FR2448533A1 - Nouveaux acides 1-(acylthio- et mercapto-1-oxoalkyl)-1,2,3,4-tetrahydroquinoleine-2-carboxyliques et leurs sels, utiles notamment comme hypotenseurs - Google Patents

Nouveaux acides 1-(acylthio- et mercapto-1-oxoalkyl)-1,2,3,4-tetrahydroquinoleine-2-carboxyliques et leurs sels, utiles notamment comme hypotenseurs

Info

Publication number
FR2448533A1
FR2448533A1 FR8002592A FR8002592A FR2448533A1 FR 2448533 A1 FR2448533 A1 FR 2448533A1 FR 8002592 A FR8002592 A FR 8002592A FR 8002592 A FR8002592 A FR 8002592A FR 2448533 A1 FR2448533 A1 FR 2448533A1
Authority
FR
France
Prior art keywords
salts
hydrogen
tetrahydroquinoleine
hydropensors
carboxyliques
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8002592A
Other languages
English (en)
French (fr)
Other versions
FR2448533B1 (US20020051482A1-20020502-M00012.png
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ATK Launch Systems LLC
Original Assignee
Morton Norwich Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton Norwich Products Inc filed Critical Morton Norwich Products Inc
Publication of FR2448533A1 publication Critical patent/FR2448533A1/fr
Application granted granted Critical
Publication of FR2448533B1 publication Critical patent/FR2448533B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FR8002592A 1979-02-07 1980-02-06 Nouveaux acides 1-(acylthio- et mercapto-1-oxoalkyl)-1,2,3,4-tetrahydroquinoleine-2-carboxyliques et leurs sels, utiles notamment comme hypotenseurs Granted FR2448533A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1016579A 1979-02-07 1979-02-07
US06/090,862 US4461896A (en) 1979-02-07 1979-11-02 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids

Publications (2)

Publication Number Publication Date
FR2448533A1 true FR2448533A1 (fr) 1980-09-05
FR2448533B1 FR2448533B1 (US20020051482A1-20020502-M00012.png) 1983-01-07

Family

ID=26680853

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8002592A Granted FR2448533A1 (fr) 1979-02-07 1980-02-06 Nouveaux acides 1-(acylthio- et mercapto-1-oxoalkyl)-1,2,3,4-tetrahydroquinoleine-2-carboxyliques et leurs sels, utiles notamment comme hypotenseurs

Country Status (16)

Country Link
US (1) US4461896A (US20020051482A1-20020502-M00012.png)
AU (1) AU527887B2 (US20020051482A1-20020502-M00012.png)
CH (1) CH645355A5 (US20020051482A1-20020502-M00012.png)
DE (1) DE3004370A1 (US20020051482A1-20020502-M00012.png)
DK (1) DK152209C (US20020051482A1-20020502-M00012.png)
ES (1) ES488313A0 (US20020051482A1-20020502-M00012.png)
FR (1) FR2448533A1 (US20020051482A1-20020502-M00012.png)
GB (1) GB2042535B (US20020051482A1-20020502-M00012.png)
GR (1) GR74103B (US20020051482A1-20020502-M00012.png)
IE (1) IE49350B1 (US20020051482A1-20020502-M00012.png)
IL (1) IL59089A (US20020051482A1-20020502-M00012.png)
IT (1) IT1145330B (US20020051482A1-20020502-M00012.png)
NL (1) NL8000641A (US20020051482A1-20020502-M00012.png)
NZ (1) NZ192613A (US20020051482A1-20020502-M00012.png)
PT (1) PT70793A (US20020051482A1-20020502-M00012.png)
SE (1) SE436031B (US20020051482A1-20020502-M00012.png)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029488A1 (de) * 1979-09-19 1981-06-03 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Bluthochdruck
EP0031741A1 (fr) * 1979-12-07 1981-07-08 SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE Nouveaux iminoacides substitués, leurs procédés de préparation et leur emploi comme inhibiteurs d'enzymes
EP0049605A1 (en) * 1980-10-03 1982-04-14 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same
EP0049658A1 (fr) * 1980-10-02 1982-04-14 Adir Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant
US4374246A (en) * 1981-06-18 1983-02-15 Norwich Eaton Pharmaceuticals, Inc. 1-N-[(1-Carboxy-3-phenylpropyl)glycyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds
EP0093805A1 (en) * 1981-02-17 1983-11-16 Warner-Lambert Company Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1H-isoindole-1-carboxylic acids and esters
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US5158959A (en) * 1980-08-30 1992-10-27 Hoechst Aktiengesellschaft Decahydroisoquinoline carboxylic acids
EP0595610A1 (en) * 1992-10-28 1994-05-04 E.R. Squibb & Sons, Inc. Benzo-fused lactams
WO1995001353A1 (en) * 1993-06-30 1995-01-12 Ciba-Geigy Ag Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ace

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
DE3044236A1 (de) * 1980-11-25 1982-06-16 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
US4599357A (en) * 1979-12-17 1986-07-08 Ciba-Geigy Corporation 1-mercaptoalkanoylindoline-2-carboxylic acids
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4390700A (en) 1980-11-10 1983-06-28 Ciba-Geigy Corporation 1-Carboxyazaalkanoyl-tetrahydroquinoline-2-carboxylic acids
US4401818A (en) 1980-12-24 1983-08-30 Ciba-Geigy Corporation 1-Carboxyalkanoyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
US5356890A (en) * 1988-06-15 1994-10-18 Brigham And Women's Hospital S-nitroso derivatives of ace inhibitors and the use thereof
US5025001A (en) * 1988-06-15 1991-06-18 Brigham And Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
US5187183A (en) * 1988-06-15 1993-02-16 Brigham & Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
GB9010394D0 (en) * 1990-05-09 1990-06-27 Ici Plc Heterocyclic compounds
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
US7803790B2 (en) * 2005-05-09 2010-09-28 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
US8916550B2 (en) * 2005-05-09 2014-12-23 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US9259535B2 (en) 2006-06-22 2016-02-16 Excelsior Medical Corporation Antiseptic cap equipped syringe
WO2008033564A1 (en) 2006-09-15 2008-03-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
WO2013009998A2 (en) 2011-07-12 2013-01-17 Pursuit Vascular, Inc. Device for delivery of antimicrobial agent into trans-dermal catheter
EP3137122B1 (en) 2014-05-02 2019-09-04 Excelsior Medical Corporation Strip package for antiseptic cap
WO2016182822A1 (en) 2015-05-08 2016-11-17 Icu Medical, Inc. Medical connectors configured to receive emitters of therapeutic agents
JP7005609B2 (ja) 2016-10-14 2022-02-10 アイシーユー・メディカル・インコーポレーテッド 医療用コネクタのための浄化キャップ
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
EP3883638A1 (en) 2018-11-21 2021-09-29 ICU Medical, Inc. Antimicrobial device comprising a cap with ring and insert
US11807621B2 (en) 2020-01-29 2023-11-07 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders
JP2024500319A (ja) 2020-12-07 2024-01-09 アイシーユー・メディカル・インコーポレーテッド 腹膜透析キャップ、システム、及び方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR837847A (fr) * 1937-05-13 1939-02-21 Ste Ind Chim Bale Agents auxiliaires pour l'impression
EP0001989A1 (en) * 1977-10-25 1979-05-30 Merck & Co. Inc. Substituted mercapto acid amides, process for their preparation, pharmaceutical composition containing same and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4104392A (en) * 1974-11-08 1978-08-01 Mitsubishi Chemical Industries Ltd. N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof, and antithrombotic compositions and methods employing them
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR837847A (fr) * 1937-05-13 1939-02-21 Ste Ind Chim Bale Agents auxiliaires pour l'impression
EP0001989A1 (en) * 1977-10-25 1979-05-30 Merck & Co. Inc. Substituted mercapto acid amides, process for their preparation, pharmaceutical composition containing same and their use

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029488A1 (de) * 1979-09-19 1981-06-03 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Bluthochdruck
EP0142739A3 (US20020051482A1-20020502-M00012.png) * 1979-09-19 1985-07-17 Hoechst Aktiengesellschaft
EP0142739A2 (de) * 1979-09-19 1985-05-29 Hoechst Aktiengesellschaft Aminosäurederivate und Verfahren zu ihrer Herstellung
EP0031741A1 (fr) * 1979-12-07 1981-07-08 SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE Nouveaux iminoacides substitués, leurs procédés de préparation et leur emploi comme inhibiteurs d'enzymes
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US5401766A (en) * 1980-08-30 1995-03-28 Hoechst Aktiengesellschaft Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof
US5158959A (en) * 1980-08-30 1992-10-27 Hoechst Aktiengesellschaft Decahydroisoquinoline carboxylic acids
EP0049658A1 (fr) * 1980-10-02 1982-04-14 Adir Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant
EP0096157A2 (en) * 1980-10-03 1983-12-21 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid
EP0096157A3 (en) * 1980-10-03 1984-09-12 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
EP0049605A1 (en) * 1980-10-03 1982-04-14 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same
EP0093805A1 (en) * 1981-02-17 1983-11-16 Warner-Lambert Company Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1H-isoindole-1-carboxylic acids and esters
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4374246A (en) * 1981-06-18 1983-02-15 Norwich Eaton Pharmaceuticals, Inc. 1-N-[(1-Carboxy-3-phenylpropyl)glycyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds
EP0595610A1 (en) * 1992-10-28 1994-05-04 E.R. Squibb & Sons, Inc. Benzo-fused lactams
WO1995001353A1 (en) * 1993-06-30 1995-01-12 Ciba-Geigy Ag Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ace
US5644055A (en) * 1993-06-30 1997-07-01 Ciba-Geigy Corporation Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ACE

