EP2186503B1 - Trennbare Zweikammerampule - Google Patents

Trennbare Zweikammerampule Download PDF

Info

Publication number
EP2186503B1
EP2186503B1 EP20090176126 EP09176126A EP2186503B1 EP 2186503 B1 EP2186503 B1 EP 2186503B1 EP 20090176126 EP20090176126 EP 20090176126 EP 09176126 A EP09176126 A EP 09176126A EP 2186503 B1 EP2186503 B1 EP 2186503B1
Authority
EP
European Patent Office
Prior art keywords
partition wall
compartment
packaging device
ring
binary composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP20090176126
Other languages
English (en)
French (fr)
Other versions
EP2186503A1 (de
Inventor
André Tartaglione
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seriplast SAS
Original Assignee
Seriplast SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0806392A external-priority patent/FR2938515B1/fr
Application filed by Seriplast SAS filed Critical Seriplast SAS
Publication of EP2186503A1 publication Critical patent/EP2186503A1/de
Application granted granted Critical
Publication of EP2186503B1 publication Critical patent/EP2186503B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/2807—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
    • B65D51/2814—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
    • B65D51/2842—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being provided with a preformed weakened line
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding

Definitions

  • the present invention relates to a device comprising two compartments intended to each contain a product such as a liquid or a powder for the preparation of binary compositions, in particular medicaments.
  • Pharmaceutical or cosmetic products may be packaged, for example, into ampoules or flasks.
  • Bulb packaging is generally used in the pharmaceutical or cosmetic field. These are disposable ampoules that have a breakable tip, this tip is broken before the first use to release their contents.
  • binary composition any composition comprising at least two components to be stored separately and mixed immediately before use.
  • Such a binary composition can be used for pharmaceutical or cosmetic purposes.
  • certain drugs or cosmetics are unstable and must be stored in powder form, yet their administration is in a liquid form.
  • the mixture of the two components, the powder substance and a liquid, for solubilization or dispersion must be done immediately before its administration.
  • the mixture may require the use of an additional device, which may compromise the possible sterility of the binary drug composition, especially because of manipulation by the user.
  • the present invention aims to remedy all or part of the various disadvantages mentioned above.
  • An object of the invention is to provide a device for packaging a binary composition which must be reconstituted at the time of its application.
  • Another object of the invention is to provide a device for packaging a binary composition which must be reconstituted in the absence of contact with the ambient environment at the time of its application.
  • the invention relates to a packaging device according to claim 1.
  • the device according to the present invention makes it possible to store two products, for example pharmaceutical or cosmetic, separately, and to ensure their mixing at the time of use of the product.
  • An ampoule according to the present invention is particularly useful for the preparation of a binary drug composition.
  • An ampoule according to the present invention does not require an outer member to effect mixing of said individual products.
  • Such a bulb also makes it possible to ensure that the quantity of each component for the mixture is correct.
  • the device comprises return means capable of returning the shutter against the opening to close the partition wall which delimits the primary compartment and the secondary compartment, after rupture of the percutable area.
  • the actuating means comprise a rod rigidly connected to the shutter so that an action on the rod causes a rupture of the breakable zone.
  • the device has a ring separating the primary compartment and the secondary compartment integrating the partition wall and the shutter connected by a breakable zone.
  • the ring has a skirt on which engages a cap delimiting the primary compartment, the cap having a cylindrical stud engaged on the rod, the cap being able to slide on the skirt between a position d shutting of the partition wall and an opening position of the partition wall in which the rod impacts the breakable zone opening the opening and placing in communication the primary compartment and the secondary compartment.
  • the mixture of the two products contained in the primary and secondary compartments is made without contact with the ambient environment.
  • the device has a body having a breakable tip engaged on the ring and delimiting the secondary compartment, which allows the composition to flow after reconstitution.
  • the ring has an annular rib against which the body and the cap rest in the open position of the wall.
  • a tamper-evident band is interposed between the cap and the annular rib whose dimension is at least equal to the stroke for breaking the percutable zone connecting the shutter to the wall of seperation.
  • the device comprises a primary body and a secondary body engaged at each end of a ring.
  • the ring has a partition wall and a shutter, secured to the rod, connected to the partition wall by a bridge of breakable material thin.
  • the primary body has a breakable tip for accessing the rod and the secondary body has a breakable tip for releasing a reconstituted composition present in the secondary compartment.
  • the rod enters the breakable tip, which allows access to the rod after breaking the tip.
  • a percutable zone is constituted by a material bridge which connects the shutter to the partition wall.
  • the percutable zone is formed by a tight fit between the shutter and the partition wall.
