GB2007663A - Sulphonylated omega - amidinophenyl- alpha -aminocarhoxylic acid amides - Google Patents

Sulphonylated omega - amidinophenyl- alpha -aminocarhoxylic acid amides

Info

Publication number
GB2007663A
GB2007663A GB7843320A GB7843320A GB2007663A GB 2007663 A GB2007663 A GB 2007663A GB 7843320 A GB7843320 A GB 7843320A GB 7843320 A GB7843320 A GB 7843320A GB 2007663 A GB2007663 A GB 2007663A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
radical containing
aminocarhoxylic
sulphonylated
amidinophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7843320A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AWD Pharma GmbH and Co KG
Original Assignee
Arzneimittelwerk Dresden GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden GmbH filed Critical Arzneimittelwerk Dresden GmbH
Publication of GB2007663A publication Critical patent/GB2007663A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom

Abstract

Compounds of the general formula:- <IMAGE> wherein R<1> is an alkylsulphonyl radical containing up to 6 carbon atoms or an arylsulphonyl radical containing 6 to 10 carbon atoms, R<2> is a hydrogen atom, an alkyl radical containing up to 8 carbon atoms, an aryl radical containing 6 to 10 carbon atoms or an aralkyl radical containing up to 3 carbon atoms in the side chain, R<3> is an alkyl radical containing up to 8 carbon atoms, an aryl radical containing 6 to 10 carbon atoms or an aralkyl radical containing up to 3 carbon atoms in the side chain, or R<2> and R<3>, together with the nitrogen atom to which they are attached, can also form a 5- to 7-membered heterocyclic ring-which can contain one or more further heteroatoms and/or can be substituted and n is 0, 1, 2 or 3; as well as the acid-addition salts thereof with physiologically acceptable inorganic and organic acids have anticoagulant activity.
GB7843320A 1977-11-07 1978-11-06 Sulphonylated omega - amidinophenyl- alpha -aminocarhoxylic acid amides Withdrawn GB2007663A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD77201898A DD142804A3 (en) 1977-11-07 1977-11-07 PROCESS FOR PREPARING NA-ALKYL-BZW.NA-ARYL-SULFONYLATED OMEGA-AMIDINOPHENYL-ALPHA-AMINOALKYLCARBONESAFEAMIDES

Publications (1)

Publication Number Publication Date
GB2007663A true GB2007663A (en) 1979-05-23

Family

ID=5510339

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7843320A Withdrawn GB2007663A (en) 1977-11-07 1978-11-06 Sulphonylated omega - amidinophenyl- alpha -aminocarhoxylic acid amides

Country Status (6)

Country Link
JP (1) JPS54106448A (en)
DD (1) DD142804A3 (en)
DE (1) DE2845941A1 (en)
FR (1) FR2407915A1 (en)
GB (1) GB2007663A (en)
SE (1) SE7811454L (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0381033A1 (en) * 1989-01-31 1990-08-08 F. Hoffmann-La Roche Ag Carboxylic-acid and sulphonic-acid amides
GB2228933A (en) * 1988-12-26 1990-09-12 Hiroyoshi Hidaka N-substituted isoquinolinyl-or naphthyl-sulphonamides
WO1992008709A1 (en) * 1990-11-15 1992-05-29 Pentapharm Ag Meta-substituted phenyl alanine derivatives
WO1993012074A1 (en) * 1991-12-19 1993-06-24 G.D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
EP0555824A1 (en) * 1992-02-13 1993-08-18 Dr. Karl Thomae GmbH N-alpha-arylsulfonylated benzimidazolylalaninamide derivatives, medicaments based thereon and process for their preparation
US5245034A (en) * 1988-12-26 1993-09-14 Kiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
US5256812A (en) * 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
WO1994017035A1 (en) * 1993-01-20 1994-08-04 Dr. Karl Thomae Gmbh Aminoacid derivates, medicaments containing these compounds and process for preparing the same
WO1994018185A1 (en) * 1993-02-10 1994-08-18 Pentapharm Ag Piperazides of substituted phenylalanine derivates as thrombin inhibitors
WO1996005189A1 (en) * 1994-08-09 1996-02-22 Pentapharm Ag Inhibitors of the benzamidine type
WO1998017655A1 (en) * 1996-10-19 1998-04-30 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
WO2001010823A1 (en) * 1999-08-07 2001-02-15 Boehringer Ingelheim Pharma Kg Carboxylic acid amides, their production and their use as drugs
WO2002062778A2 (en) * 2001-02-02 2002-08-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anti-thrombotic compounds, production and use thereof as medicaments
EP2298744A3 (en) * 2004-03-15 2011-08-10 Janssen Pharmaceutica NV Opioid receptor modulators

