FR2567123B1 - Nouveaux composes polycycliques heterocycliques derives du benzimidazole, du benzoxazole ou du benzothiazole, procede et intermediaire pour leur preparation ainsi que leur utilisation pharmaceutique, en particulier pour le traitement d'affections gastriques - Google Patents

Nouveaux composes polycycliques heterocycliques derives du benzimidazole, du benzoxazole ou du benzothiazole, procede et intermediaire pour leur preparation ainsi que leur utilisation pharmaceutique, en particulier pour le traitement d'affections gastriques

Info

Publication number
FR2567123B1
FR2567123B1 FR858510337A FR8510337A FR2567123B1 FR 2567123 B1 FR2567123 B1 FR 2567123B1 FR 858510337 A FR858510337 A FR 858510337A FR 8510337 A FR8510337 A FR 8510337A FR 2567123 B1 FR2567123 B1 FR 2567123B1
Authority
FR
France
Prior art keywords
benzoxazole
benzothiazole
benzimidazole
preparation
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR858510337A
Other languages
English (en)
Other versions
FR2567123A1 (fr
Inventor
David Cox
Anthony Howard Ingall
John Louis Suschitzky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848417271A external-priority patent/GB8417271D0/en
Priority claimed from GB848417272A external-priority patent/GB8417272D0/en
Priority claimed from GB848419738A external-priority patent/GB8419738D0/en
Priority claimed from GB848424347A external-priority patent/GB8424347D0/en
Priority claimed from GB848424346A external-priority patent/GB8424346D0/en
Priority claimed from GB848424351A external-priority patent/GB8424351D0/en
Priority claimed from GB848424350A external-priority patent/GB8424350D0/en
Priority claimed from GB848430163A external-priority patent/GB8430163D0/en
Priority claimed from GB858509406A external-priority patent/GB8509406D0/en
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of FR2567123A1 publication Critical patent/FR2567123A1/fr
Publication of FR2567123B1 publication Critical patent/FR2567123B1/fr
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70Sulfur atoms
    • C07D277/74Sulfur atoms substituted by carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR858510337A 1984-07-06 1985-07-05 Nouveaux composes polycycliques heterocycliques derives du benzimidazole, du benzoxazole ou du benzothiazole, procede et intermediaire pour leur preparation ainsi que leur utilisation pharmaceutique, en particulier pour le traitement d'affections gastriques Expired - Lifetime FR2567123B1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB848417271A GB8417271D0 (en) 1984-07-06 1984-07-06 Biologically active nitrogen heterocycles
GB848417272A GB8417272D0 (en) 1984-07-06 1984-07-06 Biologically active nitrogen heterocycles
GB848419738A GB8419738D0 (en) 1984-08-02 1984-08-02 Nitrogen heterocycles
GB848424346A GB8424346D0 (en) 1984-09-26 1984-09-26 Nitrogen heterocycles
GB848424351A GB8424351D0 (en) 1984-09-26 1984-09-26 Nitrogen heterocycles
GB848424347A GB8424347D0 (en) 1984-09-26 1984-09-26 Nitrogen heterocycles
GB848424350A GB8424350D0 (en) 1984-09-26 1984-09-26 Nitrogen heterocycles
GB848430163A GB8430163D0 (en) 1984-11-29 1984-11-29 Biologically active nitrogen heterocycles
GB858509406A GB8509406D0 (en) 1985-04-12 1985-04-12 Nitrogen heterocycles

Publications (2)

Publication Number Publication Date
FR2567123A1 FR2567123A1 (fr) 1986-01-10
FR2567123B1 true FR2567123B1 (fr) 1991-05-31

Family

ID=27576300

Family Applications (1)

Application Number Title Priority Date Filing Date
FR858510337A Expired - Lifetime FR2567123B1 (fr) 1984-07-06 1985-07-05 Nouveaux composes polycycliques heterocycliques derives du benzimidazole, du benzoxazole ou du benzothiazole, procede et intermediaire pour leur preparation ainsi que leur utilisation pharmaceutique, en particulier pour le traitement d'affections gastriques

Country Status (15)

