FR2454809A1 - Procede de production d'un activateur de plasminogene - Google Patents

Procede de production d'un activateur de plasminogene

Info

Publication number
FR2454809A1
FR2454809A1 FR8009443A FR8009443A FR2454809A1 FR 2454809 A1 FR2454809 A1 FR 2454809A1 FR 8009443 A FR8009443 A FR 8009443A FR 8009443 A FR8009443 A FR 8009443A FR 2454809 A1 FR2454809 A1 FR 2454809A1
Authority
FR
France
Prior art keywords
plasminogen activator
producing
solution
concentration
source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8009443A
Other languages
English (en)
Other versions
FR2454809B1 (fr
Inventor
Sadayuki Horiguchi
Akio Hasagawa
Mitsuru Shibukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5081979A external-priority patent/JPS55144887A/ja
Priority claimed from JP13154379A external-priority patent/JPS5655395A/ja
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Publication of FR2454809A1 publication Critical patent/FR2454809A1/fr
Application granted granted Critical
Publication of FR2454809B1 publication Critical patent/FR2454809B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/818—Aeration or oxygen transfer technique

Abstract

L'INVENTION CONCERNE UN PROCEDE DE PRODUCTION D'UN ACTIVATEUR DU PLASMINOGENE AYANT UN POIDS MOLECULAIRE DE L'ORDRE DE 45000 A 68000. SELON L'INVENTION, ON MET EN CONTACT UNE SOLUTION CONTENANT UNE SOURCE DE CARBONE ET UNE SOURCE D'AZOTE AVEC DES CELLULES DERIVEES DE REINS OU POUMONS HUMAINS ET AYANT LA CAPACITE DE PRODUIRE UN ACTIVATEUR DU PLASMINOGENE, TOUT EN MAINTENANT LE PH DE LA SOLUTION A ENVIRON 6 A 9 ET LA CONCENTRATION EN OXYGENE DISSOUS A AU MOINS 30 DE LA CONCENTRATION A LA SATURATION; ET ON SEPARE L'ACTIVATEUR RESULTANT DE LA SOLUTION TOUT EN MAINTENANT LE PH A ENVIRON 4 A 12; LE DESSIN JOINT MONTRE UN MOTIF DE DISTRIBUTION DE FILTRATION SUR GEL D'UN ACTIVATEUR DE PLASMINOGENE FORME EN UTILISANT DES CELLULES DE REINS. L'INVENTION S'APPLIQUE NOTAMMENT A L'INDUSTRIE CHIMIQUE.
FR8009443A 1979-04-26 1980-04-25 Procede de production d'un activateur de plasminogene Granted FR2454809A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5081979A JPS55144887A (en) 1979-04-26 1979-04-26 Preparation of physiologically active substance
JP13154379A JPS5655395A (en) 1979-10-12 1979-10-12 Preparation of physiologically active substance

Publications (2)

Publication Number Publication Date
FR2454809A1 true FR2454809A1 (fr) 1980-11-21
FR2454809B1 FR2454809B1 (fr) 1983-04-29

Family

ID=26391291

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8009443A Granted FR2454809A1 (fr) 1979-04-26 1980-04-25 Procede de production d'un activateur de plasminogene

Country Status (4)

Country Link
US (1) US4317882A (fr)
DE (1) DE3015699C2 (fr)
FR (1) FR2454809A1 (fr)
GB (1) GB2051075B (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100982A2 (fr) * 1982-08-02 1984-02-22 Asahi Kasei Kogyo Kabushiki Kaisha Activateur de plasminogène purifié, procédé de préparation et composition thrombolytique le contenant
WO1984001786A1 (fr) * 1982-10-28 1984-05-10 Beecham Group Plc Derives d'enzymes et leur utilisation dans le traitement de la thrombose
FR2548211A1 (fr) * 1983-06-29 1985-01-04 Choay Sa Procede de production d'un activateur tissulaire du plasminogene et activateur obtenu par ce procede
EP0208785A1 (fr) * 1985-01-14 1987-01-21 Shiseido Company Limited Complexe d'urokinase fibrinophile et procede de preparation
EP0236289A2 (fr) * 1986-02-26 1987-09-09 Monsanto Company Activateur tissulaire du plasminogène isolé des cellules humaines normales du colon
EP0241448A2 (fr) * 1986-04-09 1987-10-14 Monsanto Company Production de l'activateur du plasminogène à partir des cellules humaines normales du côlon
WO1988000615A1 (fr) * 1986-07-16 1988-01-28 Celltech Limited Procede de purification d'un activateur de plasminogene
US4853330A (en) * 1983-04-07 1989-08-01 Genentech, Inc. Human tissue plasminogen activator
EP0163751B1 (fr) * 1984-06-05 1989-09-20 Asahi Kasei Kogyo Kabushiki Kaisha Procédé de préparation d'un activateur de plasminogène
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
US5587159A (en) * 1982-05-05 1996-12-24 Genentech, Inc. Human tissue plasminogen activator

