SE7702052A - METHODS OF PREPARING 1-NITRO-9-ALKYLAMINOALKYLAMINOACRIDINS AND SALTS THEREOF - Google Patents

METHODS OF PREPARING 1-NITRO-9-ALKYLAMINOALKYLAMINOACRIDINS AND SALTS THEREOF

Info

Publication number
SE7702052A
SE7702052A SE7702052A SE7702052A SE7702052A SE 7702052 A SE7702052 A SE 7702052A SE 7702052 A SE7702052 A SE 7702052A SE 7702052 A SE7702052 A SE 7702052A SE 7702052 A SE7702052 A SE 7702052A
Authority
SE
Sweden
Prior art keywords
nitro
salts
alkylaminoalkylaminoacridins
preparing
methods
Prior art date
Application number
SE7702052A
Other languages
Swedish (sv)
Other versions
SE435504B (en
SE7702052L (en
Inventor
A Ledochowski
J Gieldanowski
C Radzikowski
B Horowska
C Kwasniewska-Rokicinska
B Wysocka-Skrzela
L Sawinska
M Medon
Original Assignee
Politechnika Gdanska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Gdanska filed Critical Politechnika Gdanska
Publication of SE7702052A publication Critical patent/SE7702052A/en
Publication of SE7702052L publication Critical patent/SE7702052L/en
Publication of SE435504B publication Critical patent/SE435504B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

1-Nitro-9-alkylaminoalkylaminoacridins and their salts, as well as a method for obtaining these compounds, is described. The 1-nitro-9-alkylaminoalkylaminoacridines have the formula 1, <IMAGE> 1 wherein R is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, isopentyl, benzyl or cyclohexyl, whereas n is equal to 2 or 3. The salts are those derived from mineral acids or organic acids. These compounds have anti-neoplastic activity.
SE7702052A 1976-02-25 1977-02-24 ANALOGY PROCEDURE FOR PREPARATION OF NEW 1-NITRO-9-ALKYLAMINOALKYLAMINOACRIDINES AND SALTS THEREOF SE435504B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL1976187520A PL106752B1 (en) 1976-02-25 1976-02-25 HOW TO RECEIVE NEW 1-NITRO-9-ALKYL-ALKYL-ALKYL-ACID AND OR THEIR SALT

Publications (3)

Publication Number Publication Date
SE7702052A true SE7702052A (en) 1977-08-26
SE7702052L SE7702052L (en) 1977-08-26
SE435504B SE435504B (en) 1984-10-01

Family

ID=19975777

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7702052A SE435504B (en) 1976-02-25 1977-02-24 ANALOGY PROCEDURE FOR PREPARATION OF NEW 1-NITRO-9-ALKYLAMINOALKYLAMINOACRIDINES AND SALTS THEREOF

Country Status (12)

Country Link
US (1) US4139531A (en)
JP (1) JPS52102282A (en)
BE (1) BE851846A (en)
CH (1) CH630901A5 (en)
DE (1) DE2707831C2 (en)
FR (1) FR2342066A1 (en)
GB (1) GB1528723A (en)
HU (1) HU174373B (en)
NL (1) NL7701810A (en)
PL (1) PL106752B1 (en)
SE (1) SE435504B (en)
SU (2) SU719498A3 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335244A (en) * 1979-11-30 1982-06-15 Bristol-Myers Company Monolactate salts of 4'-(9-acridinylamino)methanesulfon-m-anisidide
PL126407B1 (en) * 1980-04-23 1983-07-30 Politechnika Gdanska Process for preparing 1-nitro-9-hydroxyalkylaminoacridines or their salts
HU186383B (en) * 1981-02-27 1985-07-29 Biogal Gyogyszergyar Process for producing new citostatic amni-acridie-alpha, beta-bracket-d-bracket closed, or aracket-l-bracket closed-n-glycoside derivatives and salts
JPS57183452U (en) * 1981-05-12 1982-11-20
US4555572A (en) * 1983-07-19 1985-11-26 Warner-Lambert Company Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use
US4621086A (en) * 1983-07-19 1986-11-04 Warner-Lambert Company Method of treating leukemia with pyrazolo[3,4,5-kl]acridines
US4588730A (en) * 1984-06-15 1986-05-13 Warner-Lambert Company Pyrazolo[3,4,5-k1]acridine compositions and methods for their use as antimicrobials
EP1484060A3 (en) * 1998-12-02 2005-02-09 Pfizer Products Inc. Methods and compositions for restoring conformational stability of a protein of the p53 family
DE60143023D1 (en) * 2000-02-18 2010-10-21 New York Medical College Valha TUMOR-INHIBITING NITROACRIDINE COMPOSITIONS
EP1257538B1 (en) * 2000-02-18 2010-09-08 New York Medical College 9-alkylamino-1-nitroacridine derivatives
US6589961B2 (en) 2000-02-18 2003-07-08 New York Medical College 9-alkylamino-1-nitroacridine derivatives
FR2807039A1 (en) * 2000-03-31 2001-10-05 Adir NOVEL PROCESS FOR THE PREPARATION OF 11-AMINO-3-CHLORO-6,11-DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO [c, f] [1,2] -THIAZEPINE AND APPLICATION TO THE SYNTHESIS OF TIANEPTINE
EP3070078B1 (en) * 2015-03-20 2017-10-04 Politechnika Gdanska Asymmetric bis-acridines with antitumor activity and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1962277A (en) * 1927-01-11 1934-06-12 Winthrop Chem Co Inc Basic nitroderivatives of 9-aminoacridines and process for preparing the same
DE1620473C3 (en) 1964-05-25 1980-03-20 Starogardzkie Zaklady Farmaceutyczne Polfa Przedsiebiorstwo Panstwowe, Starogard Gdanski (Polen) Process for the preparation of 1-nitro-9- (3'-dimethylaminopropylamino) acridine dihydrochloride
CH517096A (en) * 1968-08-31 1971-12-31 Starogardzkie Zakl Farma Process for the production of new, biologically active 1-nitro-9- (dialkyl-aminoalkylamino) -akridine-N10-oxides
US3897435A (en) * 1968-08-31 1975-07-29 Starogadzkie Zaklady Farmaceut N-oxides of 1 -nitro-9-dialkylaminoalkylamino/acridine

Also Published As

Publication number Publication date
DE2707831A1 (en) 1977-09-01
FR2342066A1 (en) 1977-09-23
DE2707831C2 (en) 1983-02-03
SU719498A3 (en) 1980-02-29
SE435504B (en) 1984-10-01
BE851846A (en) 1977-06-16
CH630901A5 (en) 1982-07-15
GB1528723A (en) 1978-10-18
SU718009A3 (en) 1980-02-25
PL106752B1 (en) 1980-01-31
FR2342066B1 (en) 1979-07-20
JPS52102282A (en) 1977-08-27
PL187520A1 (en) 1978-11-06
HU174373B (en) 1979-12-28
SE7702052L (en) 1977-08-26
US4139531A (en) 1979-02-13
NL7701810A (en) 1977-08-29
JPS556630B2 (en) 1980-02-18

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