the protective cap

  needle 30 is made in one piece with the cover 15, for example by plastic injection, and is secured to the front wall 17 to said cover by a seeable connection of any type known per se such as pins 35 representing

Figures 2 to 6.

  As a variant and as shown in FIGS. 7 and 7a, this seeable connection may also consist of an annular band 36 which is not closed in on itself, connected to the cap 30 and to the cover 15 by two circular zones of weak breakage 37, 38 , and provided with a gripping tab 39 at the level

  of its free end, in view of its tearing.

  The assembly of the various elements of the injection device according to the invention, described above, is obtained very easily according to the following process: Firstly, the base 20 is inserted inside the cover 1S and of the cap 30 until it comes into abutment against the internal shoulder 32 of said cap, position in which: the annular groove 25 of the base 20 houses the annular rib 34 of the cap 30,

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  - The bosses 19 of the tongues 18 are in contact with the peripheral wall of the base 20, at the front of the annular groove 24 of

  said base, causing a radial expansion of said tabs. The closure plug 10 is then threaded posteriorly onto

  the base 20 and the cover 15 until bringing the flange 11 to said stopper posteriorly abuts against the front wall 17 to said cover, position in which: the base 20 is blocked longitudinally between the internal shoulder 32 of the cap 30 and the 'internal shoulder lOb of the touch or shutter 10, - the distribution duct 13 is closed by the face

rear 22 of base 20.

  The assembly thus pre-assembled is then loosely introduced by force into the interior of the syringe body 1 and then forms an injection device of the "dry needle" type intended to be pre-filled, gifts: the needle injection 28 is isolated from the chamber containing the liquid to be injected thanks to the sealing by the base 20 of the sealing duct 13, - sealing is ensured by the sealing plug 10 o on the one hand at level of the peripheral contact faces between said stopper and the syringe body 1, and on the other hand at the level of the peripheral contact faces

between this plug 10 and the base 20.

  In view of its use, and in an essential manner according to the invention, the gesture to be carried out consists in removing the cap 30. At the time of this withdrawal obtained by means of the natural gesture carried out with a view to removing the cap from a current conventional syringe , the seeable link 35 is broken then the base is entranée with the cap 30 due to the cooperation of the groove 25 and the rib 34, until the bosses 19 are received in the groove

annular 24 of said base.

  n / a The cap 30 is then completely removed, while the base 20 is blocked, without the possibility of recur, in a position where it delimits a sealed volume 50 of communication between the distribution conduit

  13 and the supply conduit 29 of the needle 28.

  It should be noted that, according to the variant shown in FIGS. 7 and 7a, the process is strictly identical once the preliminary step of tearing the annular band 36 has been carried out. The injection device represented in FIGS. 5 and 6 is made up of elements similar in their entirety to those of the injection device

above described.

  Thus, in particular, the syringe body 1 and the assembly o seal 15 / needle-protective cap 30 are strictly identical to those

  described above and will therefore not be the subject of a new detailed description.

  The base 20 and the closure plug 10 are, for their part, generally identical to those described above, the only differences occurring in the design of the "valve system" formed by the

  s rear koncon of the base 20 and the bottom wall 12 of the closure plug 10.

  Only this "valve system" is therefore described in detail below.

  below with new numerical references, it being understood that

  refer to the description above for the other components of

  the base 20 and the plug 10.

  o According to this variant, and first of all, the front face of the bottom wall 12 of the closure plug 10 is hollowed out * an axial seat 112b of generally cylindrical-ogival shape into which opens a duct

axial distribution 113.

  The base 15 of this injection device comprises, as it as previously, a cylindrical shaft 16 of external diameter combines with the internal diameter of the posterior trunk 10b of the plug 10, and in the posterior extension to said shaft, a shutter 120 of general shape

  cylindrico-ogival conjugate to that of seat 112b.

  This shutter 120 has, in addition an anterior or cylindrical section 120a of length greater than that of the cylindrical section of the seat 112b, adapted so that in the position of obturation of said seat by said obturator, the anterior portion of the front section 120a of this shutter 120

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  extends outside the seat 112, in a sealed chamber 150 delimited by the bottom wall 112 of the plug 10 and the rear end face

22 of the base 20.

