EP0562943B1 - Double chambered package - Google Patents

Double chambered package Download PDF

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Publication number
EP0562943B1
EP0562943B1 EP19930400738 EP93400738A EP0562943B1 EP 0562943 B1 EP0562943 B1 EP 0562943B1 EP 19930400738 EP19930400738 EP 19930400738 EP 93400738 A EP93400738 A EP 93400738A EP 0562943 B1 EP0562943 B1 EP 0562943B1
Authority
EP
European Patent Office
Prior art keywords
packaging according
capsule
cutting element
punch
packaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP19930400738
Other languages
German (de)
French (fr)
Other versions
EP0562943A1 (en
Inventor
Alain Behar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
S O F A B
Albea Le Treport SAS
Original Assignee
S O F A B
Sofab SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S O F A B, Sofab SA filed Critical S O F A B
Publication of EP0562943A1 publication Critical patent/EP0562943A1/en
Application granted granted Critical
Publication of EP0562943B1 publication Critical patent/EP0562943B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0078—Arrangements for separately storing several components

Definitions

  • extemporaneous drugs can be prepared by this route, for example mixing the active component and its vector or liquid support medium.
  • the shutter will be perforated, for example, using the syringe needle to inject the liquid, mix and allow any reactions to take place, then re-aspirate the product.
  • Patent publication FR-A-2 658 487 proposes receptacles with two opposite compartments which are separated by a tearable membrane and showing two external necks of opposite axial openings opposite, one constituting a mouthpiece carrying a pump, the other receiving a push plug carrying a membrane cutting member.
  • the subject of the invention is a device which is both simpler and safer.
  • This device is essentially built around a vial or socket forming a single barrel with two opposite necks, the mouth of one still carrying a pump, but that of the other receiving a capsule with an internal cutting member such as cited above.
  • Pump and capsule sealed on the barrel, the assembly is in the form of a compact cartridge of generally cylindrical appearance containing the two components of the product, capable of being kept upright both in its initial state and after shearing, mixing and successive uses. Its filling phases are independent and simple, its use requires no complicated handling and it easily constitutes a complete aseptic packaging.
  • a tubular segment 1 made of glass, having at its ends two identical rings, respectively 1a and 1b , forms the barrel intended to contain a liquid component and which receives at its upper part a pump 2 of a suitable known model with its pick-up tube 2a , and at its lower part a powder capsule 3 , of also known model, closed by a cover 4 which a punch 5 makes it possible to break by means of its blade 5a , without lose the external seal.
  • the operating button of the lower punch 5 permanently receives a cover 7 capable of serving as a base and carrier if necessary a safety ring 7a , which could be made inviolable.
  • the pump carries a conventional head 8 equipped for example with a spray nozzle 9 which itself serves as a cover in the manner of the base 7 , if necessary wearing like it a safety ring 8 a .
  • the conditioner preferably receives the barrel equipped with the pump and sets up solvent then powder capsule and pellet, the head 8 having advantageously been mounted in advance. The whole operation is done upside down and can be performed under the requisite aseptic conditions.
  • the user just needs to press the rear button of the punch 5 to pierce the seal 4 and release the powder within the solvent by inverting and agitating the device if necessary.
  • the cartridge is then used like a normal bottle fitted with a pump.
  • This device makes it possible, for example, to prepare a solution of a powder component at the time of use and to withdraw this solution by means of a pump, while minimizing the number of manipulations.
  • the device is entirely made of synthetic materials, with the possible exception of the spring of the pump 12 .
  • the latter is assembled and closed by fitting a flange 16a onto the pump body then mounted likewise on the barrel 11 .
  • the dispensing head for example provided with a nasal tip, is here delivered separately; in other cases it could obviously be placed under the cover 18 .
  • the lower opening of the barrel receives the capsule 13 , which has an internal cylindrical well 13a closed by a cover 14 and which the punch 15 closes.
  • the capsule 13 retained by a fitted collar 16b , forms the bottom of the reservoir and its profile laterally spreads the end of the intake tube 12a .
  • the collar 16b carries a tamper-evident cover 17 , the belt of which is retained by breakable bridges 17a along its heel 17b ; here, as we can see, the cover is independent of the punch 15 .
  • This punch which slides in sealed manner in the well 13a , has a blade 15a of an upper edge oblique to the tear line of the cover and which provides a cavity of volume adapted to that of the powder. Its depression (dashed lines) cuts the cover and releases the powder, the bottom of the cavity reaching substantially at that of the reservoir initially formed in the barrel by the capsule; the existence of at least one groove 15b then creates a lower passage which eliminates the dead volumes at the end of use of the product.
  • the punch here carries a rear button which, after detaching the cover 17 , would protrude from the heel of the cartridge to facilitate its initial maneuver, then disappearing so as not to compromise stability in the standing position between two successive uses.
  • the bridges 17a being placed towards the inside of the well 13a , it is possible to break them by driving in, then directly driving the punch 15 , which thus comes clearly back on the heel 17b , because the cover 17 does not fall only later.
  • the tear-off rim of the cover is sufficient in practice to retain the punch after the first use, but it is possible to provide auxiliary stop means in extreme positions 13b such as simple complementary reliefs in profile, however, which can be removed from the mold during manufacture and then interlocked with the mounting.
  • punch 15 and cover 17 are carriers of indented grooves 19 and the stop means 13b comprise a helical ramp; a rotational force on the cover 17 thus causes the punch 15 to rise.
  • the ramp would also be capable of making a bayonet to lock the punch in abutment in its high position on a shoulder such as 13c , thus obtaining a more perfect and safer seal.

