FR2410649A1 - 1-phenyl-2-pyrrolidin-2-yl-ethanols substitues, leur procede de preparation, leurs applications et medicaments les contenant - Google Patents

1-phenyl-2-pyrrolidin-2-yl-ethanols substitues, leur procede de preparation, leurs applications et medicaments les contenant

Info

Publication number
FR2410649A1
FR2410649A1 FR7833931A FR7833931A FR2410649A1 FR 2410649 A1 FR2410649 A1 FR 2410649A1 FR 7833931 A FR7833931 A FR 7833931A FR 7833931 A FR7833931 A FR 7833931A FR 2410649 A1 FR2410649 A1 FR 2410649A1
Authority
FR
France
Prior art keywords
pyrrolidin
phenyl
ethanols
substitutes
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7833931A
Other languages
English (en)
Inventor
Klaus Eistetter
Hans-Peter Kley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of FR2410649A1 publication Critical patent/FR2410649A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

1-PHENYL-PYRROLIDIN-2-YL-ETHANOLS SUBSTITUES, LEUR PROCEDE DE PREPARATION, LEURS APPLICATIONS ET MEDICAMENTS LES CONTENANT. CES 1-PHENYL-2-PYRROLIDIN-2-YL-ETHANOLS SUBSTITUES REPONDENT A LA FORMULE GENERALE I CI-DESSOUS OU R, R ET R SONT TELS QUE DEFINIS DANS LE BREVET. LE PROCEDE CONSISTE A REDUIRE UNE 1-PHENYL-2-PYRROLIDIN-2-YL-ETHANONE SUBSTITUEE OU UN DE SES SELS D'ADDITION AVEC UN ACIDE DE FORMULE GENERALE II OU III OU R, R ET R SONT TELS QUE DEFINIS DANS LE BREVET, APRES QUOI L'ON ESTERIFIE OU ETHERIFIE LE CAS ECHEANT LE COMPOSE OBTENU ETOU L'ON TRANSFORME LE CAS ECHEANT LA BASE LIBRE OBTENUE OU LE SEL D'ADDITION AVEC UN ACIDE OBTENU, L'UN DANS L'AUTRE. APPLICATION EN TANT QU'ANALGESIQUES. (CF DESSIN DANS BOPI) (CF DESSIN DANS BOPI) (CF DESSIN DANS BOPI)
FR7833931A 1977-12-02 1978-12-01 1-phenyl-2-pyrrolidin-2-yl-ethanols substitues, leur procede de preparation, leurs applications et medicaments les contenant Pending FR2410649A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU78625A LU78625A1 (de) 1977-12-02 1977-12-02 Substituierte 1-phenyl-2-pyrrolidin-2-yl-ethanole,verfahren zu ihrer herstellung,ihre verwendung und sie enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
FR2410649A1 true FR2410649A1 (fr) 1979-06-29

Family

ID=19728788

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7833931A Pending FR2410649A1 (fr) 1977-12-02 1978-12-01 1-phenyl-2-pyrrolidin-2-yl-ethanols substitues, leur procede de preparation, leurs applications et medicaments les contenant

Country Status (24)

Country Link
US (1) US4198424A (fr)
EP (1) EP0002672B1 (fr)
JP (1) JPS5490172A (fr)
AT (1) AT372944B (fr)
AU (1) AU518404B2 (fr)
BE (1) BE872484A (fr)
CA (1) CA1106382A (fr)
DE (2) DE2860991D1 (fr)
DK (1) DK547978A (fr)
ES (1) ES475643A1 (fr)
FR (1) FR2410649A1 (fr)
GB (1) GB2011885B (fr)
GR (1) GR64036B (fr)
HU (1) HU177798B (fr)
IE (1) IE47604B1 (fr)
IL (1) IL56100A (fr)
IT (1) IT7830458A0 (fr)
LU (1) LU78625A1 (fr)
NL (1) NL7811786A (fr)
NZ (1) NZ189070A (fr)
PL (1) PL116668B1 (fr)
PT (1) PT68856A (fr)
SE (1) SE7812404L (fr)
ZA (1) ZA786749B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0022408A1 (fr) * 1979-07-06 1981-01-14 Roussel-Uclaf Nouveaux dérivés de l'alpha-phényl 2-pyrrolidineméthanol et leurs sels, procédé de préparation, application à titre de médicaments et compositions les renfermant

