FR2407915A1 - Nouveaux o-amidinophenyl-a-aminoalcoyl-carboxamides na-alcoylsulfonyles et na-arylsulfonyles, procedes pour leur preparation et leurs utilisations therapeutiques - Google Patents

Nouveaux o-amidinophenyl-a-aminoalcoyl-carboxamides na-alcoylsulfonyles et na-arylsulfonyles, procedes pour leur preparation et leurs utilisations therapeutiques

Info

Publication number
FR2407915A1
FR2407915A1 FR7831496A FR7831496A FR2407915A1 FR 2407915 A1 FR2407915 A1 FR 2407915A1 FR 7831496 A FR7831496 A FR 7831496A FR 7831496 A FR7831496 A FR 7831496A FR 2407915 A1 FR2407915 A1 FR 2407915A1
Authority
FR
France
Prior art keywords
amidinophenyl
arylsulfonyl
preparation
therapeutic uses
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7831496A
Other languages
English (en)
Other versions
FR2407915B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AWD Pharma GmbH and Co KG
Original Assignee
Arzneimittelwerk Dresden GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden GmbH filed Critical Arzneimittelwerk Dresden GmbH
Publication of FR2407915A1 publication Critical patent/FR2407915A1/fr
Application granted granted Critical
Publication of FR2407915B1 publication Critical patent/FR2407915B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'INVENTION A POUR OBJET DES DERIVES SULFONYLES DE O-AMIDINOPHENYL-A-AMINOALCOYLCARBOXAMIDES, LEUR PREPARATION ET LEURS UTILISATIONS THERAPEUTIQUES. CES COMPOSES REPONDENT A LA FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE RALCOYLSULFONYLE OU ARYLSULFONYLE: RH, ALCOYLE, ARYLE OU ARALCOYLE; RALCOYLE, ARYLE OU ARALCOYLE; OU ENCORE R ET R, FORMENT AVEC L'AZOTE UN NOYAU HETEROCYCLIQUE A 5 A 7CHAINONS; N0, 1, 2 OU 3; LE GROUPE AMIDINO PEUT ETRE EN POSITION PARA OU META; CES COMPOSES PEUVENT ETRE A L'ETAT DE BASES LIBRES OU DE SELS D'ACIDES PHYSIOLOGIQUEMENT SUPPORTABLES. CES COMPOSES ONT DES PROPRIETES ANTICOAGULANTES ET SONT EXPLOITABLES EN THERAPEUTIQUE A TITRE D'ANTICOAGULANTS DIRECTS.
FR7831496A 1977-11-07 1978-11-07 Nouveaux o-amidinophenyl-a-aminoalcoyl-carboxamides na-alcoylsulfonyles et na-arylsulfonyles, procedes pour leur preparation et leurs utilisations therapeutiques Granted FR2407915A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD77201898A DD142804A3 (de) 1977-11-07 1977-11-07 Verfahren zur herstellung von na-alkyl-bzw.na-aryl-sulfonylierten omega-amidinophenyl-alpha-aminoalkylcarbonsaeureamiden

Publications (2)

Publication Number Publication Date
FR2407915A1 true FR2407915A1 (fr) 1979-06-01
FR2407915B1 FR2407915B1 (fr) 1980-12-26

Family

ID=5510339

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7831496A Granted FR2407915A1 (fr) 1977-11-07 1978-11-07 Nouveaux o-amidinophenyl-a-aminoalcoyl-carboxamides na-alcoylsulfonyles et na-arylsulfonyles, procedes pour leur preparation et leurs utilisations therapeutiques

Country Status (6)

Country Link
JP (1) JPS54106448A (fr)
DD (1) DD142804A3 (fr)
DE (1) DE2845941A1 (fr)
FR (1) FR2407915A1 (fr)
GB (1) GB2007663A (fr)
SE (1) SE7811454L (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2005741C (fr) * 1988-12-26 1998-06-02 Hiroyoshi Hidaka Sulfonoaminoquinolines ayant une activite de relaxation des muscles lisses des vaisseaux
US5245034A (en) * 1988-12-26 1993-09-14 Kiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
US5256812A (en) * 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
EP0511347A1 (fr) * 1990-11-15 1992-11-04 Pentapharm A.G. Derives de la phenylalanine metasubstitues
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
PH31294A (en) * 1992-02-13 1998-07-06 Thomae Gmbh Dr K Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them.
DE4326465A1 (de) * 1993-01-20 1995-02-09 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
ATE223392T1 (de) * 1993-02-10 2002-09-15 Pentapharm Ag Piperazide von substituierten phenylalanin- derivativen als thrombin inhibitoren
AU3107795A (en) * 1994-08-09 1996-03-07 Pentapharm Ag Inhibitors of the benzamidine type
KR0173034B1 (ko) * 1995-04-28 1999-03-30 성재갑 선택적 트롬빈 억제제
GB9621814D0 (en) * 1996-10-19 1996-12-11 British Biotech Pharm Metalloproteinase inhibitors
JP3853653B2 (ja) 1999-08-07 2006-12-06 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト カルボン酸アミド、その調製法及び医薬組成物としてのその使用
MXPA03006648A (es) * 2001-02-02 2003-10-15 Boehringer Ingelheim Pharma Compuestos antitombroticos, su preparacion y su utilizacion como medicamentos.
SI2573068T1 (sl) 2004-03-15 2015-03-31 Janssen Pharmaceutica N.V. Postopek za pripravo intermediatov spojin, ki so uporabne kot modulatorji opioidnega receptorja

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183892A1 (fr) * 1972-05-05 1973-12-21 Hoechst Ag

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183892A1 (fr) * 1972-05-05 1973-12-21 Hoechst Ag

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/69 *

Also Published As

Publication number Publication date
DD142804A3 (de) 1980-07-16
FR2407915B1 (fr) 1980-12-26
GB2007663A (en) 1979-05-23
SE7811454L (sv) 1979-05-08
DE2845941A1 (de) 1979-05-10
JPS54106448A (en) 1979-08-21

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