  According to this embodiment, in addition, the supply duct 129 has the shape of a T constitutes: - of an axial longitudinal branch 129a extending in the posterior extension of the axial bore 27 in which is sealed The injection needle 28, - of a posterior radial through branch 129b io formed in the anterior portion of the anterior trunk 120a of the shutter 120, so as to open, at each of its two ends, in the

sealed chamber 150.

  According to this embodiment, in the remote position of the base 20 shown in FIG. 5, the shutter 120 closes the distribution duct 113, and the sealed chamber 150 is isolated from the chamber of the

  container containing the liquid to be injected.

  On the other hand, as represented in FIG. 6, after removal of the needle-protecting cap 30, and consequently in the advanced injection position of the base 20, the supply conduit 129 and the distribution conduit 113 both open into room 150, authorizing

  the flow of liquid to the injection needle 28.

  The injection device represented in FIGS. 8 and 9 differs mainly from those described above by the fact that the cover and the needle-protecting cap do not consist of a single piece made

  standing but in two separate pieces adapted to be assembled by screwing.

  As above, the same reference numerals are used above to designate elements, similar in structure,

  common to the three embodiments.

  According to this third embodiment, and first of all, the closure plug 210 consists of a rear portion in the form of a cylindrical cup 211 of external diameter combined with the internal diameter of the syringe body 1, adapted for to be inserted so

  sealed in said syringe body.

  This cup 211 also comprises a bottom wall 212 similar to the bottom wall 12 of the closure plug 10 previously described - described with reference to FIGS. 2 to 4, that is to say forming a concave rear seat 212a, a convex anterior seat 212b, and in which is formed a distribution duct 213 offset from the longitudinal axis of this cup. The closure plug 210 further comprises an anterior portion 214 consisting of a cylindrical sleeve of internal diameter substantially similar to that of said cup, and of external diameter, adapted to provide an annular longitudinal space between said sleeve and the face.

syringe barrel 1.

  This cylindrical sleeve 214 comprises, finally, an external annular rib 214a formed projecting relative to its peripheral wall,

  substantially mid-length of said sleeve.

  - The lid 215 of this third embodiment comprises, meanwhile, a posterior cylindrical sleeve 216 of section adapted to stinser in the annular space between the syringe body 1 and the

  sleeve 214 of the sealing plug 210.

  At its internal peripheral face, this sleeve 216 has an internal annular groove 217 formed substantially mid-length of said sleeve and suitable for housing the annular rib 214a of the sleeve 214 of the closure plug 210, and thus ensuring relative locking in translation

  : s of the aforementioned seal and closure cap.

  In addition, this sleeve 216 has an external annular groove 218 formed at the end anterior to said sleeve and adapted to accommodate the internal annular rib 3 of the syringe body 1 and thus ensure the blocking and maintenance of the cap assembly. shutter

  n / a 210 / seal 215 inside said syringe body.

  The cover 215 further comprises an anterior annular front wall 219 forming an external flange on the periphery of the

  sleeve 216, abutting against the anterior end of the syringe body 1.

  - This cover 215 comprises, finally, a cylindrical sleeve s anterior 240 axis relative to the annular front wall 219 to said cover and

  extending projecting from the front of the front face of said front wall.

  This front sleeve 240 has an external diameter combined with that of the rear sleeve 216, and an internal diameter smaller than the internal diameters identical to said rear sleeve and the orifice of the front wall 219, adapted to form an internal radial shoulder 241 at

  level of its junction with said front wall.

  Finally, this anterior sleeve 240 has, from its

  anterior end, a longitudinal section taps 242.

  The base 220 of this third embodiment consists, for its part, of a piece of generally cylindrical shape subdivided into longitudinal trotting trunks: - an anterior trunk 221 of smaller diameter, in the peripheral wall of which is housed, at short distance from its anterior end, a non-retentive external annular groove 222, o - an intermediate kongon 223 of diameter greater than that of the anterior koncon 221, adapted to form an external radial shoulder 224 at its junction with said anterior trunk. In addition, an outer annular groove of retentive shape 225 is formed in the peripheral wall of this intermediate section, at the level of its rear end section, and a rear section 226 of external diameter combines with the internal diameter of the sleeve 214. of the closure plug 210, adapted to be inserted in a sealed manner in said sleeve, and to define, inside this sleeve 214, a sealed volume 250 delimited by the bottom wall 212 of the closure plug 210, and the rear end face 226a o said rear koncon. This posterior end face 226a of this posterior trunk 226 has, in ouke, a concave shape combined with the convex shape of the anterior seat 212b of the bottom wall 212 of the closure plug.

