CH418346A - Verfahren zur Herstellung basisch substituierter Phenylacetonitrile - Google Patents

Verfahren zur Herstellung basisch substituierter Phenylacetonitrile

Info

Publication number
CH418346A
CH418346A CH394562A CH394562A CH418346A CH 418346 A CH418346 A CH 418346A CH 394562 A CH394562 A CH 394562A CH 394562 A CH394562 A CH 394562A CH 418346 A CH418346 A CH 418346A
Authority
CH
Switzerland
Prior art keywords
preparation
basic substituted
substituted phenylacetonitriles
phenylacetonitriles
basic
Prior art date
Application number
CH394562A
Other languages
English (en)
Inventor
Ferdinand Dr Dengel
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of CH418346A publication Critical patent/CH418346A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH394562A 1961-04-01 1962-03-30 Verfahren zur Herstellung basisch substituierter Phenylacetonitrile CH418346A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEK0043374 1961-04-01
DEK43596A DE1154810B (de) 1961-04-01 1961-04-28 Verfahren zur Herstellung basisch substituierter Phenylacetonitrile

Publications (1)

Publication Number Publication Date
CH418346A true CH418346A (de) 1966-08-15

Family

ID=25983389

Family Applications (1)

Application Number Title Priority Date Filing Date
CH394562A CH418346A (de) 1961-04-01 1962-03-30 Verfahren zur Herstellung basisch substituierter Phenylacetonitrile

Country Status (6)