  • the packaging device 1 has two compartments intended to each contain a product.
  • the mixture of the two products in particular cosmetic or medicinal, is effected in a completely watertight manner. In other words, there is no contact with the ambient air during mixing between the two products as will be described.
  • the device 1 has a primary compartment 2 which can contain a first product and a secondary compartment 3 which can contain a second product.
  • the primary compartment 2 is, in the embodiment of the invention illustrated, delimited by two elements namely a cap 5 and a ring 6 on which the cap 5 engages.
  • the cap 5 comprises a substantially cylindrical skirt 8 and a circular end surface 9. Inside the cap 5, it can be seen that it is provided with a cylindrical nipple 10 extending from the end surface 9 towards the center of the cap. The end of the cylindrical stud 10 is preferably chamfered.
  • the ring 6 comprises, for its part, a cylindrical skirt 12 of which extends radially an annular rib 14 substantially at mid-height of the ring 6 in the illustrated embodiment.
  • the ring 6 comprises a partition wall 15.
  • the partition wall 15 comprises a frustoconical portion 17 which extends from the skirt 12 radially in the direction of the axis of symmetry of the ring 6.
  • the wall of separation 15 has an opening 13 which is closed by a shutter 18.
  • the shutter 18 is itself connected to a rod 16.
  • the partition wall 15 and the shutter 18 are connected by a continuous bridge 19 of material which provides a sealing on both sides of the partition wall 15 while constituting a zone of weakness which will serve as a percutable zone.
  • the junction between the partition wall 15 from the skirt 12 and the shutter 18 from the rod 16 is at a bridge of material 19 - circular in the illustrated case - thin.
  • the zone of weakness formed by the material bridge 19 therefore constitutes a break line whose function will be seen later.
  • the cap 5 is engaged on the ring 6 so that the cylindrical stud 10 is placed on the end of the rod 16, while the skirt 8 of the cap 5 slides on the skirt 12 of the ring 6.
  • tamper-proof ring 20 may be derived from molding of the cap 5.
  • the conditioning device 1 further comprises a secondary compartment which is constituted by a body 21 preferably made of plastic although it is quite possible to make it out of glass.
  • the body 21 has an open tubular portion at one of its ends, while its second end is provided with a breakable tip 24 connected to the body by a break line 25.
  • the packaging device 1 with two compartments 2 and 3 according to the invention is obtained by engaging the ring 6 in the body 21.
  • the body 21 is provided with an annular groove 26 on its inner face, while the ring 6 is provided with an annular rib 29 on its outer face, so that a snap is created when inserting the ring 6 into the body 21.
  • the body 22 Prior to the insertion of the ring 6 on the body 21, it is expected that the body 22 is filled with a product distinct from the product contained in the primary compartment 2, this product may be liquid, pasty or granular.
  • the mixing operation illustrated in figure 5 of the two products which are packaged separately and totally hermetic; is extremely simple for the user since it is sufficient, after having removed the tamperproof ring 20, to bear on the end surface 9 of the cap 5 which is transmitted to the rod 16 and causes a rupture of the partition wall 15 between the primary compartment 2 and the secondary compartment 3 .
  • the primary compartment 2 is in communication with the secondary compartment 3 and the products that were stored separately can migrate through the opening 13 towards each other so as to constitute a cosmetic or medicinal solution ready for use. employment.
  • This embodiment of the invention is quite advantageous since it is carried out in a completely confined enclosure without any contact with the ambient environment and possible contaminants.
  • FIG 7 shows, in longitudinal section, an embodiment of the invention in which the conditioning device according to the invention is provided with the return means of the shutter 18.
  • an elastic sleeve 36 is interposed between the skirt 12 of the ring 6 and the cap 5.
  • the elastic sleeve 36 which is shown in isolation at the figure 9 may comprise a base 36a which inserted into the skirt 12 of the ring 6 and a chimney 36b in which the cylindrical stud 10 engages and abuts against the cap 5.
  • the elastic ring 19 is made of an elastic material such as an elastomer, synthetic or natural.
  • the device represented in Figures 7 to 12 has a shutter 18 which is forced into an opening in the partition wall.
  • the seal between the primary compartment 2 and the secondary compartment 3 is not made by a breakable wall but is made by a tight fit between the shutter 18 and the opening 13 of the partition wall 15.
  • the percutable zone is formed by the tight fit between the shutter 18 and the opening 13 of the partition wall 15.
  • these two embodiments are substantially equivalent because they make it possible to ensure a tight separation between the primary 2 and secondary 3 compartments and they make apparent the opening of the shutter 18 after its first use. This point is important because there must be no communication between the primary 2 and secondary 3 compartments without a detectable intervention of a user.
  • the shutter 18 can be molded with the partition wall by being connected by material bridges and then forcibly engaged in the opening 13.
  • the tamperproof ring 20 can be, as shown in FIG. figure 7 , come molding with the cap 5.
  • the figure 10 shows the primary compartment 2 of the device before it is struck.
  • the Figures 11 and 12 show the device at the end of percussion.
  • the elastic sleeve 36 is crushed.
