FR2730235A1 - Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15 - Google Patents

Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15 Download PDF

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Publication number
FR2730235A1
FR2730235A1 FR9501328A FR9501328A FR2730235A1 FR 2730235 A1 FR2730235 A1 FR 2730235A1 FR 9501328 A FR9501328 A FR 9501328A FR 9501328 A FR9501328 A FR 9501328A FR 2730235 A1 FR2730235 A1 FR 2730235A1
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FR
France
Prior art keywords
zaa
phe
xaa
po2ch2
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR9501328A
Other languages
English (en)
French (fr)
Other versions
FR2730235B1 (enExample
Inventor
Vincent Dive
Jiri Jiracek
Athanasios Yiotakis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat à l'Énergie Atomique et Aux Énergies Alternatives
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to FR9501328A priority Critical patent/FR2730235A1/fr
Priority to US08/590,483 priority patent/US5776903A/en
Priority to EP96400229A priority patent/EP0725075A1/fr
Priority to JP8018967A priority patent/JPH0952900A/ja
Publication of FR2730235A1 publication Critical patent/FR2730235A1/fr
Application granted granted Critical
Publication of FR2730235B1 publication Critical patent/FR2730235B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FR9501328A 1995-02-06 1995-02-06 Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15 Granted FR2730235A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR9501328A FR2730235A1 (fr) 1995-02-06 1995-02-06 Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
US08/590,483 US5776903A (en) 1995-02-06 1996-01-24 Peptide derivatives usable as zinc endopeptidase 24-15 inhibitors
EP96400229A EP0725075A1 (fr) 1995-02-06 1996-02-02 Dérivés de peptides comportant une acide phosphinique utilisables comme inhibiteur de l'endopeptidase à zinc 24-15
JP8018967A JPH0952900A (ja) 1995-02-06 1996-02-05 亜鉛エンドペプチダーゼ２４−１５阻害剤として使用可能な新規ペプチド誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9501328A FR2730235A1 (fr) 1995-02-06 1995-02-06 Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15

Publications (2)

Publication Number Publication Date
FR2730235A1 true FR2730235A1 (fr) 1996-08-09
FR2730235B1 FR2730235B1 (enExample) 1997-02-28

Family

ID=9475861

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9501328A Granted FR2730235A1 (fr) 1995-02-06 1995-02-06 Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15

Country Status (4)

Country Link
US (1) US5776903A (enExample)
EP (1) EP0725075A1 (enExample)
JP (1) JPH0952900A (enExample)
FR (1) FR2730235A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
FR2781230B1 (fr) * 1998-07-02 2000-09-01 Commissariat Energie Atomique Derives de peptides utilisables comme inhibiteur selectif du site n-terminal de l'enzyme de conversion de l'angiotensine humaine
FR2788525B1 (fr) 1999-01-19 2002-11-29 Commissariat Energie Atomique Pseudo-peptides phosphiniques, utilisables comme inhibiteurs des metalloproteases a zinc matricielles
FR2834989B1 (fr) * 2002-01-18 2005-05-20 Commissariat Energie Atomique Derives de pseudo-peptides phosphiniques inhibant selectivement le site actif c-terminal de l'enzyme de conversion de l'angiotensine i(ace)
FR2840994B1 (fr) * 2003-01-22 2008-07-18 Commissariat Energie Atomique Methode de criblage de banques de biomolecules et ses applications
US20040001106A1 (en) * 2002-06-26 2004-01-01 John Deutscher System and process for creating an interactive presentation employing multi-media components

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276436A1 (en) * 1986-12-15 1988-08-03 F. Hoffmann-La Roche Ag Phosphinic acid derivatives
DE4036130A1 (de) * 1989-11-15 1991-05-16 Commissariat Energie Atomique Neue peptidderivate, die als bakterienkollagenase-inhibitoren verwendbar sind, und sie enthaltende pharmazeutische zusammensetzung
WO1993014112A1 (en) * 1992-01-15 1993-07-22 Merck & Co., Inc. Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents
EP0565450A1 (fr) * 1992-04-10 1993-10-13 Commissariat A L'energie Atomique Utilisation de dérivés de peptides pour la fabrication de médicaments inhibiteurs des endopeptidases 24.15 et 24.16

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676059B1 (fr) * 1991-05-02 1993-07-23 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276436A1 (en) * 1986-12-15 1988-08-03 F. Hoffmann-La Roche Ag Phosphinic acid derivatives
DE4036130A1 (de) * 1989-11-15 1991-05-16 Commissariat Energie Atomique Neue peptidderivate, die als bakterienkollagenase-inhibitoren verwendbar sind, und sie enthaltende pharmazeutische zusammensetzung
WO1993014112A1 (en) * 1992-01-15 1993-07-22 Merck & Co., Inc. Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents
EP0565450A1 (fr) * 1992-04-10 1993-10-13 Commissariat A L'energie Atomique Utilisation de dérivés de peptides pour la fabrication de médicaments inhibiteurs des endopeptidases 24.15 et 24.16

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARELLI, HELENE ET AL: "Potent inhibition of endopeptidase 24.16 and endopeptidase 24.15 by the phosphonamide peptide N-(phenylethylphosphonyl)-Gly-L-Pro-L- aminohexanoic acid", BIOCHEM. J. (1992), 287(2), 621-5 CODEN: BIJOAK;ISSN: 0306-3275 *
KNIGHT, C. GRAHAM ET AL: "Thimet oligopeptidase specificity: evidence of preferential cleavage near the C-terminus and product inhibition from kinetic analysis of peptide hydrolysis", BIOCHEM. J. (1995), 308(1), 145-50 CODEN: BIJOAK;ISSN: 0264-6021 *
S. DOULOT ET AL.: "Synthesis and analgesic effect of N-[3-[(Hydroxyamino)carbonyl]-1-oxo-2(R)-benzylporpyl]-L-isoleucyl-L-leucine, a New Potent Inhibitor of Multiple Neurotensin/Neuromedin N Degrading Enzymes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 10, 14 May 1993 (1993-05-14), WASHINGTON US, pages 1369 - 1379 *
VINCENT, BRUNO ET AL: "Phosphorus-containing peptides as mixed inhibitors of endopeptidase 3.4.24.15 and 3.4.25.16: effect on neurotensin degradation in vitro and in vivo", BR. J. PHARMACOL. (1995), 115(6), 1053-63 CODEN: BJPCBM;ISSN: 0007-1188 *

Also Published As

Publication number Publication date
FR2730235B1 (enExample) 1997-02-28
EP0725075A1 (fr) 1996-08-07
US5776903A (en) 1998-07-07
JPH0952900A (ja) 1997-02-25

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