FR2428022A1 - Acide 2-(p-prenylphenyl)propionique, ses sels pharmaceutiquement acceptables, et leur utilisation comme agents anti-inflammatoires et analgesiques - Google Patents

Acide 2-(p-prenylphenyl)propionique, ses sels pharmaceutiquement acceptables, et leur utilisation comme agents anti-inflammatoires et analgesiques

Info

Publication number
FR2428022A1
FR2428022A1 FR7914712A FR7914712A FR2428022A1 FR 2428022 A1 FR2428022 A1 FR 2428022A1 FR 7914712 A FR7914712 A FR 7914712A FR 7914712 A FR7914712 A FR 7914712A FR 2428022 A1 FR2428022 A1 FR 2428022A1
Authority
FR
France
Prior art keywords
prenylphenyl
propionic acid
inflammatory
pharmaceutically acceptable
acceptable salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7914712A
Other languages
English (en)
Other versions
FR2428022B1 (fr
Inventor
Takehiro Amano
Jiro Sawada
Michitada Sasajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of FR2428022A1 publication Critical patent/FR2428022A1/fr
Application granted granted Critical
Publication of FR2428022B1 publication Critical patent/FR2428022B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Acide 2-(p-prénylphényl)propionique et ses sels. L'acide 2-(p-prénylphényl)propionique est préparé par hydrolyse de 2-(p-préylphényl)propionitrile; les sels sont préparés à partir de l'acide libre par des procédés classiques, par exemple, par neutralisation de l'acide libre avec une base telle qu'un hydroxyde métallique ou un carbonate métallique. La présente invention est particulièrement utile pour fournir de l'acide 2-(p-prénylphényl)propionique et ses sels pharmaceutiquement acceptables, qui présentent des activités anti-inflammatoires et analgésiques importantes, avec une faible action gastro-intestinale.
FR7914712A 1978-06-10 1979-06-08 Acide 2-(p-prenylphenyl)propionique, ses sels pharmaceutiquement acceptables, et leur utilisation comme agents anti-inflammatoires et analgesiques Granted FR2428022A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7022378A JPS54163545A (en) 1978-06-10 1978-06-10 Organic carboxylic acid derivative

Publications (2)

Publication Number Publication Date
FR2428022A1 true FR2428022A1 (fr) 1980-01-04
FR2428022B1 FR2428022B1 (fr) 1983-11-25

Family

ID=13425326

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7914712A Granted FR2428022A1 (fr) 1978-06-10 1979-06-08 Acide 2-(p-prenylphenyl)propionique, ses sels pharmaceutiquement acceptables, et leur utilisation comme agents anti-inflammatoires et analgesiques

Country Status (6)

Country Link
US (1) US4251543A (fr)
JP (1) JPS54163545A (fr)
DE (1) DE2920812A1 (fr)
FR (1) FR2428022A1 (fr)
GB (1) GB2027015B (fr)
IT (1) IT1116890B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459219A1 (fr) * 1979-06-18 1981-01-09 Glaxo Group Ltd Derives d'acide alcanoique
EP0073447A1 (fr) * 1981-08-26 1983-03-09 Taisho Pharmaceutical Co. Ltd Procédé de synthèse du 1-(p-prénylphényl)-éthanol
FR2528829A1 (fr) * 1982-06-22 1983-12-23 Eisai Co Ltd Composes polyprenyliques, procedes pour leur preparation et composition therapeutique les contenant

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451129A (en) * 1981-03-05 1984-05-29 Canon Kabushiki Kaisha Camera having a plurality of built-in lenses
JPS57203035A (en) * 1981-06-05 1982-12-13 Taisho Pharmaceut Co Ltd Carboxylic acid ester
US4968718A (en) * 1988-01-25 1990-11-06 University Of Iowa Research Foundation Topically effective, nonsteroidal drug for use in external and internal eye inflammations
US5179124A (en) * 1988-01-25 1993-01-12 University Of Iowa Research Foundation Anti-inflammatory for use in external and internal eye inflammations
JPH0412466U (fr) * 1990-05-18 1992-01-31
ES2136018B1 (es) * 1997-06-17 2000-07-01 Menarini Lab Compuestos inhibidores selectivos de la ciclooxigenasa-i y su utilizacion como analgesicos, antiinflamatorios y antiartriticos.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3124M (fr) * 1961-02-02 1965-02-15 Boots Pure Drug Co Ltd

