FR2407927A1 - Nouveaux derives de phtalazine, leur procede de production, et composition pharmaceutique les contenant - Google Patents
Nouveaux derives de phtalazine, leur procede de production, et composition pharmaceutique les contenantInfo
- Publication number
- FR2407927A1 FR2407927A1 FR7831063A FR7831063A FR2407927A1 FR 2407927 A1 FR2407927 A1 FR 2407927A1 FR 7831063 A FR7831063 A FR 7831063A FR 7831063 A FR7831063 A FR 7831063A FR 2407927 A1 FR2407927 A1 FR 2407927A1
- Authority
- FR
- France
- Prior art keywords
- cardiac
- lower alkyl
- piperidino
- derivs
- phthalazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
L'INVENTION A TRAIT AU DOMAINE DE LA CHIMIE PHARMACEUTIQUE. ELLE CONCERNE DE NOUVEAUX DERIVES DE PHTALAZINE PORTANT NOTAMMENT UN GROUPE PIPERIDINO SUBSTITUE EN POSITION1. ELLE CONCERNE AUSSI UN PROCEDE A PLUSIEURS VARIANTES POUR LA PREPARATION DE CES COMPOSES. LES COMPOSES DE L'INVENTION SONT DES INHIBITEURS DE PHOSPHODIESTERASE ET DES STIMULANTS CARDIAQUES. ILS PEUVENT ETRE UTILISES DANS LE TRAITEMENT CURATIF OU PREVENTIF DE TROUBLES TELS QUE L'INSUFFISANCE CARDIAQUE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4567077 | 1977-11-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2407927A1 true FR2407927A1 (fr) | 1979-06-01 |
FR2407927B1 FR2407927B1 (fr) | 1982-07-16 |
Family
ID=10438118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7831063A Granted FR2407927A1 (fr) | 1977-11-03 | 1978-11-02 | Nouveaux derives de phtalazine, leur procede de production, et composition pharmaceutique les contenant |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS5498783A (fr) |
AR (3) | AR219561A1 (fr) |
AT (1) | AT365184B (fr) |
AU (1) | AU507007B2 (fr) |
BE (1) | BE871770A (fr) |
CA (1) | CA1114379A (fr) |
DE (1) | DE2847621A1 (fr) |
DK (1) | DK487978A (fr) |
ES (5) | ES474764A0 (fr) |
FI (1) | FI783326A (fr) |
FR (1) | FR2407927A1 (fr) |
IE (1) | IE47481B1 (fr) |
IL (1) | IL55844A (fr) |
IT (1) | IT1101279B (fr) |
LU (1) | LU80458A1 (fr) |
NL (1) | NL7810864A (fr) |
PH (1) | PH14659A (fr) |
PT (1) | PT68734A (fr) |
SE (1) | SE7811322L (fr) |
YU (3) | YU253678A (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6215356U (fr) * | 1985-07-15 | 1987-01-29 | ||
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
JP2006525273A (ja) * | 2003-05-07 | 2006-11-09 | アクテリオン ファマシューティカルズ リミテッド | 新規なピペラジン誘導体 |
CA2628570A1 (fr) | 2005-11-09 | 2007-05-18 | Combinatorx, Incorporated | Procedes, compositions et kits pour le traitement de pathologies |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
JP6251038B2 (ja) | 2011-03-01 | 2017-12-20 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcアゴニストの調製方法 |
WO2013106547A1 (fr) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation |
AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing |
CA2905435A1 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス,インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2043504A1 (fr) * | 1969-05-03 | 1971-02-19 | Aspro Nicholas Ltd |