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0173034B1 (en) * 1995-04-28 1999-03-30 성재갑 Selective thrombin inhibitor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7305936A (en) * 1972-05-05 1973-11-07

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2228933A (en) * 1988-12-26 1990-09-12 Hiroyoshi Hidaka N-substituted isoquinolinyl-or naphthyl-sulphonamides
US5081246A (en) * 1988-12-26 1992-01-14 Hiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
GB2228933B (en) * 1988-12-26 1993-03-31 Hiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
US5245034A (en) * 1988-12-26 1993-09-14 Kiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
US5399585A (en) * 1989-01-31 1995-03-21 Hoffmann-La Roche Inc. Carboxamides and sulfonamides compounds which have useful pharmaceutical utility
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
EP0381033A1 (en) * 1989-01-31 1990-08-08 F. Hoffmann-La Roche Ag Carboxylic-acid and sulphonic-acid amides
US5256812A (en) * 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
WO1992008709A1 (en) * 1990-11-15 1992-05-29 Pentapharm Ag Meta-substituted phenyl alanine derivatives
US5518735A (en) * 1990-11-15 1996-05-21 Pentapharm Ag Meta-substituted phenylalanine derivatives
US5552431A (en) * 1991-12-19 1996-09-03 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
WO1993012074A1 (en) * 1991-12-19 1993-06-24 G.D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
US5391556A (en) * 1992-02-13 1995-02-21 Karl Thomae Gmbh Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
AU663556B2 (en) * 1992-02-13 1995-10-12 Dr. Karl Thomae Gmbh Benzimidazolyl derivatives
EP0555824A1 (en) * 1992-02-13 1993-08-18 Dr. Karl Thomae GmbH N-alpha-arylsulfonylated benzimidazolylalaninamide derivatives, medicaments based thereon and process for their preparation
US5807875A (en) * 1993-01-20 1998-09-15 Dr. Karl Thomae Gmbh Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
WO1994017035A1 (en) * 1993-01-20 1994-08-04 Dr. Karl Thomae Gmbh Aminoacid derivates, medicaments containing these compounds and process for preparing the same
US5616620A (en) * 1993-01-20 1997-04-01 Karl Thomae Gmbh Amino acid derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of obesity
WO1994018185A1 (en) * 1993-02-10 1994-08-18 Pentapharm Ag Piperazides of substituted phenylalanine derivates as thrombin inhibitors
WO1996005189A1 (en) * 1994-08-09 1996-02-22 Pentapharm Ag Inhibitors of the benzamidine type
US6022873A (en) * 1996-10-19 2000-02-08 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
GB2324091A (en) * 1996-10-19 1998-10-14 British Biotech Pharm Metalloproteinase inhibitors
WO1998017655A1 (en) * 1996-10-19 1998-04-30 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
GB2324091B (en) * 1996-10-19 2000-11-15 British Biotech Pharm Metalloproteinase inhibitors
US7425641B2 (en) 1999-08-07 2008-09-16 Boehringer Ingelheim Pharma Kg Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
WO2001010823A1 (en) * 1999-08-07 2001-02-15 Boehringer Ingelheim Pharma Kg Carboxylic acid amides, their production and their use as drugs
WO2002062778A2 (en) * 2001-02-02 2002-08-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anti-thrombotic compounds, production and use thereof as medicaments
WO2002062778A3 (en) * 2001-02-02 2003-12-11 Boehringer Ingelheim Pharma Anti-thrombotic compounds, production and use thereof as medicaments
EP2298744A3 (en) * 2004-03-15 2011-08-10 Janssen Pharmaceutica NV Opioid receptor modulators
US8344011B2 (en) 2004-03-15 2013-01-01 Janssen Pharmaceutica, N.V. Compounds as opioid receptor modulators
US8609709B2 (en) 2004-03-15 2013-12-17 Janssen Pharmaceutica, N. V. Compounds as opioid receptor modulators
US8772325B2 (en) 2004-03-15 2014-07-08 Janssen Pharmaceutica, N.V. Compounds as opioid receptor modulators
US9205076B2 (en) 2004-03-15 2015-12-08 Janssen Pharmaceutica, N.V. Compounds as opioid receptor modulators
US9700542B2 (en) 2004-03-15 2017-07-11 Janssen Pharmaceutica Nv Compounds as opioid receptor modulators
US10213415B2 (en) 2004-03-15 2019-02-26 Janssen Pharmaceutica Nv Compounds as opioid receptor modulators

Also Published As

Publication number Publication date
FR2407915B1 (en) 1980-12-26
FR2407915A1 (en) 1979-06-01
SE7811454L (en) 1979-05-08
DE2845941A1 (en) 1979-05-10
DD142804A3 (en) 1980-07-16
JPS54106448A (en) 1979-08-21

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)