EP2186503B1 - Breakable two-compartment ampoule - Google Patents

Breakable two-compartment ampoule Download PDF

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Publication number
EP2186503B1
EP2186503B1 EP20090176126 EP09176126A EP2186503B1 EP 2186503 B1 EP2186503 B1 EP 2186503B1 EP 20090176126 EP20090176126 EP 20090176126 EP 09176126 A EP09176126 A EP 09176126A EP 2186503 B1 EP2186503 B1 EP 2186503B1
Authority
EP
European Patent Office
Prior art keywords
partition wall
compartment
packaging device
ring
binary composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP20090176126
Other languages
German (de)
French (fr)
Other versions
EP2186503A1 (en
Inventor
André Tartaglione
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seriplast SAS
Original Assignee
Seriplast SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0806392A external-priority patent/FR2938515B1/en
Application filed by Seriplast SAS filed Critical Seriplast SAS
Publication of EP2186503A1 publication Critical patent/EP2186503A1/en
Application granted granted Critical
Publication of EP2186503B1 publication Critical patent/EP2186503B1/en
Active legal-status Critical Current
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/2807—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
    • B65D51/2814—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
    • B65D51/2842—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being provided with a preformed weakened line
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding

Definitions

  • the present invention relates to a device comprising two compartments intended to each contain a product such as a liquid or a powder for the preparation of binary compositions, in particular medicaments.
  • Pharmaceutical or cosmetic products may be packaged, for example, into ampoules or flasks.
  • Bulb packaging is generally used in the pharmaceutical or cosmetic field. These are disposable ampoules that have a breakable tip, this tip is broken before the first use to release their contents.
  • binary composition any composition comprising at least two components to be stored separately and mixed immediately before use.
  • Such a binary composition can be used for pharmaceutical or cosmetic purposes.
  • certain drugs or cosmetics are unstable and must be stored in powder form, yet their administration is in a liquid form.
  • the mixture of the two components, the powder substance and a liquid, for solubilization or dispersion must be done immediately before its administration.
  • the mixture may require the use of an additional device, which may compromise the possible sterility of the binary drug composition, especially because of manipulation by the user.
  • the present invention aims to remedy all or part of the various disadvantages mentioned above.
  • An object of the invention is to provide a device for packaging a binary composition which must be reconstituted at the time of its application.
  • Another object of the invention is to provide a device for packaging a binary composition which must be reconstituted in the absence of contact with the ambient environment at the time of its application.
  • the invention relates to a packaging device according to claim 1.
  • the device according to the present invention makes it possible to store two products, for example pharmaceutical or cosmetic, separately, and to ensure their mixing at the time of use of the product.
  • An ampoule according to the present invention is particularly useful for the preparation of a binary drug composition.
  • An ampoule according to the present invention does not require an outer member to effect mixing of said individual products.
  • Such a bulb also makes it possible to ensure that the quantity of each component for the mixture is correct.
  • the device comprises return means capable of returning the shutter against the opening to close the partition wall which delimits the primary compartment and the secondary compartment, after rupture of the percutable area.
  • the actuating means comprise a rod rigidly connected to the shutter so that an action on the rod causes a rupture of the breakable zone.
  • the device has a ring separating the primary compartment and the secondary compartment integrating the partition wall and the shutter connected by a breakable zone.
  • the ring has a skirt on which engages a cap delimiting the primary compartment, the cap having a cylindrical stud engaged on the rod, the cap being able to slide on the skirt between a position d shutting of the partition wall and an opening position of the partition wall in which the rod impacts the breakable zone opening the opening and placing in communication the primary compartment and the secondary compartment.
  • the mixture of the two products contained in the primary and secondary compartments is made without contact with the ambient environment.
  • the device has a body having a breakable tip engaged on the ring and delimiting the secondary compartment, which allows the composition to flow after reconstitution.
  • the ring has an annular rib against which the body and the cap rest in the open position of the wall.
  • a tamper-evident band is interposed between the cap and the annular rib whose dimension is at least equal to the stroke for breaking the percutable zone connecting the shutter to the wall of seperation.
  • the device comprises a primary body and a secondary body engaged at each end of a ring.
  • the ring has a partition wall and a shutter, secured to the rod, connected to the partition wall by a bridge of breakable material thin.
  • the primary body has a breakable tip for accessing the rod and the secondary body has a breakable tip for releasing a reconstituted composition present in the secondary compartment.
  • the rod enters the breakable tip, which allows access to the rod after breaking the tip.
  • a percutable zone is constituted by a material bridge which connects the shutter to the partition wall.
  • the percutable zone is formed by a tight fit between the shutter and the partition wall.
  • the packaging device 1 has two compartments intended to each contain a product.
  • the mixture of the two products in particular cosmetic or medicinal, is effected in a completely watertight manner. In other words, there is no contact with the ambient air during mixing between the two products as will be described.
  • the device 1 has a primary compartment 2 which can contain a first product and a secondary compartment 3 which can contain a second product.
  • the primary compartment 2 is, in the embodiment of the invention illustrated, delimited by two elements namely a cap 5 and a ring 6 on which the cap 5 engages.
  • the cap 5 comprises a substantially cylindrical skirt 8 and a circular end surface 9. Inside the cap 5, it can be seen that it is provided with a cylindrical nipple 10 extending from the end surface 9 towards the center of the cap. The end of the cylindrical stud 10 is preferably chamfered.
  • the ring 6 comprises, for its part, a cylindrical skirt 12 of which extends radially an annular rib 14 substantially at mid-height of the ring 6 in the illustrated embodiment.
  • the ring 6 comprises a partition wall 15.
  • the partition wall 15 comprises a frustoconical portion 17 which extends from the skirt 12 radially in the direction of the axis of symmetry of the ring 6.
  • the wall of separation 15 has an opening 13 which is closed by a shutter 18.
  • the shutter 18 is itself connected to a rod 16.
  • the partition wall 15 and the shutter 18 are connected by a continuous bridge 19 of material which provides a sealing on both sides of the partition wall 15 while constituting a zone of weakness which will serve as a percutable zone.
  • the junction between the partition wall 15 from the skirt 12 and the shutter 18 from the rod 16 is at a bridge of material 19 - circular in the illustrated case - thin.
  • the zone of weakness formed by the material bridge 19 therefore constitutes a break line whose function will be seen later.
  • the cap 5 is engaged on the ring 6 so that the cylindrical stud 10 is placed on the end of the rod 16, while the skirt 8 of the cap 5 slides on the skirt 12 of the ring 6.
  • tamper-proof ring 20 may be derived from molding of the cap 5.
  • the conditioning device 1 further comprises a secondary compartment which is constituted by a body 21 preferably made of plastic although it is quite possible to make it out of glass.
  • the body 21 has an open tubular portion at one of its ends, while its second end is provided with a breakable tip 24 connected to the body by a break line 25.
  • the packaging device 1 with two compartments 2 and 3 according to the invention is obtained by engaging the ring 6 in the body 21.
  • the body 21 is provided with an annular groove 26 on its inner face, while the ring 6 is provided with an annular rib 29 on its outer face, so that a snap is created when inserting the ring 6 into the body 21.
