FR2406632A1 - Procede pour la preparation d'une 7-chloro-5-(2-chlorophenyl)-benzodiazepinone - Google Patents
Procede pour la preparation d'une 7-chloro-5-(2-chlorophenyl)-benzodiazepinoneInfo
- Publication number
- FR2406632A1 FR2406632A1 FR7829494A FR7829494A FR2406632A1 FR 2406632 A1 FR2406632 A1 FR 2406632A1 FR 7829494 A FR7829494 A FR 7829494A FR 7829494 A FR7829494 A FR 7829494A FR 2406632 A1 FR2406632 A1 FR 2406632A1
- Authority
- FR
- France
- Prior art keywords
- dichloro
- hydrazine
- chlorophenyl
- chloro
- phthalimidoglycine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LETCTUWBYIAROG-UHFFFAOYSA-N 7-chloro-5-(2-chlorophenyl)-1,2-benzodiazepin-3-one Chemical compound C12=CC(Cl)=CC=C2N=NC(=O)C=C1C1=CC=CC=C1Cl LETCTUWBYIAROG-UHFFFAOYSA-N 0.000 title 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- KWZYIAJRFJVQDO-UHFFFAOYSA-N (2-amino-5-chlorophenyl)-(2-chlorophenyl)methanone Chemical compound NC1=CC=C(Cl)C=C1C(=O)C1=CC=CC=C1Cl KWZYIAJRFJVQDO-UHFFFAOYSA-N 0.000 abstract 3
- QFNOPRGOBNBRAX-UHFFFAOYSA-N 2-[(1,3-dioxoisoindol-2-yl)amino]acetic acid Chemical compound C1=CC=C2C(=O)N(NCC(=O)O)C(=O)C2=C1 QFNOPRGOBNBRAX-UHFFFAOYSA-N 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- IFRGISXBQCGGSZ-UHFFFAOYSA-N (6-amino-3,6-dichlorocyclohexa-2,4-dien-1-yl)-phenylmethanone Chemical compound NC1(Cl)C=CC(Cl)=CC1C(=O)C1=CC=CC=C1 IFRGISXBQCGGSZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- CHIFCDOIPRCHCF-UHFFFAOYSA-N delorazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl CHIFCDOIPRCHCF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT28738/77A IT1087017B (it) | 1977-10-18 | 1977-10-18 | Processo per la preparazione di un 7-cloro-5-(2-clorofenil)-benzodiaze pinone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2406632A1 true FR2406632A1 (fr) | 1979-05-18 |
| FR2406632B1 FR2406632B1 (https=) | 1982-06-18 |
Family
ID=11224094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7829494A Granted FR2406632A1 (fr) | 1977-10-18 | 1978-10-17 | Procede pour la preparation d'une 7-chloro-5-(2-chlorophenyl)-benzodiazepinone |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4511510A (https=) |
| JP (1) | JPS5479293A (https=) |
| AU (1) | AU518253B2 (https=) |
| CH (1) | CH635830A5 (https=) |
| DE (1) | DE2845417A1 (https=) |
| EG (1) | EG13476A (https=) |
| FR (1) | FR2406632A1 (https=) |
| GB (1) | GB2006206B (https=) |
| IT (1) | IT1087017B (https=) |
| MX (1) | MX5106E (https=) |
| NZ (1) | NZ188656A (https=) |
| PH (1) | PH14286A (https=) |
| YU (1) | YU40535B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872053B2 (en) * | 1997-05-05 | 2005-03-29 | King Of Fans | Quick install blade arms for ceiling fans |
| DK3324977T3 (da) | 2015-07-22 | 2022-10-17 | Enanta Pharm Inc | Benzodiazepinderivater som rsv-inhibitorer |
| EP3402799B1 (en) | 2016-01-15 | 2022-05-04 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| CN110809472B (zh) | 2017-02-16 | 2023-05-23 | 英安塔制药有限公司 | 用于制备苯二氮䓬衍生物的方法 |
| WO2018226801A1 (en) | 2017-06-07 | 2018-12-13 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as rsv inhibitors |
| WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| BR112020006334A2 (pt) | 2017-09-29 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | combinação de agentes farmacêuticos como inibidores de rsv |
| US10647711B2 (en) | 2017-11-13 | 2020-05-12 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as RSV inhibitors |
| CA3080138A1 (en) * | 2017-11-13 | 2019-05-16 | Enanta Pharmaceuticals, Inc. | Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives |
| WO2019199908A1 (en) | 2018-04-11 | 2019-10-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| BR112021018335A2 (pt) | 2019-03-18 | 2021-11-23 | Enanta Pharm Inc | Derivados de benzodiazepina como inibidores de rsv |
| WO2020210246A1 (en) | 2019-04-09 | 2020-10-15 | Enanta Pharmaceuticals, Inc, | Heterocyclic compounds as rsv inhibitors |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| US12612412B2 (en) | 2021-02-26 | 2026-04-28 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| WO2023211997A1 (en) | 2022-04-27 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1695992A1 (de) * | 1967-04-24 | 1971-05-19 | Dresden Arzneimittel | Verfahren zur Herstellung von 1,4-Benzodiazepinen |
| DE2159920A1 (de) * | 1970-12-21 | 1972-06-29 | Laboratoires Pharmedical S.A., Luxemburg | Verfahren zur Herstellung von substituierten 5-Phenyl-3-H-l,4-benzodiazepinen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1063891A (en) * | 1964-01-14 | 1967-04-05 | Delmar Chem | Method for preparation of benzodiazepinones |
| US3781390A (en) * | 1969-01-22 | 1973-12-25 | Schlegel Mfg Co | Continuous molding method |
-
1977
- 1977-10-18 IT IT28738/77A patent/IT1087017B/it active
-
1978
- 1978-10-11 GB GB7840206A patent/GB2006206B/en not_active Expired
- 1978-10-15 EG EG603/78A patent/EG13476A/xx active
- 1978-10-16 AU AU40727/78A patent/AU518253B2/en not_active Expired
- 1978-10-16 YU YU2421/78A patent/YU40535B/xx unknown
- 1978-10-16 NZ NZ188656A patent/NZ188656A/xx unknown
- 1978-10-17 FR FR7829494A patent/FR2406632A1/fr active Granted
- 1978-10-17 CH CH1074278A patent/CH635830A5/de not_active IP Right Cessation
- 1978-10-18 JP JP12747078A patent/JPS5479293A/ja active Granted
- 1978-10-18 US US05/952,397 patent/US4511510A/en not_active Expired - Lifetime
- 1978-10-18 MX MX787475U patent/MX5106E/es unknown
- 1978-10-18 DE DE19782845417 patent/DE2845417A1/de active Granted
- 1978-10-18 PH PH21713A patent/PH14286A/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1695992A1 (de) * | 1967-04-24 | 1971-05-19 | Dresden Arzneimittel | Verfahren zur Herstellung von 1,4-Benzodiazepinen |
| DE2159920A1 (de) * | 1970-12-21 | 1972-06-29 | Laboratoires Pharmedical S.A., Luxemburg | Verfahren zur Herstellung von substituierten 5-Phenyl-3-H-l,4-benzodiazepinen |
Non-Patent Citations (1)
| Title |
|---|
| CA1975 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5479293A (en) | 1979-06-25 |
| PH14286A (en) | 1981-04-29 |
| MX5106E (es) | 1983-03-16 |
| YU40535B (en) | 1986-02-28 |
| NZ188656A (en) | 1981-02-11 |
| JPS6212223B2 (https=) | 1987-03-17 |
| DE2845417C2 (https=) | 1987-11-12 |
| FR2406632B1 (https=) | 1982-06-18 |
| YU242178A (en) | 1983-01-21 |
| GB2006206B (en) | 1982-01-06 |
| IT1087017B (it) | 1985-05-31 |
| US4511510A (en) | 1985-04-16 |
| GB2006206A (en) | 1979-05-02 |
| EG13476A (en) | 1981-12-31 |
| CH635830A5 (de) | 1983-04-29 |
| AU518253B2 (en) | 1981-09-24 |
| DE2845417A1 (de) | 1979-04-19 |
| AU4072778A (en) | 1980-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2406632A1 (fr) | Procede pour la preparation d'une 7-chloro-5-(2-chlorophenyl)-benzodiazepinone | |
| Sanna et al. | Synthesis and antitubercular activity of 3-aryl substituted-2-(1H (2H) benzotriazol-1 (2)-yl) acrylonitriles | |
| Ghosh et al. | Potential antileukemic and immunosuppressive drugs. 3. Effects of homocyclic ring substitution on the in vitro drug activity of 4-nitrobenzo-2, 1, 3-oxadiazoles (4-nitrobenzofurazans) and their N-oxides (4-nitrobenzofuroxans) | |
| US5229519A (en) | Process for preparing 2-halo-5-halomethylpyridines | |
| POPP et al. | Synthesis of 3-Hydroxypyridines. II. Preparation of Unsaturated Cyano Esters and Their Reaction with Diazomethane1-3 | |
| Luly et al. | Routes to mitomycins. An improved synthesis of 7-methoxymitosene using palladium catalysis | |
| US4086242A (en) | 1H- and 2H-Benzotriazoles | |
| FR2479821A1 (fr) | Derives de n4-carbamoylpiperazinopropanol utiles pour leur activite de b-blocage d'adrenaline | |
| US3822285A (en) | 9-(ypsilon-aminopropyl)-3-aminocarbazole | |
| US3975398A (en) | 9-Substituted 3-aminocarbazole compounds | |
| US3992395A (en) | Process for the preparation of chlorinated phenylhydroxylamines | |
| Diana et al. | Antiviral activity of some. beta.-diketones. 3. Aryl bis (. beta.-diketones). Antiherpetic activity | |
| US4419355A (en) | Condensed as-triazine derivatives and method of using the same | |
| Kobayashi et al. | 1, 3-Dipolar cycloaddition reaction of trifluoroacetonitrile with heterocyclic ylides | |
| Rowland et al. | On the Stereochemistry of Diaryl-Substituted Cyclohexanones Formed by Michael Reactions. Trans to Cis Isomerization of Their Ketals under Basic Conditions | |
| US3988208A (en) | 9-Substituted 3-aminocarbazole compounds and test strip indicator compositions | |
| US3849434A (en) | Process for preparing triazolobenzodiazepines | |
| Akiba et al. | Wittig-horner reaction of a phosphonate of reissert analogue a new method for introduction of alkyl groups into isoquinoline | |
| NO132800B (https=) | ||
| US4895947A (en) | Process for producing 1-acyl-2-pyrazoline derivative | |
| Allen Jr et al. | Papaverine: An attempted Rügheimer synthesis | |
| Stowell et al. | Synthesis of 2, 2', 6, 6'-tetramethylazobenzene and the azodioxy and azoxy compounds | |
| US4193922A (en) | Substituted-1,2,4-oxadiazolidine-3-one derivatives | |
| JPH0220638B2 (https=) | ||
| Vaughan | Triazine Intermediates in the Decomposition of 1-(o-Carbethoxyphenyl)-3-(o-cyanophenyl)-triazene in Aqueous Ethanol |