  • the elastic sleeve 36 exerts its return function and returns the rod and the shutter 18 to a position in which the shutter 18 abuts against the opening 13 formed in the partition wall, without being able to insert into the opening 13.
  • the elastic sleeve 36 exerts a return on the shutter 18, which allows after reconstitution of the composition to prevent it from accessing the primary compartment. In some applications, it may be preferable to prevent the reconstituted composition from entering the primary compartment. It may be preferable for the proper flow of the composition to avoid it remaining in the primary compartment.
  • the figure 13 shows another embodiment in which the function of returning the shutter 18 is performed by mechanical means.
  • the cap 5 is provided on its inner face with a thread 42, while the ring receives a thread 43 complementary.
  • This embodiment is based on the previous one, but is distinguished by the absence of this elastic return ring 19, this return being made mechanically by the threads 42 and 43.
  • the partition wall 15 is struck by exerting pressure on the cap 5 and then engaging the threads 42 and 43 of the cap 5 and the ring 6.
  • the shutter 18 is disengaged from the partition wall which puts in communication the primary compartment 2 and the secondary compartment 3.
  • compartment 2 is not necessarily a breakable bulb.
  • This compartment may comprise a pump with a plunger tube which makes it possible to extract the reconstituted product.
  • the invention can be implemented in another embodiment which is illustrated in FIGS. Figures 14 to 17 .
  • a bulb 1 according to this other embodiment comprises a primary compartment 2 and a secondary compartment 3 delimited in a sealed manner by a partition wall which has means of breaking thereof.
  • bulb 1 has a primary body 22 which delimits the primary compartment 2 and a secondary body 23 which delimits the secondary compartment 3.
  • the primary body 22 and secondary body 23 each have a frangible tip 24 respectively connected by a rupture zone 25.
  • the primary body 22 and secondary 23 may be preferably made of plastic molded or blown but could possibly be made of glass.
  • the bulb 1 is thus constituted by the primary body 22 and the secondary body 23 joined by a central ring 6 which ensures the joining of these two elements.
  • figure 15 we can refer to figure 15 to appreciate more precisely the structure of the ring 6.
  • the ring 6 comprises a partition wall 30 of annular shape. On either side of this partition wall 30 extend two cylindrical skirts 31 and 32.
  • partition wall 30 protrudes radially from the two skirts 31 and 32 which are in alignment with one another.
  • the partition wall 30 thus forms a shoulder that protrudes from the surface of the two skirts 31 and 32.
  • skirts 31 and 32 are each provided with an annular rib 34 and 35.
  • a particularity of the ring 28 is that it incorporates a rod 38 at its partition wall.
  • the rod 38 is connected to the partition wall 30 by a connection zone of small thickness which, as will be seen below, behaves as means for breaking the rod 38 relative to the partition wall 30.
  • the rod 38 has a shutter 40 which fits into an opening 41 formed in the partition wall 30 and is connected to the partition wall 30 by a bridge of thin material which constitutes a zone of weakness.
  • the figure 16 shows the primary compartment 2 in its assembled configuration.
  • the ring 6 receives a first product which, in the example shown, is present in the form of granules. This product is stored in the cavity delimited by the skirt 31 and closed by the primary body 22 which is engaged on the skirt 31.
  • the tightness of the primary compartment 2 is achieved by a large overlap between the skirt 31 and the primary body 22.
  • An inchtmontable snap is produced by the engagement of the annular rib 34 in a complementary annular groove 39 present in the primary body 22.
  • a product for example a cosmetic or a pharmaceutical product, can be sealed in the primary compartment 2.
  • the complete assembly of the device 1, as can be seen for example on the figure 5 is obtained by engaging the secondary body 23 on the ring 28.
  • the secondary body 23 previously filled, for example of a liquid, receives the ring 28 by engagement of its skirt 31 in the secondary body 23.
  • the device 1 thus comprises two compartments 2 and 3 which are separated from one another in a sealed manner and which can contain two products which must be mixed to reconstitute a composition for its application.
  • a user can act on the rod 38 to obtain the rupture of the connection zone between the rod and the partition wall 15.
  • the rod 38 can then be removed from the bulb 1, which makes it possible to create the opening 41 in the partition wall 30 through which the product contained in the primary compartment can migrate to the liquid product, in the example shown, which is contained in the secondary compartment.
  • the ampoule is used to package two products that must be mixed to reconstitute a product at the time of its application.
  • the rod of the obstruction means may be provided with an annular rib formed on its surface projecting from the rupture zone in order to snap into engagement with an annular rib formed in the surface. internal of the breakable head.
  • the two annular ribs cooperate to extract the rod and thus the obstruction means out of the body of the bulb.
  • the ampoule 1 according to the present invention makes it possible to store two products separately, and to ensure their mixing under sterile conditions if necessary.
  • the first and second products may be of different natures or the like, in particular each may be in the form of a liquid, a solid, a gas or a paste, for example.
  • An ampoule 1 according to the invention is particularly suitable for preparing a binary medicinal or cosmetic composition.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Package Specialized In Special Use (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (17)