  • the body 22 Prior to the insertion of the ring 6 on the body 21, it is expected that the body 22 is filled with a product distinct from the product contained in the primary compartment 2, this product may be liquid, pasty or granular.
  • the mixing operation illustrated in figure 5 of the two products which are packaged separately and totally hermetic; is extremely simple for the user since it is sufficient, after having removed the tamperproof ring 20, to bear on the end surface 9 of the cap 5 which is transmitted to the rod 16 and causes a rupture of the partition wall 15 between the primary compartment 2 and the secondary compartment 3 .
  • the primary compartment 2 is in communication with the secondary compartment 3 and the products that were stored separately can migrate through the opening 13 towards each other so as to constitute a cosmetic or medicinal solution ready for use. employment.
  • This embodiment of the invention is quite advantageous since it is carried out in a completely confined enclosure without any contact with the ambient environment and possible contaminants.
  • FIG 7 shows, in longitudinal section, an embodiment of the invention in which the conditioning device according to the invention is provided with the return means of the shutter 18.
  • an elastic sleeve 36 is interposed between the skirt 12 of the ring 6 and the cap 5.
  • the elastic sleeve 36 which is shown in isolation at the figure 9 may comprise a base 36a which inserted into the skirt 12 of the ring 6 and a chimney 36b in which the cylindrical stud 10 engages and abuts against the cap 5.
  • the elastic ring 19 is made of an elastic material such as an elastomer, synthetic or natural.
  • the device represented in Figures 7 to 12 has a shutter 18 which is forced into an opening in the partition wall.
  • the seal between the primary compartment 2 and the secondary compartment 3 is not made by a breakable wall but is made by a tight fit between the shutter 18 and the opening 13 of the partition wall 15.
  • the percutable zone is formed by the tight fit between the shutter 18 and the opening 13 of the partition wall 15.
  • these two embodiments are substantially equivalent because they make it possible to ensure a tight separation between the primary 2 and secondary 3 compartments and they make apparent the opening of the shutter 18 after its first use. This point is important because there must be no communication between the primary 2 and secondary 3 compartments without a detectable intervention of a user.
  • the shutter 18 can be molded with the partition wall by being connected by material bridges and then forcibly engaged in the opening 13.
  • the tamperproof ring 20 can be, as shown in FIG. figure 7 , come molding with the cap 5.
  • the figure 10 shows the primary compartment 2 of the device before it is struck.
  • the Figures 11 and 12 show the device at the end of percussion.
  • the elastic sleeve 36 is crushed.
  • the elastic sleeve 36 exerts its return function and returns the rod and the shutter 18 to a position in which the shutter 18 abuts against the opening 13 formed in the partition wall, without being able to insert into the opening 13.
  • the elastic sleeve 36 exerts a return on the shutter 18, which allows after reconstitution of the composition to prevent it from accessing the primary compartment. In some applications, it may be preferable to prevent the reconstituted composition from entering the primary compartment. It may be preferable for the proper flow of the composition to avoid it remaining in the primary compartment.
  • the figure 13 shows another embodiment in which the function of returning the shutter 18 is performed by mechanical means.
  • the cap 5 is provided on its inner face with a thread 42, while the ring receives a thread 43 complementary.
  • This embodiment is based on the previous one, but is distinguished by the absence of this elastic return ring 19, this return being made mechanically by the threads 42 and 43.
  • the partition wall 15 is struck by exerting pressure on the cap 5 and then engaging the threads 42 and 43 of the cap 5 and the ring 6.
  • the shutter 18 is disengaged from the partition wall which puts in communication the primary compartment 2 and the secondary compartment 3.
  • compartment 2 is not necessarily a breakable bulb.
  • This compartment may comprise a pump with a plunger tube which makes it possible to extract the reconstituted product.
  • the invention can be implemented in another embodiment which is illustrated in FIGS. Figures 14 to 17 .
  • a bulb 1 according to this other embodiment comprises a primary compartment 2 and a secondary compartment 3 delimited in a sealed manner by a partition wall which has means of breaking thereof.
  • bulb 1 has a primary body 22 which delimits the primary compartment 2 and a secondary body 23 which delimits the secondary compartment 3.
  • the primary body 22 and secondary body 23 each have a frangible tip 24 respectively connected by a rupture zone 25.
  • the primary body 22 and secondary 23 may be preferably made of plastic molded or blown but could possibly be made of glass.
  • the bulb 1 is thus constituted by the primary body 22 and the secondary body 23 joined by a central ring 6 which ensures the joining of these two elements.
  • figure 15 we can refer to figure 15 to appreciate more precisely the structure of the ring 6.
  • the ring 6 comprises a partition wall 30 of annular shape. On either side of this partition wall 30 extend two cylindrical skirts 31 and 32.
  • partition wall 30 protrudes radially from the two skirts 31 and 32 which are in alignment with one another.
  • the partition wall 30 thus forms a shoulder that protrudes from the surface of the two skirts 31 and 32.
  • skirts 31 and 32 are each provided with an annular rib 34 and 35.
  • a particularity of the ring 28 is that it incorporates a rod 38 at its partition wall.
  • the rod 38 is connected to the partition wall 30 by a connection zone of small thickness which, as will be seen below, behaves as means for breaking the rod 38 relative to the partition wall 30.
  • the rod 38 has a shutter 40 which fits into an opening 41 formed in the partition wall 30 and is connected to the partition wall 30 by a bridge of thin material which constitutes a zone of weakness.
  • the figure 16 shows the primary compartment 2 in its assembled configuration.
  • the ring 6 receives a first product which, in the example shown, is present in the form of granules. This product is stored in the cavity delimited by the skirt 31 and closed by the primary body 22 which is engaged on the skirt 31.
  • the tightness of the primary compartment 2 is achieved by a large overlap between the skirt 31 and the primary body 22.
  • An inchtmontable snap is produced by the engagement of the annular rib 34 in a complementary annular groove 39 present in the primary body 22.
  • a product for example a cosmetic or a pharmaceutical product, can be sealed in the primary compartment 2.
  • the complete assembly of the device 1, as can be seen for example on the figure 5 is obtained by engaging the secondary body 23 on the ring 28.
  • the secondary body 23 previously filled, for example of a liquid, receives the ring 28 by engagement of its skirt 31 in the secondary body 23.
  • the device 1 thus comprises two compartments 2 and 3 which are separated from one another in a sealed manner and which can contain two products which must be mixed to reconstitute a composition for its application.
  • a user can act on the rod 38 to obtain the rupture of the connection zone between the rod and the partition wall 15.
  • the rod 38 can then be removed from the bulb 1, which makes it possible to create the opening 41 in the partition wall 30 through which the product contained in the primary compartment can migrate to the liquid product, in the example shown, which is contained in the secondary compartment.
  • the ampoule is used to package two products that must be mixed to reconstitute a product at the time of its application.
  • the rod of the obstruction means may be provided with an annular rib formed on its surface projecting from the rupture zone in order to snap into engagement with an annular rib formed in the surface. internal of the breakable head.
  • the two annular ribs cooperate to extract the rod and thus the obstruction means out of the body of the bulb.
  • the ampoule 1 according to the present invention makes it possible to store two products separately, and to ensure their mixing under sterile conditions if necessary.
  • the first and second products may be of different natures or the like, in particular each may be in the form of a liquid, a solid, a gas or a paste, for example.
  • An ampoule 1 according to the invention is particularly suitable for preparing a binary medicinal or cosmetic composition.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Package Specialized In Special Use (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Description