-
1978
- 1978-10-24 CA CA314,085A patent/CA1114379A/fr not_active Expired
- 1978-10-30 PH PH21752A patent/PH14659A/en unknown
- 1978-10-31 LU LU80458A patent/LU80458A1/fr unknown
- 1978-11-01 SE SE7811322A patent/SE7811322L/xx unknown
- 1978-11-01 NL NL7810864A patent/NL7810864A/xx not_active Application Discontinuation
- 1978-11-01 DK DK487978A patent/DK487978A/da unknown
- 1978-11-01 FI FI783326A patent/FI783326A/fi unknown
- 1978-11-01 YU YU02536/78A patent/YU253678A/xx unknown
- 1978-11-01 IL IL55844A patent/IL55844A/xx unknown
- 1978-11-02 ES ES474764A patent/ES474764A0/es active Pending
- 1978-11-02 IT IT29369/78A patent/IT1101279B/it active
- 1978-11-02 PT PT68734A patent/PT68734A/pt unknown
- 1978-11-02 IE IE2166/78A patent/IE47481B1/en unknown
- 1978-11-02 JP JP13569778A patent/JPS5498783A/ja active Granted
- 1978-11-02 AU AU41276/78A patent/AU507007B2/en not_active Expired
- 1978-11-02 FR FR7831063A patent/FR2407927A1/fr active Granted
- 1978-11-02 AT AT0783978A patent/AT365184B/de not_active IP Right Cessation
- 1978-11-02 DE DE19782847621 patent/DE2847621A1/de not_active Ceased
- 1978-11-03 BE BE191543A patent/BE871770A/fr unknown
- 1978-11-10 AR AR274311A patent/AR219561A1/es active
-
1979
- 1979-04-26 ES ES479991A patent/ES479991A1/es not_active Expired
- 1979-04-26 ES ES479994A patent/ES479994A1/es not_active Expired
- 1979-04-26 ES ES479993A patent/ES479993A1/es not_active Expired
- 1979-04-26 ES ES479992A patent/ES479992A1/es not_active Expired
- 1979-11-02 AR AR278749A patent/AR217577A1/es active
- 1979-11-02 AR AR278750A patent/AR217578A1/es active
-
1982
- 1982-03-23 YU YU02115/82A patent/YU211582A/xx unknown
- 1982-09-23 YU YU02116/82A patent/YU211682A/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2043504A1 (fr) * | 1969-05-03 | 1971-02-19 | Aspro Nicholas Ltd |
Also Published As
Publication number | Publication date |
---|---|
DE2847621A1 (de) | 1979-05-17 |
AR217577A1 (es) | 1980-03-31 |
IE47481B1 (en) | 1984-04-04 |
PH14659A (en) | 1981-10-20 |
IT1101279B (it) | 1985-09-28 |
AU4127678A (en) | 1979-05-17 |
LU80458A1 (fr) | 1980-05-07 |
ES479992A1 (es) | 1980-09-01 |
BE871770A (fr) | 1979-05-03 |
CA1114379A (fr) | 1981-12-15 |
NL7810864A (nl) | 1979-05-07 |
FI783326A (fi) | 1979-05-04 |
IL55844A0 (en) | 1979-01-31 |
ES479994A1 (es) | 1980-08-16 |
IL55844A (en) | 1982-05-31 |
IT7829369A0 (it) | 1978-11-02 |
YU211582A (en) | 1983-02-28 |
YU253678A (en) | 1983-02-28 |
ES474764A0 (es) | 1980-08-16 |
IE782166L (en) | 1979-05-03 |
YU211682A (en) | 1983-02-28 |
SE7811322L (sv) | 1979-05-04 |
ES479993A1 (es) | 1980-08-16 |
PT68734A (en) | 1978-12-01 |
AU507007B2 (en) | 1980-01-31 |
AT365184B (de) | 1981-12-28 |
AR219561A1 (es) | 1980-08-29 |
DK487978A (da) | 1979-05-04 |
ES479991A1 (es) | 1980-08-16 |
FR2407927B1 (fr) | 1982-07-16 |
AR217578A1 (es) | 1980-03-31 |
ATA783978A (de) | 1981-05-15 |
JPS5538352B2 (fr) | 1980-10-03 |
JPS5498783A (en) | 1979-08-03 |
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