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2316211A1 (fr) 1975-07-04 1977-01-28 Dick Pierre Nouveau mode d'acces a des derives d'acides phenyl carboxyliques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3124M (fr) * 1961-02-02 1965-02-15 Boots Pure Drug Co Ltd

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459219A1 (fr) * 1979-06-18 1981-01-09 Glaxo Group Ltd Derives d'acide alcanoique
EP0073447A1 (fr) * 1981-08-26 1983-03-09 Taisho Pharmaceutical Co. Ltd Procédé de synthèse du 1-(p-prénylphényl)-éthanol
FR2528829A1 (fr) * 1982-06-22 1983-12-23 Eisai Co Ltd Composes polyprenyliques, procedes pour leur preparation et composition therapeutique les contenant

Also Published As

Publication number Publication date
US4251543A (en) 1981-02-17
IT7949331A0 (it) 1979-06-06
GB2027015B (en) 1982-07-28
DE2920812C2 (fr) 1987-05-27
GB2027015A (en) 1980-02-13
FR2428022B1 (fr) 1983-11-25
JPS622571B2 (fr) 1987-01-20
IT1116890B (it) 1986-02-10
DE2920812A1 (de) 1979-12-20
JPS54163545A (en) 1979-12-26

Similar Documents

Publication Publication Date Title
AU5230686A (en) Indene analogs of mevalonolactone
FR2428022A1 (fr) Acide 2-(p-prenylphenyl)propionique, ses sels pharmaceutiquement acceptables, et leur utilisation comme agents anti-inflammatoires et analgesiques
EP1586558A3 (fr) Inhibiteurs hydroxyethylamino contenant des bis-sulfinamides utilises pour inhiber des proteases retrovirales
FR2372217A1 (fr) Compositions intumescentes a agent gonflant, notamment pour materiaux ignifuges
ES2180541T3 (es) Nueva fosfolipasa a1, procedimiento para su preparacion y uso de la misma.
DE3365027D1 (en) Microbiocidal agents based on quinolone-carboxylic acids
CA2274003A1 (fr) Siphon auto-amorcant notamment pour irrigation
MXPA02003916A (es) Composiciones antivirales para papel tisu.
BR9710911A (pt) Um processo para a formação de um perácido e uma composição compreendendo o perácido referido.
ES553903A0 (es) Procedimiento para recemizar una n-benciliden-amida de aminoacido opticamente activa.
ES8607218A1 (es) Un procedimiento para preparar compuestos de amidina
ES2039272T3 (es) Sales opticamente activas a base de un tiazolidin-4-carboxilato sustituido y 3-cloro-2-hidroxipropiltrimetilamonio, su preparacion y empleo.
ATE60331T1 (de) Zwischenverbindungen zur synthese von carbonsaeuren.
AU3429784A (en) Use of quinoline derivatives for the protection of cultivated plants
AU3716093A (en) Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostere type
GR3035865T3 (en) Process for preparation of 5-hydroxymethylthiazole
BR9809143A (pt) Processo para sintetizar composto
JPS5697266A (en) Proline derivative and its preparation
EP0170260A3 (fr) 9-Oxo-15-alpha hydroxy-16-phénoxy et 16-phénoxy substitués 17,18,19,20-tétranorprosta-4,5,13(E)-triénoates
JPS5714554A (en) Production of 2-(substituted phenoxy)phenylacetic acid
FR2708929A1 (fr) Procédé de préparation d'esters d'acide cyclopropane-1,1-dicarboxylique.
ES482949A1 (es) Un procedimiento para la preparacion de compuestos derivadosde piridoxina
ES8600197A1 (es) Procedimiento para la obtencion de nuevas benzofenonas sustituidas.
ES8603806A1 (es) Procedimiento para preparar nuevas n-(naftilalquil)-hidroxi-laminas
AU538931B2 (en) (n-thenyl-2-methyl) amino-2-imidazoline

Legal Events

Date Code Title Description
ST Notification of lapse