FR2649106A2 - Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament - Google Patents

Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament Download PDF

Info

Publication number
FR2649106A2
FR2649106A2 FR8908695A FR8908695A FR2649106A2 FR 2649106 A2 FR2649106 A2 FR 2649106A2 FR 8908695 A FR8908695 A FR 8908695A FR 8908695 A FR8908695 A FR 8908695A FR 2649106 A2 FR2649106 A2 FR 2649106A2
Authority
FR
France
Prior art keywords
sep
dihydro
oxo
azetidinyl
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8908695A
Other languages
English (en)
French (fr)
Other versions
FR2649106B1 (enExample
Inventor
Juan Pares Corominas
Augusto Colombo Pinol
Jordi Frigola Constansa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to FR8908695A priority Critical patent/FR2649106A2/fr
Priority to NO901171A priority patent/NO177302C/no
Priority to EP90400684A priority patent/EP0388298B1/fr
Priority to DE69020199T priority patent/DE69020199T2/de
Priority to DK90400684.8T priority patent/DK0388298T3/da
Priority to HU901570A priority patent/HU206702B/hu
Priority to YU50590A priority patent/YU47430B/sh
Priority to AT90400684T priority patent/ATE124039T1/de
Priority to CA002012223A priority patent/CA2012223A1/en
Priority to AU51375/90A priority patent/AU638437B2/en
Priority to PT93450A priority patent/PT93450B/pt
Priority to ES9000945A priority patent/ES2022006A6/es
Priority to KR1019900003679A priority patent/KR940006595B1/ko
Priority to JP2068014A priority patent/JPH075586B2/ja
Publication of FR2649106A2 publication Critical patent/FR2649106A2/fr
Priority to SU915001502A priority patent/RU2044735C1/ru
Priority to AU47469/93A priority patent/AU648212B2/en
Priority to US08/191,153 priority patent/US5393758A/en
Application granted granted Critical
Publication of FR2649106B1 publication Critical patent/FR2649106B1/fr
Priority to GR950402431T priority patent/GR3017304T3/el
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8908695A 1989-01-29 1989-06-29 Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament Granted FR2649106A2 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR8908695A FR2649106A2 (fr) 1989-06-29 1989-06-29 Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament
NO901171A NO177302C (no) 1989-03-16 1990-03-13 Analogifremgangsmåte til fremstilling av terapeutisk aktive substituerte azetidinylkinolon(naftyridon)karboksylsyrederivater
DE69020199T DE69020199T2 (de) 1989-03-16 1990-03-14 Durch Azetidine substituierte Derivate von Pyridon-Carboxylsäure, ihre Herstellung und Verwendung als Arzneimittel.
DK90400684.8T DK0388298T3 (da) 1989-03-16 1990-03-14 Azetidinylsubstituerede derivater af pyridoncarboxylsyrer, deres fremstilling og anvendelse som lægemidler
HU901570A HU206702B (en) 1989-03-16 1990-03-14 Process for producing substituted azetidinyl-carboxylic acid derivatives and pharmaceutical compositions containing them
YU50590A YU47430B (sh) 1989-03-16 1990-03-14 Supstituisani derivati azetidinil piridon karboksilnih kiselina i postupak njihove izrade
AT90400684T ATE124039T1 (de) 1989-03-16 1990-03-14 Durch azetidine substituierte derivate von pyridon-carboxylsäure, ihre herstellung und verwendung als arzneimittel.
EP90400684A EP0388298B1 (fr) 1989-03-16 1990-03-14 Dérivés d'acides pyridone carboxyliques azétidinyl substitues, leur préparation et leur application en tant que médicaments
CA002012223A CA2012223A1 (en) 1989-03-16 1990-03-15 Substituted azetidinylpyridonecarboxylic acid derivatives, their preparation and their application as medicinal products
AU51375/90A AU638437B2 (en) 1989-03-16 1990-03-15 Substituted azetidinylpyridonecarboxylic acid derivatives, their preparation and their application as medicinal products
PT93450A PT93450B (pt) 1989-03-16 1990-03-15 Processo para a preparacao de novos derivados azetidinicos de acidos piridinocarboxilicos e de composicoes farmaceuticas que os contem
ES9000945A ES2022006A6 (es) 1989-03-16 1990-03-16 Procedimiento para la preparacion de compuestos de acidos piridona carboxilicos azetidinil substituidos.
KR1019900003679A KR940006595B1 (ko) 1989-03-16 1990-03-16 피리돈카르복실산의 아제티딘 유도체, 그의 제조방법 및 이를 함유하는 의약품조성물
JP2068014A JPH075586B2 (ja) 1989-03-16 1990-03-16 置換アゼチジニルピリドンカルボン酸誘導体、その製法及びその医薬用途
SU915001502A RU2044735C1 (ru) 1989-03-16 1991-09-18 Производные азетидина или их фармацевтически приемлемые соли, обладающие антимикробной активностью
AU47469/93A AU648212B2 (en) 1989-03-16 1993-09-21 Azetidine compounds
US08/191,153 US5393758A (en) 1989-01-29 1994-02-03 Substituted azetidinylpyridone naphthyridine carboxylic acid derivatives and their application as medical products
GR950402431T GR3017304T3 (en) 1989-03-16 1995-09-06 Derivatives of pyridone carboxylic acids substituted by an azetidine, their preparation and their use as medicines.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8908695A FR2649106A2 (fr) 1989-06-29 1989-06-29 Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament

Publications (2)

Publication Number Publication Date
FR2649106A2 true FR2649106A2 (fr) 1991-01-04
FR2649106B1 FR2649106B1 (enExample) 1994-12-16

Family

ID=9383262

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8908695A Granted FR2649106A2 (fr) 1989-01-29 1989-06-29 Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament

Country Status (1)

Country Link
FR (1) FR2649106A2 (enExample)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0106489A2 (en) * 1982-09-09 1984-04-25 Warner-Lambert Company Antibacterial agents
EP0047005B1 (en) * 1980-09-02 1984-11-14 Daiichi Seiyaku Co., Ltd. Benzoxazine derivatives
JPS6089480A (ja) * 1983-10-21 1985-05-20 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体
JPS60126284A (ja) * 1983-12-09 1985-07-05 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体およびその塩
JPS61126082A (ja) * 1984-11-22 1986-06-13 Dainippon Pharmaceut Co Ltd アミノピロリジン誘導体、そのエステルおよびその塩
EP0314362A2 (en) * 1987-10-26 1989-05-03 Pfizer Inc. Azetidinyl quinolone carboxylic acids and esters
EP0324298A1 (fr) * 1987-12-29 1989-07-19 Laboratorios Del Dr. Esteve, S.A. Dérivés des acides 7-(1-azétidinyl)-1,4-dihydro-4-oxoquinoléine-3-carboxyliques, leur préparation et leur application en tant que médicaments

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0047005B1 (en) * 1980-09-02 1984-11-14 Daiichi Seiyaku Co., Ltd. Benzoxazine derivatives
EP0106489A2 (en) * 1982-09-09 1984-04-25 Warner-Lambert Company Antibacterial agents
JPS6089480A (ja) * 1983-10-21 1985-05-20 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体
JPS60126284A (ja) * 1983-12-09 1985-07-05 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体およびその塩
JPS61126082A (ja) * 1984-11-22 1986-06-13 Dainippon Pharmaceut Co Ltd アミノピロリジン誘導体、そのエステルおよびその塩
EP0314362A2 (en) * 1987-10-26 1989-05-03 Pfizer Inc. Azetidinyl quinolone carboxylic acids and esters
EP0324298A1 (fr) * 1987-12-29 1989-07-19 Laboratorios Del Dr. Esteve, S.A. Dérivés des acides 7-(1-azétidinyl)-1,4-dihydro-4-oxoquinoléine-3-carboxyliques, leur préparation et leur application en tant que médicaments

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEM. PHARM. BULL., vol. 32, no. 12, 1984, pages 4907-4913; I. HAYAKAWA et al.: "Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-deÜ[1,4Übenzoxazine-6-carboxylic acids" *
CHEMICAL ABSTRACTS, CHEMICAL SUBSTANCE INDEX, FURAZAN-NIN, vol. 106, partie 3, janvier-juin 1987, pages 5278CS,5280CS, Chemical Abstracts Service, Columbus, Ohio, US; "1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-azetidinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-"; "1,8-Naphthyridine-3-carboxyilc acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-[3-Ä(trifluoroacetyl)aminoÜ-1-azetidinylÜ-, ethyl ester" * Résumé * & CHEMICAL ABSTRACTS, vol. 106, no. 1, 5 janvier 1987, résumé no. 4995h, Columbus, Ohio, US; & JP-A-61 126 082 (DAINIPPON PHARMACEUTICAL CO. LTD) 13-06-1986 *
CHEMICAL ABSTRACTS, ELEVENTH COLLECTIVE INDEX, vol. 96-105, 1982-1986, CHEMICAL SUBSTANCES Molybdenum alloy-Nichilon, pages 42560CS,42557CS, Chemical Abstracts Service, Columbus, Ohio, US; "1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-"; "1,8-Naphthyridine-3-carboxylic acid, 1-cyxlopropyl-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-, ethyl ester" * Résumé * & CHEMICAL ABSTRACTS, vol. 104, no. 7, 17 février 1986, page 521, résumé no. 50861t, Columbus, Ohio, US; & JP-A-60 126 284 (DAINIPPON PHARMACEUTICAL CO. LTD) 05-07-1985 *
CHEMICAL ABSTRACTS, ELEVENTH COLLECTIVE INDEX, vol. 96-105, 1982-1986, CHEMICAL SUBSTANCES Molydemun alloy-Nichilon, pages 42560SC,42557CS, Chemical Abstracts Service, Columbus, Ohio, US; "1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-Ä(trifluoroacety)aminoÜ-1-azetidinylÜ-, ethyl ester"; "1,8-Naphthyridline-3-carboxylic acid, 7-3(3-amino-1-azetidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-"; "1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-azetidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4oxo-, monohydrochloride" *Résumé * & CHEMICAL ABSTRACTS, vol. 103, no. 17, 28 octobre 1985, page 720, *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 12, 1984, pages 1543-1548, American Chemical Society; H. EGAWA et al.: "Pyridonecarboxylic acids as antibacterial agents. 4. Synthesis and antibacterial activity of 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and its analogues" *
résumé no. 141933p, Columbus, Ohio, US; & JP-A-60 089 480 (DAINIPPON PHARMACEUTICAL CO. LTD) 20-05-1985 *

Also Published As

Publication number Publication date
FR2649106B1 (enExample) 1994-12-16

Similar Documents

Publication Publication Date Title
US6031102A (en) Optically active pyridonecarboxylic acid derivatives
US5849757A (en) Pyridonecarboxylic acid derivatives substituted by a bicyclic amino group as antibacterials
EP0324298A1 (fr) Dérivés des acides 7-(1-azétidinyl)-1,4-dihydro-4-oxoquinoléine-3-carboxyliques, leur préparation et leur application en tant que médicaments
FR2614620A1 (fr) Derives de la 1,4-dihydro-4-oxonaphtyridine et leurs sels, procede pour leur production et agents anti-bacteriens les contenant
EP0593766B1 (en) Pyridonecarboxylic acid derivative
JP2010001315A (ja) キノロン類及びナフチリジン類の製造方法における環化工程
US6586604B2 (en) Tricyclic amine derivatives
EP0388298B1 (fr) Dérivés d'acides pyridone carboxyliques azétidinyl substitues, leur préparation et leur application en tant que médicaments
EP0919553B1 (en) cis-SUBSTITUTED AMINOCYCLOPROPANE DERIVATIVES
JP2582515B2 (ja) 抗菌剤としての７−〔３−（１，１−ジアルキルメチル−１−アミノ）−１−ピロリジニル〕−キノロンおよびナフチリドンの光学異性体
SU1586517A3 (ru) Способ получени оптически чистых (5R, 6S)-6-[1(R)-гидроксиэтил]-2-метоксиметилпенем-3-карбоновой кислоты или ее сложных эфиров, или ее солей с щелочными металлами
FR2649106A2 (fr) Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament
WO1993007144A1 (fr) Derives de benzonaphtyridine-1,8 et compositions antimicrobiennes
FR2676445A1 (fr) Derives de pyridone amino acide azetidinyl substitues, leur preparation et leur application en tant que medicaments.
KR100497942B1 (ko) 광학활성을 유발하는 7-피롤리딘 치환체를 갖는 광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법
CN1094941C (zh) 吡啶并苯并噁嗪衍生物
FR2625200A1 (en) 7-(1-Azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their application as medicaments
FR2644455A1 (fr) Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicaments
EP0816355B1 (en) Heterocyclic spiro derivatives
FR2654728A2 (fr) Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament.
RU1792416C (ru) Способ получени N @ -/1,2-цис-2-галогеноциклопропил/-замещенной пиридонкарбоновой кислоты
JP2994759B2 (ja) 新規なキノロン−またはナフチリドン−カルボン酸誘導体もしくはそれらの塩
KR20010029698A (ko) 광학활성을 유발하는 7-피롤리딘 치환체를 갖는광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법
HK1002108B (en) Optically active pyridonecarboxylic acid derivatives

Legal Events

Date Code Title Description
ST Notification of lapse
ST Notification of lapse