FR2684999B1 - - Google Patents

Info

Publication number
FR2684999B1
FR2684999B1 FR9115601A FR9115601A FR2684999B1 FR 2684999 B1 FR2684999 B1 FR 2684999B1 FR 9115601 A FR9115601 A FR 9115601A FR 9115601 A FR9115601 A FR 9115601A FR 2684999 B1 FR2684999 B1 FR 2684999B1
Authority
FR
France
Prior art keywords
factor vii
free
cryoprecipitate
high purity
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9115601A
Other languages
English (en)
French (fr)
Other versions
FR2684999A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AQUITAINE DEV TRANSF SANGUINE
Original Assignee
AQUITAINE DEV TRANSF SANGUINE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9115601A priority Critical patent/FR2684999A1/fr
Application filed by AQUITAINE DEV TRANSF SANGUINE filed Critical AQUITAINE DEV TRANSF SANGUINE
Priority to DE92403234T priority patent/DE547932T1/de
Priority to ES92403234T priority patent/ES2056782T3/es
Priority to AT92403234T priority patent/ATE142255T1/de
Priority to DK92403234.5T priority patent/DK0547932T3/da
Priority to DE69213421T priority patent/DE69213421T2/de
Priority to EP92403234A priority patent/EP0547932B1/fr
Priority to US07/988,776 priority patent/US5344918A/en
Priority to JP4354440A priority patent/JP2533050B2/ja
Publication of FR2684999A1 publication Critical patent/FR2684999A1/fr
Priority to GR930300094T priority patent/GR930300094T1/el
Application granted granted Critical
Publication of FR2684999B1 publication Critical patent/FR2684999B1/fr
Priority to GR960403286T priority patent/GR3021875T3/el
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FR9115601A 1991-12-16 1991-12-16 Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag. Granted FR2684999A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR9115601A FR2684999A1 (fr) 1991-12-16 1991-12-16 Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag.
ES92403234T ES2056782T3 (es) 1991-12-16 1992-12-01 Procedimiento de fabricacion de un concentrado de factor vii activado de alta pureza.
AT92403234T ATE142255T1 (de) 1991-12-16 1992-12-01 Verfahren zur herstellung eines aktivierten faktor vii-konzentrates mit einer hohen reinheit
DK92403234.5T DK0547932T3 (da) 1991-12-16 1992-12-01 Fremgangsmåde til fremstilling af et koncentrat af aktiveret faktor VII med høj renhed
DE69213421T DE69213421T2 (de) 1991-12-16 1992-12-01 Verfahren zur Herstellung eines aktivierten Faktor VII-Konzentrates mit einer hohen Reinheit
EP92403234A EP0547932B1 (fr) 1991-12-16 1992-12-01 Procédé de fabrication d'un concentré de facteur VII activé de haute pureté
DE92403234T DE547932T1 (de) 1991-12-16 1992-12-01 Verfahren zur Herstellung eines aktivierten Faktor VII-Konzentrates mit einer hohen Reinheit.
US07/988,776 US5344918A (en) 1991-12-16 1992-12-10 Process for the manufacture of a high-purity activated factor VII concentrate essentially free of vitamin K-dependent factors and factors VIIIC and VIIICAg
JP4354440A JP2533050B2 (ja) 1991-12-16 1992-12-16 高純度活性因子ＶＩＩａの濃縮物の製造方法
GR930300094T GR930300094T1 (en) 1991-12-16 1993-09-30 Process for preparing an activated factor VII concentrate having a high purity
GR960403286T GR3021875T3 (en) 1991-12-16 1996-12-04 Process for preparing an activated factor VII concentrate having a high purity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9115601A FR2684999A1 (fr) 1991-12-16 1991-12-16 Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag.

Publications (2)

Publication Number Publication Date
FR2684999A1 FR2684999A1 (fr) 1993-06-18
FR2684999B1 true FR2684999B1 (OSRAM) 1995-05-05

Family

ID=9420096

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9115601A Granted FR2684999A1 (fr) 1991-12-16 1991-12-16 Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag.

Country Status (9)

Country Link
US (1) US5344918A (OSRAM)
EP (1) EP0547932B1 (OSRAM)
JP (1) JP2533050B2 (OSRAM)
AT (1) ATE142255T1 (OSRAM)
DE (2) DE547932T1 (OSRAM)
DK (1) DK0547932T3 (OSRAM)
ES (1) ES2056782T3 (OSRAM)
FR (1) FR2684999A1 (OSRAM)
GR (2) GR930300094T1 (OSRAM)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5664362A (en) * 1993-09-03 1997-09-09 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Fishing lure which releases the involuntary biting reflex of largemouth bass and other fishes within the family centrachidae
DE19538716A1 (de) * 1995-10-18 1997-04-24 Behringwerke Ag Verfahren zur Quantifizierung von aktiviertem Gerinnungsfaktor VII (FVIIa)
DE19531637A1 (de) * 1995-08-28 1997-03-06 Immuno Ag Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung
DE19538715A1 (de) 1995-10-18 1997-04-30 Behringwerke Ag Verfahren zur Reinigung von Faktor VII und aktiviertem Faktor VII
AU781717B2 (en) * 1998-04-24 2005-06-09 Csl Behring Gmbh Process for the preparation in pure form of the protease activating blood clotting factor VII, its proenzyme or mixture of both proteins by means of ion-exchange chromatography
AT408613B (de) * 1998-06-17 2002-01-25 Immuno Ag Pharmazeutisches faktor vii-präparat
US6258577B1 (en) 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
US6277337B1 (en) 1998-07-21 2001-08-21 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US7049110B2 (en) 1998-07-21 2006-05-23 Gambro, Inc. Inactivation of West Nile virus and malaria using photosensitizers
US7498156B2 (en) 1998-07-21 2009-03-03 Caridianbct Biotechnologies, Llc Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
US6451987B1 (en) 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
US6444788B1 (en) * 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
US7094378B1 (en) 2000-06-15 2006-08-22 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US7220747B2 (en) 1999-07-20 2007-05-22 Gambro, Inc. Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
DE19937218A1 (de) * 1999-08-06 2001-02-08 Aventis Behring Gmbh Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
US7648699B2 (en) 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
US7985588B2 (en) 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
TW590780B (en) 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
ES2325653T3 (es) 2001-12-21 2009-09-11 Novo Nordisk Health Care Ag Composicion liquida de polipeptidos del factor vii.
DK2283856T3 (da) 2002-06-21 2017-11-20 Novo Nordisk Healthcare Ag Stabiliserede, faste sammensætninger af Faktor VIIa-polypeptider
RU2364626C2 (ru) 2003-03-18 2009-08-20 Ново Нордиск Хелт Кэр Аг Способ получения, способ очистки и способ стабилизации полипептидов фактора vii, ix и x
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
CA2525224A1 (en) 2003-05-23 2004-12-02 Michael Bech Jensen Protein stabilization in solution
ATE547114T1 (de) 2003-06-25 2012-03-15 Novo Nordisk Healthcare Ag Flüssige zusammensetzungen von factor vii polypeptiden
EP1656158B1 (en) 2003-08-14 2016-03-09 Novo Nordisk Health Care AG Liquid, aqueous pharmaceutical composition of factor vii polypeptides
MXPA06001814A (es) * 2003-08-21 2006-05-04 Novo Nordisk As Separacion de polipeptidos que comprenden un aminoacido racemizado.
CN1917861B (zh) 2003-12-19 2012-03-21 诺和诺德医疗保健公司 因子vii多肽的稳定化固体组合物
CN102718859A (zh) * 2004-09-29 2012-10-10 诺和诺德医疗保健公司 通过分级洗脱从阴离子交换材料中纯化批量凝血因子vii多肽
ES2257225B1 (es) * 2006-02-17 2007-03-16 Grifols, S.A Preparacion terapeutica de fviia de muy alta pureza y metodo para su obtencion.
FR2901707B1 (fr) * 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
FR2904558B1 (fr) * 2006-08-01 2008-10-17 Lab Francais Du Fractionnement "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"
FR2917414B1 (fr) * 2007-06-15 2012-07-13 Lab Francais Du Fractionnement Facteur vii/viia humain modifie et composition pharmaceutique contenant celui-ci
FR2942231B1 (fr) 2009-02-19 2015-03-20 Lfb Biotechnologies Acides nucleiques se liant specifiquement au facteur vii/viia humain, et utilisations
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
EP2687595B1 (en) 2012-07-19 2018-05-30 Laboratoire Français du Fractionnement et des Biotechnologies Method for purifying transgenic factor VII