Country Link
US (1) US3261859A (de)
BE (1) BE615861A (de)
CH (1) CH418346A (de)
DE (1) DE1154810B (de)
FR (1) FR2663M (de)
GB (1) GB999612A (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957845A (en) * 1962-04-27 1976-05-18 Knoll A.G. Chemische Fabriken Trifluoromethyl-substituted phenyl acetonitriles
DE1518545A1 (de) * 1965-04-01 1970-01-15 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer Phenylcyclohexylalkylamine und ihrer Salze
US3485873A (en) * 1966-12-21 1969-12-23 Sterling Drug Inc N-benzyl-n-methyl-omega-phenyl-omega-cycloalkyl-lower-alkylamines
DE1793383C3 (de) * 1968-09-10 1979-03-01 Knoll Ag, 6700 Ludwigshafen 4-Cyan-4-phenyl-aminocyclohexane und deren wasserlösliche Salze, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US3998965A (en) * 1973-12-15 1976-12-21 Aspro-Nicholas Limited 4-Aminoalkyl-4-cyano-4-phenyl-butanoic acid esters
DE2631222C3 (de) * 1976-07-12 1979-01-04 Knoll Ag, 6700 Ludwigshafen Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE2658500C2 (de) * 1976-12-23 1986-10-09 Knoll Ag, 6700 Ludwigshafen Pharmazeutische Präparate mit kardioprotektiver Wirkung
DE2816190A1 (de) 1978-04-14 1979-10-25 Bayer Ag Neue benzodioxolderivate
DE2946545A1 (de) 1979-11-17 1981-05-27 Basf Ag, 6700 Ludwigshafen Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen
DE3034221A1 (de) 1980-09-11 1982-04-22 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung basisch substituierter phenylacetonitrile
DE3113901A1 (de) * 1981-04-07 1982-10-28 Basf Ag, 6700 Ludwigshafen Wirkstoffzubereitung zur oralen applikation
DE3144150A1 (de) 1981-04-10 1982-12-09 Basf Ag, 6700 Ludwigshafen (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel
DE3121766A1 (de) * 1981-06-02 1982-12-16 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung basisch substituierter phenylacetonitrile
DE3344755A1 (de) * 1983-12-10 1985-06-20 Basf Ag, 6700 Ludwigshafen 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten
DE3468863D1 (en) * 1984-06-15 1988-02-25 Heumann Ludwig & Co Gmbh Method for the preparation of phenylacetonitrile substituted by a basic radical
DE3433383A1 (de) * 1984-09-12 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phenyl-acetonitril-derivate
US4612329A (en) * 1984-10-17 1986-09-16 Hokuriku Pharmaceutical Co., Ltd. Pharmaceutical alpha-aminoalkyl-alpha-alkylphenylacetonitriles
DE3440881A1 (de) * 1984-11-06 1986-05-15 Schering AG, Berlin und Bergkamen, 1000 Berlin Pharmazeutische zusammensetzung, ihre herstellung und verwendung
DE3635930A1 (de) * 1986-10-22 1988-04-28 Basf Ag Wirkstoffe zur anwendung bei der behandlung von tumoren
FR2588258B1 (fr) * 1985-10-04 1989-12-15 Adir Nouveaux derives d'amino-5 valeronitrile, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
DE3535949A1 (de) * 1985-10-09 1987-04-09 Basf Ag Kombinationspraeparat
PH23152A (en) * 1985-10-18 1989-05-19 Searle & Co Bicyclo-substituted phenylacetonitrile derivatives
US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives
US4667038A (en) * 1985-12-02 1987-05-19 Syntex (U.S.A.) Inc. Tetrahydroisoquinoline derivatives
DE3542994A1 (de) * 1985-12-05 1987-06-11 Basf Ag Basisch substituierte phenylacetaldehyde, ihre herstellung und diese enthaltende arzneimittel
DE3603032A1 (de) * 1986-01-31 1987-08-06 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
CS258534B1 (en) * 1986-07-18 1988-08-16 Ludvik Blaha Derivatives of valeronitrile and method of their preparation
DE3634389A1 (de) * 1986-10-09 1988-04-21 Knoll Ag Verwendung von anipamil
IT1215409B (it) * 1987-04-08 1990-02-08 Alfa Chem Ital Processo per la sintesi dell'alfa-(1-metiletil)-3,4-dimetossibenzeneacetonitrile.
DE3741415C1 (en) * 1987-12-07 1989-07-06 Luitpold Werk Chem Pharm Use of 5-[N-(3,4-dimethoxyphenylethyl)-N-methylamino]-2-(3,4-dimethoxyphenyl) -2-isopropylvaleronitril ("verapamil") or its pharmaceutically suitable salts for the percutaneous treatment of chronic venous insufficiency
US4833162A (en) * 1988-02-03 1989-05-23 American Cyanamid Company Substituted benzeneacetonitriles and their use as calcium channel blockers
US5350771A (en) * 1989-03-22 1994-09-27 Peter K. T. Pang Method and treatment for hypertension using combination therapy involving exogenous calcium and calcium channel blockers
US5886012A (en) * 1989-03-22 1999-03-23 Peter K. T. Pang Method of treatment for disease associated with excessive PHF using combination therapy involving exogenous calcium and calcium channel blockers
EP0722735A1 (de) * 1989-03-22 1996-07-24 PANG, Peter K. T. Hypertensiver Faktor des Parathyroids
DE3921006A1 (de) * 1989-06-27 1991-01-03 Knoll Ag Verwendung von nor-verapamil und nor-gallopamil als antiarteriosklerotica
US5486539A (en) * 1989-12-21 1996-01-23 G. D. Searle & Co. Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5162569A (en) * 1989-12-21 1992-11-10 G. D. Searle & Co. Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5247119A (en) * 1990-12-12 1993-09-21 G. D. Searle & Co. Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
DE4203547A1 (de) * 1992-02-07 1993-08-12 Knoll Ag Verfahren zur racemattrennung von verapamil
US5451604A (en) * 1993-07-26 1995-09-19 G. D. Searle & Co. Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives
US6083532A (en) * 1995-03-01 2000-07-04 Duramed Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers and tablet formed therefrom
US5695781A (en) * 1995-03-01 1997-12-09 Hallmark Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
WO2004093813A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
WO2004093816A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
CA2574958A1 (en) * 2004-07-26 2006-02-09 Cotherix, Inc. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
MX2007005137A (es) * 2004-11-23 2007-06-22 Warner Lambert Co Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
WO2006083779A2 (en) * 2005-01-31 2006-08-10 Mylan Laboratories, Inc. Pharmaceutical composition comprising hydroxylated nebivolol
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (de) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Kombinationstherapie mit Fasudil zur Behandlung von pulmonaler Hypertonie
JP2009513660A (ja) * 2005-10-26 2009-04-02 旭化成ファーマ株式会社 肺動脈性高血圧の治療用併用療法におけるファスジル
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
PT2170050E (pt) * 2007-06-20 2014-09-04 Milestone Pharmaceuticals Inc Bloqueadores de canais de cálcio de fenilalquilamina de atuação curta e suas utilizações
WO2009032286A2 (en) 2007-09-06 2009-03-12 Nektar Therapeutics Al, Corporation Oligomer-calcium channel blocker conjugates
WO2009086464A1 (en) 2007-12-26 2009-07-09 Sicor Inc. Process for preparing n-methyl-3, 4 dimethoxyphenylethylamine
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
US10144703B2 (en) 2015-05-12 2018-12-04 Piramal Enterprises Limited Process for the preparation of Verapamil hydrochloride
RS66416B1 (sr) 2019-01-18 2025-02-28 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2268108A (en) * 1938-03-11 1941-12-30 Ici Ltd Insecticidal composition
US2446804A (en) * 1943-03-09 1948-08-10 Hoffmann La Roche 3-aryl-3-carbalkoxy piperidines and pyrrolidines and synthesis thereof
US2486794A (en) * 1943-06-25 1949-11-01 Ciba Pharm Prod Inc 1-alkyl-4-(meta-hydroxyphenyl)-piperidyl-(4)-alkylketones and their production
US2527527A (en) * 1948-10-14 1950-10-31 Sterling Drug Inc Methylenedioxy tertiary amines
US3116311A (en) * 1959-09-24 1963-12-31 Delmar Chem Aminonitriles and process for their preparation

