FR2789077A1 - Derives de perazole, leur preparation et leur application en therapeutique - Google Patents

Derives de perazole, leur preparation et leur application en therapeutique Download PDF

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Publication number
FR2789077A1
FR2789077A1 FR9901143A FR9901143A FR2789077A1 FR 2789077 A1 FR2789077 A1 FR 2789077A1 FR 9901143 A FR9901143 A FR 9901143A FR 9901143 A FR9901143 A FR 9901143A FR 2789077 A1 FR2789077 A1 FR 2789077A1
Authority
FR
France
Prior art keywords
sep
formula
compound
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR9901143A
Other languages
English (en)
French (fr)
Inventor
Gilles Victor Car Courtemanche
Jean Bertin
Gerard Defosse
Philippe R Bovy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR9901143A priority Critical patent/FR2789077A1/fr
Priority to AU30604/00A priority patent/AU3060400A/en
Priority to EP00900674A priority patent/EP1150972A1/fr
Priority to JP2000597290A priority patent/JP2002539085A/ja
Priority to PCT/FR2000/000191 priority patent/WO2000046220A1/fr
Priority to CO00005432A priority patent/CO5140090A1/es
Publication of FR2789077A1 publication Critical patent/FR2789077A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR9901143A 1999-02-02 1999-02-02 Derives de perazole, leur preparation et leur application en therapeutique Withdrawn FR2789077A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR9901143A FR2789077A1 (fr) 1999-02-02 1999-02-02 Derives de perazole, leur preparation et leur application en therapeutique
AU30604/00A AU3060400A (en) 1999-02-02 2000-01-28 Triazole and tetrazole derivatives, and their therapeutic use
EP00900674A EP1150972A1 (fr) 1999-02-02 2000-01-28 Derives de triazoles et tetrazoles, et leur utilisation en therapeutique
JP2000597290A JP2002539085A (ja) 1999-02-02 2000-01-28 トリアゾール及びテトラゾールの誘導体ならびにその治療上の使用
PCT/FR2000/000191 WO2000046220A1 (fr) 1999-02-02 2000-01-28 Derives de triazoles et tetrazoles, et leur utilisation en therapeutique
CO00005432A CO5140090A1 (es) 1999-02-02 2000-01-31 Derivados de pirazol, su preparacion y su aplicacion en terapeutica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9901143A FR2789077A1 (fr) 1999-02-02 1999-02-02 Derives de perazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
FR2789077A1 true FR2789077A1 (fr) 2000-08-04

Family

ID=9541473

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9901143A Withdrawn FR2789077A1 (fr) 1999-02-02 1999-02-02 Derives de perazole, leur preparation et leur application en therapeutique

Country Status (6)

Country Link
EP (1) EP1150972A1 (ja)
JP (1) JP2002539085A (ja)
AU (1) AU3060400A (ja)
CO (1) CO5140090A1 (ja)
FR (1) FR2789077A1 (ja)
WO (1) WO2000046220A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002006272A1 (fr) * 2000-07-18 2002-01-24 Sanofi-Synthelabo Derives de polyfluoroalkyltriazole, leur preparation et leur utilisation en therapeutique

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002364291B2 (en) 2001-12-20 2007-08-02 Merck Serono Sa Triazoles as oxytocin antagonists

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610717A (en) * 1985-11-26 1986-09-09 Shell Oil Company Certain 5-(R-oxy)-1-phenyl or (3-(trifluoromethyl)phenyl)triazoles, useful for controlling undesired plant growth
EP0263213A1 (en) * 1986-10-09 1988-04-13 The Upjohn Company C20 Through C26 amino steroids
US5438149A (en) * 1994-05-27 1995-08-01 Fmc Corporation Difluoromethylation of a phenyl triazolinone
WO1998004546A1 (fr) * 1996-07-25 1998-02-05 Synthelabo Derives de benzimidazole, leurs preparations et leurs applications en therapeutique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610717A (en) * 1985-11-26 1986-09-09 Shell Oil Company Certain 5-(R-oxy)-1-phenyl or (3-(trifluoromethyl)phenyl)triazoles, useful for controlling undesired plant growth
EP0263213A1 (en) * 1986-10-09 1988-04-13 The Upjohn Company C20 Through C26 amino steroids
US5438149A (en) * 1994-05-27 1995-08-01 Fmc Corporation Difluoromethylation of a phenyl triazolinone
WO1998004546A1 (fr) * 1996-07-25 1998-02-05 Synthelabo Derives de benzimidazole, leurs preparations et leurs applications en therapeutique

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BERNARDINI, ANTOINE ET AL: "Synthesis of halo-1,2,4-triazoles substituted at the 1 or 4 positions", BULL. SOC. CHIM. FR. (1975), (3-4, PT. 2), 647-53, XP002118298 *
BULL. SOC. CHIM. BELG. (1986), 95(2), 141-2 *
CHEMICAL ABSTRACTS, vol. 106, no. 19, 11 May 1987, Columbus, Ohio, US; abstract no. 156441, RAHMAN, LOAY K. A.: "Synthesis of dibenzo[d,g][1,2,4]triazolo[4,3-a][1,3]diazocine-8-one and dibenzo[d,g][1,2,4]triazolo[4,3-a][1,3]oxazocine-8-one" XP002118299 *
CHEMICAL ABSTRACTS, vol. 56, no. 9, 30 April 1962, Columbus, Ohio, US; abstract no. 10133e, BALLI ET AL: "Azidinium salts" XP002118302 *
CHEMICAL ABSTRACTS, vol. 59, no. 10, 11 November 1963, Columbus, Ohio, US; abstract no. 11473d, GEHLEN ET AL: "Nitrosamines of 3-amino-1,2,4-triazoles" XP002118301 *
CHEMICAL ABSTRACTS, vol. 63, no. 10, 8 November 1965, Columbus, Ohio, US; abstract no. 13242f, I.L. SHEGAL ET AL: "Alkylation proucts of 4-phenyl-1,2,4-triazoline-3-thone" XP002118300 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TAKEHARA, KOJI ET AL: "Synthesis and bleaching activity of 3-propargylthio-4-(substituted phenyl)-4H-1,2,4-triazoles", XP002118303, retrieved from STN Database accession no. 123:339901 *
GLINKA, J. ET AL: "Substituent and coordination effects in singlet reactions of 3-diazo-3H-1,2,4-triazoles with substituted benzenes and nitro compounds", TETRAHEDRON LETT. (1987), 28(28), 3221-4, XP002118296 *
KHIM. GETEROTSIKL. SOEDIN. , AKAD. NAUK. LATV., no. 3, 1965, pages 449 - 454 *
LIEBIGS ANNALEN DER CHEMIE, vol. 647, 1961, pages 1 - 10 *
LIEBIGS ANNALEN DER CHEMIE, vol. 665, 1963, pages 144 - 149 *
NIPPON NOYAKU GAKKAISHI (1995), 20(3), 291-7 *
VAN LEUSEN, A. M. ET AL: "Chemistry of sulfonylmethyl isocyanides. 11. Synthesis of 1,2,4-triazoles from tosylmethyl isocyanide and aryldiazonium compounds", J. ORG. CHEM. (1976), 41(4), 711-13, XP002118297 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002006272A1 (fr) * 2000-07-18 2002-01-24 Sanofi-Synthelabo Derives de polyfluoroalkyltriazole, leur preparation et leur utilisation en therapeutique

Also Published As

Publication number Publication date
CO5140090A1 (es) 2002-03-22
EP1150972A1 (fr) 2001-11-07
JP2002539085A (ja) 2002-11-19
AU3060400A (en) 2000-08-25
WO2000046220A1 (fr) 2000-08-10

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ST Notification of lapse