JPH0952900A - 亜鉛エンドペプチダーゼ２４−１５阻害剤として使用可能な新規ペプチド誘導体 - Google Patents

亜鉛エンドペプチダーゼ２４−１５阻害剤として使用可能な新規ペプチド誘導体

Info

Publication number
JPH0952900A
JPH0952900A JP8018967A JP1896796A JPH0952900A JP H0952900 A JPH0952900 A JP H0952900A JP 8018967 A JP8018967 A JP 8018967A JP 1896796 A JP1896796 A JP 1896796A JP H0952900 A JPH0952900 A JP H0952900A
Authority
JP
Japan
Prior art keywords
zaa
xaa
phe
formula
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8018967A
Other languages
English (en)
Japanese (ja)
Inventor
Vincent Dive
ディブ ビンセン
Jiri Jiracek
ジラセック ジリ
Athanasios Yiotakis
イオタキス アサナシオス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Publication of JPH0952900A publication Critical patent/JPH0952900A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP8018967A 1995-02-06 1996-02-05 亜鉛エンドペプチダーゼ２４−１５阻害剤として使用可能な新規ペプチド誘導体 Pending JPH0952900A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9501328A FR2730235A1 (fr) 1995-02-06 1995-02-06 Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
FR9501328 1995-02-06

Publications (1)

Publication Number Publication Date
JPH0952900A true JPH0952900A (ja) 1997-02-25

Family

ID=9475861

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8018967A Pending JPH0952900A (ja) 1995-02-06 1996-02-05 亜鉛エンドペプチダーゼ２４−１５阻害剤として使用可能な新規ペプチド誘導体

Country Status (4)

Country Link
US (1) US5776903A (enExample)
EP (1) EP0725075A1 (enExample)
JP (1) JPH0952900A (enExample)
FR (1) FR2730235A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
FR2781230B1 (fr) * 1998-07-02 2000-09-01 Commissariat Energie Atomique Derives de peptides utilisables comme inhibiteur selectif du site n-terminal de l'enzyme de conversion de l'angiotensine humaine
FR2788525B1 (fr) 1999-01-19 2002-11-29 Commissariat Energie Atomique Pseudo-peptides phosphiniques, utilisables comme inhibiteurs des metalloproteases a zinc matricielles
FR2834989B1 (fr) * 2002-01-18 2005-05-20 Commissariat Energie Atomique Derives de pseudo-peptides phosphiniques inhibant selectivement le site actif c-terminal de l'enzyme de conversion de l'angiotensine i(ace)
FR2840994B1 (fr) * 2003-01-22 2008-07-18 Commissariat Energie Atomique Methode de criblage de banques de biomolecules et ses applications
US20040001106A1 (en) * 2002-06-26 2004-01-01 John Deutscher System and process for creating an interactive presentation employing multi-media components

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW23187A1 (en) * 1986-12-15 1988-06-29 Hoffmann La Roche Phosphinic acid derivatives
FR2654430B1 (fr) * 1989-11-15 1995-01-06 Commissariat Energie Atomique Nouveaux derives de peptides, utilisables comme inhibiteurs des collagenases bacteriennes.
FR2676059B1 (fr) * 1991-05-02 1993-07-23 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
JPH07503016A (ja) * 1992-01-15 1995-03-30 メルク　エンド　カンパニー　インコーポレーテッド 変形防止剤としての置換されたホスフィン酸含有ペプチジル誘導体
FR2689764B1 (fr) * 1992-04-10 1995-05-12 Commissariat Energie Atomique Utilisation de dérivés de peptides pour la fabrication de médicaments inhibiteurs des endopeptidases 24.15 et 24.16.

Also Published As

Publication number Publication date
FR2730235A1 (fr) 1996-08-09
US5776903A (en) 1998-07-07
FR2730235B1 (enExample) 1997-02-28
EP0725075A1 (fr) 1996-08-07

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