FR2499569A1 - Nouveaux derives de 1-benzyl- 4-(4-(2-pyrimidinylamino)benzyl)-2,3- dioxopiperazines, leurs sels, un procede de preparation de ces derives et sels et un agent carcinostatique les contenant - Google Patents

Nouveaux derives de 1-benzyl- 4-(4-(2-pyrimidinylamino)benzyl)-2,3- dioxopiperazines, leurs sels, un procede de preparation de ces derives et sels et un agent carcinostatique les contenant Download PDF

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Publication number
FR2499569A1
FR2499569A1 FR8201925A FR8201925A FR2499569A1 FR 2499569 A1 FR2499569 A1 FR 2499569A1 FR 8201925 A FR8201925 A FR 8201925A FR 8201925 A FR8201925 A FR 8201925A FR 2499569 A1 FR2499569 A1 FR 2499569A1
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FR
France
Prior art keywords
benzyl
compound
formula
radical
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8201925A
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English (en)
French (fr)
Other versions
FR2499569B1 (no
Inventor
T Hori
C Yoshida
Y Kiba
R Takeno
J Nakano
J Nitta
S Kishimoto
S Murakami
H Tsuda
I Saikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
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Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of FR2499569A1 publication Critical patent/FR2499569A1/fr
Application granted granted Critical
Publication of FR2499569B1 publication Critical patent/FR2499569B1/fr
Granted legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8201925A 1981-02-06 1982-02-05 Nouveaux derives de 1-benzyl- 4-(4-(2-pyrimidinylamino)benzyl)-2,3- dioxopiperazines, leurs sels, un procede de preparation de ces derives et sels et un agent carcinostatique les contenant Granted FR2499569A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56015837A JPS57140783A (en) 1981-02-06 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Publications (2)

Publication Number Publication Date
FR2499569A1 true FR2499569A1 (fr) 1982-08-13
FR2499569B1 FR2499569B1 (no) 1985-02-22

Family

ID=11899943

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8201925A Granted FR2499569A1 (fr) 1981-02-06 1982-02-05 Nouveaux derives de 1-benzyl- 4-(4-(2-pyrimidinylamino)benzyl)-2,3- dioxopiperazines, leurs sels, un procede de preparation de ces derives et sels et un agent carcinostatique les contenant

Country Status (12)

Country Link
JP (1) JPS57140783A (no)
KR (1) KR880001105B1 (no)
AU (1) AU537512B2 (no)
BE (1) BE892032A (no)
CH (1) CH651036A5 (no)
DE (1) DE3204074A1 (no)
ES (2) ES8304970A1 (no)
FR (1) FR2499569A1 (no)
GB (1) GB2094296B (no)
IT (1) IT1154274B (no)
NL (1) NL8200451A (no)
SE (1) SE449101B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1244542C (zh) * 1996-12-24 2006-03-08 中外制药株式会社 具有nos抑制作用的芳香族胺衍生物
TWI803615B (zh) * 2018-04-11 2023-06-01 日商三菱瓦斯化學股份有限公司 二氰基烷及雙(胺甲基)烷之製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2461705A1 (fr) * 1979-07-24 1981-02-06 Toyama Chemical Co Ltd Nouveaux derives de 1-(4-aminobenzyl)-2,3-dioxopiperazine et leurs sels d'addition d'acides, a action carcinostatique, et procedes pour les preparer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2461705A1 (fr) * 1979-07-24 1981-02-06 Toyama Chemical Co Ltd Nouveaux derives de 1-(4-aminobenzyl)-2,3-dioxopiperazine et leurs sels d'addition d'acides, a action carcinostatique, et procedes pour les preparer

Also Published As

Publication number Publication date
AU8024082A (en) 1982-08-12
JPS6366319B2 (no) 1988-12-20
GB2094296A (en) 1982-09-15
DE3204074C2 (no) 1987-12-23
AU537512B2 (en) 1984-06-28
ES8402285A1 (es) 1984-01-16
ES509391A0 (es) 1983-03-16
IT1154274B (it) 1987-01-21
ES518304A0 (es) 1984-01-16
FR2499569B1 (no) 1985-02-22
CH651036A5 (de) 1985-08-30
BE892032A (fr) 1982-08-05
ES8304970A1 (es) 1983-03-16
NL8200451A (nl) 1982-09-01
KR880001105B1 (ko) 1988-06-29
KR830009090A (ko) 1983-12-17
SE449101B (sv) 1987-04-06
JPS57140783A (en) 1982-08-31
IT8247729A0 (it) 1982-02-05
GB2094296B (en) 1985-02-13
SE8200679L (sv) 1982-09-22
DE3204074A1 (de) 1982-10-28

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