FR2623811B1 - Procede de preparation d'acides phosphiniques utilises pour preparer des inhibiteurs de l'enzyme de conversion de l'angiotensine, et intermediaires ainsi obtenus - Google Patents
Procede de preparation d'acides phosphiniques utilises pour preparer des inhibiteurs de l'enzyme de conversion de l'angiotensine, et intermediaires ainsi obtenusInfo
- Publication number
- FR2623811B1 FR2623811B1 FR888812769A FR8812769A FR2623811B1 FR 2623811 B1 FR2623811 B1 FR 2623811B1 FR 888812769 A FR888812769 A FR 888812769A FR 8812769 A FR8812769 A FR 8812769A FR 2623811 B1 FR2623811 B1 FR 2623811B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- intermediates
- enzyme inhibitors
- acids used
- phosphinic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000015427 Angiotensins Human genes 0.000 title 1
- 108010064733 Angiotensins Proteins 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 239000002532 enzyme inhibitor Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3264—Esters with hydroxyalkyl compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/102,694 US4873356A (en) | 1987-09-30 | 1987-09-30 | Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2623811A1 FR2623811A1 (fr) | 1989-06-02 |
| FR2623811B1 true FR2623811B1 (fr) | 1991-11-15 |
Family
ID=22291193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR888812769A Expired - Lifetime FR2623811B1 (fr) | 1987-09-30 | 1988-09-29 | Procede de preparation d'acides phosphiniques utilises pour preparer des inhibiteurs de l'enzyme de conversion de l'angiotensine, et intermediaires ainsi obtenus |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4873356A (fr) |
| JP (1) | JP2716746B2 (fr) |
| KR (1) | KR890005133A (fr) |
| CN (1) | CN1032443A (fr) |
| CA (1) | CA1336433C (fr) |
| DE (1) | DE3833082A1 (fr) |
| FI (1) | FI884200A (fr) |
| FR (1) | FR2623811B1 (fr) |
| GB (1) | GB2210370B (fr) |
| HU (1) | HU205126B (fr) |
| IE (1) | IE61587B1 (fr) |
| IT (1) | IT1226859B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5008399A (en) * | 1990-01-19 | 1991-04-16 | E. R. Squibb & Sons, Inc. | Diastereoselective preparation of phosphinate esters |
| US6384022B1 (en) * | 1996-06-17 | 2002-05-07 | Guilford Pharmaceuticals Inc. | Prodrugs of NAALAdase inhibitors |
| DE60106497D1 (de) * | 2001-04-30 | 2004-11-18 | Lupin Lab Ltd | Ein verfahren zur herstellung von natrium fosinopril |
| KR100690647B1 (ko) | 2004-07-29 | 2007-03-09 | 엘지전자 주식회사 | 바스켓 승강장치를 구비한 냉장고 |
| CN100497335C (zh) * | 2005-10-27 | 2009-06-10 | 上海医药工业研究院 | 取代氧膦基乙酸的光学拆分方法 |
| CN100488969C (zh) * | 2005-10-27 | 2009-05-20 | 上海医药工业研究院 | 光学活性的取代氧膦基乙酸盐及其用途 |
| IT1394407B1 (it) * | 2009-05-25 | 2012-06-15 | Dipharma Francis Srl | Procedimento per la preparazione di fosinopril e suoi intermedi |
| IT1406151B1 (it) | 2010-12-06 | 2014-02-14 | Dipharma Francis Srl | Procedimento per la preparazione di fosinopril e suoi intermedi |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4396772A (en) * | 1981-11-23 | 1983-08-02 | F. R. Squibb & Sons, Inc. | Phosphinylalkanoyl amino acids |
| US4448772A (en) * | 1982-04-22 | 1984-05-15 | E. R. Squibb & Sons, Inc. | Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension |
| US4468519A (en) * | 1982-06-14 | 1984-08-28 | E. R. Squibb & Sons, Inc. | Esters of phosphinylalkanoyl substituted prolines |
| US4602092A (en) * | 1983-09-19 | 1986-07-22 | E. R. Squibb & Sons, Inc. | Method for making phosphinic acid intermediates |
-
1987
- 1987-09-30 US US07/102,694 patent/US4873356A/en not_active Expired - Lifetime
-
1988
- 1988-08-31 CA CA000576217A patent/CA1336433C/fr not_active Expired - Fee Related
- 1988-09-13 FI FI884200A patent/FI884200A/fi not_active Application Discontinuation
- 1988-09-27 GB GB8822596A patent/GB2210370B/en not_active Expired - Lifetime
- 1988-09-29 CN CN88109034A patent/CN1032443A/zh active Pending
- 1988-09-29 KR KR1019880012595A patent/KR890005133A/ko not_active Application Discontinuation
- 1988-09-29 HU HU885069A patent/HU205126B/hu unknown
- 1988-09-29 DE DE3833082A patent/DE3833082A1/de not_active Ceased
- 1988-09-29 FR FR888812769A patent/FR2623811B1/fr not_active Expired - Lifetime
- 1988-09-29 IT IT8822122A patent/IT1226859B/it active
- 1988-09-30 JP JP63248943A patent/JP2716746B2/ja not_active Expired - Lifetime
- 1988-10-29 IE IE293888A patent/IE61587B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE61587B1 (en) | 1994-11-16 |
| IT8822122A0 (it) | 1988-09-29 |
| FI884200A (fi) | 1989-03-31 |
| GB8822596D0 (en) | 1988-11-02 |
| GB2210370B (en) | 1992-01-15 |
| FR2623811A1 (fr) | 1989-06-02 |
| FI884200A0 (fi) | 1988-09-13 |
| US4873356A (en) | 1989-10-10 |
| IT1226859B (it) | 1991-02-19 |
| JP2716746B2 (ja) | 1998-02-18 |
| HUT48632A (en) | 1989-06-28 |
| CN1032443A (zh) | 1989-04-19 |
| GB2210370A (en) | 1989-06-07 |
| CA1336433C (fr) | 1995-07-25 |
| JPH01106894A (ja) | 1989-04-24 |
| DE3833082A1 (de) | 1989-04-13 |
| HU205126B (en) | 1992-03-30 |
| KR890005133A (ko) | 1989-05-13 |
| IE882938L (en) | 1989-03-30 |
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