FR2575753B1 - Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2575753B1
FR2575753B1 FR8500140A FR8500140A FR2575753B1 FR 2575753 B1 FR2575753 B1 FR 2575753B1 FR 8500140 A FR8500140 A FR 8500140A FR 8500140 A FR8500140 A FR 8500140A FR 2575753 B1 FR2575753 B1 FR 2575753B1
Authority
FR
France
Prior art keywords
polycyclic structure
preparation
pharmaceutical compositions
same
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8500140A
Other languages
English (en)
French (fr)
Other versions
FR2575753A1 (fr
Inventor
Michel Vincent
Georges Remond
Claude Cudennec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR8500140A priority Critical patent/FR2575753B1/fr
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to PT81793A priority patent/PT81793B/pt
Priority to CA000499067A priority patent/CA1270596A/fr
Priority to DE8686400010T priority patent/DE3660010D1/de
Priority to NZ214722A priority patent/NZ214722A/xx
Priority to JP61000483A priority patent/JPS61161298A/ja
Priority to IE2186A priority patent/IE58273B1/en
Priority to EP86400010A priority patent/EP0190058B1/fr
Priority to AU51854/86A priority patent/AU578781B2/en
Priority to AT86400010T priority patent/ATE31537T1/de
Priority to OA58759A priority patent/OA08182A/xx
Priority to GR860023A priority patent/GR860023B/el
Priority to ES550716A priority patent/ES8707552A1/es
Priority to ZA86105A priority patent/ZA86105B/xx
Publication of FR2575753A1 publication Critical patent/FR2575753A1/fr
Priority to US06/933,093 priority patent/US4720484A/en
Application granted granted Critical
Publication of FR2575753B1 publication Critical patent/FR2575753B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
FR8500140A 1985-01-07 1985-01-07 Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired FR2575753B1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR8500140A FR2575753B1 (fr) 1985-01-07 1985-01-07 Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AT86400010T ATE31537T1 (de) 1985-01-07 1986-01-06 Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE8686400010T DE3660010D1 (en) 1985-01-07 1986-01-06 Peptide derivatives with a polycyclic nitrogen structure, process for their preparation and pharmaceutical compositions containing them
NZ214722A NZ214722A (en) 1985-01-07 1986-01-06 Tuftsin analogue tetrapeptides
JP61000483A JPS61161298A (ja) 1985-01-07 1986-01-06 テトラペプチド、その製造法およびそれらを含有する調剤組成物
IE2186A IE58273B1 (en) 1985-01-07 1986-01-06 Novel peptide derivatives having a nitrogenous polycyclic structure, process for the preparation thereof and pharmaceutical compositions containing them
EP86400010A EP0190058B1 (fr) 1985-01-07 1986-01-06 Nouveaux dérivés peptidiques à structure polycyclique azotée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
AU51854/86A AU578781B2 (en) 1985-01-07 1986-01-06 Novel peptide derivatives having a nitrogenous polycyclic structure, process for the preparation thereof and pharmaceutical compositions containing them
PT81793A PT81793B (pt) 1985-01-07 1986-01-06 Processo para a preparacao de novos derivados peptidicos com estrutura policiclica azotada
CA000499067A CA1270596A (fr) 1985-01-07 1986-01-06 Derives peptidiques a structure polycyclique azotee et leur procede de preparation
OA58759A OA08182A (fr) 1985-01-07 1986-01-07 Nouveaux dérivés peptidiques à structure polycyclique azotée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GR860023A GR860023B (en) 1985-01-07 1986-01-07 Method for the preparation of peptidic derivatives with a azote polycyclic structure
ES550716A ES8707552A1 (es) 1985-01-07 1986-01-07 Procedimiento de preparacion de nuevos derivados tetrapep- tidos de estructura policiclica nitrogenada,asi como sus sales de adicion a un acido o una base farmaceuticamente aceptables
ZA86105A ZA86105B (en) 1985-01-07 1986-01-07 Peptide derivatives having a nitrogenous polycyclic structure,process for the preparation thereof and pharmaceutical compositions containing them
US06/933,093 US4720484A (en) 1985-01-07 1986-11-20 Peptide compounds having a nitrogenous polycyclic structure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8500140A FR2575753B1 (fr) 1985-01-07 1985-01-07 Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2575753A1 FR2575753A1 (fr) 1986-07-11
FR2575753B1 true FR2575753B1 (fr) 1987-02-20

Family

ID=9315046

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8500140A Expired FR2575753B1 (fr) 1985-01-07 1985-01-07 Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (15)