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5314604B2 (OSRAM) * 1972-12-20 1978-05-18
JPS57206620A (en) * 1981-06-12 1982-12-18 Cutter Lab Blood coagulation promoter and manufacture
US4540473A (en) * 1983-11-22 1985-09-10 International Business Machines Corporation Copper plating bath having increased plating rate, and method
US4470969A (en) * 1983-12-02 1984-09-11 Miles Laboratories, Inc. Process for producing a concentrate of coagulation factors VII and VIIa
US4473553A (en) * 1983-12-02 1984-09-25 Miles Laboratories, Inc. Process for producing a lipoprotein-poor concentrate of coagulation factors VII and VIIa
FR2632524B1 (fr) * 1988-06-09 1992-03-13 Fondation Nale Transfusion San Procede de preparation d'une fraction concentree en facteur viia et son application a titre de medicament

Also Published As

Publication number Publication date
DE547932T1 (de) 1994-02-03
ES2056782T1 (es) 1994-10-16
ATE142255T1 (de) 1996-09-15
EP0547932B1 (fr) 1996-09-04
DE69213421D1 (de) 1996-10-10
GR3021875T3 (en) 1997-03-31
US5344918A (en) 1994-09-06
DK0547932T3 (da) 1997-02-10
DE69213421T2 (de) 1997-04-03
EP0547932A1 (fr) 1993-06-23
GR930300094T1 (en) 1993-09-30
JP2533050B2 (ja) 1996-09-11
JPH05345799A (ja) 1993-12-27
FR2684999A1 (fr) 1993-06-18
ES2056782T3 (es) 1997-02-16

Similar Documents

Publication Publication Date Title
FR2684999B1 (OSRAM)
BG102733A (en) New substituted cyclic amino acids as pharmaceutical forms
CA1267496C (en) PURIFICATION AND ACTIVATION OF INSOLUBLE INCLUSION BODY PROTEINS
EP0723555A4 (en) CHEMICAL PROTEINS WITH BLOCK SUPPLEMENT ACTIVATION
EP0355572A3 (en) Peptide derivatives, their production and use
DE3687007D1 (en) 6-thioxanthinderivate.
EP0233013A3 (en) Modified enzyme
ATE195124T1 (de) Kondensierte pyrrolo(2,3-c) carbazole-6-one die die aktivität von gamma interferon potenzieren
ES8302017A1 (es) Procedimiento para la preparacion de un alto concentrado de factor viii (ahf).
AU3687593A (en) A method of producing a factor VIII preparation
AU5732190A (en) Glycoprotein hormone receptor molecules
AU5023585A (en) Reclining chair with coupled footrest
EP0373540A3 (en) Method for purifying fibroblast growth factor protein
EP0282363A3 (en) Method for preparation of a concentrate of alpha-1-antitrypsin from a human plasma fraction, and its use as a pharmaceutical
PL314801A1 (en) Method of purifying vitamin-k-dependent proteins by using a membrane chromatography process
MY119366A (en) A process for the preparation of factor ix from biological sources
DK0378432T3 (da) Peptider, deres anvendelse til inhibering af modningen af T-lymfocytter og aktiviteten af makrofager samt fremgangsmåder til deres fremstilling
HUT53125A (en) Process for producing peptides with anticoagulant activity
ES8507000A1 (es) Metodo para la preparacion y purificacion de concentrados de factor viii antihemofilia de la sangre
MY103874A (en) Process for the preparation of 5-chloro-3-chlorosulpho- nyl-2-thiophenecarboxylic acid esters.
EP0151482A3 (en) Heat defribinogenation of ahf preparation
AU590712B2 (en) Immune interferon and method for its purification
IL132504A0 (en) Methods for reducing fibrinogen
GB8706801D0 (en) Rocking wheel chair
IT1196069B (it) Procedimento per la preparazione dell'ubidecarenone