US3957845A
(en)
*
|
1962-04-27 |
1976-05-18 |
Knoll A.G. Chemische Fabriken |
Trifluoromethyl-substituted phenyl acetonitriles
|
DE1518545A1
(de)
*
|
1965-04-01 |
1970-01-15 |
Boehringer Mannheim Gmbh |
Verfahren zur Herstellung neuer Phenylcyclohexylalkylamine und ihrer Salze
|
US3485873A
(en)
*
|
1966-12-21 |
1969-12-23 |
Sterling Drug Inc |
N-benzyl-n-methyl-omega-phenyl-omega-cycloalkyl-lower-alkylamines
|
DE1793383C3
(de)
*
|
1968-09-10 |
1979-03-01 |
Knoll Ag, 6700 Ludwigshafen |
4-Cyan-4-phenyl-aminocyclohexane und deren wasserlösliche Salze, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
|
US3998965A
(en)
*
|
1973-12-15 |
1976-12-21 |
Aspro-Nicholas Limited |
4-Aminoalkyl-4-cyano-4-phenyl-butanoic acid esters
|
DE2631222C3
(de)
*
|
1976-07-12 |
1979-01-04 |
Knoll Ag, 6700 Ludwigshafen |
Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
|
DE2658500C2
(de)
*
|
1976-12-23 |
1986-10-09 |
Knoll Ag, 6700 Ludwigshafen |
Pharmazeutische Präparate mit kardioprotektiver Wirkung
|
DE2816190A1
(de)
|
1978-04-14 |
1979-10-25 |
Bayer Ag |
Neue benzodioxolderivate
|
DE2946545A1
(de)
*
|
1979-11-17 |
1981-05-27 |
Basf Ag, 6700 Ludwigshafen |
Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen
|
DE3034221A1
(de)
|
1980-09-11 |
1982-04-22 |
Basf Ag, 6700 Ludwigshafen |
Verfahren zur herstellung basisch substituierter phenylacetonitrile
|
DE3113901A1
(de)
*
|
1981-04-07 |
1982-10-28 |
Basf Ag, 6700 Ludwigshafen |
Wirkstoffzubereitung zur oralen applikation
|
DE3144150A1
(de)
|
1981-04-10 |
1982-12-09 |
Basf Ag, 6700 Ludwigshafen |
(omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel
|
DE3121766A1
(de)
*
|
1981-06-02 |
1982-12-16 |
Basf Ag, 6700 Ludwigshafen |
Verfahren zur herstellung basisch substituierter phenylacetonitrile
|
DE3344755A1
(de)
*
|
1983-12-10 |
1985-06-20 |
Basf Ag, 6700 Ludwigshafen |
1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten
|
EP0165322B1
(fr)
*
|
1984-06-15 |
1988-01-20 |
LUDWIG HEUMANN & CO GMBH |
Méthode de préparation de phénylacétonitrile substitué par un radical basique
|
DE3440881A1
(de)
*
|
1984-11-06 |
1986-05-15 |
Schering AG, Berlin und Bergkamen, 1000 Berlin |
Pharmazeutische zusammensetzung, ihre herstellung und verwendung
|
DE3635930A1
(de)
*
|
1986-10-22 |
1988-04-28 |
Basf Ag |
Wirkstoffe zur anwendung bei der behandlung von tumoren
|
DE3535949A1
(de)
*
|
1985-10-09 |
1987-04-09 |
Basf Ag |
Kombinationspraeparat
|
FI86633C
(fi)
*
|
1985-10-18 |
1992-09-25 |
Searle & Co |
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara bicyklosubstituerade fenylacetonitrilderivat.
|
US4593042A
(en)
*
|
1985-10-18 |
1986-06-03 |
G. D. Searle & Co. |
Bicyclo-substituted phenylacetonitrile derivatives
|
US4667038A
(en)
*
|
1985-12-02 |
1987-05-19 |
Syntex (U.S.A.) Inc. |
Tetrahydroisoquinoline derivatives
|
DE3542994A1
(de)
*
|
1985-12-05 |
1987-06-11 |
Basf Ag |
Basisch substituierte phenylacetaldehyde, ihre herstellung und diese enthaltende arzneimittel
|
DE3603032A1
(de)
*
|
1986-01-31 |
1987-08-06 |
Basf Ag |
Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
|
DE3634389A1
(de)
*
|
1986-10-09 |
1988-04-21 |
Knoll Ag |
Verwendung von anipamil
|
IT1215409B
(it)
*
|
1987-04-08 |
1990-02-08 |
Alfa Chem Ital |
Processo per la sintesi dell'alfa-(1-metiletil)-3,4-dimetossibenzeneacetonitrile.
