FR2455052A1 - Procede pour la preparation de bis-indole-alcaloides et de leurs sels acides d'addition, nouveaux bis-indole-alcaloides ainsi obtenus et compositions pharmaceutiques renfermant ces produits - Google Patents
Procede pour la preparation de bis-indole-alcaloides et de leurs sels acides d'addition, nouveaux bis-indole-alcaloides ainsi obtenus et compositions pharmaceutiques renfermant ces produitsInfo
- Publication number
- FR2455052A1 FR2455052A1 FR8009037A FR8009037A FR2455052A1 FR 2455052 A1 FR2455052 A1 FR 2455052A1 FR 8009037 A FR8009037 A FR 8009037A FR 8009037 A FR8009037 A FR 8009037A FR 2455052 A1 FR2455052 A1 FR 2455052A1
- Authority
- FR
- France
- Prior art keywords
- alkaloids
- indole
- bis
- acid addition
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROCEDE POUR LA PREPARATION DE BIS-INDOLE-ALCALOIDES ET DE LEURS SELS ACIDES D'ADDITION, NOUVEAUX BIS-INDOLE-ALCALOIDES AINSI OBTENUS ET COMPOSITIONS PHARMACEUTIQUES RENFERMANT CES PRODUITS. LA PRESENTE INVENTION DECRIT UN PROCEDE D'OXYDATION DE LA VINBLASTINE, DE LA LEUROSINE OU D'UN SEL ACIDE D'ADDITION DE CES COMPOSES, CONSISTANT A FAIRE REAGIR CES PRODUITS AVEC L'ACIDE CHROMIQUE OU UN BICHROMATE DE METAL ALCALIN A UNE TEMPERATURE DE -30C A -90C EN PRESENCE D'UN SOLVANT ORGANIQUE NON MISCIBLE AVEC L'EAU DANS LEQUEL LES ALCALOIDES SONT FACILEMENT SOLUBLES, D'ANHYDRIDE ACETIQUE ET EVENTUELLEMENT D'ACIDE ACETIQUE ET GLACIAL ETOU D'UN VOLUME D'ETHANOL ALLANT JUSQU'A 10 PAR RAPPORT AU VOLUME DU SOLVANT ORGANIQUE NON MISCIBLE AVEC L'EAU; A REGLER LE PH DU MELANGE REACTIONNEL A 8 A 10 ET A ISOLER LES PRODUITS OBTENUS ETOU A LES SOUMETTRE A UN TRAITEMENT ULTERIEUR. UTILISATION DES COMPOSES OBTENUS COMME INGREDIENTS ACTIFS DE COMPOSITIONS PHARMACEUTIQUES COMME AGENTS ANTITUMEURS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU79RI708A HU178706B (en) | 1979-04-23 | 1979-04-23 | Process for preparing bis-indole alkaloids and acid addition salts thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2455052A1 true FR2455052A1 (fr) | 1980-11-21 |
FR2455052B1 FR2455052B1 (fr) | 1983-10-28 |
Family
ID=11001093
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8009037A Granted FR2455052A1 (fr) | 1979-04-23 | 1980-04-22 | Procede pour la preparation de bis-indole-alcaloides et de leurs sels acides d'addition, nouveaux bis-indole-alcaloides ainsi obtenus et compositions pharmaceutiques renfermant ces produits |
FR8023400A Expired FR2464268B1 (fr) | 1979-04-23 | 1980-10-31 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8023400A Expired FR2464268B1 (fr) | 1979-04-23 | 1980-10-31 |
Country Status (11)
Country | Link |
---|---|
US (2) | US4298525A (fr) |
EP (1) | EP0018231B1 (fr) |
JP (1) | JPS565489A (fr) |
AT (1) | ATE4215T1 (fr) |
CA (1) | CA1142922A (fr) |
DE (1) | DE3064210D1 (fr) |
ES (1) | ES490758A0 (fr) |
FR (2) | FR2455052A1 (fr) |
GB (1) | GB2049677B (fr) |
HU (1) | HU178706B (fr) |
SU (1) | SU980627A3 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2492384A1 (fr) * | 1980-10-22 | 1982-04-23 | Richter Gedeon Vegyeszet | Procede de preparation de nouveaux composes cytostatiques et compositions pharmaceutiques les contenant |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU183385B (en) * | 1980-04-02 | 1984-04-28 | Lilly Co Eli | Process for preparing vinca dimer derivatives |
US4303584A (en) * | 1980-04-02 | 1981-12-01 | Eli Lilly And Company | Method of preparing vincristine |
HU181746B (en) * | 1980-10-22 | 1983-11-28 | Richter Gedeon Vegyeszet | Process for preparing vinblastine and leurosidine derivatives |