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2121050B (en) * 1979-07-05 1986-03-26 Genentech Inc Preparation of functional human urokinase proteins
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
ZA831399B (en) * 1982-03-05 1984-02-29 Health Lab Service Board New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them
US5112755A (en) * 1982-04-15 1992-05-12 Genentech, Inc. Preparation of functional human urokinase proteins
SU1662352A3 (ru) * 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US5011795A (en) 1983-01-19 1991-04-30 Genentech, Inc. Human tPA production using vectors coding for DHFR protein
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
JPS60158115A (ja) * 1984-01-30 1985-08-19 Meiji Milk Prod Co Ltd プラズミノーゲンアクチベーターの製造法
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
US4550080A (en) * 1984-06-05 1985-10-29 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
US4661453A (en) * 1984-06-19 1987-04-28 American Biogenetic Sciences, Inc. Production of tissue plasminogen activator factor
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
IL78937A (en) * 1985-05-28 1990-11-29 Wellcome Found Pharmaceutical compositions containing tissue-plasminogen activator
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
US4788144A (en) * 1985-06-28 1988-11-29 International Minerals & Chemical Corp. Fermentation process for the high level production of swine growth
US4762784A (en) * 1985-07-15 1988-08-09 International Minerals & Chemical Corp. Fermemtation process for the high level production of bovine growth hormone
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc A process for producing a biologically active tissue plasminogen activator
US4929560A (en) * 1988-02-03 1990-05-29 Damon Biotech, Inc. Recovery of tissue plasminogen activator
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
US7674384B2 (en) * 2003-07-18 2010-03-09 Bj Services Company Method of reclaiming brine solutions using an organic chelant
US7144512B2 (en) * 2003-07-18 2006-12-05 Bj Services Company Method of reclaiming brine solutions using an organic chelant
US7678281B2 (en) * 2003-07-18 2010-03-16 Bj Services Company Method of reclaiming brine solutions using an organic chelant
CN111760556B (zh) * 2020-07-09 2023-06-30 江苏尤里卡生物科技有限公司 一种尿激酶吸附剂及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3930944A (en) * 1975-03-31 1976-01-06 Abbott Laboratories Urokinase production
FR2306263A1 (fr) * 1975-03-31 1976-10-29 Abbott Lab Procede ameliore pour produire de l'urokinase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2128744C3 (de) * 1971-06-09 1979-03-29 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Verfahren zur Massenkultivation von Zellen und Geweben

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3930944A (en) * 1975-03-31 1976-01-06 Abbott Laboratories Urokinase production
FR2306263A1 (fr) * 1975-03-31 1976-10-29 Abbott Lab Procede ameliore pour produire de l'urokinase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1978 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728566A (en) * 1982-05-05 1998-03-17 Genentech, Inc. Tissue plasminogen activator derivatives
US6284247B1 (en) 1982-05-05 2001-09-04 Genentech, Inc. Human tissue plasminogen activators
US6274335B1 (en) 1982-05-05 2001-08-14 Genentech, Inc. Method of treatment using recombinant human tissue plasminogen activator
US5869314A (en) * 1982-05-05 1999-02-09 Genentech, Inc. Tissue plasminogen activators and derivatives thereof as produced by recombinant means
US5753486A (en) * 1982-05-05 1998-05-19 Genentech, Inc. Human tissue plasminogen activator
US5728565A (en) * 1982-05-05 1998-03-17 Genentech, Inc. Methods of preparing tissue plasminogen activator derivatives
US5702938A (en) * 1982-05-05 1997-12-30 Genetech, Inc. Human tissue plasminogen activator
US5587159A (en) * 1982-05-05 1996-12-24 Genentech, Inc. Human tissue plasminogen activator
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
EP0100982A3 (en) * 1982-08-02 1984-07-25 Asahi Kasei Kogyo Kabushiki Kaisha Novel purified plasminogen activator, process for its production and thrombolytic composition containing it
EP0100982A2 (fr) * 1982-08-02 1984-02-22 Asahi Kasei Kogyo Kabushiki Kaisha Activateur de plasminogène purifié, procédé de préparation et composition thrombolytique le contenant
WO1984001786A1 (fr) * 1982-10-28 1984-05-10 Beecham Group Plc Derives d'enzymes et leur utilisation dans le traitement de la thrombose
US4853330A (en) * 1983-04-07 1989-08-01 Genentech, Inc. Human tissue plasminogen activator
EP0133070A3 (fr) * 1983-06-29 1987-02-04 Choay S.A. Procédé de production d'un activateur tissulaire du plasminogène et activateur obtenu par ce procédé
EP0133070A2 (fr) * 1983-06-29 1985-02-13 Choay S.A. Procédé de production d'un activateur tissulaire du plasminogène et activateur obtenu par ce procédé
FR2548211A1 (fr) * 1983-06-29 1985-01-04 Choay Sa Procede de production d'un activateur tissulaire du plasminogene et activateur obtenu par ce procede
EP0163751B1 (fr) * 1984-06-05 1989-09-20 Asahi Kasei Kogyo Kabushiki Kaisha Procédé de préparation d'un activateur de plasminogène
EP0208785A4 (fr) * 1985-01-14 1988-06-16 Terumo Corp Complexe d'urokinase fibrinophile et procede de preparation.
EP0208785A1 (fr) * 1985-01-14 1987-01-21 Shiseido Company Limited Complexe d'urokinase fibrinophile et procede de preparation
EP0236289A3 (fr) * 1986-02-26 1988-12-07 Monsanto Company Activateur tissulaire du plasminogène isolé des cellules humaines normales du colon
EP0236289A2 (fr) * 1986-02-26 1987-09-09 Monsanto Company Activateur tissulaire du plasminogène isolé des cellules humaines normales du colon
EP0241448A3 (fr) * 1986-04-09 1988-01-07 Monsanto Company Production de l'activateur du plasminogène à partir des cellules humaines normales du côlon
EP0241448A2 (fr) * 1986-04-09 1987-10-14 Monsanto Company Production de l'activateur du plasminogène à partir des cellules humaines normales du côlon
WO1988000615A1 (fr) * 1986-07-16 1988-01-28 Celltech Limited Procede de purification d'un activateur de plasminogene

Also Published As

Publication number Publication date
FR2454809B1 (fr) 1983-04-29
DE3015699A1 (de) 1980-10-30
US4317882A (en) 1982-03-02
GB2051075B (en) 1983-03-09
GB2051075A (en) 1981-01-14
DE3015699C2 (de) 1982-07-15

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