|
DE3741415C1
(en)
*
|
1987-12-07 |
1989-07-06 |
Luitpold Werk Chem Pharm |
Use of 5-[N-(3,4-dimethoxyphenylethyl)-N-methylamino]-2-(3,4-dimethoxyphenyl) -2-isopropylvaleronitril ("verapamil") or its pharmaceutically suitable salts for the percutaneous treatment of chronic venous insufficiency
|
US4833162A
(en)
*
|
1988-02-03 |
1989-05-23 |
American Cyanamid Company |
Substituted benzeneacetonitriles and their use as calcium channel blockers
|
US5350771A
(en)
*
|
1989-03-22 |
1994-09-27 |
Peter K. T. Pang |
Method and treatment for hypertension using combination therapy involving exogenous calcium and calcium channel blockers
|
EP0722735A1
(fr)
*
|
1989-03-22 |
1996-07-24 |
PANG, Peter K. T. |
Facteur hypertensif de la parathyroide
|
US5886012A
(en)
*
|
1989-03-22 |
1999-03-23 |
Peter K. T. Pang |
Method of treatment for disease associated with excessive PHF using combination therapy involving exogenous calcium and calcium channel blockers
|
DE3921006A1
(de)
*
|
1989-06-27 |
1991-01-03 |
Knoll Ag |
Verwendung von nor-verapamil und nor-gallopamil als antiarteriosklerotica
|
US5486539A
(en)
*
|
1989-12-21 |
1996-01-23 |
G. D. Searle & Co. |
Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
|
US5162569A
(en)
*
|
1989-12-21 |
1992-11-10 |
G. D. Searle & Co. |
Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
|
US5247119A
(en)
*
|
1990-12-12 |
1993-09-21 |
G. D. Searle & Co. |
Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
|
DE4203547A1
(de)
*
|
1992-02-07 |
1993-08-12 |
Knoll Ag |
Verfahren zur racemattrennung von verapamil
|
US5451604A
(en)
*
|
1993-07-26 |
1995-09-19 |
G. D. Searle & Co. |
Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives
|
US6083532A
(en)
*
|
1995-03-01 |
2000-07-04 |
Duramed Pharmaceuticals, Inc. |
Sustained release formulation containing three different types of polymers and tablet formed therefrom
|
US5695781A
(en)
*
|
1995-03-01 |
1997-12-09 |
Hallmark Pharmaceuticals, Inc. |
Sustained release formulation containing three different types of polymers
|
AP2005003232A0
(en)
|
2002-08-19 |
2005-03-31 |
Pfizer Prod Inc |
Combination therapy for hyperproliferative diseases.
|
WO2004093813A2
(fr)
*
|
2003-04-22 |
2004-11-04 |
Pharmacia Corporation |
Compositions renfermant un inhibiteur selectif a l'egard de la cyclooxygenase 2 et un agent de modulation du calcium pour le traitement de la douleur, de l'inflammation ou de troubles dus a l'inflammation
|
US20050159403A1
(en)
*
|
2003-04-22 |
2005-07-21 |
Pharmacia Corporation |
Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage
|
US20050037063A1
(en)
*
|
2003-07-21 |
2005-02-17 |
Bolton Anthony E. |
Combined therapies
|
CN101090714A
(zh)
*
|
2004-07-26 |
2007-12-19 |
康泽里克斯公司 |
通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症
|
US20060063803A1
(en)
*
|
2004-09-23 |
2006-03-23 |
Pfizer Inc |
4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
|
CA2590533C
(fr)
*
|
2004-11-23 |
2010-09-07 |
Warner-Lambert Company Llc |
Derives d'acide 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoique comme inhibiteurs de hmg co-a reductase pour le traitement de l'hyperlipidemie
|
JP2008528626A
(ja)
*
|
2005-01-31 |
2008-07-31 |
マイラン ラボラトリーズ インク. |
ヒドロキシル化されたネビボロールを含む薬学的組成物
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
US7893050B2
(en)
*
|
2005-10-26 |
2011-02-22 |
Asahi Kasei Pharma Corporation |
Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
|
EP2351569B1
(fr)
|
2005-10-26 |
2012-08-22 |
Asahi Kasei Pharma Corporation |
Fasudil dans des thérapies combinées pour le traitement de l'hypertension artérielle pulmonaire
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
US7919506B2
(en)
|
2006-03-10 |
2011-04-05 |
Pfizer Inc. |
Dibenzyl amine compounds and derivatives
|
US8404896B2
(en)
|
2006-12-01 |
2013-03-26 |
Bristol-Myers Squibb Company |
N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
|
PL2170050T3
(pl)
|
2007-06-20 |
2014-12-31 |
Milestone Pharmaceuticals Inc |
Krótkodziałające fenyloalkiloaminowe blokery kanału wapniowego i ich zastosowania
|
WO2009032286A2
(fr)
|
2007-09-06 |
2009-03-12 |
Nektar Therapeutics Al, Corporation |
Conjugués oligomère - bloqueur de canaux calciques
|
US20090171110A1
(en)
*
|
2007-12-26 |
2009-07-02 |
Albani Davide |
Process for preparing n-methyl-3, 4-dimethoxyphenylethylamine
|
US8883844B2
(en)
|
2010-09-24 |
2014-11-11 |
Nitrogenix Inc. |
Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
|
BR112015026513A2
(pt)
|
2013-04-17 |
2017-07-25 |
Pfizer |
derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
|
WO2016055901A1
(fr)
|
2014-10-08 |
2016-04-14 |
Pfizer Inc. |
Composés d'amide substitué
|
WO2016181292A1
(fr)
*
|
2015-05-12 |
2016-11-17 |
Piramal Enterprises Limited |
Procédé de préparation de chlorhydrate de vérapamil
|
MX2021008533A
(es)
|
2019-01-18 |
2021-08-19 |
Astrazeneca Ab |
Inhibidores de la pcsk9 y metodos de uso de los mismos.
|