Also Published As

Publication number Publication date
GB999612A (en) 1965-07-28
BE615861A (fr) 1962-10-01
US3261859A (en) 1966-07-19
FR2663M (fr) 1964-07-20
DE1154810B (de) 1963-09-26

Similar Documents

Publication Publication Date Title
CH418346A (de) Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
CH420067A (de) Verfahren zur Herstellung von ortho-Alkylphenolen
CH425813A (de) Verfahren zur Herstellung von Trialkalinitrilotriacetat
AT255031B (de) Verfahren zur Herstellung von 1-Glykosyl-6-azauracilen
CH419146A (de) Verfahren zur Herstellung von 3-Phenyl-7-pyrazolyl-cumarinen
CH429741A (de) Verfahren zur Herstellung von basisch substituierten Triazolidinen
CH420186A (de) Verfahren zur Herstellung von 2-Amino-benzophenonen
CH420185A (de) Verfahren zur Herstellung von 5-Mononucleotiden
AT241687B (de) Verfahren zur Herstellung von α-Aminobenzylpenicillin
AT239438B (de) Verfahren zur Herstellung von α-Aminobenzylpenicillin
CH420135A (de) Verfahren zur Herstellung von 16-Alkylpregnenen
CH421120A (de) Verfahren zur Herstellung von Sulfapyrimidinen
CH413836A (de) Verfahren zur Herstellung von Distilbazolen
CH430685A (de) Verfahren zur Herstellung von substituierten Acylanthranilsäureaniliden
AT252893B (de) Verfahren zur Herstellung von Carbonylverbindungen
CH438304A (de) Verfahren zur Herstellung von Benzolsulfonylsemicarbaziden
CH401026A (de) Verfahren zur Herstellung von B-Ketoamiden
CH401949A (de) Verfahren zur Herstellung von 1-Alkyl-1-alkoxy-3-arylharnstoff
CH410932A (de) Verfahren zur Herstellung von 7a-Alkylthio-steroiden
CH410929A (de) Verfahren zur Herstellung von Jononverbindungen
CH481064A (de) Verfahren zur Herstellung von substituierten Acylanthranilsäureaniliden
CH423787A (de) Verfahren zur Herstellung basisch substituierter Anthradipyrazole
CH425781A (de) Verfahren zur Herstellung von ungesättigten 16-Methylen-3-keto-steroiden
CH420137A (de) Verfahren zur Herstellung von ungesättigten 6-Methyl-16-methylen-3-keto-steroiden
AT232511B (de) Verfahren zur Herstellung von substituierten Piperidinoalkanolen