Landscapes

  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Package Specialized In Special Use (AREA)

Description

Il est connu d'élaborer par mélange de deux composants des produits d'une conservation limitée pouvant aller de quelques minutes à quelques semaines ; on peut notamment préparer par cette voie des médicaments extemporanés, mélangeant par exemple le composant actif et son vecteur ou milieu de support liquide.It is known to produce, by mixing two components, products of limited preservation which can range from a few minutes to a few weeks; in particular, extemporaneous drugs can be prepared by this route, for example mixing the active component and its vector or liquid support medium.

Ainsi il est usuel de stocker séparément une poudre dans une ampoule ou un flacon bouché par un obturateur élastique et son solvant dans une autre ampoule ou une seringue jetable. Pour utilisation, on perforera par exemple l'obturateur à l'aide de l'aiguille de la seringue pour injecter le liquide, faire le mélange et laisser s'effectuer les réactions éventuelles, puis réaspirer le produit.Thus it is usual to store separately a powder in an ampoule or a bottle closed by an elastic obturator and its solvent in another ampoule or a disposable syringe. For use, the shutter will be perforated, for example, using the syringe needle to inject the liquid, mix and allow any reactions to take place, then re-aspirate the product.

Il a encore été proposé de fixer dans l'embouchure d'un flacon renfermant un liquide une capsule équipée d'un organe apte à en cisailler le fond sous l'effet d'un poussoir pour libérer son contenu : il faut ensuite enlever la capsule pour prélever le produit, par exemple en adaptant à sa place une pompe miniature destinée à distribuer celui-ci par petites doses successives.It has also been proposed to fix in the mouth of a bottle containing a liquid a capsule equipped with a member capable of shearing the bottom under the effect of a pusher to release its content: the capsule must then be removed to take the product, for example by adapting in its place a miniature pump intended to dispense it in small successive doses.

On a aussi conçu des flacons à deux cols superposés, le premier intermédiaire que ferme un tampon élastique, le second externe que ferme un obturateur équipé d'un poussoir déformable : pour utilisation, une pression manuelle sur le poussoir chasse le tampon, directement ou sous l'effet de la surpression engendrée, et permet le mélange ; on peut prévoir sur l'obturateur un embout conique qu'il suffit de décapsuler pour mettre en place une seringue de prélèvement.We have also designed bottles with two superimposed necks, the first intermediate that closes an elastic pad, the second external that closes a shutter equipped with a deformable pusher: for use, manual pressure on the pusher drives the pad, directly or under the effect of the overpressure generated, and allows mixing; a conical tip can be provided on the obturator which it suffices to uncap to place a sampling syringe.

La publication de brevet FR-A-2 658 487 propose des récipients à deux compartiments opposés que sépare une membrane déchirable et montrant deux cols externes d'ouvertures axiales opposées en vis à vis, l'une constituant une embouchure porteuse d'une pompe, l'autre recevant un bouchon poussoir porteur d'un organe de découpe de la membrane.Patent publication FR-A-2 658 487 proposes receptacles with two opposite compartments which are separated by a tearable membrane and showing two external necks of opposite axial openings opposite, one constituting a mouthpiece carrying a pump, the other receiving a push plug carrying a membrane cutting member.

L'invention a pour objet un dispositif à la fois plus simple et plus sur.The subject of the invention is a device which is both simpler and safer.

Ce dispositif est essentiellement construit autour d'une fiole ou douille formant un fût unique à deux cols opposés, l'embouchure de l'un encore porteuse d'une pompe, mais celle de l'autre recevant une capsule à organe de découpe interne telle que citée précédemment. Pompe et capsule scellées sur le fût, l'ensemble se présente sous forme d'une cartouche compacte d'allure généralement cylindrique renfermant les deux composants du produit, susceptible d'être conservée debout aussi bien dans son état initial qu'après cisaillement, mélange et utilisations successives. Ses phases de remplissage sont indépendantes et simples, son emploi n'exige aucune manipulation compliquée et il constitue aisément un conditionnement aseptique complet.This device is essentially built around a vial or socket forming a single barrel with two opposite necks, the mouth of one still carrying a pump, but that of the other receiving a capsule with an internal cutting member such as cited above. Pump and capsule sealed on the barrel, the assembly is in the form of a compact cartridge of generally cylindrical appearance containing the two components of the product, capable of being kept upright both in its initial state and after shearing, mixing and successive uses. Its filling phases are independent and simple, its use requires no complicated handling and it easily constitutes a complete aseptic packaging.

D'autres caractéristiques ressortiront de deux exemples, décrits ci-dessous en référence aux dessins. Ceux-ci montrent :

  • figure 1 : une coupe longitudinale d'une première version,
  • figure 2 : une coupe longitudinale, plus détaillée, d'une deuxième version,
  • figure 3 : une coupe semblable d'une variante de celle-ci.
Other characteristics will emerge from two examples, described below with reference to the drawings. These show:
  • FIG. 1 : a longitudinal section of a first version,
  • FIG. 2 : a more detailed longitudinal section of a second version,
  • f igure 3 : a similar section of a variant thereof.

Dans l'exemple représenté figure 1, un segment tubulaire 1, en verre, possédant à ses extrémités deux bagues identiques, respectivement 1a et 1b, forme le fût destiné à contenir un composant liquide et qui reçoit à sa partie haute une pompe 2 d'un modèle connu adéquat avec son tube de prise 2a, et à sa partie basse une capsule de poudre 3, de modèle également connu, fermée par un opercule 4 qu'un poinçon 5 permet de rompre par l'intermédiaire de sa lame 5a, sans perdre l'étanchéité externe.In the example shown in FIG. 1 , a tubular segment 1 , made of glass, having at its ends two identical rings, respectively 1a and 1b , forms the barrel intended to contain a liquid component and which receives at its upper part a pump 2 of a suitable known model with its pick-up tube 2a , and at its lower part a powder capsule 3 , of also known model, closed by a cover 4 which a punch 5 makes it possible to break by means of its blade 5a , without lose the external seal.

