FR2405957A1 - N-benzylanthracyclines et composition pharmaceutique les contenant - Google Patents

N-benzylanthracyclines et composition pharmaceutique les contenant

Info

Publication number
FR2405957A1
FR2405957A1 FR7829428A FR7829428A FR2405957A1 FR 2405957 A1 FR2405957 A1 FR 2405957A1 FR 7829428 A FR7829428 A FR 7829428A FR 7829428 A FR7829428 A FR 7829428A FR 2405957 A1 FR2405957 A1 FR 2405957A1
Authority
FR
France
Prior art keywords
benzylanthracyclines
pharmaceutical composition
composition containing
derivatives
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7829428A
Other languages
English (en)
Other versions
FR2405957B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of FR2405957A1 publication Critical patent/FR2405957A1/fr
Application granted granted Critical
Publication of FR2405957B1 publication Critical patent/FR2405957B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention a trait au domaine de la chimie médicale. Elle concerne des dérivés N-benzyliques et N,N-dibenzyliques de l'adriamycine et de la daunomycine, composés du type de l'anthracycline. Les nouveaux dérivés de l'invention sont doués de propriétés anticancéreuses et sont actifs, par exemple, contre la leucémie P 388 chez la souris. Les dérivés N,N-dibenzyliques se caractérisent remarquablement par une perte des propriétés de liaison à l'ADN.
FR7829428A 1977-10-17 1978-10-16 N-benzylanthracyclines et composition pharmaceutique les contenant Granted FR2405957A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84278777A 1977-10-17 1977-10-17

Publications (2)

Publication Number Publication Date
FR2405957A1 true FR2405957A1 (fr) 1979-05-11
FR2405957B1 FR2405957B1 (fr) 1981-03-20

Family

ID=25288238

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7829428A Granted FR2405957A1 (fr) 1977-10-17 1978-10-16 N-benzylanthracyclines et composition pharmaceutique les contenant

Country Status (6)

Country Link
JP (1) JPS5470255A (fr)
CA (1) CA1111028A (fr)
DE (1) DE2844993A1 (fr)
FR (1) FR2405957A1 (fr)
GB (1) GB2007645B (fr)
IT (1) IT1109281B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2571966A1 (fr) * 1984-10-22 1986-04-25 Erba Farmitalia Compositions therapeutiques contenant des anthracyclines-glucosides.
FR2585569A1 (fr) * 1985-08-02 1987-02-06 Erba Farmitalia Solutions injectables, pretes a l'emploi, contenant un agent antitumeur du type anthracycline-glucoside
FR2607702A1 (fr) * 1986-12-05 1988-06-10 Erba Farmitalia Solutions injectables pretes a l'emploi contenant un agent anti-tumeur du type anthracycline-glucoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US6284738B1 (en) 1985-08-02 2001-09-04 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL124284B1 (en) * 1979-10-17 1983-01-31 Politechnika Gdanska Process for preparing n-glycosyl derivatives of antibiotics from anthracyclines group
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
SE0401066D0 (sv) * 2004-04-22 2004-04-22 Stefan Sjoeberg Chemical Derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/72 *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2571966A1 (fr) * 1984-10-22 1986-04-25 Erba Farmitalia Compositions therapeutiques contenant des anthracyclines-glucosides.
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
FR2585569A1 (fr) * 1985-08-02 1987-02-06 Erba Farmitalia Solutions injectables, pretes a l'emploi, contenant un agent antitumeur du type anthracycline-glucoside
US7005421B2 (en) 1985-08-02 2006-02-28 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US6632799B2 (en) 1985-08-02 2003-10-14 Upjohn Co Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US6596697B2 (en) 1985-08-02 2003-07-22 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US6284738B1 (en) 1985-08-02 2001-09-04 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US6087340A (en) * 1985-08-02 2000-07-11 Pharmacia & Upjohn, Inc. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
EP0273603A3 (en) * 1986-12-05 1988-07-20 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
EP0659435A1 (fr) * 1986-12-05 1995-06-28 PHARMACIA S.p.A. Solutions injectables prêtes à l'emploi contenant un agent anti-tumeur du type anthracycline-glucoside
EP0438183A1 (fr) * 1986-12-05 1991-07-24 PHARMACIA S.p.A. Solutions injectables prêtes à l'emploi contenant un agent anti-tumeur du type anthracycline-glucoside
EP1283044A2 (fr) * 1986-12-05 2003-02-12 Pharmacia Italia S.p.A. Solutions injectables prêtes à l'emploi qui contiennent un anthracycline glycoside anti-tumeur
EP1283044A3 (fr) * 1986-12-05 2003-05-14 Pharmacia Italia S.p.A. Solutions injectables prêtes à l'emploi qui contiennent un anthracycline glycoside anti-tumeur
BE1000540A5 (fr) * 1986-12-05 1989-01-24 Erba Carlo Spa Solutions injectables pretes a l'emploi contenant un agent antitumeur du type anthracycline-glucoside.
EP0273603A2 (fr) * 1986-12-05 1988-07-06 FARMITALIA CARLO ERBA S.r.l. Solutions injectables prêtes à l'emploi contenant un agent antitumeur du type anthracycline glucoside
FR2607702A1 (fr) * 1986-12-05 1988-06-10 Erba Farmitalia Solutions injectables pretes a l'emploi contenant un agent anti-tumeur du type anthracycline-glucoside

Also Published As

Publication number Publication date
IT1109281B (it) 1985-12-16
JPS5470255A (en) 1979-06-05
IT7851494A0 (it) 1978-10-13
CA1111028A (fr) 1981-10-20
GB2007645B (en) 1982-05-12
DE2844993A1 (de) 1979-04-19
FR2405957B1 (fr) 1981-03-20
JPS6320839B2 (fr) 1988-04-30
GB2007645A (en) 1979-05-23

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