La présente invention concerne un dispositif comportant deux compartiments destinés à contenir chacun un produit tel qu'un liquide ou une poudre pour la préparation de compositions binaires notamment médicamenteuses.The present invention relates to a device comprising two compartments intended to each contain a product such as a liquid or a powder for the preparation of binary compositions, in particular medicaments.

Les produits pharmaceutiques ou cosmétiques peuvent être conditionnés, par exemple, en ampoules ou flacons.Pharmaceutical or cosmetic products may be packaged, for example, into ampoules or flasks.

Le conditionnement en ampoules est généralement utilisé dans le domaine pharmaceutique ou cosmétique. Il s'agit d'ampoules à usage unique qui possèdent un embout cassable, cet embout est cassé avant la première utilisation afin de libérer leur contenu.Bulb packaging is generally used in the pharmaceutical or cosmetic field. These are disposable ampoules that have a breakable tip, this tip is broken before the first use to release their contents.

Il est connu de conditionner des liquides, notamment des produits pharmaceutiques, dans des ampoules sécables tels que celles décrites dans la demande de brevet EP A 1 918 214 .It is known to package liquids, especially pharmaceuticals, in breakable ampoules such as those described in the patent application. EP 1 918 214 .

Ces ampoules sont cependant peu adaptées au conditionnement de compositions qui doivent être reconstituées à partir de plusieurs produits. Il est également connu du document WO-A-02023086 de conditionner un liquide ou une poudre dans une ampoule et de connecter cette ampoule à une poche contenant un autre liquide pour obtenir le mélange des composants.These bulbs, however, are not very suitable for packaging compositions that must be reconstituted from several products. It is also known from the document WO-A-02023086 to pack a liquid or a powder in a light bulb and to connect this bulb to a pocket containing another liquid to obtain the mixture of the components.

Au sens de la présente invention, il est entendu par composition binaire toute composition comportant au moins deux composants devant être stockés séparément et mélangés immédiatement avant utilisation. Une telle composition binaire peut être utilisée à des fins pharmaceutiques ou cosmétiques. En particulier, et bien que la plupart des médicaments soient disponibles sous formes galéniques liquides, certaines substances médicamenteuses ou cosmétiques sont instables et doivent être stockées sous forme de poudre, leur administration se faisant néanmoins sous une forme liquide. Le mélange des deux composants, la substance en poudre et un liquide, pour la mise en solubilisation ou la dispersion doit se faire immédiatement avant son administration.Within the meaning of the present invention, it is understood by binary composition any composition comprising at least two components to be stored separately and mixed immediately before use. Such a binary composition can be used for pharmaceutical or cosmetic purposes. In particular, and although most of the drugs are available in liquid dosage forms, certain drugs or cosmetics are unstable and must be stored in powder form, yet their administration is in a liquid form. The mixture of the two components, the powder substance and a liquid, for solubilization or dispersion must be done immediately before its administration.

Les flacons tels que décrits dans la demande de brevet EP A 1 918214 ne sont pas adaptés à des compositions médicamenteuses binaires. En effet, si un des composants peut y être stocké, l'autre composant doit être stocké dans un autre flacon et le mélange des deux composants n'est pas aisé et présente des inconvénients.The vials as described in the patent application EP 1 918214 are not suitable for binary drug compositions. Indeed, if one of the components can be stored there, the other component must be stored in another bottle and the mixture of the two components is not easy and has disadvantages.

Premièrement le mélange peut nécessiter l'utilisation d'un dispositif supplémentaire, ce qui peut compromettre la stérilité éventuelle de la composition médicamenteuse binaire, du fait notamment de la manipulation par l'utilisateur.Firstly the mixture may require the use of an additional device, which may compromise the possible sterility of the binary drug composition, especially because of manipulation by the user.

Ensuite, les quantités respectives de chaque composant peuvent ne pas être correctement respectées. Or, les proportions de chaque composant intervenant dans une composition médicamenteuse binaire sont souvent primordiales pour que la composition ait les effets désirés.Then, the respective quantities of each component may not be correctly met. However, the proportions of each component involved in a binary drug composition are often essential for the composition to have the desired effects.

Enfin, les manipulations nécessaires pour assurer le mélange des composants peuvent être compliquées par les petites dimensions des pièces et par leur fragilité, rendant le mélange difficile.Finally, the manipulations necessary to ensure the mixing of the components can be complicated by the small dimensions of the parts and by their fragility, making mixing difficult.

De manière générale, le conditionnement séparé de deux produits qui doivent être mélangés pour former une composition n'est pas réglé de manière satisfaisante.In general, the separate packaging of two products which must be mixed to form a composition is not satisfactorily adjusted.

Dans ce contexte technique, la présente invention a pour objet de remédier en tout ou partie aux différents inconvénients cités précédemment.In this technical context, the present invention aims to remedy all or part of the various disadvantages mentioned above.

Un but de l'invention est de proposer un dispositif permettant le conditionnement d'une composition binaire qui doit être reconstituée au moment de son application.An object of the invention is to provide a device for packaging a binary composition which must be reconstituted at the time of its application.

Un autre but de l'invention est de proposer un dispositif permettant le conditionnement d'une composition binaire qui doit être reconstituée en l'absence de contact avec le milieu ambiant au moment de son application.Another object of the invention is to provide a device for packaging a binary composition which must be reconstituted in the absence of contact with the ambient environment at the time of its application.

L'invention concerne un dispositif de conditionnement selon la revendication 1.The invention relates to a packaging device according to claim 1.

Ainsi, le dispositif selon la présente invention permet de stocker deux produits, par exemple pharmaceutique ou cosmétique, de façon séparée, et d'assurer leur mélange au moment de l'utilisation du produit. Une ampoule selon la présente invention est particulièrement utile pour la préparation d'une composition médicamenteuse binaire. Une ampoule selon la présente invention ne nécessite pas d'élément extérieur pour effectuer le mélange desdits produits individuels. Une telle ampoule permet également de s'assurer que la quantité de chaque composant pour le mélange est correcte.Thus, the device according to the present invention makes it possible to store two products, for example pharmaceutical or cosmetic, separately, and to ensure their mixing at the time of use of the product. An ampoule according to the present invention is particularly useful for the preparation of a binary drug composition. An ampoule according to the present invention does not require an outer member to effect mixing of said individual products. Such a bulb also makes it possible to ensure that the quantity of each component for the mixture is correct.

Selon un aspect de l'invention, il peut être prévu que le dispositif comprenne des moyens de rappel susceptibles de ramener l'obturateur contre l'ouverture pour refermer la paroi de séparation qui délimite le compartiment primaire et le compartiment secondaire, après rupture de la zone percutable.According to one aspect of the invention, it can be provided that the device comprises return means capable of returning the shutter against the opening to close the partition wall which delimits the primary compartment and the secondary compartment, after rupture of the percutable area.

Selon une forme de réalisation, les moyens d'actionnement comprennent une tige liée rigidement à l'obturateur de sorte qu'une action sur la tige entraîne une rupture de la zone cassable.According to one embodiment, the actuating means comprise a rod rigidly connected to the shutter so that an action on the rod causes a rupture of the breakable zone.

Selon une possibilité, le dispositif présente une bague séparant le compartiment primaire et le compartiment secondaire intégrant la paroi de séparation et l'obturateur reliés par une zone cassable.According to one possibility, the device has a ring separating the primary compartment and the secondary compartment integrating the partition wall and the shutter connected by a breakable zone.

Selon une forme d'exécution de l'invention, la bague présente une jupe sur laquelle s'engage un capuchon délimitant le compartiment primaire, le capuchon possédant un téton cylindrique engagé sur la tige, le capuchon pouvant coulisser sur la jupe entre une position d'obturation de la paroi de séparation et une position d'ouverture de la paroi de séparation dans laquelle la tige percute la zone cassable ouvrant l'ouverture et mettant en communication le compartiment primaire et le compartiment secondaire.According to one embodiment of the invention, the ring has a skirt on which engages a cap delimiting the primary compartment, the cap having a cylindrical stud engaged on the rod, the cap being able to slide on the skirt between a position d shutting of the partition wall and an opening position of the partition wall in which the rod impacts the breakable zone opening the opening and placing in communication the primary compartment and the secondary compartment.

Dans cette forme d'exécution de l'invention, le mélange des deux produits contenus dans les compartiments primaire et secondaire se fait sans contact avec le milieu ambiant.In this embodiment of the invention, the mixture of the two products contained in the primary and secondary compartments is made without contact with the ambient environment.

Il est prévu que le dispositif présente un corps possédant un embout sécable engagé sur la bague et délimitant le compartiment secondaire, ce qui permet d'écouler la composition après sa reconstitution.It is expected that the device has a body having a breakable tip engaged on the ring and delimiting the secondary compartment, which allows the composition to flow after reconstitution.

En pratique, la bague présente une nervure annulaire contre laquelle s'appuient le corps et le capuchon en position d'ouverture de la paroi.In practice, the ring has an annular rib against which the body and the cap rest in the open position of the wall.

Pour empêcher une percussion accidentelle du dispositif, il est envisagé qu'une bande d'inviolabilité soit interposée entre le capuchon et la nervure annulaire dont la dimension est au moins égale à la course permettant de rompre la zone percutable reliant l'obturateur à la paroi de séparation.To prevent accidental percussion of the device, it is envisaged that a tamper-evident band is interposed between the cap and the annular rib whose dimension is at least equal to the stroke for breaking the percutable zone connecting the shutter to the wall of seperation.

Dans une autre forme d'éxécution de l'invention, le dispositif comprend un corps primaire et un corps secondaire engagés à chaque extrémité d'une bague.In another embodiment of the invention, the device comprises a primary body and a secondary body engaged at each end of a ring.

La bague présente une paroi de séparation et un obturateur, solidaire de la tige, relié à la paroi de séparation par un pont de matière cassable de faible épaisseur.The ring has a partition wall and a shutter, secured to the rod, connected to the partition wall by a bridge of breakable material thin.

Dans cette forme de réalisation, le corps primaire présente un embout sécable permettant d'accéder à la tige et le corps secondaire possède un embout sécable permettant de libérer une composition reconstituée présente dans le compartiment secondaire.In this embodiment, the primary body has a breakable tip for accessing the rod and the secondary body has a breakable tip for releasing a reconstituted composition present in the secondary compartment.

Pour permettre sa préhension, la tige pénètre dans l'embout cassable, ce qui permet d'accéder à la tige après rupture de l'embout.To allow its grip, the rod enters the breakable tip, which allows access to the rod after breaking the tip.

Selon une la zone percutable est constituées par un pont de matière qui relie l'obturateur à la paroi de séparation.According to a percutable zone is constituted by a material bridge which connects the shutter to the partition wall.

Selon une autre possibilité, la zone percutable est constituée par un ajustement serré entre l'obturateur et la paroi de séparation.According to another possibility, the percutable zone is formed by a tight fit between the shutter and the partition wall.

Pour sa bonne compréhension, l'invention est décrite en référence aux dessins ci-annexés représentant à titre d'exemples non limitatifs plusieurs formes de réalisation d'un dispositif de conditionnement à deux compartiments selon celui-ci.

  • Figure 1 représente une vue en coupe longitudinale un dispositif de conditionnement selon une première forme de réalisation en cours d'utilisation, Figures 2 et 3 représentent cette ampoule en vue éclatée,
  • Figures 4 et 5 représentent une partie de cette ampoule à une échelle agrandie respectivement en position de stockage et en position percutée,
  • Figure 6 montre en perspective une autre forme de réalisation de l'invention ,
  • Figure 7 est une vue coupe longitudinale de la forme de réalisation de l'invention montrée à la figure 6,
  • Figures 8 et 9 montrent en perspective deux composants isolés de cette forme de réalisation,
  • Figures 10 à 12 montrent en perpective le dispositif selon cette forme de réalisation en cours de fonctionement,
  • Figure 13 montre en coupe transversale une autre forme de réalisation de l'invention dans laquelle le dispositif comprend une pompe,
  • Figure 14 montre une autre forme de réalistion de l'invention dans laquelle le dispositif présente une forme générale d'ampoules,
  • Figure 15 est une vue éclatée de cette ampoule,
  • Figure 16 montre une partie de cette ampoule,
  • Figure 17 représente cette ampoule en cours d'utilisation.
For a good understanding, the invention is described with reference to the accompanying drawings showing by way of non-limiting examples several embodiments of a two-compartment packaging device according thereto.
  • Figure 1 is a longitudinal sectional view of a packaging device according to a first embodiment in use, Figures 2 and 3 represent this bulb in exploded view,
  • Figures 4 and 5 represent a part of this bulb on an enlarged scale respectively in the storage position and in the impacted position,
  • Figure 6 shows in perspective another embodiment of the invention,
  • Figure 7 is a longitudinal sectional view of the embodiment of the invention shown in FIG. figure 6 ,
  • Figures 8 and 9 show in perspective two isolated components of this embodiment,
  • Figures 10 to 12 show in perspective the device according to this embodiment being operated,
  • Figure 13 shows in cross-section another embodiment of the invention in which the device comprises a pump,
  • Figure 14 shows another embodiment of the invention in which the device has a general shape of bulbs,
  • Figure 15 is an exploded view of this bulb,
  • Figure 16 shows a part of this bulb,
  • Figure 17 represents this bulb in use.

Par souci de simplification, les éléments de l'invention qui sont communs à ses différentes formes de réalisation possèdent les mêmes références.For the sake of simplification, the elements of the invention which are common to its various embodiments have the same references.

Dans un premier mode de réalisation de l'invention, comme on peut le voir sur la figure 1, le dispositif de conditionnement 1 possède deux compartiments destinés à contenir chacun un produit.In a first embodiment of the invention, as can be seen on the figure 1 , the packaging device 1 has two compartments intended to each contain a product.

Dans cette forme de réalisation du dispositif, le mélange des deux produits notamment cosmétiques ou médicamenteux s'effectue de manière totalement étanche. En d'autres termes, il n'y a aucun contact avec l'air ambiant lors du mélange entre les deux produits comme cela va être décrit.In this embodiment of the device, the mixture of the two products, in particular cosmetic or medicinal, is effected in a completely watertight manner. In other words, there is no contact with the ambient air during mixing between the two products as will be described.

Comme on peut le voir, par exemple, sur la figure 1, le dispositif 1 présente un compartiment primaire 2 qui peut contenir un premier produit et un compartiment secondaire 3 qui peut contenir un second produit.As can be seen, for example, on the figure 1 , the device 1 has a primary compartment 2 which can contain a first product and a secondary compartment 3 which can contain a second product.

Le compartiment primaire 2 est, dans la forme de réalisation de l'invention illustrée, délimité par deux éléments à savoir un capuchon 5 et une bague 6 sur laquelle s'engage le capuchon 5.The primary compartment 2 is, in the embodiment of the invention illustrated, delimited by two elements namely a cap 5 and a ring 6 on which the cap 5 engages.

Le capuchon 5 comprend une jupe 8 sensiblement cylindrique et une surface d'extrémité 9 circulaire. A l'intérieur du capuchon 5, on peut voir que celui-ci est pourvu d'un téton cylindrique 10 qui s'étend depuis la surface d'extrémité 9 en direction du centre du capuchon. L'extrémité du téton cylindrique 10 est de préférence chanfreinée.The cap 5 comprises a substantially cylindrical skirt 8 and a circular end surface 9. Inside the cap 5, it can be seen that it is provided with a cylindrical nipple 10 extending from the end surface 9 towards the center of the cap. The end of the cylindrical stud 10 is preferably chamfered.

La bague 6 comprend, pour sa part, une jupe cylindrique 12 de laquelle s'étend radialement une nervure annulaire 14 sensiblement à mi hauteur de la bague 6 dans l'exemple de réalisation illustré.The ring 6 comprises, for its part, a cylindrical skirt 12 of which extends radially an annular rib 14 substantially at mid-height of the ring 6 in the illustrated embodiment.

De façon tout à fait originale, la bague 6 comprend une paroi de séparation 15.In a very original way, the ring 6 comprises a partition wall 15.

Comme on peut le voir plus particulièrement à la figure 4 qui représente le compartiment primaire 2 à une échelle agrandie, la paroi de séparation 15 comprend une portion tronconique 17 qui s'étend depuis la jupe 12 radialement en direction de l'axe de symétrie de la bague 6. En son centre, la paroi de séparation 15 possède une ouverture 13 qui est fermée par un obturateur 18. L'obturateur 18 est lui-même relié à une tige 16. La paroi de séparation 15 et l'obturateur 18 sont reliés par un pont 19 continu de matière qui assure une étanchéité de part et d'autre de la paroi de séparation 15 tout en constituant une zone de faiblesse qui servira de zone percutable.As can be seen more particularly in figure 4 which represents the primary compartment 2 on an enlarged scale, the partition wall 15 comprises a frustoconical portion 17 which extends from the skirt 12 radially in the direction of the axis of symmetry of the ring 6. In its center, the wall of separation 15 has an opening 13 which is closed by a shutter 18. The shutter 18 is itself connected to a rod 16. The partition wall 15 and the shutter 18 are connected by a continuous bridge 19 of material which provides a sealing on both sides of the partition wall 15 while constituting a zone of weakness which will serve as a percutable zone.

La jonction entre la paroi de séparation 15 issue de la jupe 12 et l'obturateur 18 issu de la tige 16 se fait au niveau d'un pont de matière 19 - circulaire dans le cas illustré - de faible épaisseur.The junction between the partition wall 15 from the skirt 12 and the shutter 18 from the rod 16 is at a bridge of material 19 - circular in the illustrated case - thin.

La zone de faiblesse formée par le pont de matière 19 constitue donc une ligne de rupture dont on verra plus loin la fonction.The zone of weakness formed by the material bridge 19 therefore constitutes a break line whose function will be seen later.

Le capuchon 5 est engagé sur la bague 6 de telle sorte que le téton cylindrique 10 vient se placer sur l'extrémité de la tige 16, tandis que la jupe 8 du capuchon 5 glisse sur la jupe 12 de la bague 6.The cap 5 is engaged on the ring 6 so that the cylindrical stud 10 is placed on the end of the rod 16, while the skirt 8 of the cap 5 slides on the skirt 12 of the ring 6.

Il est prévu un ajustement radial entre la jupe 8 du capuchon 5 et la jupe 12 de la bague 6 pour que, une fois engagé sur la bague 6, le capuchon 5 forme avec celle-ci une enceinte étanche.It is provided a radial adjustment between the skirt 8 of the cap 5 and the skirt 12 of the ring 6 so that, once engaged on the ring 6, the cap 5 forms with it a sealed enclosure.

Ainsi, préalablement à l'engagement du capuchon 5 sur la bague 6, il est possible d'introduire dans la bague 6 un produit liquide, pâteux ou granuleux qui n'est pas représenté sur les figures 1 à 4.Thus, prior to the engagement of the cap 5 on the ring 6, it is possible to introduce into the ring 6 a liquid, pasty or granular product which is not shown on the Figures 1 to 4 .

Comme le montre la figure 4, dans une variante d'exécution, il est envisagé de placer une bague d'inviolabilité 20 entre l'extrémité de la jupe 8 du capuchon 5 et la nervure annulaire 14 qui s'étend radialement depuis la jupe 12 de la bague 6. La bague d'inviolabilité 20 peut être issue de moulage du capuchon 5.As shown in figure 4 , in an alternative embodiment, it is envisaged to place a tamper-proof ring 20 between the end of the skirt 8 of the cap 5 and the annular rib 14 which extends radially from the skirt 12 of the ring 6. tamperproof ring 20 may be derived from molding of the cap 5.

Le dispositif de conditionnement 1 comporte, de plus, un compartiment secondaire qui est constitué par un corps 21 préférentiellement en matière plastique bien qu'il soit tout à fait envisageable de le réaliser en verre.The conditioning device 1 further comprises a secondary compartment which is constituted by a body 21 preferably made of plastic although it is quite possible to make it out of glass.

Le corps 21 présente une partie tubulaire ouverte à l'une de ses extrémités, tandis que sa seconde extrémité est pourvue d'un embout sécable 24 relié au corps par une ligne de rupture 25.The body 21 has an open tubular portion at one of its ends, while its second end is provided with a breakable tip 24 connected to the body by a break line 25.

Le dispositif de conditionnement 1 à deux compartiments 2 et 3 selon l'invention est obtenu en engageant la bague 6 dans le corps 21.The packaging device 1 with two compartments 2 and 3 according to the invention is obtained by engaging the ring 6 in the body 21.

Pour cela, il est prévu que le corps 21 soit pourvu d'une rainure annulaire 26 sur sa face interne, tandis que la bague 6 est pourvue d'une nervure annulaire 29 sur sa face externe, de sorte qu'il se créé un encliquetage lors de l'insertion de la bague 6 dans le corps 21.For this, it is expected that the body 21 is provided with an annular groove 26 on its inner face, while the ring 6 is provided with an annular rib 29 on its outer face, so that a snap is created when inserting the ring 6 into the body 21.

Préalablement à l'insertion de la bague 6 sur le corps 21, il est prévu que le corps 22 soit rempli d'un produit distinct du produit contenu dans le compartiment primaire 2, ce produit pouvant être liquide, pâteux ou granuleux.Prior to the insertion of the ring 6 on the body 21, it is expected that the body 22 is filled with a product distinct from the product contained in the primary compartment 2, this product may be liquid, pasty or granular.

L'opération de mélange, illustrée à la figure 5, des deux produits qui sont conditionnés de façon séparée et totalement hermétique ; se fait de manière extrêmement simple pour l'utilisateur puisqu'il lui suffit, après avoir enlevé la bague d'inviolabilité 20, d'exercer un appui sur la surface d'extrémité 9 du capuchon 5 qui se transmet à la tige 16 et entraîne une rupture de la paroi de séparation 15 entre le compartiment primaire 2 et le compartiment secondaire 3.The mixing operation, illustrated in figure 5 of the two products which are packaged separately and totally hermetic; is extremely simple for the user since it is sufficient, after having removed the tamperproof ring 20, to bear on the end surface 9 of the cap 5 which is transmitted to the rod 16 and causes a rupture of the partition wall 15 between the primary compartment 2 and the secondary compartment 3 .

La course du capuchon 5 se termine lorsque l'extrémité de sa jupe 8 vient en appui sur la nervure annulaire 14.The stroke of the cap 5 ends when the end of its skirt 8 bears on the annular rib 14.

Dans cet état, le compartiment primaire 2 est en communication avec le compartiment secondaire 3 et les produits qui étaient stockés séparément peuvent migrer par l'ouverture 13 l'un vers l'autre de manière à constituer une solution cosmétique ou médicamenteuse prête à l'emploi.In this state, the primary compartment 2 is in communication with the secondary compartment 3 and the products that were stored separately can migrate through the opening 13 towards each other so as to constitute a cosmetic or medicinal solution ready for use. employment.

Il est à noter que lors de la percussion de la paroi de séparation 15 l'extrémité de la tige 16 s'engage dans le téton cylindrique 10 et se coince dans ce dernier. Ainsi, la tige 16 et son obturateur 18 restent solidaires du capuchon 5, ce qui évite qu'ils migrent vers le compartiment secondaire 3.It should be noted that during the percussion of the partition wall 15 the end of the rod 16 engages in the cylindrical stud 10 and gets stuck in the latter. Thus, the rod 16 and its shutter 18 remain attached to the cap 5, which prevents them from migrating to the secondary compartment 3.

Cette forme d'exécution de l'invention s'avère tout à fait avantageuse puisqu'elle est réalisée dans une enceinte totalement confinée sans aucun contact avec le milieu ambiant et d'éventuels contaminants.This embodiment of the invention is quite advantageous since it is carried out in a completely confined enclosure without any contact with the ambient environment and possible contaminants.

La figure 7 montre, en coupe longitudinale, une forme de réalisation de l'invention dans laquelle le dispositif de conditionnement selon l'invention est doté des moyens de rappel de l'obturateur 18.The figure 7 shows, in longitudinal section, an embodiment of the invention in which the conditioning device according to the invention is provided with the return means of the shutter 18.

Comme on peut le voir sur cette figure, un manchon élastique 36 est interposé entre la jupe 12 de la bague 6 et le capuchon 5.As can be seen in this figure, an elastic sleeve 36 is interposed between the skirt 12 of the ring 6 and the cap 5.

En se reportant à la figure 8 qui montre la bague 6 en perspective, on peut voir que celui-ci est doté de quatre nervures 44 internes qui servent d'appui au manchon élastique 36.Referring to the figure 8 which shows the ring 6 in perspective, it can be seen that it has four internal ribs 44 which serve as support for the elastic sleeve 36.

