FR2470385A1 - Systeme, procede et appareil pour l'analyse automatique d'echantillons de fluide - Google Patents
Systeme, procede et appareil pour l'analyse automatique d'echantillons de fluide Download PDFInfo
- Publication number
- FR2470385A1 FR2470385A1 FR8023563A FR8023563A FR2470385A1 FR 2470385 A1 FR2470385 A1 FR 2470385A1 FR 8023563 A FR8023563 A FR 8023563A FR 8023563 A FR8023563 A FR 8023563A FR 2470385 A1 FR2470385 A1 FR 2470385A1
- Authority
- FR
- France
- Prior art keywords
- sample
- segments
- samples
- pipeline
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 46
- 238000004458 analytical method Methods 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 15
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 96
- 238000002347 injection Methods 0.000 claims abstract description 44
- 239000007924 injection Substances 0.000 claims abstract description 44
- 239000000126 substance Substances 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims description 8
- 239000003550 marker Substances 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 238000009736 wetting Methods 0.000 claims 3
- 230000007717 exclusion Effects 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001276 controlling effect Effects 0.000 claims 1
- 238000012545 processing Methods 0.000 abstract description 5
- 239000000523 sample Substances 0.000 description 103
- 238000011109 contamination Methods 0.000 description 14
- 230000015654 memory Effects 0.000 description 10
- 238000010586 diagram Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000005206 flow analysis Methods 0.000 description 2
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000190070 Sarracenia purpurea Species 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000003936 working memory Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/096,703 US4253846A (en) | 1979-11-21 | 1979-11-21 | Method and apparatus for automated analysis of fluid samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2470385A1 true FR2470385A1 (fr) | 1981-05-29 |
| FR2470385B1 FR2470385B1 (cg-RX-API-DMAC10.html) | 1985-04-26 |
Family
ID=22258669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8023563A Granted FR2470385A1 (fr) | 1979-11-21 | 1980-11-05 | Systeme, procede et appareil pour l'analyse automatique d'echantillons de fluide |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4253846A (cg-RX-API-DMAC10.html) |
| JP (1) | JPS56124052A (cg-RX-API-DMAC10.html) |
| AU (1) | AU529407B2 (cg-RX-API-DMAC10.html) |
| BE (1) | BE886132A (cg-RX-API-DMAC10.html) |
| CA (1) | CA1139125A (cg-RX-API-DMAC10.html) |
| CH (1) | CH654416A5 (cg-RX-API-DMAC10.html) |
| DE (1) | DE3042915A1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2470385A1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB2064114B (cg-RX-API-DMAC10.html) |
| IT (1) | IT1134355B (cg-RX-API-DMAC10.html) |
| NL (1) | NL8005809A (cg-RX-API-DMAC10.html) |
| SE (1) | SE465390B (cg-RX-API-DMAC10.html) |
Cited By (21)
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|---|---|---|---|---|
| US9017623B2 (en) | 2007-02-06 | 2015-04-28 | Raindance Technologies, Inc. | Manipulation of fluids and reactions in microfluidic systems |
| US9068699B2 (en) | 2007-04-19 | 2015-06-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US9328344B2 (en) | 2006-01-11 | 2016-05-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US10639597B2 (en) | 2006-05-11 | 2020-05-05 | Bio-Rad Laboratories, Inc. | Microfluidic devices |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| US11077415B2 (en) | 2011-02-11 | 2021-08-03 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| US11168353B2 (en) | 2011-02-18 | 2021-11-09 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US11174509B2 (en) | 2013-12-12 | 2021-11-16 | Bio-Rad Laboratories, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| US11187702B2 (en) | 2003-03-14 | 2021-11-30 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US11254968B2 (en) | 2010-02-12 | 2022-02-22 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US11390917B2 (en) | 2010-02-12 | 2022-07-19 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US11511242B2 (en) | 2008-07-18 | 2022-11-29 | Bio-Rad Laboratories, Inc. | Droplet libraries |
| US11635427B2 (en) | 2010-09-30 | 2023-04-25 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
| US11786872B2 (en) | 2004-10-08 | 2023-10-17 | United Kingdom Research And Innovation | Vitro evolution in microfluidic systems |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US11898193B2 (en) | 2011-07-20 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Manipulating droplet size |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US12352673B2 (en) | 2009-03-23 | 2025-07-08 | Bio-Rad Laboratories, Inc. | Manipulation of microfluidic droplets |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS576338A (en) * | 1980-06-12 | 1982-01-13 | Kyoto Daiichi Kagaku:Kk | Method and device for measuring degree of flocculation of finely divided particles quantitatively |
| US4300906A (en) * | 1980-10-06 | 1981-11-17 | Technicon Instruments Corp. | Method for the operation of automated analysis apparatus |
| GB2097692B (en) * | 1981-01-10 | 1985-05-22 | Shaw Stewart P D | Combining chemical reagents |
| US4399362A (en) * | 1981-02-27 | 1983-08-16 | Instrumentation Laboratory Inc. | Liquid handling apparatus |
| AT377366B (de) * | 1981-05-25 | 1985-03-11 | List Hans | Analysengeraet, insbesondere zur untersuchung von fluessigkeitsproben |
| US4429584A (en) | 1981-12-01 | 1984-02-07 | The Upjohn Company | Microprocessor controllable automatic sampler |
| JPS58154662A (ja) * | 1982-03-10 | 1983-09-14 | Hitachi Ltd | 前処理機能を備えた自動分析装置 |
| US4526754A (en) * | 1982-07-30 | 1985-07-02 | Technicon Instruments Corporation | Sample transport system |
| US4467565A (en) * | 1982-08-02 | 1984-08-28 | Chicago Pneumatic Tool Company | Rotary and orbital sander |
| CA1238900A (en) * | 1982-11-15 | 1988-07-05 | Stephen Saros | Single channel continuous slug flow mixing of discrete fluid components |
| US4853336A (en) * | 1982-11-15 | 1989-08-01 | Technicon Instruments Corporation | Single channel continuous flow system |
| US4517302A (en) * | 1982-11-15 | 1985-05-14 | Technicon Instruments Corporation | Continuous flow metering apparatus |
| DE3503980C2 (de) * | 1985-02-06 | 1987-01-02 | Bernd Dr.med. 8900 Augsburg Schottdorf | Verfahren und Vorrichtung zum automatischen Analysieren von Fluidproben im Durchfluß |
| AU582641B2 (en) * | 1985-04-11 | 1989-04-06 | Technicon Instruments Corportion | Minimum carryover container, and analysis system incorporating the same |
| US5192504A (en) * | 1985-04-11 | 1993-03-09 | Technicon Instruments Corporation | Flushable low carryover container |
| US4865993A (en) * | 1985-04-11 | 1989-09-12 | Technicon Instruments Corporation | Minimum carryover container, and analysis system incorporating the same |
| US4669756A (en) * | 1985-05-20 | 1987-06-02 | Technicon Instruments Corporation | Zero dead volume connector |
| DK228686A (da) * | 1985-05-21 | 1986-11-22 | Technicon Instr | Kopformet apparat indeholdende mindst to ublandbare vaesker, til selektiv vaesketilfoersel til et analyseringsinstrument |
| US4798803A (en) * | 1985-07-10 | 1989-01-17 | The Dow Chemical Company | Method for titration flow injection analysis |
| US4873633A (en) * | 1985-10-18 | 1989-10-10 | Cetus Corporation | User controlled off-center light absorbance reading adjuster in a liquid handling and reaction system |
| US4935346A (en) * | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
| US4971912A (en) * | 1987-07-14 | 1990-11-20 | Technicon Instruments Corporation | Apparatus and method for the separation of immiscible liquids |
| US5149658A (en) * | 1987-07-14 | 1992-09-22 | Technicon Instruments Corporation | Method for the separation and/or formation of immiscible liquid streams |
| US4826770A (en) * | 1987-09-24 | 1989-05-02 | General Electric Company | Carbon dioxide monitoring of composites |
| US5073500A (en) * | 1988-01-08 | 1991-12-17 | Inax Corporation | Method and apparatus for detecting urinary constituents |
| AU3182289A (en) * | 1988-02-10 | 1989-09-22 | Nygene Corporation | Process for producing biochemicals |
| CA1328359C (en) * | 1989-03-27 | 1994-04-12 | Michael D. Mintz | Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling |
| DE3931971C2 (de) * | 1989-09-25 | 1994-09-22 | Knapp Guenter Univ Prof Dipl I | Vorrichtung zur Aufbereitung von flüssigen Analysenproben |
| US5591644A (en) * | 1990-05-11 | 1997-01-07 | Albert Einstein College Of Medicine Of Yeshiva University | Sensitive on line assay of chromatographic effluent |
| US5094961A (en) * | 1990-12-13 | 1992-03-10 | Coulter Corporation | Aspiration method for hematology analyzing apparatus |
| US5399497A (en) * | 1992-02-26 | 1995-03-21 | Miles, Inc. | Capsule chemistry sample liquid analysis system and method |
| US5268147A (en) * | 1992-02-26 | 1993-12-07 | Miles, Inc. | Reversible direction capsule chemistry sample liquid analysis system and method |
| CA2125546A1 (en) * | 1993-08-13 | 1995-02-14 | David Kleinschmitt | Method and apparatus for discriminating between liquids and gases |
| DE4411266C2 (de) * | 1994-03-31 | 2001-05-17 | Danfoss As | Analyseverfahren und Analysevorrichtung |
| FR2719902B1 (fr) * | 1994-05-11 | 1996-07-05 | Pasteur Sanofi Diagnostics | Système d'analyse optique d'un échantillon de mélange réactionnel. |
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| AU785424B2 (en) * | 2000-07-26 | 2007-05-17 | Regents Of The University Of California, The | Manipulation of live cells and inorganic objects with optical micro beam arrays |
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Also Published As
| Publication number | Publication date |
|---|---|
| AU6415380A (en) | 1981-05-28 |
| FR2470385B1 (cg-RX-API-DMAC10.html) | 1985-04-26 |
| BE886132A (fr) | 1981-05-13 |
| IT8026089A0 (it) | 1980-11-19 |
| JPH0230471B2 (cg-RX-API-DMAC10.html) | 1990-07-06 |
| CH654416A5 (de) | 1986-02-14 |
| CA1139125A (en) | 1983-01-11 |
| US4253846A (en) | 1981-03-03 |
| DE3042915A1 (de) | 1981-09-03 |
| IT1134355B (it) | 1986-08-13 |
| SE465390B (sv) | 1991-09-02 |
| JPS56124052A (en) | 1981-09-29 |
| NL8005809A (nl) | 1981-06-16 |
| GB2064114B (en) | 1983-06-29 |
| GB2064114A (en) | 1981-06-10 |
| AU529407B2 (en) | 1983-06-02 |
| SE8007044L (sv) | 1981-05-22 |
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