Country Link
EP (1) EP0174717B1 (fr)
AU (1) AU580607B2 (fr)
CA (1) CA1341314C (fr)
CH (1) CH666265A5 (fr)
DE (1) DE3585252D1 (fr)
DK (1) DK174021B1 (fr)
FI (1) FI89046C (fr)
FR (1) FR2567123B1 (fr)
GR (1) GR851618B (fr)
HK (1) HK60194A (fr)
IL (1) IL75687A (fr)
LU (1) LU85989A1 (fr)
NO (1) NO168355C (fr)
NZ (1) NZ212664A (fr)
PT (1) PT80783B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4640985A (en) * 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
JO1406B1 (en) * 1984-11-02 1986-11-30 سميث كلاين اند فرينش لابوراتوريز ليمتد Chemical compounds
DK8600939A (fr) * 1985-03-05 1986-09-06
EP0232399A1 (fr) * 1985-08-21 1987-08-19 Byk Gulden Lomberg Chemische Fabrik GmbH Nouvelles amines, leur procede de fabrication, leur utilisation, et medicaments les contenant
AR243167A1 (es) 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
JPS62246587A (ja) * 1986-03-17 1987-10-27 ピ−ピ−ジ− インダストリイズ,インコ−ポレイテツド 除草活性を有する置換ベンゾオキサゾロン(またはベンゾチアゾロン)化合物
ES2038612T3 (es) * 1986-03-28 1993-08-01 Otsuka Pharmaceutical Co., Ltd. Compuestos de hidroquinolina, composiciones que los contienen y procedimientos para prepararlas.
AU619444B2 (en) * 1986-06-02 1992-01-30 Nippon Chemiphar Co. Ltd. 2-(2-aminobenzylsulfinyl)- benzimidazole derivatives
EP0251536A1 (fr) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, leur préparation, formulation et utilisation comme inhibiteurs de sécrétion d'acide gastrique
WO1988002367A1 (fr) * 1986-09-27 1988-04-07 Fisons Plc Composes
SE8604566D0 (sv) * 1986-10-27 1986-10-27 Haessle Ab Novel compunds
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
AU597628B2 (en) * 1987-03-30 1990-06-07 Higuchi, Yoshinari Hydroquinoline compounds, compositions containing same and process for preparing same
US4942245A (en) * 1987-04-20 1990-07-17 Kyorin Pharmaceutical Co., Ltd. Benzimidazole Derivatives
IT1216522B (it) * 1988-03-25 1990-03-08 Dompe Farmaceutici Spa Derivati alchiltiobenzimidazolici attivi farmacologicamente eprocedimento per la loro preparazione.
US5294629A (en) * 1988-11-22 1994-03-15 Meiji Seika Kaisha, Ltd. Benzothiazole and benzimidazole derivatives and antiulcer agent containing the same
EP0370436A3 (fr) * 1988-11-22 1990-10-31 Meiji Seika Kaisha Ltd. Benzothiazoles et benzimidazole et compositions anti-ulcère les contenant
JP2933739B2 (ja) * 1990-04-09 1999-08-16 明治製菓株式会社 チアゾールまたはイミダゾール誘導体および抗潰瘍剤
EP2022789A1 (fr) * 2007-08-06 2009-02-11 Farmaprojects, S.A. Procédé pour la préparation d'un inhibiteur de la sécrétion d'acide gastrique
CL2017001982A1 (es) * 2017-08-03 2018-04-20 Neuroinnovation Ltda Nuevos compuestos derivados de piridinmetilsulfinilbenzoxazoles y piridinmetilsulfinibenzotiazoles, marcados radiactivamente o con fluorescencia y sus composiciones, como biomarcadores especificos para el diagnostico de enfermedades neurodegenerativas y patologías involucradas con la proteína tau.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1003821A (fr) 1947-02-28 1952-03-26 Francolor Sa Procédé d'obtention d'un produit organique contenant du soufre et de l'oxygène, et son application comme accélérateur de vulcanisation
US2585155A (en) 1949-10-29 1952-02-12 Francolor Sa Benzothiazole-2-dimethylsulfinamide and process for preparing the same
US3541060A (en) 1967-06-01 1970-11-17 Monsanto Chemicals Accelerating vulcanization with benzothiazole-2-sulfinamides
BE738304A (fr) 1968-10-02 1970-03-02
FR2037001A1 (fr) 1969-04-30 1970-12-31 Ugine Kuhlmann Nouveaux dérivés du mercaptobenzothiazole
BE788805A (fr) * 1971-09-22 1973-01-02 Lafon Victor Nouveaux derives antalgiques de la serie des arylamines soufrees
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (fr) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
GR81595B (fr) 1983-06-18 1984-12-11 Wyeth John & Brother Ltd
CA1259070A (fr) 1983-07-01 1989-09-05 Upjohn Company (The) Derives de substitution de 2-¬noyaux condenses (3,4- 4,5-, 5,6-)-pyridylalcoylenesulfinyl|- benzimidazoles
GB8417171D0 (en) 1984-07-05 1984-08-08 Beecham Group Plc Compounds
SE8404065D0 (sv) 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU4640985A (en) 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
EP0178438A1 (fr) 1984-09-19 1986-04-23 Beecham Group Plc Composés
JO1406B1 (en) * 1984-11-02 1986-11-30 سميث كلاين اند فرينش لابوراتوريز ليمتد Chemical compounds
US4738709A (en) * 1985-01-10 1988-04-19 Ppg Industries, Inc. Herbicidally active substituted benzisoxazoles
DK8600939A (fr) * 1985-03-05 1986-09-06

