FR2537970B1 - Nouveaux derives aminoalkoxy aromatiques, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives aminoalkoxy aromatiques, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2537970B1
FR2537970B1 FR8221053A FR8221053A FR2537970B1 FR 2537970 B1 FR2537970 B1 FR 2537970B1 FR 8221053 A FR8221053 A FR 8221053A FR 8221053 A FR8221053 A FR 8221053A FR 2537970 B1 FR2537970 B1 FR 2537970B1
Authority
FR
France
Prior art keywords
therapeutics
application
preparation process
aromatic derivatives
aminoalkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8221053A
Other languages
English (en)
Other versions
FR2537970A1 (fr
Inventor
Guy Bourgery
Alain Lacour
Bernard Pourrias
Raphael Santamaria
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GR70145A priority Critical patent/GR78370B/el
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR8221053A priority patent/FR2537970B1/fr
Priority to SE8207224A priority patent/SE453916B/sv
Priority to CA000418154A priority patent/CA1197243A/fr
Priority to CH3696/85A priority patent/CH661509A5/fr
Priority to CH7473/82A priority patent/CH655313A5/fr
Priority to US06/451,537 priority patent/US4536500A/en
Priority to GB08236432A priority patent/GB2113680B/en
Priority to LU84548A priority patent/LU84548A1/fr
Priority to DE19823247860 priority patent/DE3247860A1/de
Priority to ES518518A priority patent/ES8308864A1/es
Priority to NL8204978A priority patent/NL8204978A/nl
Priority to IT24964/82A priority patent/IT1191152B/it
Priority to DE3250049A priority patent/DE3250049C2/de
Priority to AU91934/82A priority patent/AU9193482A/en
Publication of FR2537970A1 publication Critical patent/FR2537970A1/fr
Priority to GB08506732A priority patent/GB2154587B/en
Priority to US06/748,862 priority patent/US4732896A/en
Priority to SE8505219A priority patent/SE8505219D0/xx
Application granted granted Critical
Publication of FR2537970B1 publication Critical patent/FR2537970B1/fr
Priority to US07/147,268 priority patent/US4831051A/en
Priority to JP3033043A priority patent/JPH04210944A/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8221053A 1981-12-24 1982-12-15 Nouveaux derives aminoalkoxy aromatiques, leur procede de preparation et leur application en therapeutique Expired FR2537970B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GR70145A GR78370B (fr) 1981-12-24 1982-04-13
FR8221053A FR2537970B1 (fr) 1982-12-15 1982-12-15 Nouveaux derives aminoalkoxy aromatiques, leur procede de preparation et leur application en therapeutique
SE8207224A SE453916B (sv) 1981-12-24 1982-12-17 Nya aromatiska aminoalkoxiderivat, deras framstellningssett och lekemedel anvendbart som kalciumantagonist
CA000418154A CA1197243A (fr) 1981-12-24 1982-12-20 Derives aromatiques renfermant une chaine aminoalcoxy et leurs sels; preparation de ces derives et des sels; utilisation comme medicaments
CH3696/85A CH661509A5 (fr) 1981-12-24 1982-12-21 Cetones aromatiques.
CH7473/82A CH655313A5 (fr) 1981-12-24 1982-12-21 Derives aminoalkoxy aromatiques, leur procede de preparation et medicaments les renfermant.
US06/451,537 US4536500A (en) 1981-12-24 1982-12-21 Aromatic derivatives comprising an aminoalkoxy chain and pharmaceutical compositions thereof
LU84548A LU84548A1 (fr) 1981-12-24 1982-12-22 Nouveaux derives aminoalkoxy aromatiques,leur procede de preparation et leur application en therapeutique
GB08236432A GB2113680B (en) 1981-12-24 1982-12-22 New aromatic derivatives comprising an aminoalkoxy chain having an activity antagomistic to calcium
ES518518A ES8308864A1 (es) 1981-12-24 1982-12-23 Procedimiento para la fabricacion de nuevos derivados aminoalcoxi aromaticos.
DE19823247860 DE3247860A1 (de) 1981-12-24 1982-12-23 Aromatische aminoalkoxyderivate, verfahren zu ihrer herstellung und deren therapeutische verwendung
NL8204978A NL8204978A (nl) 1981-12-24 1982-12-23 Nieuwe aromatische aminoalkoxyverbindingen, werkwijze voor hun bereiding en hun toepassing in de geneeskunde.
IT24964/82A IT1191152B (it) 1981-12-24 1982-12-23 Derivati aminoalcossi aromatici,loro procedimento di preparazione e loro applicazione in terapia
DE3250049A DE3250049C2 (de) 1981-12-24 1982-12-23 Aminoalkoxyaromatische Derivate
AU91934/82A AU9193482A (en) 1981-12-24 1982-12-24 Amino alkoxy aromatics
GB08506732A GB2154587B (en) 1981-12-24 1985-03-15 Aminoalkoxy-substituted aromatic ketones
US06/748,862 US4732896A (en) 1981-12-24 1985-06-26 Aromatic derivatives comprising an aminoalkoxy chain, the salts thereof, the process for preparing these derivatives and salts and the application thereof in therapeutics
SE8505219A SE8505219D0 (sv) 1981-12-24 1985-11-06 Derives aminoalkoxy aromatiques et leur procede de preparation
US07/147,268 US4831051A (en) 1981-12-24 1988-01-22 Aromatic derivatives comprising an aminoalkoxy chain, the salts thereof, the process for preparing these derivatives and salts and the application thereof in therapeutics
JP3033043A JPH04210944A (ja) 1981-12-24 1991-02-27 アミノアルコキシ芳香族化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8221053A FR2537970B1 (fr) 1982-12-15 1982-12-15 Nouveaux derives aminoalkoxy aromatiques, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2537970A1 FR2537970A1 (fr) 1984-06-22
FR2537970B1 true FR2537970B1 (fr) 1986-08-14

Family

ID=9280143

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8221053A Expired FR2537970B1 (fr) 1981-12-24 1982-12-15 Nouveaux derives aminoalkoxy aromatiques, leur procede de preparation et leur application en therapeutique

Country Status (1)

Country Link
FR (1) FR2537970B1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017572A (en) * 1988-04-22 1991-05-21 Delalande S.A. Derivatives of 1-[3-(4-hydroxyphenyl) 1-hydroxy 1-propyl] benzene substituted in position 2 by an aminoalkyleneoxy chain, the method of preparing same and the application thereof to therapeutics

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1894865A (en) * 1930-08-28 1933-01-17 Soc Of Chemical Ind Basic ether of aromatic ketones
FR1077722A (fr) * 1952-04-24 1954-11-10 Hoffmann La Roche Procédé pour la préparation d'amino-cétones aromatiques
GB872997A (en) * 1957-01-26 1961-07-19 Pharmacia Ab Substituted ún-aminoalkoxy-acyl benzenes and processes for their manufacture
FR1315712A (fr) * 1960-05-25 1963-01-25 Guidotti & Co Spa Lab Méthode de préparation de [o (bêta-diéthylaminoéthoxyphényl)]-1-phényl-3-propanone
GB1022648A (en) * 1961-11-08 1966-03-16 Guidotti & C Spa Labor A process for making a series of ª‰-phenyl-propiophenone derivatives, substituted in the 2- and 4-positions and derivatives thereby obtained
GB1111336A (en) * 1964-07-24 1968-04-24 Fisons Pharmaceuticals Ltd Aryl ketones
CH513114A (fr) * 1970-08-06 1971-09-30 Recordati Chem Pharm Procédé de préparation d'alcools 0-(2-dialcoylamino-éthoxy)-a-alcoylbenzyliques
FR2274295A1 (fr) * 1974-06-13 1976-01-09 Delalande Sa Nouveaux benzodioxanes 1,4, leur procede de preparation et leur application en therapeutique
FR2330390A2 (fr) * 1975-11-05 1977-06-03 Delalande Sa Nouvelles benzodioxanes-1,4, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
FR2537970A1 (fr) 1984-06-22

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ST Notification of lapse