FR2715654B1 - Dérivé de N-[3-(1,2,3,4-tétrahydroisoquinoléin-2-yl)-propyl]-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide, leur préparation et leur application en thérapeutique. - Google Patents

Dérivé de N-[3-(1,2,3,4-tétrahydroisoquinoléin-2-yl)-propyl]-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide, leur préparation et leur application en thérapeutique.

Info

Publication number
FR2715654B1
FR2715654B1 FR9401199A FR9401199A FR2715654B1 FR 2715654 B1 FR2715654 B1 FR 2715654B1 FR 9401199 A FR9401199 A FR 9401199A FR 9401199 A FR9401199 A FR 9401199A FR 2715654 B1 FR2715654 B1 FR 2715654B1
Authority
FR
France
Prior art keywords
tetrahydroisoquinoline
tetrahydronaphthalene
propyl
therapeutic
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9401199A
Other languages
English (en)
Other versions
FR2715654A1 (fr
Inventor
Paul Howard Williams
Jean-Claude Muller
Jonathan Frost
Pascal George
Patrick Pasau
Regine Bartsch
Corinne Rousselle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR9401199A priority Critical patent/FR2715654B1/fr
Priority to TW084100833A priority patent/TW281667B/zh
Priority to CN95101654A priority patent/CN1069309C/zh
Priority to FI950458A priority patent/FI950458A/fi
Priority to DK95400216T priority patent/DK0666250T3/da
Priority to NO950379A priority patent/NO307825B1/no
Priority to PL95307039A priority patent/PL179247B1/pl
Priority to SI9530050T priority patent/SI0666250T1/xx
Priority to NZ270443A priority patent/NZ270443A/en
Priority to RU95101375A priority patent/RU2138479C1/ru
Priority to ES95400216T priority patent/ES2114277T3/es
Priority to AU11544/95A priority patent/AU680078B2/en
Priority to CZ1995269A priority patent/CZ286703B6/cs
Priority to AT95400216T priority patent/ATE163178T1/de
Priority to EP95400216A priority patent/EP0666250B1/fr
Priority to HU9500309A priority patent/HU214870B/hu
Priority to JP7015893A priority patent/JPH07304717A/ja
Priority to CA002141729A priority patent/CA2141729A1/fr
Priority to KR1019950001834A priority patent/KR100294727B1/ko
Priority to IL11253195A priority patent/IL112531A/en
Priority to ZA95835A priority patent/ZA95835B/xx
Priority to SK129-95A priority patent/SK280913B6/sk
Priority to DE69501596T priority patent/DE69501596T2/de
Priority to US08/382,578 priority patent/US5550162A/en
Publication of FR2715654A1 publication Critical patent/FR2715654A1/fr
Application granted granted Critical
Publication of FR2715654B1 publication Critical patent/FR2715654B1/fr
Priority to US08/653,233 priority patent/US5663183A/en
Priority to GR980400701T priority patent/GR3026517T3/el
Priority to HK98104748A priority patent/HK1005618A1/xx
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9401199A 1994-02-03 1994-02-03 Dérivé de N-[3-(1,2,3,4-tétrahydroisoquinoléin-2-yl)-propyl]-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide, leur préparation et leur application en thérapeutique. Expired - Fee Related FR2715654B1 (fr)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FR9401199A FR2715654B1 (fr) 1994-02-03 1994-02-03 Dérivé de N-[3-(1,2,3,4-tétrahydroisoquinoléin-2-yl)-propyl]-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide, leur préparation et leur application en thérapeutique.
TW084100833A TW281667B (fr) 1994-02-03 1995-01-28
CN95101654A CN1069309C (zh) 1994-02-03 1995-01-30 N-(-氨基丙基)n-苯基-5,6,7,8-四氢化萘-2-羧酰胺衍生物、制法及应用
KR1019950001834A KR100294727B1 (ko) 1994-02-03 1995-02-02 N-(3-아미노프로필)-n-페닐-5,6,7,8-테트라히드로나프탈렌-2-카르복사미드유도체,이것의제조방법및이것의치료에의이용
NO950379A NO307825B1 (no) 1994-02-03 1995-02-02 Karboksamidforbindelser, deres fremstilling, og farmasøytiske preparater inneholdende slike forbindelser
PL95307039A PL179247B1 (pl) 1994-02-03 1995-02-02 PochodneN-(3-aminopropylo)-N-fenylo-5,6,7,8-tetrahydronaftaleno-2-karboksyamidu, sposób ich wytwarzania i srodek farmaceutyczny zawierajacy te zwiazki PL PL PL PL
SI9530050T SI0666250T1 (en) 1994-02-03 1995-02-02 Derivatives of N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide having neuroprotective and anti-ischemic properties, their preparation and their use, in therapy
NZ270443A NZ270443A (en) 1994-02-03 1995-02-02 N-(3-aminopropyl)-n-phenyl-5,6,7,8-tetra-hydronaphthalene-2-c arboxamide derivatives; pharmaceutical compositions
RU95101375A RU2138479C1 (ru) 1994-02-03 1995-02-02 Производные n-(3-аминопропил)-n-фенил-5,6,7,8-тетрагидронафталин-2-карбоксамида, способ их получения и фармацевтическая композиция
ES95400216T ES2114277T3 (es) 1994-02-03 1995-02-02 Un compuesto eventualmente bajo la forma de isomero optico puro o mezcla de tales isomeros, su procedimiento de preparacion, medicamento y composicion farmaceutica a base del mismo.
AU11544/95A AU680078B2 (en) 1994-02-03 1995-02-02 N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2- carboxamide derivatives, their preparation and their therapeutic use
CZ1995269A CZ286703B6 (en) 1994-02-03 1995-02-02 Carboxamide derivative, process of its preparation, medicament formed by this derivative and pharmaceutical composition in which said derivative is comprised
AT95400216T ATE163178T1 (de) 1994-02-03 1995-02-02 Derivate des n-(3-aminopropyl)-n-phenyl-5,6,7,8- tetrahydronaphthalen-2-carboxamides mit neuroprotektiven und antischaemischen eigenschaften, ihre herstellung und ihre therapeutische verwendung
EP95400216A EP0666250B1 (fr) 1994-02-03 1995-02-02 Dérivés de N-(3-aminopropyl)-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide ayant des propriétés neuroprotectrices et anti-ischémiques, leur préparation et leur application en thérapeutique
FI950458A FI950458A (fi) 1994-02-03 1995-02-02 N-(3-aminopropyyli)-N-fenyyli-5,6,7,8-tetrahydronaftalen-2-karboksamidijohdannaiset, niiden valmistus ja terapeuttinen käyttö
JP7015893A JPH07304717A (ja) 1994-02-03 1995-02-02 Ｎ−（３−アミノプロピル）−ｎ−フェニル−５，６，７，８−テトラヒドロナフタレン−２−カルボキサミド誘導体、それらの製造およびそれらの治療への適用
CA002141729A CA2141729A1 (fr) 1994-02-03 1995-02-02 Derives de n-(3-aminopropyl)-n-phenyl-5,6,7,8-tetrahydro-naphtalene -2-carboxamide; methode de preparation et utilisation dans des application therapeutiques
DK95400216T DK0666250T3 (da) 1994-02-03 1995-02-02 Derivater af N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalen-2-carboxamid med nervebeskyttende og antiiskæmiske ege
IL11253195A IL112531A (en) 1994-02-03 1995-02-02 Derivatives of - N -) 3 - Aminopropyl (-N - Phenyl - 5, 6, 7, 8 Tetrahydronaphthalene - 2 - Carboxine Preparation and their medical use
ZA95835A ZA95835B (en) 1994-02-03 1995-02-02 N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydro-naphthalene-2-carboxamide derivatives their preparation and their therapeutic use
SK129-95A SK280913B6 (sk) 1994-02-03 1995-02-02 Deriváty n-(3-aminopropyl)-n-fenyl-5,6,7,8-tetrahydronaftalén- -2-karboxamidu, spôsob ich prípravy a farmaceutické prostriedky obsahujúce tieto deriváty
DE69501596T DE69501596T2 (de) 1994-02-03 1995-02-02 Derivate des N-(3-Aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalen-2-carboxamides mit neuroprotektiven und antischaemischen Eigenschaften, ihre Herstellung und ihre therapeutische Verwendung
HU9500309A HU214870B (hu) 1994-02-03 1995-02-02 N-(3-Amino-propil)-N-fenil-5,6,7,8-tetrahidronaftalin-2-karboxamid-származékok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények
US08/382,578 US5550162A (en) 1994-02-03 1995-02-20 N-(-3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydro-naphthalene-2-carboxamide derivatives, their preparation and their therapeutic use
US08/653,233 US5663183A (en) 1994-02-03 1996-05-24 N-(3-Aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide derivatives, their preparation and their therapeutic use
GR980400701T GR3026517T3 (en) 1994-02-03 1998-04-03 Derivatives of N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide having neuroprotective and anti-ischemic properties, their preparation and their use, in therapy.
HK98104748A HK1005618A1 (en) 1994-02-03 1998-06-02 Derivatives of n-(3-aminopropyl)-n-phenyl-5,6,7,8-tetrahydronaphthalene-2- carboxamide having neuroprotective and anti-ischemic properties their preparation and their use in therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9401199A FR2715654B1 (fr) 1994-02-03 1994-02-03 Dérivé de N-[3-(1,2,3,4-tétrahydroisoquinoléin-2-yl)-propyl]-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide, leur préparation et leur application en thérapeutique.

Publications (2)

Publication Number Publication Date
FR2715654A1 FR2715654A1 (fr) 1995-08-04
FR2715654B1 true FR2715654B1 (fr) 1996-03-22

Family

ID=9459718

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9401199A Expired - Fee Related FR2715654B1 (fr) 1994-02-03 1994-02-03 Dérivé de N-[3-(1,2,3,4-tétrahydroisoquinoléin-2-yl)-propyl]-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide, leur préparation et leur application en thérapeutique.

Country Status (1)

Country Link
FR (1) FR2715654B1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3483206A (en) * 1967-12-15 1969-12-09 Ciba Geigy Corp N-isoquinolylalkanoyl-n-arylamines
FR2618149B1 (fr) * 1987-07-16 1989-09-22 Synthelabo Derives de n-aminoalkyl n-phenyl arylamides, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
FR2715654A1 (fr) 1995-08-04

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