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  210, suitable for sealing the distribution duct 213

leading to the level of said seat.

  The base 220 comprises, lastly, an axial bore 227 opening out at its front end face and extending over a length substantially equal to the cumulative length of the anterior 221 and intermediate sections 223, said bore being conventionally intended when sealing a single-point injection needle 228. In addition, this base 220 is conventionally pierced, in the extension of this axial bore 227, of an axial duct 229 for supplying liquid to the needle d 'injection 228,

  io emerging at the level of the rear end face 226a of said base.

  The needle guard cap 230 of this third embodiment comprises, for its part, firstly, an anterior portion 231 having the general cylindrical shape of a needle guard cap of conventional type. Internally, this front portion 231 is subdivided into two longitudinal sections 231a, 231c of general cylindrical shapes and of different internal diameters, separated by an internal radial shoulder 231b: a front section 231a extending over the longest length of this front portion 231, and a posterior section 231c of short length compared to

  o that of the front section 231 a, and of diameter greater than that of the latter.

  In addition, a non-retentive annular internal rib 232 is formed projecting inside the posterior trunk 231c, a short distance from the shoulder 23 lb. The needle-protective cap 230 further comprises, in the posterior extension of its front portion 231, a cylindrical sleeve 233 threaded externally, of diameter and thread suitable for being screwed to

  the inside of the tap sleeve 240 of the cover 215.

  In addition, this cylindrical sleeve 233 has an external flange 234, with a frontal abutment against the anterior end face of the threaded sleeve 240, when said cylindrical sleeve is inserted.

  longitudinally and screws inside said tap sleeve.

  This cylindrical sleeve 233 has, in addition, an internal diameter combined with the external diameter of the intermediate section 223 of the base 220, and greater than that of the rear section 231c of the front portion 231 of the cap 230, adapted to delimit an internal radial shoulder 235 at the junction between said posterior section 231c and

rear sleeve 233.

  The needle guard cap 230 according to this embodiment is. moreover, posteriorly extended by an annular ring 236 of generally cylindrical shape, connected to the rear end face of the

  io cylindrical sleeve threaded 233 by a seeable connection 237 of the pin type.

  This annular ring 236 has an internal diameter combined with the external diameter of the intermediate section 223 of the base 220, adapted to allow insertion of said base inside said ring and the

cylindrical sleeve 233.

  s This annular ring 236 is further subdivided longitudinally into two sectors: - a cylindrical front sector 238 of section adapted to slide inside the cylindrical sleeve 233, along the intermediate section 223 of the base 220, o - a posterior sector 239 of frustoconical shape, presenting at its junction with the anterior sector 238, a diameter adapted to form an annular shoulder 245 radial with respect to the peripheral face to said anterior sector, of frontal abutment against the radial shoulder

internal 241 of the cover 215.

  Finally, this annular ring 236 comprises at least one tongue 246 which is radially elastic, protruding inside the said ring, so as to be kept compressed against the peripheral internal face of this ring 236, by the intermediate section of the base. 220, in the position

moved back from said base.

  n / a This tab 246 is. in addition, attached to the ring 236 at the rear end of this rear, so as to be able to expand radially and come to be housed in the retentive groove 225 of said base, in the advanced injection position of this rear , and so enpecher

  any recur ulterior of this base 220.

  When using this injection device, the removal by unscrewing the cap 230 entrance, first, a rupture of the seeable link 237 which therefore constitutes a guarantee of the inviolability of the injection device.

Claims (4)

  1 / - Single-use injection device, characterized in that it comprises in combination: - a tubular container (1) endowed with sealing means (10, 15; 210, 215) at one of its longitudinal ends , said sealed shutter means delimiting a chamber intended to be filled with a liquid, and comprising a conduit (13; 113; 213) for distributing liquid opening into said chamber, - a needle holder base (20; 220) pierced with a liquid supply pipe (29; 229) of said needle, said base being axially movable relative to the sealed closure means (10, 15; 210, 215), so as to be able to move between a retracted position, cites the closed position, where it closes the distribution duct (13; 1 13; 213) of the latter, and an advanced position, cites the injection position, where it allows the flow of liquid from the chamber to the needle (28; 128; 228) through the supply duct (29; 229) of said base, - a cap (30; 230) of suitable shape to cover the base (20; 220), provided with means (35; 36-39; 233) of detachable connection with the sealing means (10, 15; 210, 215), or axial stop means combined (32; 224, 235), formed on the base (20; 220) and the cap (30; 230), and arranged so as to maintain said base in its closed position when the latter is capped to said cap connected to the sealing means (10, 15; 210, 215), - and axial stop means (23; 226, 236) arranged in such a way as to limit the axial displacement travel of the base ( 20; 220), once the cap (30; 230) detaches from the sealing means (10, 15; 210, 215).   2 / - Injection device according to claim 1, characterized in that the base (20; 220) and the cap (30; 230) comprise relative locking members in conjugated translation (25, 34; 222, 232) arranged, on the one hand, so as to cooperate in the closed position of the base (20; 220) or the latter is in abutment against the axial abutment means (32; 23 2839892   224, 235) determining said closed position, and on the other hand, so as to allow a relative axial displacement of the cap (30; 230) relative to the base (20; 220), in the injection position of the base where the latter is in abutment against the axial abutment means (23; 226; 236) determining said injection position.   3t- injection device according to one of claims 1   or 2, characterized in that the sealed closure means (10, 15; 210, 215) and the base (20; 220) comprise relative locking means in translation (18, 19, 24; 225, 246) of said base relative to said sealing means io sealed, household on the one hand, so as to allow a displacement of the base (20; 220) from its closed position to its injection position, and, secondly, for blocking in translation said base relative to said means   sealed closure in said injection position.   4 / - Injection device according to one of claims 1   is a 3, characterized in that the sealed closure means comprise: - a closure plug (10; 210) made of an impermeable elastic material having the shape of a cylindrical hollow body of section adapted to be inserted into the container (1), said closure plug having a bottom wall (12; 112, 212) delimiting the chamber of said container, in which a through distribution conduit (13; 113; 213)   - a cover (15; 215) endowed with a front wall (17; 219) pierced with an orifice of suitable diameter to allow the passage of the base (20; 220), and of a cylindrical sleeve (16; 216) of diameter adapted to fit together with the closure plug (10; 210), so that said sleeve and plug define a guide duct for said base, relative locking means in translation (214a) of the plug shutter (10; 210) and of the cover (15; 215), - and relative locking means in translation (3; 3, o 218) of ['shutter cap assembly (10; 210) / operculum (15; 215) by relative to the container (1).   / - Injection device according to claims 3 and 4   taken together, characterized in that the means for blocking in translation of the base (20; 220) in its injection position comprise at least one stop element (18, 246) radially deformable, so as to be maintained compresses radially inside the sleeve (16; 216) of the cover (15; 215), in the closed position of the base (20; 220) and when the latter is moved towards its position of injection, and to expand in a blocking reservation (24; 225), suitable for housing it in the position of injection of the base (20; 220).   o 6 / - Injection device according to one of claims 4   or 5, characterized in that the cap (10) and the lercercule (15) wind made in one direction and wind connected by detachable connection means consist of a seeable connection (35; 36, 39) extending between said hood and front wall (17; 219) said seal.   i5 7 / - Injection device according to one of claims 4   or 5, characterized in that the cap (230) and the cover (215) are made up of two separate pieces comprising combined assembly means (242, 233) by screwing.   8 / - Injection arrangement according to claim 7, characterized in that it comprises a canceled crown * e (236) made of a senl holding with the cap (230) and connected to the rear end of the latter by a seeable link (237), said annular ring being adapted to be housed inside the sleeve (216) of the cover (215), in a fixed position in translation inside said sleeve.