ES8707552A1 - Procedimiento de preparacion de nuevos derivados tetrapep- tidos de estructura policiclica nitrogenada,asi como sus sales de adicion a un acido o una base farmaceuticamente aceptables - Google Patents

Procedimiento de preparacion de nuevos derivados tetrapep- tidos de estructura policiclica nitrogenada,asi como sus sales de adicion a un acido o una base farmaceuticamente aceptables

Info

Publication number
ES8707552A1
ES8707552A1 ES550716A ES550716A ES8707552A1 ES 8707552 A1 ES8707552 A1 ES 8707552A1 ES 550716 A ES550716 A ES 550716A ES 550716 A ES550716 A ES 550716A ES 8707552 A1 ES8707552 A1 ES 8707552A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
peptide derivatives
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550716A
Other languages
English (en)
Other versions
ES550716A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES8707552A1 publication Critical patent/ES8707552A1/es
Publication of ES550716A0 publication Critical patent/ES550716A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEIDMIENTO PARA LA PREPARACION DE DERIVADOS TETRAPEPTIDOS DE ESTRUCTURA POLICICLICA NITROGENADA, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS O BASES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN PROTEGER LA FUNCION AMIDA DE UN DERIVADO DE FORMULA (II), POR UN RADICAL TERC-BUTOXICARBONILO BAJO LA ACCION DEL CARBONATO DE DITERC-BUTILO, EN UN DERIVADO DE FORMULA GENERAL (III), EN LA QUE A, CON LOS ATOMOS DE CARBONO Y DE NITROGENO A LOS QUE ESTA ENLAZADA, TIENE LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA GENERAL (I). EL PROCESO CONTINUA CON CONDENSACIONES, PROTECCIONES Y DESPROTECCIONES, HASTA OBTENER EL COMPUESTO DE FORMULA GENERAL (I) BUSCADO. DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS UTILIZADAS EN EL TRATAMIENTO DE ENFERMEDADES AUTO-INMUNES, Y EN EL TRATAMIENTO DE CANCERES.
ES550716A 1985-01-07 1986-01-07 Procedimiento de preparacion de nuevos derivados tetrapep- tidos de estructura policiclica nitrogenada,asi como sus sales de adicion a un acido o una base farmaceuticamente aceptables Expired ES8707552A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8500140A FR2575753B1 (fr) 1985-01-07 1985-01-07 Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
ES8707552A1 true ES8707552A1 (es) 1987-08-01
ES550716A0 ES550716A0 (es) 1987-08-01

Family

ID=9315046

Family Applications (1)

Application Number Title Priority Date Filing Date
ES550716A Expired ES8707552A1 (es) 1985-01-07 1986-01-07 Procedimiento de preparacion de nuevos derivados tetrapep- tidos de estructura policiclica nitrogenada,asi como sus sales de adicion a un acido o una base farmaceuticamente aceptables

Country Status (15)

Country Link
US (1) US4720484A (es)
EP (1) EP0190058B1 (es)
JP (1) JPS61161298A (es)
AT (1) ATE31537T1 (es)
AU (1) AU578781B2 (es)
CA (1) CA1270596A (es)
DE (1) DE3660010D1 (es)
ES (1) ES8707552A1 (es)
FR (1) FR2575753B1 (es)
GR (1) GR860023B (es)
IE (1) IE58273B1 (es)
NZ (1) NZ214722A (es)
OA (1) OA08182A (es)
PT (1) PT81793B (es)
ZA (1) ZA86105B (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2616663B1 (fr) * 1987-06-16 1989-08-18 Adir Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
US5648333A (en) * 1988-11-24 1997-07-15 Hoechst Aktiengesellschaft Peptides having bradykinin antagonist action
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
FR2649110B1 (fr) * 1989-06-29 1994-10-21 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5028593A (en) * 1989-08-15 1991-07-02 Board Of Regents, The University Of Texas System Tuftsin analogs
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
EP0454302A3 (en) * 1990-03-30 1992-10-14 Banyu Pharmaceutical Co., Ltd. Tuftsin derivatives
FR2663336B1 (fr) * 1990-06-18 1992-09-04 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
US6177405B1 (en) * 1992-07-22 2001-01-23 Kenji Nishioka Cyclic analogs of tuftsin
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
CA2216532A1 (en) * 1995-03-29 1996-10-31 S. Jane Desolms Inhibitors of farnesyl-protein transferase
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
UA79749C2 (en) 1996-10-18 2007-07-25 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
SV2003000617A (es) * 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
EP1404704B9 (en) * 2001-07-11 2008-02-20 Vertex Pharmaceuticals Incorporated Bridged bicyclic serine protease inhibitors
JP2005519098A (ja) * 2002-03-01 2005-06-30 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 変形性関節症の治療方法
TW201127828A (en) 2003-09-05 2011-08-16 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
US8076353B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
DK1737461T3 (da) 2004-03-15 2013-03-18 Ptc Therapeutics Inc Carbolin-derivater til inhibering af angiogenese
AU2005228950B2 (en) 2004-03-23 2012-02-02 Genentech, Inc. Azabicyclo-octane inhibitors of IAP
AR048927A1 (es) * 2004-04-07 2006-06-14 Novartis Ag Compuestos heterociclicos como inhibidores de proteinas de apoptosis (iap); composiciones farmaceuticas que los contienen y su uso en el tratamiento de una enfermedad proliferativa
CA2570321C (en) * 2004-07-02 2013-10-08 Genentech, Inc. Inhibitors of iap
EA019420B1 (ru) * 2004-12-20 2014-03-31 Дженентех, Инк. Пирролидиновые ингибиторы иап (ингибиторов апоптоза)
AU2006275413B2 (en) * 2005-08-02 2012-07-19 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
US8247557B2 (en) * 2005-12-19 2012-08-21 Genentech, Inc. IAP inhibitors
WO2007098270A2 (en) 2006-02-27 2007-08-30 Vertex Pharmaceuticals Incorporated Co-crystals comprising vx-950 and pharmaceutical compositions comprising the same
BRPI0709567A2 (pt) * 2006-03-16 2011-07-12 Vertex Pharma inibidores deuterados de protease de hepatite c
PE20110224A1 (es) * 2006-08-02 2011-04-05 Novartis Ag PROCEDIMIENTO PARA LA SINTESIS DE UN PEPTIDOMIMETICO DE Smac INHIBIDOR DE IAP, Y COMPUESTOS INTERMEDIARIOS PARA LA SINTESIS DEL MISMO
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
CA2671607A1 (en) * 2006-12-19 2008-07-03 Genentech, Inc. Imidazopyridine inhibitors of iap
CA2679426A1 (en) * 2007-02-27 2008-09-04 Luc Farmer Inhibitors of serine proteases
TW200846343A (en) * 2007-02-27 2008-12-01 Vertex Pharma Co-crystals and pharmaceutical compositions comprising the same
JP5368428B2 (ja) * 2007-04-30 2013-12-18 ジェネンテック， インコーポレイテッド Ｉａｐのインヒビター
CL2008002549A1 (es) * 2007-08-30 2010-09-03 Vertex Pharma Cocristal que comprende vx-950 y un formador de cocristal seleccionado de acido 3-metoxi-4hidroxibenzoico,acido 2,4-dihidroxibenzoico y acido 2,5-dihidroxibenzoico; metodo de preparacion; composicion farmaceutica que comprende el cocristal, util como agente antiviral en el tratamiento del hcv.
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JP2011529962A (ja) 2008-08-02 2011-12-15 ジェネンテック， インコーポレイテッド Ｉａｐのインヒビター
AU2009282978A1 (en) * 2008-08-16 2010-02-25 Genentech, Inc. Azaindole inhibitors of IAP
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
BR112014016548A8 (pt) 2012-01-06 2017-07-04 Board Of Regents Of The Univ Of Oklahoma tensoativos baseados em sulfóxido
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BR112015000494A2 (pt) 2012-07-12 2017-06-27 Novus Int Inc matriz e composições da camada para a proteção dos biotivos
AU2016353076A1 (en) 2015-11-12 2018-05-10 Novus International Inc. Sulfur-containing compounds as solvents
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions

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JPS5647895B2 (es) * 1973-06-08 1981-11-12
US4353823A (en) * 1981-09-01 1982-10-12 Chipens Gunar I Synthetic analog of tuftisin

Also Published As

Publication number Publication date
JPS61161298A (ja) 1986-07-21
OA08182A (fr) 1987-10-30
PT81793B (pt) 1988-05-27
GR860023B (en) 1986-05-06
IE860021L (en) 1986-07-07
AU578781B2 (en) 1988-11-03
US4720484A (en) 1988-01-19
FR2575753A1 (fr) 1986-07-11
IE58273B1 (en) 1993-08-25
ZA86105B (en) 1986-10-29
EP0190058A1 (fr) 1986-08-06
PT81793A (fr) 1986-02-01
CA1270596A (fr) 1990-06-19
DE3660010D1 (en) 1988-02-04
ATE31537T1 (de) 1988-01-15
ES550716A0 (es) 1987-08-01
FR2575753B1 (fr) 1987-02-20
JPH0229080B2 (es) 1990-06-27
EP0190058B1 (fr) 1987-12-23
NZ214722A (en) 1988-09-29
AU5185486A (en) 1986-07-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505