Le manchon élastique 36 qui est représenté de façon isolée à la figure 9 peut comprendre une base 36a qui insérée dans la jupe 12 de la bague 6 et une cheminée 36b dans laquelle s'engage le téton cylindrique 10 et vient en appui contre le capuchon 5.The elastic sleeve 36 which is shown in isolation at the figure 9 may comprise a base 36a which inserted into the skirt 12 of the ring 6 and a chimney 36b in which the cylindrical stud 10 engages and abuts against the cap 5.

La bague élastique 19 est réalisée dans une matière élastique telle qu'un élastomère, synthétique ou naturelle.The elastic ring 19 is made of an elastic material such as an elastomer, synthetic or natural.

On note que le dispositif représenté aux figures 7 à 12 présente un obturateur 18 qui est emmanché à force dans une ouverture pratiquée dans la paroi de séparation. Dans cette forme de réalisation, l'étanchéité entre le compartiment primaire 2 et le compartiment secondaire 3 n'est pas réalisée par une paroi sécable mais est réalisée par un ajustement serré entre l'obturateur 18 et l'ouverture 13 de la paroi de séparation 15. La zone percutable est réalisée par l'ajustement serré entre l'obturateur 18 et l'ouverture 13 de la paroi de séparation 15.It is noted that the device represented in Figures 7 to 12 has a shutter 18 which is forced into an opening in the partition wall. In this embodiment, the seal between the primary compartment 2 and the secondary compartment 3 is not made by a breakable wall but is made by a tight fit between the shutter 18 and the opening 13 of the partition wall 15. The percutable zone is formed by the tight fit between the shutter 18 and the opening 13 of the partition wall 15.

En termes fonctionnels, ces deux formes de réalisation sont sensiblement équivalentes car elles permettent d'assurer une séparation étanche entre les compartiments primaire 2 et secondaire 3 et elles rendent apparente l'ouverture de l'obturateur 18 après sa première utilisation. Ce point est d'importance car il ne doit pas se produire de mise en communication entre les compartiments primaire 2 et secondaire 3 sans une intervention détectable d'un utilisateur.In functional terms, these two embodiments are substantially equivalent because they make it possible to ensure a tight separation between the primary 2 and secondary 3 compartments and they make apparent the opening of the shutter 18 after its first use. This point is important because there must be no communication between the primary 2 and secondary 3 compartments without a detectable intervention of a user.

De manière pratique, l'obturateur 18 peut être moulé avec la paroi de séparation en étant relié par des ponts de matière pour être ensuite engagé en force dans l'ouverture 13.Conveniently, the shutter 18 can be molded with the partition wall by being connected by material bridges and then forcibly engaged in the opening 13.

La bague d'inviolabilité 20 peut être, comme le montre la figure 7, venue de moulage avec le capuchon 5.The tamperproof ring 20 can be, as shown in FIG. figure 7 , come molding with the cap 5.

La figure 10 montre le compartiment primaire 2 du dispositif avant son percutage. Les figures 11 et 12 montrent le dispositif en fin de percutage.The figure 10 shows the primary compartment 2 of the device before it is struck. The Figures 11 and 12 show the device at the end of percussion.

En exerçant un appui sur le capuchon 5, la tige 16 et l'obturateur 18 sont poussés hors de la bague 6 mettant ainsi le compartiment primaire 2 en communication avec le compartiment secondaire 3.By pressing on the cap 5, the rod 16 and the shutter 18 are pushed out of the ring 6 thus putting the primary compartment 2 in communication with the secondary compartment 3.

En pratique, l'utilisateur doit exercer une pression élevée sur le capuchon pour séparer l'obturateur 18 de la paroi de séparation 15.In practice, the user must exert a high pressure on the cap to separate the shutter 18 from the partition wall 15.

Au cours du percutage de la paroi de séparation 15, le manchon élastique 36 est écrasé. Lorsque l'action sur le capuchon 5 cesse, le manchon élastique 36 exerce sa fonction de rappel et fait rentrer la tige et l'obturateur 18 jusqu'à une position dans laquelle l'obturateur 18 vient en appui contre l'ouverture 13 pratiquée dans la paroi de séparation, sans pour autant pourvoir s'insérer dans l'ouverture 13.During the engagement of the partition wall 15, the elastic sleeve 36 is crushed. When the action on the cap 5 ceases, the elastic sleeve 36 exerts its return function and returns the rod and the shutter 18 to a position in which the shutter 18 abuts against the opening 13 formed in the partition wall, without being able to insert into the opening 13.

Le manchon élastique 36 exerce un rappel sur l'obturateur 18, ce qui permet après la reconstitution de la composition d'interdire à celle-ci l'accès au compartiment primaire. Dans certaines applications, il peut être préférable d'éviter que la composition reconstituée ne pénètre dans le compartiment primaire. Il peut s'avérer préférable pour le bon écoulement de la composition d'éviter qu'elle ne reste dans le compartiment primaire.The elastic sleeve 36 exerts a return on the shutter 18, which allows after reconstitution of the composition to prevent it from accessing the primary compartment. In some applications, it may be preferable to prevent the reconstituted composition from entering the primary compartment. It may be preferable for the proper flow of the composition to avoid it remaining in the primary compartment.

La figure 13 montre une autre forme de réalisation dans laquelle la fonction de rappel de l'obturateur 18 est réalisée par des moyens mécaniques.The figure 13 shows another embodiment in which the function of returning the shutter 18 is performed by mechanical means.

Dans cette forme de réalisation, il est prévu que le capuchon 5 soit doté sur sa face intérieure d'un filetage 42, tandis que la bague reçoit un filetage 43 complémentaire. Cette forme de réalisation est basée sur la précédente mais s'en distingue par l'absence de cette bague élastique 19 de rappel, ce rappel étant réalisé mécaniquement par les filetages 42 et 43.In this embodiment, it is provided that the cap 5 is provided on its inner face with a thread 42, while the ring receives a thread 43 complementary. This embodiment is based on the previous one, but is distinguished by the absence of this elastic return ring 19, this return being made mechanically by the threads 42 and 43.

La mise en oeuvre du dispositif dans cette forme de réalisation est similaire.The implementation of the device in this embodiment is similar.

La paroi de séparation 15 est percutée en exerçant une pression sur le capuchon 5 puis en mettant en prise les filetages 42 et 43 du capuchon 5 et de la bague 6. L'obturateur 18 est désolidarisé de la paroi de séparation ce qui met en communication le compartiment primaire 2 et le compartiment secondaire 3.The partition wall 15 is struck by exerting pressure on the cap 5 and then engaging the threads 42 and 43 of the cap 5 and the ring 6. The shutter 18 is disengaged from the partition wall which puts in communication the primary compartment 2 and the secondary compartment 3.

Par rotation du capuchon, il est possible d'ouvrir et de fermer l'ouverture de la paroi de séparation.By rotating the cap, it is possible to open and close the opening of the partition wall.

Il est à noter que le compartiment 2 n'est pas nécessairement une ampoule sécable. Ce compartiment peut comprendre une pompe avec un tube plongeur qui permet d'extraire le produit reconstitué.It should be noted that the compartment 2 is not necessarily a breakable bulb. This compartment may comprise a pump with a plunger tube which makes it possible to extract the reconstituted product.

L'invention peut être mise en oeuvre dans une autre forme de réalisation qui est illustrée aux figures 14 à 17.The invention can be implemented in another embodiment which is illustrated in FIGS. Figures 14 to 17 .

Une ampoule 1 selon cette autre forme de réalisation comporte un compartiment primaire 2 et un compartiment secondaire 3 délimités de manière étanche par une paroi de séparation qui possède des moyens de rupture de celui-ci.A bulb 1 according to this other embodiment comprises a primary compartment 2 and a secondary compartment 3 delimited in a sealed manner by a partition wall which has means of breaking thereof.

Comme on peut le voir, par exemple sur la figure 14, l'ampoule 1 possède un corps primaire 22 qui délimite le compartiment primaire 2 et un corps secondaire 23 qui délimite le compartiment secondaire 3.As can be seen, for example on the figure 14 , bulb 1 has a primary body 22 which delimits the primary compartment 2 and a secondary body 23 which delimits the secondary compartment 3.