US4375432A (en) * | 1981-05-12 | 1983-03-01 | Eli Lilly And Company | Method of preparing vincristine |
JPS587510U (ja) * | 1981-07-09 | 1983-01-18 | 日本ポリセロ工業株式会社 | 播種機 |
LU84640A1 (fr) * | 1983-02-10 | 1984-11-08 | Onmichem S A | Nouveau procede d'obtention de la vincristine et du sulfate de vincristine |
US4619935A (en) * | 1983-03-17 | 1986-10-28 | Eli Lilly And Company | Stable oncolytic formulations |
JPS615706A (ja) * | 1984-06-19 | 1986-01-11 | 株式会社新潟鐵工所 | 種蒔装置 |
HU193318B (en) * | 1985-06-12 | 1987-09-28 | Richter Gedeon Vegyeszet | Process for producing new bis- indol derivatives |
HU198074B (en) * | 1985-06-12 | 1989-07-28 | Richter Gedeon Vegyeszet | Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds |
JPH0618410Y2 (ja) * | 1988-04-27 | 1994-05-18 | トピー工業株式会社 | 播種装置 |
CN103965219A (zh) * | 2014-05-14 | 2014-08-06 | 湖北宏中药业有限公司 | 长春新碱及硫酸长春新碱的合成方法 |
CN107880064A (zh) * | 2017-10-09 | 2018-04-06 | 广州普星药业有限公司 | 一种半合成硫酸长春新碱的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3097137A (en) * | 1960-05-19 | 1963-07-09 | Canadian Patents Dev | Vincaleukoblastine |
US3205220A (en) * | 1961-10-26 | 1965-09-07 | Lilly Co Eli | Leurosidine and leurocristine and their production |
US3392173A (en) * | 1964-03-09 | 1968-07-09 | Lilly Co Eli | Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation |
US3370057A (en) * | 1964-04-27 | 1968-02-20 | Lilly Co Eli | Leurosine |
US3354163A (en) * | 1966-12-15 | 1967-11-21 | Eli Lillty And Company | Nu-desmethylvinblastine |
US3899493A (en) * | 1972-12-29 | 1975-08-12 | Richter Gedeon Vegyeszet | Chromic acid oxidation of vinblastine sulfate to form vincristine |
HU165986B (fr) * | 1973-02-16 | 1974-12-28 | ||
US4110330A (en) * | 1977-05-27 | 1978-08-29 | Eli Lilly And Company | 5'-Acetonylvincristine and related compounds |
-
1979
- 1979-04-23 HU HU79RI708A patent/HU178706B/hu not_active IP Right Cessation
- 1979-07-27 US US06/061,353 patent/US4298525A/en not_active Expired - Lifetime
-
1980
- 1980-03-06 SU SU802891907A patent/SU980627A3/ru active
- 1980-03-11 JP JP2985280A patent/JPS565489A/ja active Granted
- 1980-04-08 US US06/138,340 patent/US4310528A/en not_active Expired - Lifetime
- 1980-04-22 ES ES80490758A patent/ES490758A0/es active Granted
- 1980-04-22 CA CA000350361A patent/CA1142922A/fr not_active Expired
- 1980-04-22 GB GB8013175A patent/GB2049677B/en not_active Expired
- 1980-04-22 EP EP80301290A patent/EP0018231B1/fr not_active Expired
- 1980-04-22 FR FR8009037A patent/FR2455052A1/fr active Granted
- 1980-04-22 AT AT80301290T patent/ATE4215T1/de not_active IP Right Cessation
- 1980-04-22 DE DE8080301290T patent/DE3064210D1/de not_active Expired
- 1980-10-31 FR FR8023400A patent/FR2464268B1/fr not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2492384A1 (fr) * | 1980-10-22 | 1982-04-23 | Richter Gedeon Vegyeszet | Procede de preparation de nouveaux composes cytostatiques et compositions pharmaceutiques les contenant |
Also Published As
Publication number | Publication date |
---|---|
FR2464268B1 (fr) | 1983-11-04 |
HU178706B (en) | 1982-06-28 |
JPS565489A (en) | 1981-01-20 |
FR2455052B1 (fr) | 1983-10-28 |
EP0018231B1 (fr) | 1983-07-20 |
ES8105008A1 (es) | 1981-05-16 |
CA1142922A (fr) | 1983-03-15 |
EP0018231A2 (fr) | 1980-10-29 |
FR2464268A1 (fr) | 1981-03-06 |
JPS6332797B2 (fr) | 1988-07-01 |
GB2049677A (en) | 1980-12-31 |
GB2049677B (en) | 1983-06-15 |
US4298525A (en) | 1981-11-03 |
US4310528A (en) | 1982-01-12 |
ES490758A0 (es) | 1981-05-16 |
ATE4215T1 (de) | 1983-08-15 |
DE3064210D1 (en) | 1983-08-25 |
SU980627A3 (ru) | 1982-12-07 |
EP0018231A3 (en) | 1981-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |