FR2537133A1 - Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent - Google Patents
Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent Download PDFInfo
- Publication number
- FR2537133A1 FR2537133A1 FR8220492A FR8220492A FR2537133A1 FR 2537133 A1 FR2537133 A1 FR 2537133A1 FR 8220492 A FR8220492 A FR 8220492A FR 8220492 A FR8220492 A FR 8220492A FR 2537133 A1 FR2537133 A1 FR 2537133A1
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- FR
- France
- Prior art keywords
- temperature
- product
- total
- general formula
- piperazinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title description 9
- 238000002360 preparation method Methods 0.000 title description 5
- 229940126601 medicinal product Drugs 0.000 title description 2
- -1 dimethylsulfamoyl Chemical group 0.000 abstract description 31
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract description 6
- 229910052717 sulfur Chemical group 0.000 abstract description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract description 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 4
- 239000001257 hydrogen Substances 0.000 abstract description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract description 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract description 3
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract description 3
- 239000000935 antidepressant agent Substances 0.000 abstract description 3
- 229940005513 antidepressants Drugs 0.000 abstract description 3
- 125000004663 dialkyl amino group Chemical group 0.000 abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 abstract description 3
- 239000001301 oxygen Substances 0.000 abstract description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract description 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract description 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract description 2
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- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical class O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract description 2
- 239000011593 sulfur Chemical group 0.000 abstract description 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 125000004434 sulfur atom Chemical group 0.000 description 3
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- ZXRWQRYMEYRQKX-UHFFFAOYSA-N 5-ethoxypyrrolidin-2-one Chemical compound CCOC1CCC(=O)N1 ZXRWQRYMEYRQKX-UHFFFAOYSA-N 0.000 description 2
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- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 2
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- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Luminescent Compositions (AREA)
- Steroid Compounds (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8220492A FR2537133A1 (fr) | 1982-12-07 | 1982-12-07 | Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent |
| CS839041A CS240982B2 (en) | 1982-12-07 | 1983-12-02 | Production method of pyrrolidine derivatives |
| DD83257518A DD213216A5 (de) | 1982-12-07 | 1983-12-05 | Verfahren zur herstellung eines neuen pynolidin-derivates |
| PL1983244921A PL141385B1 (en) | 1982-12-07 | 1983-12-05 | Method of obtaining novel pyrrolidine derivatives |
| FI834453A FI76320C (fi) | 1982-12-07 | 1983-12-05 | Foerfarande foer framstaellning av nya 4-fenylalkyl-5-piperazin-1-ylpyrrolidinderivat, vilka har antidepressiv verkan. |
| GR73154A GR72855B (enExample) | 1982-12-07 | 1983-12-05 | |
| ZA839070A ZA839070B (en) | 1982-12-07 | 1983-12-06 | New therapeutically useful pyrrolidine derivatives |
| NO834481A NO158218C (no) | 1982-12-07 | 1983-12-06 | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive pyrrolidin-derivater. |
| HU834166A HU191903B (en) | 1982-12-07 | 1983-12-06 | Process for preparing 5-pyrrolidinones and -pyrrolidine-thiones |
| IL70396A IL70396A (en) | 1982-12-07 | 1983-12-06 | Pyrrolidine derivatives,processes for their preparation and pharmaceutical compositions containing the same |
| IE2867/83A IE56453B1 (en) | 1982-12-07 | 1983-12-06 | New therapeutically useful pyrrolidine derivatives |
| JP58229251A JPS59110670A (ja) | 1982-12-07 | 1983-12-06 | 治療学的に有用な新規なピロリジン誘導体類 |
| EP83402354A EP0110795B1 (fr) | 1982-12-07 | 1983-12-06 | Nouveaux dérivés de la pyrrolidine, leur préparation et les médicaments qui les contiennent |
| NZ206498A NZ206498A (en) | 1982-12-07 | 1983-12-06 | Pyrrolidine derivatives and pharmaceutical compositions |
| PT77774A PT77774B (fr) | 1982-12-07 | 1983-12-06 | Nouveaux derives de la pyrrolidine leur preparation et les medicaments qui les contiennent |
| US06/558,775 US4547504A (en) | 1982-12-07 | 1983-12-06 | Substituted phenyl piperazinyl pyrrolidin-2-ones and related compounds useful as anti-depressants and their use |
| MA20187A MA19966A1 (fr) | 1982-12-07 | 1983-12-06 | Nouveaux derives de la pyrrolidine et leur preparation |
| CA000442681A CA1208645A (fr) | 1982-12-07 | 1983-12-06 | Procede pour la preparation de derives de la pyrrolidine et les derives ainsi obtenus |
| AU22108/83A AU560075B2 (en) | 1982-12-07 | 1983-12-06 | Pyrrolidine derivatives |
| SU833673511A SU1240359A3 (ru) | 1982-12-07 | 1983-12-06 | Способ получени производных пирролидина |
| DE8383402354T DE3362566D1 (en) | 1982-12-07 | 1983-12-06 | Pyrrolidine derivatives, their preparation and medicines containing them |
| DK562783A DK562783A (da) | 1982-12-07 | 1983-12-06 | Pyrrolidinderivater og deres fremstilling samt laegemidler indeholdende saadanne derivater |
| AT83402354T ATE18548T1 (de) | 1982-12-07 | 1983-12-06 | Pyrrolidin-derivate, herstellung und verwendung als heilmittel. |
| BG063371A BG40808A3 (bg) | 1982-12-07 | 1983-12-07 | Метод за получаване на производни на пиролидина |
| MX846983A MX155447A (es) | 1982-12-07 | 1983-12-07 | Procedimiento de preparacion de derivados de la pirrolidina |
| ES527897A ES8406436A1 (es) | 1982-12-07 | 1983-12-07 | Procedimiento para la obtencion de derivados de la pirrolidina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8220492A FR2537133A1 (fr) | 1982-12-07 | 1982-12-07 | Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2537133A1 true FR2537133A1 (fr) | 1984-06-08 |
| FR2537133B1 FR2537133B1 (enExample) | 1985-05-17 |
Family
ID=9279863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8220492A Granted FR2537133A1 (fr) | 1982-12-07 | 1982-12-07 | Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4547504A (enExample) |
| EP (1) | EP0110795B1 (enExample) |
| JP (1) | JPS59110670A (enExample) |
| AT (1) | ATE18548T1 (enExample) |
| AU (1) | AU560075B2 (enExample) |
| BG (1) | BG40808A3 (enExample) |
| CA (1) | CA1208645A (enExample) |
| CS (1) | CS240982B2 (enExample) |
| DD (1) | DD213216A5 (enExample) |
| DE (1) | DE3362566D1 (enExample) |
| DK (1) | DK562783A (enExample) |
| ES (1) | ES8406436A1 (enExample) |
| FI (1) | FI76320C (enExample) |
| FR (1) | FR2537133A1 (enExample) |
| GR (1) | GR72855B (enExample) |
| HU (1) | HU191903B (enExample) |
| IE (1) | IE56453B1 (enExample) |
| IL (1) | IL70396A (enExample) |
| MA (1) | MA19966A1 (enExample) |
| NO (1) | NO158218C (enExample) |
| NZ (1) | NZ206498A (enExample) |
| PL (1) | PL141385B1 (enExample) |
| PT (1) | PT77774B (enExample) |
| SU (1) | SU1240359A3 (enExample) |
| ZA (1) | ZA839070B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK93087A (da) * | 1986-02-27 | 1987-08-28 | Duphar Int Res | Hidtil ukendte aryl substituerede (n-piperidinyl)methyl- og (n-piperazinyl)methylazoler med antipsykotiske egenskaber |
| ES2076253T3 (es) * | 1989-05-19 | 1995-11-01 | Hoechst Roussel Pharma | N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos. |
| US5066663A (en) * | 1990-05-21 | 1991-11-19 | Warner-Lambert Company | Substituted-hetero-cyclopentanones and cyclopentenones and derivatives thereof acting at muscarinic receptors |
| DE19540027A1 (de) * | 1995-10-27 | 1997-04-30 | Gruenenthal Gmbh | Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe |
| US6897213B1 (en) | 1995-11-21 | 2005-05-24 | Warner-Lambert Company | Heterocycles as cholecystokinin (CCK) ligands |
| US5969138A (en) * | 1996-11-01 | 1999-10-19 | Mitsui Chemicals, Inc. | Pyrrolidinone derivatives |
| DE69829875T2 (de) * | 1997-10-14 | 2006-03-09 | Mitsubishi Pharma Corp. | Piperazin-verbindungen und ihre medizinische verwendung |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247549A (en) * | 1978-12-27 | 1981-01-27 | Ici Americas Inc. | Piperazine-1-carboxylic acid esters possessing antidepressant or analgesic activity |
-
1982
- 1982-12-07 FR FR8220492A patent/FR2537133A1/fr active Granted
-
1983
- 1983-12-02 CS CS839041A patent/CS240982B2/cs unknown
- 1983-12-05 GR GR73154A patent/GR72855B/el unknown
- 1983-12-05 DD DD83257518A patent/DD213216A5/de unknown
- 1983-12-05 FI FI834453A patent/FI76320C/fi not_active IP Right Cessation
- 1983-12-05 PL PL1983244921A patent/PL141385B1/pl unknown
- 1983-12-06 US US06/558,775 patent/US4547504A/en not_active Expired - Fee Related
- 1983-12-06 MA MA20187A patent/MA19966A1/fr unknown
- 1983-12-06 DE DE8383402354T patent/DE3362566D1/de not_active Expired
- 1983-12-06 IE IE2867/83A patent/IE56453B1/xx unknown
- 1983-12-06 NZ NZ206498A patent/NZ206498A/en unknown
- 1983-12-06 DK DK562783A patent/DK562783A/da not_active Application Discontinuation
- 1983-12-06 HU HU834166A patent/HU191903B/hu unknown
- 1983-12-06 AU AU22108/83A patent/AU560075B2/en not_active Ceased
- 1983-12-06 AT AT83402354T patent/ATE18548T1/de not_active IP Right Cessation
- 1983-12-06 SU SU833673511A patent/SU1240359A3/ru active
- 1983-12-06 JP JP58229251A patent/JPS59110670A/ja active Pending
- 1983-12-06 IL IL70396A patent/IL70396A/xx not_active IP Right Cessation
- 1983-12-06 PT PT77774A patent/PT77774B/pt unknown
- 1983-12-06 ZA ZA839070A patent/ZA839070B/xx unknown
- 1983-12-06 EP EP83402354A patent/EP0110795B1/fr not_active Expired
- 1983-12-06 CA CA000442681A patent/CA1208645A/fr not_active Expired
- 1983-12-06 NO NO834481A patent/NO158218C/no unknown
- 1983-12-07 ES ES527897A patent/ES8406436A1/es not_active Expired
- 1983-12-07 BG BG063371A patent/BG40808A3/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247549A (en) * | 1978-12-27 | 1981-01-27 | Ici Americas Inc. | Piperazine-1-carboxylic acid esters possessing antidepressant or analgesic activity |
Non-Patent Citations (1)
| Title |
|---|
| CHEMICAL ABSTRACTS, vol. 94, no. 4, 26 janvier 1981, page 570, no. 30707u, Columbus, Ohio, USA * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |