FR2428032B1 - - Google Patents

Info

Publication number
FR2428032B1
FR2428032B1 FR7817388A FR7817388A FR2428032B1 FR 2428032 B1 FR2428032 B1 FR 2428032B1 FR 7817388 A FR7817388 A FR 7817388A FR 7817388 A FR7817388 A FR 7817388A FR 2428032 B1 FR2428032 B1 FR 2428032B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7817388A
Other languages
French (fr)
Other versions
FR2428032A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7817388A priority Critical patent/FR2428032A1/fr
Priority to US06/045,143 priority patent/US4348393A/en
Priority to CA329,220A priority patent/CA1129859A/en
Priority to LU81370A priority patent/LU81370A1/fr
Priority to ZA792799A priority patent/ZA792799B/xx
Priority to SE7904970A priority patent/SE446733B/sv
Priority to AU47862/79A priority patent/AU525787B2/en
Priority to BE0/195621A priority patent/BE876831A/xx
Priority to GR59290A priority patent/GR69969B/el
Priority to DE19792923295 priority patent/DE2923295A1/de
Priority to NL7904528A priority patent/NL7904528A/xx
Priority to GB7920102A priority patent/GB2028306B/en
Priority to CH540079A priority patent/CH642069A5/fr
Priority to ES481909A priority patent/ES8100279A1/es
Priority to GB8021771A priority patent/GB2054575B/en
Priority to IT7923395A priority patent/IT1206305B/it
Priority to JP7295479A priority patent/JPS5551064A/ja
Publication of FR2428032A1 publication Critical patent/FR2428032A1/fr
Priority to US06/119,073 priority patent/US4287351A/en
Priority to SE8001674A priority patent/SE447381B/sv
Priority to NL8001539A priority patent/NL8001539A/nl
Priority to CH216180A priority patent/CH639962A5/fr
Priority to ES490110A priority patent/ES8106509A1/es
Priority to ES490114A priority patent/ES490114A0/es
Priority to ES490113A priority patent/ES490113A0/es
Priority to ES490112A priority patent/ES8102105A1/es
Priority to IT8022284A priority patent/IT1206307B/it
Priority to FR8012423A priority patent/FR2458547B2/fr
Priority to JP6772281A priority patent/JPS56167666A/ja
Application granted granted Critical
Publication of FR2428032B1 publication Critical patent/FR2428032B1/fr
Priority to FR8208858A priority patent/FR2506769A2/fr
Priority to US06/388,867 priority patent/US4413001A/en
Priority to US06/388,866 priority patent/US4526786A/en
Priority to US06/389,136 priority patent/US4435415A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7817388A 1978-06-09 1978-06-09 Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique Granted FR2428032A1 (fr)

Priority Applications (32)

Application Number Priority Date Filing Date Title
FR7817388A FR2428032A1 (fr) 1978-06-09 1978-06-09 Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
US06/045,143 US4348393A (en) 1978-06-09 1979-06-04 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
LU81370A LU81370A1 (fr) 1978-06-09 1979-06-06 Nouvelles n-aryle oxazolidinones,oxazolidinethiones,pyrrolidinones,pyrrolidines et thiazolidinones,leur procede de preparation et leur application en therapeutique
ZA792799A ZA792799B (en) 1978-06-09 1979-06-06 Novel n-aryl oxazolidinones,oxazolidinethiones,pyrrolidinones,pyrrolidinines and thiazolidinones,process for their preparation and their application in therapeutics
CA329,220A CA1129859A (en) 1978-06-09 1979-06-06 N-aryle oxazolidinones, oxazolidinethiones and pyrrolidinones, their process of preparation and their application in therapeutics
AU47862/79A AU525787B2 (en) 1978-06-09 1979-06-07 N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
SE7904970A SE446733B (sv) 1978-06-09 1979-06-07 Nya n-aryloxazolidinoner, oxazolidintioner, pyrrolidinoner, pyrrolidiner och tiazolidinoner och sett att framstella desamma samt kompositioner derav
BE0/195621A BE876831A (fr) 1978-06-09 1979-06-07 Nouvelles n-aryle oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines et thiazolidinones, leur procede de preparation et leur application en therapeutique
GR59290A GR69969B (enrdf_load_stackoverflow) 1978-06-09 1979-06-07
NL7904528A NL7904528A (nl) 1978-06-09 1979-06-08 Nieuwe n-aryloxazolidinonen, oxazolidinethionen, pyrro- lidinonen, pyrrolidinen en thiazolidinonen.
GB7920102A GB2028306B (en) 1978-06-09 1979-06-08 Aryl oxazolidinones oxazolidinethiones pyrrolidinones pyrrolidines and thiazolidinones their process of proparation and their therapeutic application
CH540079A CH642069A5 (fr) 1978-06-09 1979-06-08 N-aryle oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines et thiazolidinones, leurs procedes de preparation, et medicaments les contenant.
ES481909A ES8100279A1 (es) 1978-06-09 1979-06-08 Procedimiento para la preparacion de nuevas aril-3 eter-5 o-xazolidinonas-2
GB8021771A GB2054575B (en) 1978-06-09 1979-06-08 N-aryl oxazolidinones and pyrrolidinones and their processes
IT7923395A IT1206305B (it) 1978-06-09 1979-06-08 N-aril-ossazolidinoni, -ossazolidintioni, -pirrolidinoni, -pirrolidine e -tiazolidinoni, loro procedimento di preparazione eloro applicazione in terapia.
DE19792923295 DE2923295A1 (de) 1978-06-09 1979-06-08 Neue n-aryl-oxazolidinone, -oxazolidinthione, -pyrrolidinone, -pyrrolidine und -thiazolidinone, verfahren zu ihrer herstellung und solche verbindungen enthaltende arzneimittel
JP7295479A JPS5551064A (en) 1978-06-09 1979-06-09 Novel aryloxazolidinone*oxazolidinethione* pyrrolidinone*pyrrolidine and thiazolidinone* their manufacture and their therapeutic application
US06/119,073 US4287351A (en) 1978-06-09 1980-02-06 3-Parahydroxyphenyl-5-methylether-2-oxazolidinone compounds
SE8001674A SE447381B (sv) 1978-06-09 1980-03-04 Nya n-aryloxazolidinoner och pyrrolidinoner
NL8001539A NL8001539A (nl) 1978-06-09 1980-03-14 Nieuwe n-aryl-oxazolidinonen en n-arylpyrrolidinonen.
CH216180A CH639962A5 (fr) 1978-06-09 1980-03-19 N-aryle oxazolidinones et pyrrolidinones.
ES490114A ES490114A0 (es) 1978-06-09 1980-03-31 Metodo de preparar nuevas aril-3 eter-5 oxazolidinonas-2
ES490112A ES8102105A1 (es) 1978-06-09 1980-03-31 Procedimiento de preparar oxazolidinationas
ES490113A ES490113A0 (es) 1978-06-09 1980-03-31 Metodo de preparacion de aril-3 aminometil-5 oxazolidinonas-2 nuevas
ES490110A ES8106509A1 (es) 1978-06-09 1980-03-31 Procedimiento de preparar aril-3 ester-5 oxazolidinonas-2 y oxazolidinationas-2 nuevas
IT8022284A IT1206307B (it) 1978-06-09 1980-05-23 N-aril-ossazolidinoni e -pirrolidinoni, e procedimenti per la loro preparazione.
FR8012423A FR2458547B2 (fr) 1978-06-09 1980-06-04 Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique
JP6772281A JPS56167666A (en) 1978-06-09 1981-05-07 N-aryloxazolidinone, pyrrolidinone and their manufacture
FR8208858A FR2506769A2 (fr) 1978-06-09 1982-05-19 Para-((cyano-5 n pentyl-1) phenyl)-3 methoxymethyl-5 oxazolidinone-2, son procede de preparation et ses applications en therapeutique
US06/389,136 US4435415A (en) 1978-06-09 1982-06-16 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
US06/388,866 US4526786A (en) 1978-06-09 1982-06-16 N-Substituted phenyl-5-aminomethyl oxazolidinones and their method of use
US06/388,867 US4413001A (en) 1978-06-09 1982-06-16 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7817388A FR2428032A1 (fr) 1978-06-09 1978-06-09 Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2428032A1 FR2428032A1 (fr) 1980-01-04
FR2428032B1 true FR2428032B1 (enrdf_load_stackoverflow) 1981-10-16

Family

ID=9209330

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817388A Granted FR2428032A1 (fr) 1978-06-09 1978-06-09 Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique

Country Status (3)

Country Link
JP (2) JPS5551064A (enrdf_load_stackoverflow)
FR (1) FR2428032A1 (enrdf_load_stackoverflow)
ZA (1) ZA792799B (enrdf_load_stackoverflow)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2506769A2 (fr) * 1978-06-09 1982-12-03 Delalande Sa Para-((cyano-5 n pentyl-1) phenyl)-3 methoxymethyl-5 oxazolidinone-2, son procede de preparation et ses applications en therapeutique
FR2458547B2 (fr) * 1978-06-09 1986-05-16 Delalande Sa Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
FR2528046B1 (fr) * 1982-06-08 1985-06-21 Delalande Sa Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation
JPS608277A (ja) * 1983-06-07 1985-01-17 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー アミノメチルオキソオキサゾリジニルベンゼン誘導体
FR2609029B1 (fr) * 1986-12-30 1989-12-08 Delalande Sa Derives 5-aminoethyles de l'oxazolidinone-2, leur procede de preparation et leur application en therapeutique
FR2603279B1 (fr) * 1986-09-03 1988-12-16 Rech Ind Benzyloxy-phenyl-oxazolidinones, procede de preparation et utilisation en therapeutique
EP0259228B1 (fr) * 1986-09-03 1992-06-03 Delalande S.A. Dérivés 5-aminoéthylés de l'oxazolidinone-2, leur procédé de préparation et leur application en thérapeutique
WO2007116960A1 (ja) * 2006-04-06 2007-10-18 Research Foundation Itsuu Laboratory 炭素環を有するオキサゾリジノン誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1602544A (en) * 1968-10-29 1970-12-21 Acetylenic 2-oxazolidinones
GB1250538A (enrdf_load_stackoverflow) * 1969-03-18 1971-10-20
CH618682A5 (enrdf_load_stackoverflow) * 1975-11-07 1980-08-15 Ciba Geigy Ag

Also Published As

Publication number Publication date
ZA792799B (en) 1980-08-27
FR2428032A1 (fr) 1980-01-04
JPS635391B2 (enrdf_load_stackoverflow) 1988-02-03
JPS56167666A (en) 1981-12-23
JPH039106B2 (enrdf_load_stackoverflow) 1991-02-07
JPS5551064A (en) 1980-04-14

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