Also Published As

Publication number Publication date
FI89046C (fi) 1993-08-10
FR2567123A1 (fr) 1986-01-10
DK301885A (da) 1986-01-07
FI852622L (fi) 1986-01-07
EP0174717A1 (fr) 1986-03-19
IL75687A (en) 1990-03-19
EP0174717B1 (fr) 1992-01-22
FI852622A0 (fi) 1985-07-03
GR851618B (fr) 1985-11-26
CA1341314C (fr) 2001-11-06
DK174021B1 (da) 2002-04-22
NZ212664A (en) 1989-04-26
AU4444185A (en) 1986-01-09
PT80783A (en) 1985-08-01
AU580607B2 (en) 1989-01-19
NO168355B (no) 1991-11-04
CH666265A5 (fr) 1988-07-15
DK301885D0 (da) 1985-07-02
NO852729L (no) 1986-01-07
LU85989A1 (fr) 1986-02-12
NO168355C (no) 1992-02-12
HK60194A (en) 1994-07-08
PT80783B (pt) 1989-10-04
DE3585252D1 (de) 1992-03-05
FI89046B (fi) 1993-04-30
IL75687A0 (en) 1985-11-29

Similar Documents

Publication Publication Date Title
FR2567123B1 (fr) Nouveaux composes polycycliques heterocycliques derives du benzimidazole, du benzoxazole ou du benzothiazole, procede et intermediaire pour leur preparation ainsi que leur utilisation pharmaceutique, en particulier pour le traitement d'affections gastriques
ES510042A0 (es) "un procedimiento de preparacion de nuevas carboxamidas heterociclicas".
FR2540490B1 (fr) Procede de resolution d'isomeres optiques, les isomeres ainsi produits et leur application pharmaceutique
LU81297A1 (fr) Procede enzymatique microbiologique pour la production d'aminoacides optiquement actifs en partant d'hydantoines et/ou de derives carbamoyle racemiques
FR2397403A1 (fr) Nouveaux derives de 1-acyl 2-cyano-aziridine, procede pour leur preparation et compositions pharmaceutiques contenant ces composes
MY106038A (en) 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents.
FR2504127B1 (fr) Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments
BE893492A (fr) Procede de preparation d'esters d'acides apovincaminiques, esters ainsi obtenus et compositions pharmaceutiques prepares avec ces esters
FR2565105B1 (fr) Composition pharmaceutique stable pour le traitement de la cetose et procede pour la preparer
PT85278A (fr) Procede de preparation d:une fraction immunogene active a liegard des bilharzioses et de compositions immunisantes la contenant
BE894228A (fr) Composition pharmaceutique pour le traitement de l'atherosclerose
FR2603285B1 (fr) Procede de silylation d'imides aromatiques et silylimides ainsi prepares
FR2640140B1 (fr) Compositions pour le traitement de phlebectasies et leur procede de preparation
FR2620931B1 (fr) Dispositif et procede pour le traitement d'affections des gencives
FR2566408B1 (fr) Nouveaux pro-medicaments heterocycliques d'oxicams anti-inflammatoires et leur procede de preparation
FR2562798B1 (fr) Agent pharmaceutique pour le traitement du psoriasis
FR2585020B1 (fr) Nouvelle substance biologiquement active, appelee girolline, extraite de l'eponge pseudaxinyssa cantharella, son procede de preparation et les compositions pharmaceutiques qui la contiennent
OA08609A (fr) Composition pharmaceutique pour le traitement des infections bactériennes.
FR2533917B1 (fr) Derives 15-cycloaliphatiques de 13,14-bisdeshydro-carboprostacyclines et procede pour leur preparation
BE894154A (fr) Procede de preparation d'esters des acides alkoxyvincaminiques et alkoxyapovincaminiques
FR2615852B1 (fr) Procede pour la preparation et l'isolement de nitriles aromatiques
FR2619489B1 (fr) Electroplasmolyseur pour le traitement de matieres vegetales
FR2518995B1 (fr) Procede de preparation de derives heterocycliques d'acide acetique et derives ainsi obtenus
FR2518998B1 (fr) Nouveaux derives heterocycliques d'acide acetique et procede pour leur preparation
BE883791A (fr) Amides d'acides pyrrolidine-(2)-one(1)-yle-alcoylcarboxyliques, leur preparation et leur utilisation pour le traitement de troubles de l'irrigation cerebrale