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2436779A1 (fr) * 1978-09-22 1980-04-18 Pharmindustrie Derives de pyrrolidine-2 methanol utilisables comme medicaments
US4379161A (en) * 1979-06-07 1983-04-05 Michel Thominet Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics
FR2479218A2 (fr) * 1980-04-01 1981-10-02 Ile De France Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthesiques locaux
FR2460935A1 (fr) * 1979-07-06 1981-01-30 Ile De France Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthetiques locaux
EP0114758B1 (fr) * 1983-01-24 1986-11-12 Syntex (U.S.A.) Inc. +/- 2-((3,4-Méthylènedioxy)phénéthyl)-5-((3-carboxamido-4-hydroxy-alpha-hydroxybenzyl)-pyrrolidines, compositions pharmaceutiques les contenant, procédé de préparation et composés intermédiaires
NO840241L (no) * 1983-01-24 1984-07-25 Syntex Inc Fremgangsmaate for fremstilling av terapeutisk aktive 2-((fenetyl)-5-((3,4-metylendioksy)-alfa-hydroksylbenzyl)pyrrolidiner
ITRE940021A1 (it) * 1994-03-29 1995-09-29 Cgm Spa Dispositivo perfezionato porta-ago per penetrazione nel corpo, quale ago per infusioni, prelievi e usi simili.
US7403118B2 (en) * 2005-11-29 2008-07-22 Checkpoint Systems, Inc. Security device with perimeter alarm

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077982A (en) * 1968-01-19 1978-03-07 Fmc Corporation 5-Benzyloxy-1,3-dioxanes
GB1186481A (en) * 1968-03-25 1970-04-02 Parke Davis & Co New Pyrrolidine Compounds and Methods for their Production
GB1186660A (en) * 1968-09-11 1970-04-02 Parke Davis & Co New Pyrrolidine Compounds and Methods for their Production
GB1198973A (en) * 1969-02-07 1970-07-15 Parke Davis & Co Pyrrolidine Compounds with an Unsaturated Substituent and Methods for their Production
GB1283452A (en) * 1970-07-24 1972-07-26 Parke Davis & Co Substituted 1,3-dialkylpyrrolidines and processes for their production
DE2701705A1 (de) * 1976-01-28 1977-08-04 Sandoz Ag Neue organische verbindungen, ihre verwendung und herstellung
US4123545A (en) * 1977-06-30 1978-10-31 Sandoz Ltd. N-Propyl-3(β-hydroxyethyl)-3-(meta-hydroxyphenyl)-pyrrolidine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0022408A1 (fr) * 1979-07-06 1981-01-14 Roussel-Uclaf Nouveaux dérivés de l'alpha-phényl 2-pyrrolidineméthanol et leurs sels, procédé de préparation, application à titre de médicaments et compositions les renfermant
FR2460929A1 (fr) * 1979-07-06 1981-01-30 Roussel Uclaf Nouveaux derives de l'a-phenyl 2-pyrrolidinemethanol et leur sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Also Published As

Publication number Publication date
JPS5490172A (en) 1979-07-17
IT7830458A0 (it) 1978-12-01
IL56100A0 (en) 1979-03-12
US4198424A (en) 1980-04-15
ZA786749B (en) 1979-11-28
PL211409A1 (pl) 1979-08-13
HU177798B (en) 1981-12-28
IE782386L (en) 1979-06-02
EP0002672A3 (en) 1979-07-25
SE7812404L (sv) 1979-06-03
IE47604B1 (en) 1984-05-02
LU78625A1 (de) 1979-06-13
AU518404B2 (en) 1981-10-01
BE872484A (fr) 1979-06-01
AU4212278A (en) 1979-06-07
DE2860991D1 (en) 1981-11-19
GB2011885B (en) 1982-06-30
GR64036B (en) 1980-01-19
DK547978A (da) 1979-06-03
PT68856A (de) 1978-12-01
ATA860278A (de) 1983-01-15
EP0002672B1 (fr) 1981-08-26
EP0002672A2 (fr) 1979-07-11
CA1106382A (fr) 1981-08-04
IL56100A (en) 1981-12-31
ES475643A1 (es) 1980-01-16
AT372944B (de) 1983-11-25
NZ189070A (en) 1981-05-01
NL7811786A (nl) 1979-06-06
GB2011885A (en) 1979-07-18
PL116668B1 (en) 1981-06-30
DE2852088A1 (de) 1979-06-13

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