  1. Vorrichtung zur Verpackung mit einer binären Zusammensetzung, wobei die Vorrichtung eine primäre (2) Abteilung umfasst, die ein erstes Produkt enthält, und eine sekundäre (3) Abteilung, die ein zweites Produkt enthält, wobei die primäre Abteilung (2) und die sekundäre Abteilung (3) auf dichte Weise durch eine Trennwand (15, 30) begrenzt sind, umfassend eine Öffnung, die durch einen Pfropfen verschlossen ist (18), verbunden mit der Trennwand durch einen einschlagbaren Bereich, dadurch gekennzeichnet, dass der Pfropfen (18) ein integrales Stück mit Betätigungsmitteln bildet, die ermöglichen, den einschlagbaren Bereich zu brechen, um die Öffnung freizusetzen und die primäre Abteilung (2) mit dem sekundären Abteilung (2) zu verbinden.
  2. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 1, dadurch gekennzeichnet, dass die Betätigungsmittel einen Schaft (16, 38) umfassen, der starr mit dem Pfropfen verbunden ist, so dass eine Einwirkung auf den Schaft zu einem Bruch des einschlagbaren Bereichs führt.
  3. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass die Vorrichtung einen Ring (6) aufweist, der die primäre Abteilung (2) und die sekundäre Abteilung (3) trennt und die Trennwand und den Pfropfen, verbunden durch einen einschlagbaren Bereich, integriert.
  4. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 3, dadurch gekennzeichnet, dass der Ring (6) einen Mantel (12) aufweist, auf den eine Kappe (5) eingreift, die die primäre Abteilung (2) begrenzt, wobei die Kappe (5) einen zylindrischen Zapfen (10) aufweist, der auf den Schaft (16) eingreift, wobei die Kappe (5) auf dem Mantel (12) zwischen einer Verschlussposition der Trennwand und einer Öffnungsposition der Trennwand gleiten kann, wobei der Schaft (16) auf den einschlagbaren Bereich einschlägt und die Öffnung öffnet und die primäre Abteilung (2) mit der sekundären Abteilung (3) verbindet.
  5. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 4, dadurch gekennzeichnet, dass die Vorrichtung Rückholmittel umfasst, die den Pfropfen gegen die Öffnung zurückbringen können, um die Trennwand, die die primäre Abteilung (2) und die sekundäre Abteilung (3) trennt, nach dem Bruch des einschlagbaren Bereichs erneut zu schließen.
  6. Vorrichtung zur Verpackung mit einer binären Zusammensetzung nach Anspruch 5, dadurch gekennzeichnet, dass die Rückholmittel eine elastische Muffe (36) umfassen, die zwischen der Kappe (5) und dem Ring (6) eingeschoben ist und die Rückholung des Pfropfens (18) gegen die Trennwand sicherstellt.
  7. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 6, dadurch gekennzeichnet, dass die elastische Muffe (36) eine Basis umfasst, die in den Mantel (12) des Rings (6) eingeführt ist, und einen Kamin, in den der zylindrische Zapfen eingreift und auf der Kappe (5) aufliegt.
  8. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 5, dadurch gekennzeichnet, dass die Kappe (5) auf ihrer inneren Seite mit einem Gewinde versehen ist, das durch die Drehung der Kappe (5) ermöglicht, den Pfropfen gegen die Trennwand zurückzuholen.
  9. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach einem der Ansprüche 4 bis 8, dadurch gekennzeichnet, dass der Ring (6) eine ringförmige Rippe (14) aufweist, gegen die der Körper (21) und die Kappe (5) in der Öffnungsposition der Wand aufliegen.
  10. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 9, dadurch gekennzeichnet, dass ein Garantieband (20) zwischen die Kappe (5) und die ringförmige Rippe (14) eingeschoben ist, dessen Abmessung mindestens gleich dem Weg ist, der ermöglicht, den einschlagbaren Bereich einzuschlagen, der den Pfropfen (18) mit der Trennwand verbindet.
  11. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 3, dadurch gekennzeichnet, dass die Vorrichtung einen Körper (23) aufweist, der eine trennbare Tülle (24) umfasst, die auf den Ring (6) eingreift und die sekundäre Abteilung (3) begrenzt.
  12. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 2, dadurch gekennzeichnet, dass die Vorrichtung einen primären Körper (22) und einen sekundären Körper (23) aufweist, die auf jedes Ende eines Rings (28) eingreifen.
  13. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 12, dadurch gekennzeichnet, dass der Ring (28) eine Trennwand (30) und einen Pfropfen (40) aufweist, der fest mit dem Schaft (38) verbinden ist, der durch eine Materialbrücke mit geringer Dicke mit der Trennwand (30) verbunden ist.
  14. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 13, dadurch gekennzeichnet, dass der primäre Körper (22) eine trennbare Tülle (24) aufweist, die ermöglicht, auf den Schaft (38) zuzugreifen, und dadurch, dass der sekundäre Körper (23) eine trennbare Tülle (24) aufweist, die ermöglicht, eine wieder hergestellte Zusammensetzung, die in der sekundären Abteilung (3) vorhanden ist, freizugeben.
  15. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach Anspruch 14, dadurch gekennzeichnet, dass der Schaft (38) in die trennbare Tülle (24) eindringt.
  16. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach einem der Ansprüche 1 bis 15, dadurch gekennzeichnet, dass der einschlagbare Bereich aus einer Materialbrücke gebildet ist, die den Pfropfen (18) mit der Trennwand (15) verbindet.
  17. Vorrichtung (1) zur Verpackung mit einer binären Zusammensetzung nach einem der Ansprüche 1 bis 16, dadurch gekennzeichnet, dass der einschlagbare Bereich aus einer Presspassung zwischen dem Pfropfen (18) und der Trennwand (15) gebildet ist.
EP20090176126 2008-11-14 2009-11-16 Trennbare Zweikammerampule Active EP2186503B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0806392A FR2938515B1 (fr) 2008-11-14 2008-11-14 Ampoule secable a deux compartiments
FR0954125A FR2938513B1 (fr) 2008-11-14 2009-06-18 Ampoule secable a deux compartiments

Publications (2)

Publication Number Publication Date
EP2186503A1 EP2186503A1 (de) 2010-05-19
EP2186503B1 true EP2186503B1 (de) 2012-05-16

Family

ID=42102909

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20090176126 Active EP2186503B1 (de) 2008-11-14 2009-11-16 Trennbare Zweikammerampule

Country Status (3)

Country Link
EP (1) EP2186503B1 (de)
ES (1) ES2384427T3 (de)
FR (1) FR2938513B1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109292272A (zh) * 2018-11-07 2019-02-01 周慧 一种推压式及时混料瓶及使用方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109675452A (zh) * 2018-12-30 2019-04-26 周慧 一种推压式及时混合料体瓶及其使用方法
CN109720740A (zh) * 2019-02-20 2019-05-07 周慧 一种推压式及时混料瓶及使用方法
CN110482031A (zh) * 2019-08-08 2019-11-22 江门敬记塑胶厂有限公司 两种内容物混合容器

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1718599A (en) * 1927-12-17 1929-06-25 Arthur E Smith Syringe construction
DE69714449D1 (de) 1997-11-19 2002-09-05 Ford Global Tech Inc Auswuchten eines Antriebsstrangs
GB2335179A (en) * 1998-03-11 1999-09-15 Bespak Plc A dispenser having two compartments
FR2819174B1 (fr) * 2001-01-08 2003-06-13 Pierre Frezza Ampoule pour le conditionnement et le transfert d'un liquide ou d'une poudre a usage medical dans un contenant
DK1833532T3 (da) * 2004-12-24 2011-06-06 Collyn Patent Holdings Pty Ltd Sikkerhedssprøjte
FR2908110B1 (fr) 2006-11-03 2011-05-20 Seriplast Ampoule comportant un corps creux et une tete avec possibilite de rupture entre le corps et la tete.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109292272A (zh) * 2018-11-07 2019-02-01 周慧 一种推压式及时混料瓶及使用方法

Also Published As

Publication number Publication date
FR2938513B1 (fr) 2015-08-07
ES2384427T3 (es) 2012-07-04
EP2186503A1 (de) 2010-05-19
FR2938513A1 (fr) 2010-05-21

Similar Documents

Publication Publication Date Title
EP0850178B1 (de) Vorrichtung mit originalitätssicherung zum anschluss an einen geschlossenen behälter
EP1611024B1 (de) Kapsel mit zerstörbarem deckel, sowie behälterverschluss und behälter mit einer solchen kapsel
CA2837816C (fr) Dispositif de connexion entre un recipient et un contenant, procede d'assemblage et d'utilisation d'un tel dispositif
EP0295265B1 (de) Vorrichtung zum aufbewahren von flüssigen oder von flüssigen und festen substanzen
EP2718198B1 (de) Stoppvorrichtung und behälter damit
EP1150639A1 (de) Verbindungsvorrichtung zwischen behälter und gebrauchsfertige anordnung mit einer solchen vorrichtung
FR2717086A1 (fr) Dispositif de seringue pour le mélange de deux composés.
FR2722765A1 (fr) Recipient permettant le stockage d'au moins deux produits, le melange de ces produits et la distribution du melange ainsi obtenu
EP2186503B1 (de) Trennbare Zweikammerampule
CA2299595C (fr) Conditionnement pour effectuer le melange d'un produit a plusieurs composantes
EP0238371A1 (de) Behälter mit einer viskosen Flüssigkeit, die beim ersten Verbrauch mit einem Zusatz versehen werden kann
WO1998049994A1 (fr) Dispositif de mise en solution d'un produit lyophilise, contenu dans une cartouche a usage unique utilisee dans un dispositif d'injection sans aiguille
EP1005429A1 (de) Mischflasche zur abgabe einer mischung aus zwei vor der abgabe voneinander getrennten produkten und zur deren injekton mittels einer spritze
FR3033319B1 (fr) Recipient destine a recevoir une dose determinee d'au moins deux produits de meme nature ou de nature differente
EP0562943B1 (de) Zweikammerpackung
FR2708204A1 (fr) Dispositif de seringue pour le mélange de deux composés.
FR3087336A1 (fr) Dispositif de connexion temporaire de deux recipients
FR2938515A1 (fr) Ampoule secable a deux compartiments
EP3383342B1 (de) Vorrichtung zur verbindung eines behälters und behälter und verbindungsanordnung mit solch einer vorrichtung
FR2705898A1 (fr) Dispositif de seringue pour le mélange de deux composés.
FR2708469A1 (fr) Dispositif de seringue pour le mélange de deux composés.
FR2688487A1 (fr) Recipient a deux compartiments.
FR2715311A1 (fr) Dispositif de seringue pour le mélange de deux composés.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

AX Request for extension of the european patent

Extension state: AL BA RS

17P Request for examination filed

Effective date: 20100715

17Q First examination report despatched

Effective date: 20100806

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602009006992

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: A61J0001060000

Ipc: B65D0051280000

RIC1 Information provided on ipc code assigned before grant

Ipc: A61J 1/06 20060101ALI20111128BHEP

Ipc: B65D 51/28 20060101AFI20111128BHEP

Ipc: A61J 1/20 20060101ALI20111128BHEP

Ipc: B65D 1/09 20060101ALI20111128BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TARTAGLIONE, ANDRE

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 557989

Country of ref document: AT

Kind code of ref document: T

Effective date: 20120615

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: FRENCH

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2384427

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20120704

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602009006992

Country of ref document: DE

Effective date: 20120719

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20120516

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

Effective date: 20120516

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120816

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120916

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 557989

Country of ref document: AT

Kind code of ref document: T

Effective date: 20120516

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120917

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120817

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20130219

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602009006992

Country of ref document: DE

Effective date: 20130219

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120816

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121116

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121130

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121116

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20091116

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131130

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120516

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 7

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 8

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 9

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20230914

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20230830

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20231218

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20231109

Year of fee payment: 15

Ref country code: DE

Payment date: 20230915

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20231113

Year of fee payment: 15