Les corps primaire 22 et secondaire 23 possèdent chacun un embout cassable 24 reliés respectivement par une zone de rupture 25.The primary body 22 and secondary body 23 each have a frangible tip 24 respectively connected by a rupture zone 25.

Les corps primaire 22 et secondaire 23 peuvent être réalisés de préférence en matière plastique moulée ou souflée mais pourraient éventuellement être réalisés en verre.The primary body 22 and secondary 23 may be preferably made of plastic molded or blown but could possibly be made of glass.

L'ampoule 1 est ainsi constituée par le corps primaire 22 et par le corps secondaire 23 réunis par une bague 6 centrale qui assure la jonction de ces deux éléments.The bulb 1 is thus constituted by the primary body 22 and the secondary body 23 joined by a central ring 6 which ensures the joining of these two elements.

On peut se reporter, par exemple, à la figure 15 pour apprécier plus précisément la structure de la bague 6.For example, we can refer to figure 15 to appreciate more precisely the structure of the ring 6.

La bague 6 comprend une paroi de séparation 30 de forme annulaire. De part et d'autre de cette paroi de séparation 30, s'étendent deux jupes cylindriques 31 et 32.The ring 6 comprises a partition wall 30 of annular shape. On either side of this partition wall 30 extend two cylindrical skirts 31 and 32.

Dans l'exemple illustré à la figure 15, on peut constater que les jupes cylindriques 31 et 32 sont asymétriques.In the example shown in figure 15 it can be seen that the cylindrical skirts 31 and 32 are asymmetrical.

On peut noter que la paroi de séparation 30 déborde radialement des deux jupes 31 et 32 qui sont dans l'alignement l'une de l'autre.It may be noted that the partition wall 30 protrudes radially from the two skirts 31 and 32 which are in alignment with one another.

La paroi de séparation 30 forme donc un épaulement qui dépasse de la surface des deux jupes 31 et 32.The partition wall 30 thus forms a shoulder that protrudes from the surface of the two skirts 31 and 32.

A proximité de la paroi de séparation 30, on peut noter que les jupes 31 et 32 sont chacune pourvue d'une nervure annulaire 34 et 35.In the vicinity of the partition wall 30, it can be noted that the skirts 31 and 32 are each provided with an annular rib 34 and 35.

Une particularité de la bague 28 est qu'elle intègre une tige 38 au niveau de sa paroi de séparation. La tige 38 est reliée à la paroi de séparation 30 par une zone de liaison de faible épaisseur qui, comme on le verra plus loin, se comporte comme des moyens de rupture de la tige 38 par rapport à la paroi de séparation 30. De façon concrète, la tige 38 possède un obturateur 40 qui s'intègre dans une ouverture 41 pratiquée dans la paroi de séparation 30 et est reliée à la paroi de séparation 30 par un pont de matière de faible épaisseur qui constitue une zone de faiblesse.A particularity of the ring 28 is that it incorporates a rod 38 at its partition wall. The rod 38 is connected to the partition wall 30 by a connection zone of small thickness which, as will be seen below, behaves as means for breaking the rod 38 relative to the partition wall 30. In a concrete, the rod 38 has a shutter 40 which fits into an opening 41 formed in the partition wall 30 and is connected to the partition wall 30 by a bridge of thin material which constitutes a zone of weakness.

La figure 16 montre le compartiment primaire 2 dans sa configuration assemblée. Dans cette configuration, comme on peut le voir sur cette figure, la bague 6 reçoit un premier produit qui, dans l'exemple représenté, est présent sous forme de granulés. Ce produit est stocké dans la cavité délimitée par la jupe 31 et fermée par le corps primaire 22 qui est engagé sur la jupe 31.The figure 16 shows the primary compartment 2 in its assembled configuration. In this configuration, as can be seen in this figure, the ring 6 receives a first product which, in the example shown, is present in the form of granules. This product is stored in the cavity delimited by the skirt 31 and closed by the primary body 22 which is engaged on the skirt 31.

L'étanchéité du compartiment primaire 2 est réalisée par un chevauchement important entre la jupe 31 et le corps primaire 22.The tightness of the primary compartment 2 is achieved by a large overlap between the skirt 31 and the primary body 22.

Un encliquetage indémontable est réalisé par l'engagement de la nervure annulaire 34 dans une gorge annulaire 39 complémentaire présente dans le corps primaire 22.An indémontable snap is produced by the engagement of the annular rib 34 in a complementary annular groove 39 present in the primary body 22.

Ainsi, comme le montre la figure 17, un produit par exemple cosmétique ou pharmaceutique peut être conditionné de façon étanche dans le compartiment primaire 2.So, as shown in figure 17 a product, for example a cosmetic or a pharmaceutical product, can be sealed in the primary compartment 2.

L'assemblage complet du dispositif 1, tel qu'on peut le voir par exemple sur la figure 5, est obtenu en engageant le corps secondaire 23 sur la bague 28. Ainsi, le corps secondaire 23 préalablement rempli, par exemple d'un liquide, reçoit la bague 28 par engagement de sa jupe 31 dans le corps secondaire 23.The complete assembly of the device 1, as can be seen for example on the figure 5 , is obtained by engaging the secondary body 23 on the ring 28. Thus, the secondary body 23 previously filled, for example of a liquid, receives the ring 28 by engagement of its skirt 31 in the secondary body 23.

Comme le montre la figure 14, le dispositif 1 comprend donc deux compartiments 2 et 3 qui sont séparés l'un de l'autre de manière étanche et qui peuvent contenir deux produits qui doivent être mélangés pour reconstituer une composition en vue de son application.As shown in figure 14 , the device 1 thus comprises two compartments 2 and 3 which are separated from one another in a sealed manner and which can contain two products which must be mixed to reconstitute a composition for its application.

La reconstitution s'obtient, comme cela est illustré à la figure 18.The reconstitution is obtained, as illustrated in Figure 18.

Il est prévu de casser l'embout sécable 24 du corps primaire 22 pour pouvoir accéder à la tige 38.It is intended to break the breakable tip 24 of the primary body 22 to access the rod 38.

Ainsi, un utilisateur peut agir sur la tige 38 pour obtenir la rupture de la zone de liaison entre la tige et la paroi de séparation 15. La tige 38 peut alors être retirée de l'ampoule 1, ce qui permet de créer l'ouverture 41 dans la paroi de séparation 30 par laquelle le produit contenu dans le compartiment primaire peut migrer vers le produit liquide, dans l'exemple représenté, qui est contenu dans le compartiment secondaire.Thus, a user can act on the rod 38 to obtain the rupture of the connection zone between the rod and the partition wall 15. The rod 38 can then be removed from the bulb 1, which makes it possible to create the opening 41 in the partition wall 30 through which the product contained in the primary compartment can migrate to the liquid product, in the example shown, which is contained in the secondary compartment.

Dans cette seconde forme de réalisation, l'ampoule permet de conditionner deux produits qui doivent être mélangés pour reconstituer un produit au moment de son application.In this second embodiment, the ampoule is used to package two products that must be mixed to reconstitute a product at the time of its application.

Dans un mode de réalisation non représenté, la tige des moyens d'obstruction peut être munie d'une nervure annulaire ménagée sur sa surface faisant saillie de la zone de rupture afin de venir s'engager par encliquetage avec une nervure annulaire ménagée dans la surface interne de la tête sécable. Ainsi, lorsque l'utilisateur sépare la tête sécable du corps, les deux nervures annulaires coopèrent pour extraire la tige et donc les moyens d'obstruction hors du corps de l'ampoule.In a not shown embodiment, the rod of the obstruction means may be provided with an annular rib formed on its surface projecting from the rupture zone in order to snap into engagement with an annular rib formed in the surface. internal of the breakable head. Thus, when the user separates the breakable head from the body, the two annular ribs cooperate to extract the rod and thus the obstruction means out of the body of the bulb.

Ainsi, l'ampoule 1 selon la présente invention permet de stocker deux produits de façon séparée, et d'assurer leur mélange dans des conditions stériles si besoin est. Bien entendu les premier et second produits peuvent être de natures différentes ou semblables, en particulier chacun peut se présenter sous la forme d'un liquide, d'un solide, d'un gaz ou d'une pâte, par exemple. Une ampoule 1 selon l'invention est particulièrement adaptée pour préparer une composition médicamenteuse ou cosmétique binaire.Thus, the ampoule 1 according to the present invention makes it possible to store two products separately, and to ensure their mixing under sterile conditions if necessary. Of course the first and second products may be of different natures or the like, in particular each may be in the form of a liquid, a solid, a gas or a paste, for example. An ampoule 1 according to the invention is particularly suitable for preparing a binary medicinal or cosmetic composition.

Bien entendu les exemples de réalisations évoqués ci-dessus ne présentent aucun caractère limitatif et d'autres améliorations peuvent être apportées à l'ampoule 1 selon l'invention, sans pour autant sortir du cadre de l'invention où d'autres formes de l'ampoule peuvent être réalisées.Of course the examples of embodiments mentioned above are not limiting in nature and further improvements can be made to the bulb 1 according to the invention, without departing from the scope of the invention where other forms of 'bulb can be realized.

Claims (17)

  1. A device for packaging a binary composition, the device comprising a primary compartment (2) containing a first product and a second compartment (3) containing a second product, the primary compartment (2) and the secondary compartment (3) being sealably delimited by a partition wall (15, 30) comprising an opening closed by an obturator (18) connected to the partition wall by a breakable zone, characterized in that the obturator (18) is integral with an actuating means making it possible to break the breakable zone to free the opening and put the primary compartment (2) in communication with the secondary compartment (3).
  2. The binary composition packaging device (1) according to claim 1, characterized in that the actuating means comprises a rod (16, 38) rigidly connected to the obturator, so that acting on the rod causes a break in the breakable zone.
  3. The binary composition packaging device (1) according to claim 1 or 2, characterized in that the device has a ring (6) separating the primary compartment (2) and the secondary compartment (3) and integrating the partition wall and the obturator connected by a breakable zone.
  4. The binary composition packaging device (1) according to claim 3, characterized in that the ring (6) has a skirt (12) on which a cover (5) is engaged delimiting the primary compartment (2), the cover (5) having a cylindrical head (10) engaged on the rod (16), the cover (5) being able to slide on the skirt (12) between a covering position of the partition wall and an open position of the partition wall in which the rod (16) breaks the breakable zone to open the opening and put the primary compartment (2) and the secondary compartment (3) in communication.
  5. The binary composition packaging device (1) according to claim 4, characterized in that the device comprises a return means capable of bring the obturator back against the opening to close the partition wall that delimits the primary compartment (2) and the secondary compartment (3), after breaking the breakable zone.
  6. The binary composition packaging device (1) according to claim 5, characterized in that the return means comprises an elastic sleeve (36) inserted between the cover (5) and the ring (6) ensuring the return of the obturator (18) against the partition wall.
  7. The binary composition packaging device (1) according to claim 6, characterized in that the elastic sleeve (36) comprises a base that is inserted into the skirt (12) of the ring (6) and a shaft in which the cylindrical head is engaged and bears against the cover (5).
  8. The binary composition packaging device (1) according to claim 5, characterized in that the cover (5) is provided with a thread on the inner surface thereof and in that the ring is provided with a thread making it possible to bring the obturator back against the partition wall by rotating the cover (5).
  9. The binary composition packaging device (1) according to one of claims 4 to 8, characterized in that the ring (6) has an annular rib (14) against which the body (21) and the cover (5) bear in the open position of the wall.
  10. The binary composition packaging device (1) according to claim 9, characterized in that a tamper-evident strip (20) is inserted between the cover (5) and the annular rib (14) whereof the size is at least equal to the travel making it possible to break the breakable zone connecting the obturator (18) to the partition wall.
  11. The binary composition packaging device (1) according to claim 3, characterized in that the device has a body (23) having a frangible tip (24), engaged on the ring (6) and delimiting the secondary compartment (3).
  12. The binary composition packaging device (1) according to claim 2, characterized in that the device comprises a primary body (22) and a secondary body (23) engaged at each end of a ring (28).
  13. The binary composition packaging device (1) according to claim 12, characterized in that the ring (28) has a partition wall (30) and an obturator (40) secured to the rod (38) connected to the partition wall (30) by a thin bridge of material.
  14. The binary composition packaging device (1) according to claim 13, characterized in that the primary body (22) has a frangible tip (24) making it possible to access the rod (38) and in that the secondary body (23) has a frangible tip (24) making it possible to release a reconstituted composition present in the secondary compartment (3).
  15. The binary composition packaging device (1) according to claim 14, characterized in that the rod (38) penetrates the frangible tip (24).
  16. The binary composition packaging device (1) according to one of claims 1 to 15, characterized in that the breakable zone is made up of a bridge of material that connects the obturator (18) to the partition wall (15).
  17. The binary composition packaging device (1) according to one of claims 1 to 16, characterized in that the breakable zone is formed by a tight adjustment between the obturator (18) and the partition wall (15).
EP20090176126 2008-11-14 2009-11-16 Breakable two-compartment ampoule Active EP2186503B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0806392A FR2938515B1 (en) 2008-11-14 2008-11-14 SECURE BULB WITH TWO COMPARTMENTS
FR0954125A FR2938513B1 (en) 2008-11-14 2009-06-18 SECURE BULB WITH TWO COMPARTMENTS

Publications (2)

Publication Number Publication Date
EP2186503A1 EP2186503A1 (en) 2010-05-19
EP2186503B1 true EP2186503B1 (en) 2012-05-16

Family

ID=42102909

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20090176126 Active EP2186503B1 (en) 2008-11-14 2009-11-16 Breakable two-compartment ampoule

Country Status (3)

Country Link
EP (1) EP2186503B1 (en)
ES (1) ES2384427T3 (en)
FR (1) FR2938513B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109292272A (en) * 2018-11-07 2019-02-01 周慧 A kind of timely mixing bottle of push-press type and application method

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109675452A (en) * 2018-12-30 2019-04-26 周慧 A kind of push-press type mixes Material bottle and its application method in time
CN109720740A (en) * 2019-02-20 2019-05-07 周慧 A kind of timely mixing bottle of push-press type and application method
CN110482031A (en) * 2019-08-08 2019-11-22 江门敬记塑胶厂有限公司 Two kinds of content mixing vessels

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Publication number Priority date Publication date Assignee Title
US1718599A (en) * 1927-12-17 1929-06-25 Arthur E Smith Syringe construction
DE69714449D1 (en) 1997-11-19 2002-09-05 Ford Global Tech Inc Balancing a drive train
GB2335179A (en) * 1998-03-11 1999-09-15 Bespak Plc A dispenser having two compartments
FR2819174B1 (en) * 2001-01-08 2003-06-13 Pierre Frezza BULB FOR PACKAGING AND TRANSFERRING LIQUID OR POWDER FOR MEDICAL USE IN A CONTAINER
US20100010472A1 (en) * 2004-12-24 2010-01-14 Ian Marshall Moore Safety syringe
FR2908110B1 (en) 2006-11-03 2011-05-20 Seriplast BULB COMPRISING A HOLLOW BODY AND A HEAD WITH POSSIBILITY OF RUPTURE BETWEEN THE BODY AND THE HEAD.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109292272A (en) * 2018-11-07 2019-02-01 周慧 A kind of timely mixing bottle of push-press type and application method

Also Published As

Publication number Publication date
FR2938513A1 (en) 2010-05-21
ES2384427T3 (en) 2012-07-04
FR2938513B1 (en) 2015-08-07
EP2186503A1 (en) 2010-05-19

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