Country Link
US (1) US4720484A (enrdf_load_stackoverflow)
EP (1) EP0190058B1 (enrdf_load_stackoverflow)
JP (1) JPS61161298A (enrdf_load_stackoverflow)
AT (1) ATE31537T1 (enrdf_load_stackoverflow)
AU (1) AU578781B2 (enrdf_load_stackoverflow)
CA (1) CA1270596A (enrdf_load_stackoverflow)
DE (1) DE3660010D1 (enrdf_load_stackoverflow)
ES (1) ES8707552A1 (enrdf_load_stackoverflow)
FR (1) FR2575753B1 (enrdf_load_stackoverflow)
GR (1) GR860023B (enrdf_load_stackoverflow)
IE (1) IE58273B1 (enrdf_load_stackoverflow)
NZ (1) NZ214722A (enrdf_load_stackoverflow)
OA (1) OA08182A (enrdf_load_stackoverflow)
PT (1) PT81793B (enrdf_load_stackoverflow)
ZA (1) ZA86105B (enrdf_load_stackoverflow)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2616663B1 (fr) * 1987-06-16 1989-08-18 Adir Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
US5648333A (en) * 1988-11-24 1997-07-15 Hoechst Aktiengesellschaft Peptides having bradykinin antagonist action
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
FR2649110B1 (fr) * 1989-06-29 1994-10-21 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5028593A (en) * 1989-08-15 1991-07-02 Board Of Regents, The University Of Texas System Tuftsin analogs
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
EP0454302A3 (en) * 1990-03-30 1992-10-14 Banyu Pharmaceutical Co., Ltd. Tuftsin derivatives
FR2663336B1 (fr) * 1990-06-18 1992-09-04 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
US6177405B1 (en) * 1992-07-22 2001-01-23 Kenji Nishioka Cyclic analogs of tuftsin
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
CA2216532A1 (en) * 1995-03-29 1996-10-31 S. Jane Desolms Inhibitors of farnesyl-protein transferase
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
CN1133649C (zh) 1996-10-18 2004-01-07 沃泰克斯药物股份有限公司 丝氨酸蛋白酶、特别是丙型肝炎病毒ns3蛋白酶的抑制剂
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
MXPA04000293A (es) 2001-07-11 2004-05-04 Vertex Pharma Inhibidores de serina proteasa biciclica de puente.
EP1482927A1 (en) * 2002-03-01 2004-12-08 Warner-Lambert Company LLC Method of treating osteoarthritis
UY28500A1 (es) 2003-09-05 2005-04-29 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
US8076352B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
BRPI0508814B8 (pt) * 2004-03-15 2021-05-25 Ptc Therapeutics Inc derivados de carbolina, bem como uso dos mesmos e composição farmacêutica
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076353B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
AU2005228950B2 (en) 2004-03-23 2012-02-02 Genentech, Inc. Azabicyclo-octane inhibitors of IAP
CN1964970B (zh) * 2004-04-07 2011-08-03 诺瓦提斯公司 Iap的抑制剂
AU2005270104A1 (en) * 2004-07-02 2006-02-09 Genentech, Inc. Inhibitors of IAP
KR101278732B1 (ko) * 2004-12-20 2013-07-09 제넨테크, 인크. Ｉａｐ의 피롤리딘 억제제
NZ565540A (en) * 2005-08-02 2011-06-30 Vertex Pharma Inhibitors of serine proteases
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) * 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
CN101374829A (zh) * 2005-12-19 2009-02-25 健泰科生物技术公司 Iap的抑制剂
EP2340836A1 (en) 2006-02-27 2011-07-06 Vertex Pharmceuticals Incorporated Co-crystals comprising VX-950 and their pharmaceutical compositions
CA2646229A1 (en) * 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Deuterated hepatitis c protease inhibitors
PE20110217A1 (es) * 2006-08-02 2011-04-01 Novartis Ag DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
BRPI0719481A2 (pt) * 2006-12-19 2014-02-11 Genentech Inc " composto, método de indução de apoptose em uma célula, de sensibilização de uma célula, para inibir a ligação de uma proteína iap a uma proteína caspase, para tratar uma doença ou condição associada com a superexpressão de uma proteína iap e para tratar câncer"
EP2134717A2 (en) * 2007-02-27 2009-12-23 Vertex Pharmceuticals Incorporated Inhibitors of serine proteases
GEP20125645B (en) * 2007-02-27 2012-09-25 Vertex Pharma Co-crystals and pharmaceutical compositions comprising the same
AU2008245447C1 (en) * 2007-04-30 2014-11-20 Genentech, Inc. Inhibitors of IAP
ATE530546T1 (de) * 2007-08-30 2011-11-15 Vertex Pharma Kokristalle und pharmazeutische zusammensetzungen damit
EP2240506B1 (en) * 2008-01-11 2012-12-26 Genentech, Inc. Inhibitors of iap
JP2011529962A (ja) 2008-08-02 2011-12-15 ジェネンテック， インコーポレイテッド Ｉａｐのインヒビター
NZ590500A (en) * 2008-08-16 2012-06-29 Genentech Inc Azaindole inhibitors of iap
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
BR112014016548A8 (pt) 2012-01-06 2017-07-04 Board Of Regents Of The Univ Of Oklahoma tensoativos baseados em sulfóxido
RS57845B1 (sr) 2012-02-09 2018-12-31 Novus Int Inc Ciklični dimeri koji sadrže heteroatom
CA2878617A1 (en) 2012-07-12 2014-01-16 Houston Stephen Smith Matrix and layer compositions for protection of bioactives
CN112707851A (zh) 2015-11-12 2021-04-27 诺华丝国际股份有限公司 作为溶剂的含硫化合物
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions

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JPS5647895B2 (enrdf_load_stackoverflow) * 1973-06-08 1981-11-12
US4353823A (en) * 1981-09-01 1982-10-12 Chipens Gunar I Synthetic analog of tuftisin

Also Published As

Publication number Publication date
IE860021L (en) 1986-07-07
NZ214722A (en) 1988-09-29
AU578781B2 (en) 1988-11-03
DE3660010D1 (en) 1988-02-04
ES8707552A1 (es) 1987-08-01
IE58273B1 (en) 1993-08-25
PT81793A (fr) 1986-02-01
PT81793B (pt) 1988-05-27
US4720484A (en) 1988-01-19
OA08182A (fr) 1987-10-30
ES550716A0 (es) 1987-08-01
JPH0229080B2 (enrdf_load_stackoverflow) 1990-06-27
ZA86105B (en) 1986-10-29
JPS61161298A (ja) 1986-07-21
FR2575753A1 (fr) 1986-07-11
EP0190058A1 (fr) 1986-08-06
GR860023B (en) 1986-05-06
EP0190058B1 (fr) 1987-12-23
AU5185486A (en) 1986-07-10
CA1270596A (fr) 1990-06-19
ATE31537T1 (de) 1988-01-15

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