Pompe et capsule sont fixées à l'aide de collerettes 6, serties sur les bagues.Pump and capsule are fixed using flanges 6 , crimped on the rings.

Le bouton de manoeuvre du poinçon inférieur 5 reçoit à demeure un capot 7 apte à servir de culot et porteur au besoin d'une bague de sécurité 7a, qui pourrait être rendue inviolable. De même la pompe porte une tête classique 8 équipée par exemple d'une buse de pulvérisation 9 qui sert elle-même de capot à la façon du culot 7, portant le cas échéant comme lui une bague de sécurité 8a .The operating button of the lower punch 5 permanently receives a cover 7 capable of serving as a base and carrier if necessary a safety ring 7a , which could be made inviolable. Likewise the pump carries a conventional head 8 equipped for example with a spray nozzle 9 which itself serves as a cover in the manner of the base 7 , if necessary wearing like it a safety ring 8 a .

Le conditionneur reçoit de préférence le fût équipé de la pompe et met en place solvant puis capsule de poudre et culot, la tête 8 ayant avantageusement été montée d'avance. L'ensemble de l'opération se fait tête en bas et peut être effectué dans les conditions requises d'aseptie.The conditioner preferably receives the barrel equipped with the pump and sets up solvent then powder capsule and pellet, the head 8 having advantageously been mounted in advance. The whole operation is done upside down and can be performed under the requisite aseptic conditions.

Il suffit à l'utilisateur d'appuyer sur le bouton arrière du poinçon 5 pour percer l'opercule 4 et libérer la poudre au sein du solvant en renversant et agitant au besoin l'appareil. La cartouche s'utilise ensuite comme un flacon normal équipé d'une pompe.The user just needs to press the rear button of the punch 5 to pierce the seal 4 and release the powder within the solvent by inverting and agitating the device if necessary. The cartridge is then used like a normal bottle fitted with a pump.

Ce dispositif permet par exemple de préparer au moment de l'utilisation une solution d'un composant en poudre et de prélever cette solution au moyen d'une pompe, en minimisant le nombre de manipulations.This device makes it possible, for example, to prepare a solution of a powder component at the time of use and to withdraw this solution by means of a pump, while minimizing the number of manipulations.

Dans le cas de la figure 2, dont le repérage est homologue, le dispositif est entièrement constitué de matières synthétiques, à l'exception sans doute du ressort de la pompe 12. Celle-ci est assemblée et fermée par emboîtement d'une collerette 16a sur le corps de pompe puis montée de même sur le fût 11. La tête distributrice, munie par exemple d'un embout nasal, est ici livrée séparément ; dans d'autres cas elle pourrait évidemment être placée sous le capot 18.In the case of FIG. 2 , the registration of which is homologous, the device is entirely made of synthetic materials, with the possible exception of the spring of the pump 12 . The latter is assembled and closed by fitting a flange 16a onto the pump body then mounted likewise on the barrel 11 . The dispensing head, for example provided with a nasal tip, is here delivered separately; in other cases it could obviously be placed under the cover 18 .

L'ouverture inférieure du fût reçoit la capsule 13, dotée d'un puits cylindrique interne 13a clos par un opercule 14 et que ferme le poinçon 15. La capsule 13, retenue par une collerette emboîtée 16b, forme le fond du réservoir et son profil écarte latéralement l'extrémité du tube de prise 12a. La collerette 16b porte un capot d'inviolabilité 17 dont la ceinture est retenue par des ponts ruptibles 17a le long de son talon 17b ; ici, comme on peut le voir, le capot est indépendant du poinçon 15.The lower opening of the barrel receives the capsule 13 , which has an internal cylindrical well 13a closed by a cover 14 and which the punch 15 closes. The capsule 13 , retained by a fitted collar 16b , forms the bottom of the reservoir and its profile laterally spreads the end of the intake tube 12a . The collar 16b carries a tamper-evident cover 17 , the belt of which is retained by breakable bridges 17a along its heel 17b ; here, as we can see, the cover is independent of the punch 15 .