Also Published As

Publication number Publication date
ES8102559A1 (es) 1981-01-16
ES488313A0 (es) 1981-01-16
NZ192613A (en) 1981-10-19
AU527887B2 (en) 1983-03-31
DK152209C (da) 1988-06-20
SE8000209L (sv) 1980-08-08
IT8047730A0 (it) 1980-01-28
IE800014L (en) 1980-08-07
GB2042535B (en) 1983-01-26
CH645355A5 (de) 1984-09-28
SE436031B (sv) 1984-11-05
IT1145330B (it) 1986-11-05
GR74103B (US20020051482A1-20020502-M00012.png) 1984-06-06
GB2042535A (en) 1980-09-24
FR2448533B1 (US20020051482A1-20020502-M00012.png) 1983-01-07
DE3004370C2 (US20020051482A1-20020502-M00012.png) 1989-10-26
AU5472780A (en) 1980-08-14
DE3004370A1 (de) 1980-08-14
DK51280A (da) 1980-08-08
IL59089A0 (en) 1980-05-30
IE49350B1 (en) 1985-09-18
IL59089A (en) 1982-08-31
US4461896A (en) 1984-07-24
NL8000641A (nl) 1980-08-11
PT70793A (en) 1980-03-01
DK152209B (da) 1988-02-08

Similar Documents

Publication Publication Date Title
FR2448533A1 (fr) Nouveaux acides 1-(acylthio- et mercapto-1-oxoalkyl)-1,2,3,4-tetrahydroquinoleine-2-carboxyliques et leurs sels, utiles notamment comme hypotenseurs
FR2456733A1 (fr) Nouveaux acides 2-(mercapto-1-oxo(alkyl inferieur))-1,2,3,4-tetrahydroisoquinoleine-3-carboxyliques, utiles notamment comme inhibiteurs de l'enzyme de conversion de l'angiotensine i
HUP9800462A2 (hu) Aril-szulfonil-amino-hidroxámsav-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
FR2452485A1 (fr) Nouveaux acides et esters 4-amino-3-quinoleinecarboxyliques, utiles notamment comme agents antisecretoires et anti-ulcere
FR2592048A1 (fr) Inhibiteurs d'ureido-renine, a action therapeutique
HUP9902092A2 (hu) Metalloproteináz gátló benzolszulfonamidszármazékok, intermedierjeik, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények
ES8800958A1 (es) Un procedimiento para preparar nuevos dipeptidos con actividad inhibidora de renina.
FR2391723A1 (fr) Composition therapeutique a base de cetone aliphatique pour le traitement des ulceres peptiques
IL77717A (en) Pharmaceutical compositions containing derivatives of imidazole,their preparation and some novel compounds of this type
GB1438265A (US20020051482A1-20020502-M00012.png)
FR2450820A1 (fr) Nouveaux derives d'acides 1- (o-mercaptoacyl) -4,5-dihydropyrazole-5-carboxyliques, utiles notamment comme agents hypotenseurs, et leur procede de preparation
ATE41772T1 (de) Polymethoxybenzyl-piperazin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen.
ATE26273T1 (de) 3-indolcarboxamid-verbindungen.
ATE13765T1 (de) 2-(1,4-benzodioxan-2-ylalkyl)-imidazole, deren herstellung und sie enthaltende pharmazeutische mittel.
ES2080726T3 (es) Compuestos aromaticos o heteroaromaticos nitrosustituidos para su utilizacion en el tratamiento del cancer.
FR2362845A1 (fr) Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant
EP0201094A3 (de) Neue Derivate von Thieno[2,3-d]-imidazolen und Verfahren zu ihrer Herstellung
FR2395272A1 (fr) Nouveaux medicaments derives de l'acide amidinopenicillanique
FR2361395A1 (fr) Derives de la xanthine par substitution basique
ATE23148T1 (de) Antivirus alpha-alpha-dialkyl adamantylethylamine.
US4138432A (en) Amides of phosphonoacetic acid
US4092412A (en) Treatment of herpes simplex infections
IT1124697B (it) Derivati di creatinolo o-fosfato ad azione terapeutica,procedimento per la sua preparazione e relativ-e composizioni farmaceutiche
FR2455596A1 (fr) Nouveaux antibiotiques presentant une activite antibacterienne, leur procede de production, leur souche servant a leur obtention et les compositions pharmaceutiques les contenant
FR2455569A1 (fr) Nouvelles isoprenylamines et leurs sels acides d'addition et leur utilisation comme substances actives dans des compositions pharmaceutiques antivirales pour animaux vertebres

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse