CO5140090A1 - Derivados de pirazol, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de pirazol, su preparacion y su aplicacion en terapeutica

Info

Publication number
CO5140090A1
CO5140090A1 CO00005432A CO00005432A CO5140090A1 CO 5140090 A1 CO5140090 A1 CO 5140090A1 CO 00005432 A CO00005432 A CO 00005432A CO 00005432 A CO00005432 A CO 00005432A CO 5140090 A1 CO5140090 A1 CO 5140090A1
Authority
CO
Colombia
Prior art keywords
alkyl
amino
aminosulfonyl
pirazol
therapeutics
Prior art date
Application number
CO00005432A
Other languages
English (en)
Inventor
Courtemanche Gilles
Jean Bertin
Gerard Defosse
Philippe R Bovy
Crespin Olivier
Fett Eykmar
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of CO5140090A1 publication Critical patent/CO5140090A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuesto de fórmula (I)<EMI FILE="00005432_1" ID="1" IMF=JPEG >en la cual, el par (A,B) representa (N,N), (N,C) ó (C,N), n = O si A representa un átomo de nitrógeno, si no n = 1, m = O si B representa un átomo de nitrógeno, si no m = 1, R1 y R2 representan, independientemente uno de otro, un átomo de hidrógeno, un grupo C1-6 alquilo, C2-6 alquenilo o ciclo C3-6 alquilo,Ar1 representa un radical fenilo o un radical piridilo sustituido por los grupos R3, R ´3 y R´ ´3,Ar2 representa un radical fenilo sustituido por los grupos R4 y R´4, donde R3, R´3, R´ ´3, R4 y R´4 representan, independientemente uno de otro, un átomo de hidrógeno, un átomo de halógeno, un grupo C1-4 alquilo, hidroxi, C1-4 alcoxi, ciano, nitro, perfluoroC1-2 alquilo, amino, C1-4alquilamino, di(C1-4 alquil)-amino, C1-4 alcoxicarbonil-amino, (C1-4 alcoxicarbonil)(C1-4 alquil)-amino, aminosulfonilo, C1-4 alquil-aminosulfonilo o di(C1-4 alquil)-aminosulfonilo, así como sus sales, N-óxidos e hidratos.
CO00005432A 1999-02-02 2000-01-31 Derivados de pirazol, su preparacion y su aplicacion en terapeutica CO5140090A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9901143A FR2789077A1 (fr) 1999-02-02 1999-02-02 Derives de perazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO5140090A1 true CO5140090A1 (es) 2002-03-22

Family

ID=9541473

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00005432A CO5140090A1 (es) 1999-02-02 2000-01-31 Derivados de pirazol, su preparacion y su aplicacion en terapeutica

Country Status (6)

Country Link
EP (1) EP1150972A1 (es)
JP (1) JP2002539085A (es)
AU (1) AU3060400A (es)
CO (1) CO5140090A1 (es)
FR (1) FR2789077A1 (es)
WO (1) WO2000046220A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811989A1 (fr) * 2000-07-18 2002-01-25 Sanofi Synthelabo Derives de polyfluoroalkytriazole, leur preparation et leur application en therapeutique
EP1458381B1 (en) 2001-12-20 2005-11-30 Applied Research Systems ARS Holding N.V. Triazoles as oxytocin antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0263213B1 (en) * 1986-10-09 1995-09-06 The Upjohn Company C20 Through C26 amino steroids
US4610717A (en) * 1985-11-26 1986-09-09 Shell Oil Company Certain 5-(R-oxy)-1-phenyl or (3-(trifluoromethyl)phenyl)triazoles, useful for controlling undesired plant growth
US5438149A (en) * 1994-05-27 1995-08-01 Fmc Corporation Difluoromethylation of a phenyl triazolinone
FR2751647B1 (fr) * 1996-07-25 1998-09-11 Synthelabo Derives de benzimidazole, leurs preparations et leurs applications en therapeutique

Also Published As

Publication number Publication date
JP2002539085A (ja) 2002-11-19
WO2000046220A1 (fr) 2000-08-10
AU3060400A (en) 2000-08-25
EP1150972A1 (fr) 2001-11-07
FR2789077A1 (fr) 2000-08-04

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