Ce poinçon, qui coulisse de façon étanche dans le puits 13a, possède une lame 15a d'arête supérieure oblique par rapport à la ligne de déchirure de l'opercule et qui ménage une cavité de volume adapté à celui de la poudre. Son enfoncement (traits mixtes) découpe l'opercule et libère la poudre, le fond de la cavité parvenant sensiblement au niveau de celui du réservoir initialement formé dans le fût par la capsule ; l'existence d'au moins une saignée 15b crée alors un passage inférieur qui supprime les volumes morts en fin d'utilisation du produit.This punch, which slides in sealed manner in the well 13a , has a blade 15a of an upper edge oblique to the tear line of the cover and which provides a cavity of volume adapted to that of the powder. Its depression (dashed lines) cuts the cover and releases the powder, the bottom of the cavity reaching substantially at that of the reservoir initially formed in the barrel by the capsule; the existence of at least one groove 15b then creates a lower passage which eliminates the dead volumes at the end of use of the product.

Le poinçon porte ici un bouton arrière qui, après détachement du capot 17, ferait saillie sur le talon de la cartouche pour faciliter sa manoeuvre initiale, s'effaçant ensuite pour ne pas compromettre la stabilité en position debout entre deux utilisations successives. En fait, les ponts 17a se trouvant placés vers l'intérieur du puits 13a, il est possible de les rompre par enfoncement, entraînant alors directement le poinçon 15, qui vient ainsi franchement en retrait sur le talon 17b, car le capot 17 ne tombe qu'ultérieurement.The punch here carries a rear button which, after detaching the cover 17 , would protrude from the heel of the cartridge to facilitate its initial maneuver, then disappearing so as not to compromise stability in the standing position between two successive uses. In fact, the bridges 17a being placed towards the inside of the well 13a , it is possible to break them by driving in, then directly driving the punch 15 , which thus comes clearly back on the heel 17b , because the cover 17 does not fall only later.

Le rebord de déchirage de l'opercule suffit en pratique à retenir le poinçon après la première utilisation mais on peut prévoir des moyens auxiliaires d'arrêt en positions extrêmes 13b tels que de simples reliefs complémentaires de profil permettant cependant démoulage à la fabrication puis emboîtement au montage.The tear-off rim of the cover is sufficient in practice to retain the punch after the first use, but it is possible to provide auxiliary stop means in extreme positions 13b such as simple complementary reliefs in profile, however, which can be removed from the mold during manufacture and then interlocked with the mounting.

Dans la variante représentée sur la figure 3, poinçon 15 et capot 17 sont porteurs de cannelures indentées 19 et les moyens d'arrêt 13b comprennent une rampe hélicoïdale ; un effort de rotation sur le capot 17 provoque ainsi la montée du poinçon 15. La rampe serait en outre susceptible de faire baïonnette pour verrouiller le poinçon en butée dans sa position haute sur un épaulement tel que 13c, obtenant ainsi une étanchéité plus parfaite et plus sure.In the variant shown in Figure 3 , punch 15 and cover 17 are carriers of indented grooves 19 and the stop means 13b comprise a helical ramp; a rotational force on the cover 17 thus causes the punch 15 to rise. The ramp would also be capable of making a bayonet to lock the punch in abutment in its high position on a shoulder such as 13c , thus obtaining a more perfect and safer seal.

Il serait d'ailleurs encore possible d'employer un organe de découpe travaillant en simple rotation, par exemple à lame excentrique.It would also be possible to use a cutting member working in simple rotation, for example with an eccentric blade.

Claims (12)

  1. Packaging for the conservation, then mixing, of two components and for the recovery of the thus obtained product, the packaging being constituted of a barrel (1) having two external necks defining mutually opposite and opposed axial openings, the one forming a mouth carrying a pump (2), the other receiving a capsule (3) containing the one of the components and being the carrier of a cutting element (5) equipped with an operating button and mounted in leaktight manner, the barrel thus closed at its two ends holding the second component.
  2. Packaging according to claim 1, characterized in that it forms a cartridge capable of being stored upright both in its inital condition and after its first use.
  3. Packaging according to claim 1, characterized in that, at least on the capsule, it is carrier of a safety ring (7a, 8a, 17a).
  4. Packaging according to claims 2 and 3 taken together, characterized in that the safety ring is inviolable.
  5. Packaging according to claim 2, characterized in that the operating button of the cutting element permanently carries a cap (7) suitable for serving as a base.
  6. Packaging according to claim 4, characterized in that the operating button for the cutting element (15) is covered by a cap (17) held along a line of rupture on a heel (17b) of the cartridge.
  7. Packaging according to claim 2, characterized in that the cutting element forms a punch (15) carrying a rear button which, when pushed in, retracts behind a heel (17b) of the cartridge.
  8. Packaging according to claims 4 and 5 taken together, characterized in that the cap (17) of the cutting element is independent of this element and is detached after it has been pushed in.
  9. Packaging according to claim 1, characterized in that, the pump being equipped with an intake tube (12a) while the capsule forms the base of the reservoir, the profile of said capsule pushes the end of said tube to the side.
  10. Packaging according to claim 1, characterized in that the cutting element constitutes a punch (15) having a blade forming a cavity, the base of which, after having been put into operation, is situated substantially at the level of the base initially formed in the barrel by the capsule, a lower passage (15b) eliminating dead spaces at the end of use of the product.
  11. Packaging according to claim 10, characterized in that arresting means in the extreme positions (13b) lock the punch at its upper limiting position.
  12. Packaging according to one of claims 1 to 11, characterized in that it is entirely assembled by tight fitting together of the components.
EP19930400738 1992-03-23 1993-03-22 Double chambered package Expired - Lifetime EP0562943B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9203436A FR2688759B1 (en) 1992-03-23 1992-03-23 DOUBLE PACKAGING.
FR9203436 1992-03-23

Publications (2)

Publication Number Publication Date
EP0562943A1 EP0562943A1 (en) 1993-09-29
EP0562943B1 true EP0562943B1 (en) 1996-09-25

Family

ID=9427938

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19930400738 Expired - Lifetime EP0562943B1 (en) 1992-03-23 1993-03-22 Double chambered package

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EP (1) EP0562943B1 (en)
DE (1) DE69304968T2 (en)
FR (1) FR2688759B1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0821975A1 (en) * 1996-07-31 1998-02-04 Novartis AG (Novartis SA) (Novartis Inc.) Dosing device for fluids
DE19749514A1 (en) * 1997-11-08 1999-05-12 Pfeiffer Erich Gmbh & Co Kg Delivery of a mixture of media for e.g. pharmaceutical products
US6745763B2 (en) * 1998-10-27 2004-06-08 Garth T. Webb Vaporizing device for administering sterile medication
US6382204B1 (en) 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
CN106395078A (en) * 2016-10-17 2017-02-15 无锡市日升化工有限公司 Liquid storage barrel having high-efficiency settling preventing function

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3760986A (en) * 1970-08-19 1973-09-25 Schuyler Dev Corp Dispensing bottles with pump means for simultaneous dispensing
GB2220930A (en) * 1988-06-07 1990-01-24 Fisons Plc Introducing additive into a container
FR2658487B1 (en) * 1990-02-21 1993-12-24 Valois DEVICE FOR NEBULIZING A MEDICINAL PRODUCT CONSISTING OF A MIXTURE TO BE FORMED AT THE TIME OF THE ISSUE.

Also Published As

Publication number Publication date
DE69304968D1 (en) 1996-10-31
DE69304968T2 (en) 1997-03-27
FR2688759B1 (en) 1994-06-10
FR2688759A1 (en) 1993-09-24
EP0562943A1 (en) 1993-09-29

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